CA2065299A1 - Direct radiolabeling of antibodies and other proteins with technetium or rhenium - Google Patents
Direct radiolabeling of antibodies and other proteins with technetium or rheniumInfo
- Publication number
- CA2065299A1 CA2065299A1 CA002065299A CA2065299A CA2065299A1 CA 2065299 A1 CA2065299 A1 CA 2065299A1 CA 002065299 A CA002065299 A CA 002065299A CA 2065299 A CA2065299 A CA 2065299A CA 2065299 A1 CA2065299 A1 CA 2065299A1
- Authority
- CA
- Canada
- Prior art keywords
- addition
- accomplished
- technetium
- rhenium
- radiolabeling
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Proteins containing one or more disulfide bonds are radiolabeled with radionuclides of technetium or rhenium for use in diagnosis and treatment of a variety of pathologic conditions. Radiolabeling is accomplished by partial reduction of the disulfide bonds of he protein using Sn (II), or using other seducing agents followed by the addition of Sn (II), removal of excess reducing agent and reduction by-products; and addition of a specified amount of pertechnetate or perrhenate reducing agent, such as stan-nous tartrate; with the addition accomplished in such a manner that further reduction of the protein is limited. The,resulting pro-duct may be stored frozen or lyophilized, with radiolabeling accomplished by the addition of pertechnetate ar perrhenate solu-tion.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/391,474 US5078985A (en) | 1989-08-09 | 1989-08-09 | Radiolabeling antibodies and other proteins with technetium or rhenium by regulated reduction |
US07/391,474 | 1989-08-09 | ||
PCT/US1990/004461 WO1991001754A1 (en) | 1989-08-09 | 1990-08-08 | Direct radiolabeling of antibodies and other proteins with technetium or rhenium |
US07/565,275 US5102990A (en) | 1989-08-09 | 1990-08-08 | Direct radiolabeling of antibodies and other proteins with technetium or rhenium |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2065299A1 true CA2065299A1 (en) | 1991-02-10 |
CA2065299C CA2065299C (en) | 2001-07-24 |
Family
ID=27013516
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002065299A Expired - Fee Related CA2065299C (en) | 1989-08-09 | 1990-08-08 | Direct radiolabeling of antibodies and other proteins with technetium or rhenium |
Country Status (10)
Country | Link |
---|---|
US (3) | US5102990A (en) |
EP (1) | EP0486622B1 (en) |
JP (2) | JP3070763B2 (en) |
AT (1) | ATE172879T1 (en) |
AU (1) | AU650629B2 (en) |
CA (1) | CA2065299C (en) |
DE (1) | DE69032742T2 (en) |
DK (1) | DK0486622T3 (en) |
ES (1) | ES2125854T3 (en) |
WO (1) | WO1991001754A1 (en) |
Families Citing this family (128)
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-
1990
- 1990-08-08 ES ES90915377T patent/ES2125854T3/en not_active Expired - Lifetime
- 1990-08-08 DE DE69032742T patent/DE69032742T2/en not_active Expired - Fee Related
- 1990-08-08 US US07/565,275 patent/US5102990A/en not_active Ceased
- 1990-08-08 WO PCT/US1990/004461 patent/WO1991001754A1/en active IP Right Grant
- 1990-08-08 AT AT90915377T patent/ATE172879T1/en not_active IP Right Cessation
- 1990-08-08 AU AU65434/90A patent/AU650629B2/en not_active Ceased
- 1990-08-08 JP JP2514313A patent/JP3070763B2/en not_active Expired - Fee Related
- 1990-08-08 DK DK90915377T patent/DK0486622T3/en active
- 1990-08-08 CA CA002065299A patent/CA2065299C/en not_active Expired - Fee Related
- 1990-08-08 EP EP90915377A patent/EP0486622B1/en not_active Expired - Lifetime
-
1992
- 1992-04-06 US US07/864,470 patent/US5277893A/en not_active Expired - Lifetime
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1995
- 1995-02-16 US US08/389,269 patent/USRE35500E/en not_active Expired - Lifetime
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1999
- 1999-08-11 JP JP11227755A patent/JP2000053590A/en active Pending
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DK0486622T3 (en) | 1999-07-19 |
JP2000053590A (en) | 2000-02-22 |
WO1991001754A1 (en) | 1991-02-21 |
EP0486622A4 (en) | 1992-08-12 |
DE69032742T2 (en) | 1999-06-17 |
EP0486622B1 (en) | 1998-11-04 |
AU650629B2 (en) | 1994-06-30 |
ATE172879T1 (en) | 1998-11-15 |
US5102990A (en) | 1992-04-07 |
CA2065299C (en) | 2001-07-24 |
AU6543490A (en) | 1991-03-11 |
DE69032742D1 (en) | 1998-12-10 |
JPH05508699A (en) | 1993-12-02 |
EP0486622A1 (en) | 1992-05-27 |
US5277893A (en) | 1994-01-11 |
ES2125854T3 (en) | 1999-03-16 |
JP3070763B2 (en) | 2000-07-31 |
USRE35500E (en) | 1997-05-06 |
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