CA2186764A1 - High-alkaline protease and its use - Google Patents
High-alkaline protease and its useInfo
- Publication number
- CA2186764A1 CA2186764A1 CA002186764A CA2186764A CA2186764A1 CA 2186764 A1 CA2186764 A1 CA 2186764A1 CA 002186764 A CA002186764 A CA 002186764A CA 2186764 A CA2186764 A CA 2186764A CA 2186764 A1 CA2186764 A1 CA 2186764A1
- Authority
- CA
- Canada
- Prior art keywords
- protease
- alkaline protease
- subtilisin
- compositions
- industrial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091005804 Peptidases Proteins 0.000 title abstract 5
- 239000004365 Protease Substances 0.000 title abstract 5
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 title abstract 4
- 102000035195 Peptidases Human genes 0.000 abstract 1
- 108090000787 Subtilisin Proteins 0.000 abstract 1
- 108010020132 microbial serine proteinases Proteins 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
- C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/39—Organic or inorganic per-compounds
Abstract
The invention relates to a novel high-alkaline protease, its use in the industrial or domestic fields and also compositions for said uses containing this protease. The protease of the invention is a selected triple mutant derived from certain precursor proteases from the subtilisin group, especially of the "subtilisin 309" type.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEP4411223.8 | 1994-03-31 | ||
DE4411223A DE4411223A1 (en) | 1994-03-31 | 1994-03-31 | Use of alkaline proteases in commercial textile washing processes |
PCT/EP1995/001141 WO1995027049A1 (en) | 1994-03-31 | 1995-03-27 | High-alkaline protease and its use |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2186764A1 true CA2186764A1 (en) | 1995-10-12 |
CA2186764C CA2186764C (en) | 2005-08-09 |
Family
ID=6514333
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002186764A Expired - Lifetime CA2186764C (en) | 1994-03-31 | 1995-03-27 | High-alkaline protease and its use |
CA002146063A Expired - Lifetime CA2146063C (en) | 1994-03-31 | 1995-03-31 | Use of alkaline proteases in industrial textile washing processes |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002146063A Expired - Lifetime CA2146063C (en) | 1994-03-31 | 1995-03-31 | Use of alkaline proteases in industrial textile washing processes |
Country Status (13)
Country | Link |
---|---|
US (3) | US6190904B1 (en) |
EP (2) | EP0753058B1 (en) |
JP (2) | JPH10505741A (en) |
CN (1) | CN1148406A (en) |
AT (2) | ATE269404T1 (en) |
AU (2) | AU710223B2 (en) |
BR (2) | BR9507237A (en) |
CA (2) | CA2186764C (en) |
DE (3) | DE4411223A1 (en) |
DK (2) | DK0753058T3 (en) |
FI (2) | FI116681B (en) |
NZ (1) | NZ282821A (en) |
WO (1) | WO1995027049A1 (en) |
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4411223A1 (en) * | 1994-03-31 | 1995-10-05 | Solvay Enzymes Gmbh & Co Kg | Use of alkaline proteases in commercial textile washing processes |
DE19535082A1 (en) | 1995-09-21 | 1997-03-27 | Henkel Ecolab Gmbh & Co Ohg | Paste-like detergent and cleaning agent |
JP4030603B2 (en) * | 1995-11-02 | 2008-01-09 | ノボザイムス アクティーゼルスカブ | Alkaline protease, method for producing the same, use and microorganism producing the protease |
DE19615776A1 (en) | 1996-04-20 | 1997-10-23 | Henkel Kgaa | Solubility-enhanced enzyme granules |
DE19636035A1 (en) | 1996-09-05 | 1998-03-12 | Henkel Ecolab Gmbh & Co Ohg | Paste-like detergent and cleaning agent |
JP2001503269A (en) | 1996-11-04 | 2001-03-13 | ノボ ノルディスク アクティーゼルスカブ | Subtilase variants and compositions |
BR9712473B1 (en) | 1996-11-04 | 2009-08-11 | subtilase variants and compositions. | |
ATE371052T1 (en) * | 1996-12-04 | 2007-09-15 | Novozymes North America Inc | ALKALINE ENZYMATIC BOILING OF COTTON TEXTILES |
DE19703364A1 (en) | 1997-01-30 | 1998-08-06 | Henkel Ecolab Gmbh & Co Ohg | Paste-like detergent and cleaning agent |
EP1009815B1 (en) | 1997-08-29 | 2008-01-30 | Novozymes A/S | Protease variants and compositions |
BR9811412A (en) | 1997-08-29 | 2000-08-22 | Novo Nordisk As | Subtilase enzyme variant having improved detergent washing performance, isolated DNA sequence, expression vector, microbial host cell, processes for producing a variant and for identifying a protease variant, composition, and, use of a subtilase variant |
ES2367505T3 (en) * | 1997-10-23 | 2011-11-04 | Danisco Us Inc. | PROTEASE VARIANTS WITH MULTIPLE SUBSTITUTIONS WITH ALTERED NET LOAD FOR USE IN DETERGENTS. |
US6773907B2 (en) | 1997-11-21 | 2004-08-10 | Peter Kamp Hansen | Subtilase enzymes |
US6780629B2 (en) | 1997-11-21 | 2004-08-24 | Novozymes A/S | Subtilase enzymes |
WO1999027082A1 (en) | 1997-11-21 | 1999-06-03 | Novo Nordisk A/S | Protease variants and compositions |
DE19857687A1 (en) | 1998-12-15 | 2000-06-21 | Henkel Ecolab Gmbh & Co Ohg | Pasty detergent |
EP1803817B1 (en) | 1998-12-18 | 2011-04-06 | Novozymes A/S | Subtilase enzymes of the I-S1 and I-S2 sub-groups having an additional amino acid residue in an active site loop region |
DE19904512A1 (en) | 1999-02-04 | 2000-08-17 | Henkel Ecolab Gmbh & Co Ohg | Method for cleaning refillable bottles |
EP1183342B2 (en) | 1999-05-20 | 2012-06-13 | Novozymes A/S | Subtilase enzymes of the i-s1 and i-s2 sub-groups having at least one additional amino acid residue between positions 128 and 129 |
AU4392500A (en) | 1999-05-20 | 2000-12-12 | Novozymes A/S | Subtilase enzymes of the i-s1 and i-s2 sub-groups having at least one additionalamino acid residue between positions 132 and 133 |
DE60040284D1 (en) | 1999-05-20 | 2008-10-30 | Novozymes As | SUBTILASE ENZYMES OF I-S1 AND I-S2 SUB-GROUPS WITH AT LEAST ONE ADDITIONAL AMINO ACID BETWEEN POSITIONS 129 AND 130 |
ATE407201T1 (en) | 1999-05-20 | 2008-09-15 | Novozymes As | SUBTILASE ENZYMES OF THE I-S1 AND I-S2 SUBGROUPS WITH AT LEAST ONE ADDITIONAL AMINO ACID RESIDUE BETWEEN POSITIONS 126 AND 127 |
WO2000071691A1 (en) | 1999-05-20 | 2000-11-30 | Novozymes A/S | Subtilase enzymes of the i-s1 and i-s2 sub-groups having at least one additional amino acid residue between positions 125 and 126 |
DE60040285D1 (en) | 1999-05-20 | 2008-10-30 | Novozymes As | SUBTILASE ENZYMES OF I-S1 AND I-S2 SUB-GROUPS WITH AT LEAST ONE ADDITIONAL AMINO ACID BETWEEN ITEM 127 AND 128 |
US6727085B2 (en) | 1999-12-15 | 2004-04-27 | Fanoe Tina Sejersgaard | Subtilase variants having an improved wash performance on egg stains |
US6777218B1 (en) | 2000-03-14 | 2004-08-17 | Novozymes A/S | Subtilase enzymes having an improved wash performance on egg stains |
CA2406607C (en) * | 2000-04-26 | 2011-08-02 | Land O'lakes, Inc. | A method of treating soy proteins and a soy protein product produced by this method |
CN1303210C (en) * | 2000-12-29 | 2007-03-07 | 四川大学 | Detersile proteinase and its production process and usage and microbe producing the said proteinase |
US7183248B2 (en) * | 2001-08-23 | 2007-02-27 | Treyco Supply Co. | Enzymatic cleaner having high pH stability |
EP1448836A4 (en) * | 2001-11-02 | 2008-01-02 | Novozymes North America Inc | Modification of printed and dyed materials |
DE10162727A1 (en) * | 2001-12-20 | 2003-07-10 | Henkel Kgaa | New alkaline protease from Bacillus gibsonii (DSM 14391) and washing and cleaning agents containing this new alkaline protease |
DE10162728A1 (en) | 2001-12-20 | 2003-07-10 | Henkel Kgaa | New alkaline protease from Bacillus gibsonii (DSM 14393) and washing and cleaning agents containing this new alkaline protease |
DE10163883A1 (en) * | 2001-12-22 | 2003-07-10 | Henkel Kgaa | New alkaline protease from Bacillus sp. (DSM 14390) and detergents and cleaning agents containing this new alkaline protease |
DE10163884A1 (en) | 2001-12-22 | 2003-07-10 | Henkel Kgaa | New alkaline protease from Bacillus sp. (DSM 14392) and detergents and cleaning agents containing this new alkaline protease |
EP2341070A3 (en) | 2002-03-29 | 2011-10-19 | Genencor International, Inc. | Ehanced protein expression in bacillus |
BRPI0313080A2 (en) | 2002-07-30 | 2017-05-23 | Genencor Int | formulations with reduced aerosol generation |
DE10262050A1 (en) * | 2002-09-05 | 2004-09-23 | Technische Universität Dresden | Genetic variants in the MMP-2 gene as etiological factors of various diseases |
CN102766545B (en) | 2003-05-07 | 2014-08-06 | 诺维信公司 | Variant subtilisin enzymes (subtilases) |
EP1678296B1 (en) | 2003-10-23 | 2011-07-13 | Novozymes A/S | Protease with improved stability in detergents |
CA2562208A1 (en) * | 2004-04-09 | 2006-03-30 | Genencor International, Inc. | Pcka modifications and enhanced protein expression in bacillus |
US20070010416A1 (en) * | 2004-10-22 | 2007-01-11 | Novozymes A/S | Protease with improved stability in detergents |
US8137477B2 (en) * | 2005-03-22 | 2012-03-20 | Gumlink A/S | Method of cleaning a surface attached with at least one chewing gum lump |
EP2013339B1 (en) | 2006-04-20 | 2013-09-11 | Novozymes A/S | Savinase variants having an improved wash performance on egg stains |
US20080090745A1 (en) * | 2006-10-13 | 2008-04-17 | Fox Bryan P | Expression of Streptomyces subtilism inhibitor (SSI) proteins in Bacillus and Streptomyces sp. |
AU2008226792B2 (en) | 2007-03-12 | 2013-06-06 | Danisco Us Inc. | Modified proteases |
DK2147098T3 (en) | 2007-04-30 | 2013-10-14 | Danisco Us Inc | Use of protein hydrolysates for stabilizing metalloprotease detergent formulations |
DK2460823T3 (en) * | 2007-05-10 | 2014-05-05 | Danisco Us Inc | MODIFIED SECRETION SYSTEM FOR INCREASED EXPRESSION OF POLYPEPTIDES IN BACTERIA |
CN101903519B (en) | 2007-12-21 | 2013-07-31 | 丹尼斯科美国公司 | Enhanced protein production in bacillus |
JP5659143B2 (en) * | 2008-03-28 | 2015-01-28 | ダニスコ・ユーエス・インク | A method for amplifying a genetic locus in bacterial cells |
AR076941A1 (en) | 2009-06-11 | 2011-07-20 | Danisco Us Inc | BACILLUS CEPA FOR A GREATER PROTEIN PRODUCTION |
DK3095861T3 (en) * | 2010-05-06 | 2019-09-23 | Procter & Gamble | CONSUMER PRODUCTS WITH PROTEASE VARIETIES |
JP5829844B2 (en) * | 2011-06-24 | 2015-12-09 | 太邦株式会社 | Method for producing water-soluble elastin peptide |
TWI586629B (en) * | 2012-10-01 | 2017-06-11 | 羅格斯新澤西州立大學 | Precursors and transport methods for hydrothermal liquid phase sintering (hlps) |
US10179892B2 (en) | 2013-11-11 | 2019-01-15 | Ecolab Usa Inc. | Multiuse, enzymatic detergent and methods of stabilizing a use solution |
WO2015102814A1 (en) | 2013-12-31 | 2015-07-09 | Danisco Us Inc. | Enhanced protein expression |
CN107250371B (en) | 2014-12-16 | 2021-11-30 | 丹尼斯科美国公司 | Enhanced protein expression |
KR20170093247A (en) | 2014-12-19 | 2017-08-14 | 다니스코 유에스 인크. | Enhanced protein expression |
CA3035451C (en) | 2016-09-07 | 2022-06-28 | Ecolab Usa Inc. | Detergent compositions containing an enzyme stabilized by phosphonates |
CN110520520B (en) | 2017-02-24 | 2024-03-22 | 丹尼斯科美国公司 | Compositions and methods for increasing protein production in bacillus licheniformis |
EP3655537A1 (en) | 2017-08-23 | 2020-05-27 | Danisco US Inc. | Methods and compositions for efficient genetic modifications of bacillus licheniformis strains |
EP3682010A1 (en) | 2017-09-13 | 2020-07-22 | Danisco US Inc. | Modified 5'-untranslated region (utr) sequences for increased protein production in bacillus |
WO2019089898A1 (en) | 2017-11-02 | 2019-05-09 | Danisco Us Inc | Freezing point depressed solid matrix compositions for melt granulation of enzymes |
FI3735478T3 (en) | 2018-01-03 | 2023-10-26 | Danisco Us Inc | Mutant and genetically modified bacillus cells and methods thereof for increased protein production |
KR20220127844A (en) | 2020-01-15 | 2022-09-20 | 다니스코 유에스 인크. | Compositions and methods for enhancing protein production in Bacillus licheniformis |
CN117881772A (en) | 2021-08-20 | 2024-04-12 | 丹尼斯科美国公司 | Polynucleotides encoding novel nucleases, compositions thereof and methods for eliminating DNA from protein preparations |
WO2023225459A2 (en) | 2022-05-14 | 2023-11-23 | Novozymes A/S | Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
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GB1234445A (en) * | 1967-10-03 | 1971-06-03 | ||
US4594362A (en) * | 1983-07-06 | 1986-06-10 | Creative Products Resource Associates, Ltd. | Friable foam textile cleaning stick |
US4980288A (en) * | 1986-02-12 | 1990-12-25 | Genex Corporation | Subtilisin with increased thermal stability |
US5324653A (en) * | 1988-02-11 | 1994-06-28 | Gist-Brocades N.V. | Recombinant genetic means for the production of serine protease muteins |
PT89702B (en) * | 1988-02-11 | 1994-04-29 | Gist Brocades Nv | PROCESS FOR PREPARING NEW PROTEOLITIC ENZYMES AND DETERGENTS THAT CONTAINS THEM |
US5116741A (en) * | 1988-04-12 | 1992-05-26 | Genex Corporation | Biosynthetic uses of thermostable proteases |
JPH03505976A (en) * | 1989-05-17 | 1991-12-26 | アムジエン・インコーポレーテツド | Multiple mutant subtilisin |
US5665587A (en) * | 1989-06-26 | 1997-09-09 | Novo Nordisk A/S | Modified subtilisins and detergent compositions containing same |
ES2227508T3 (en) * | 1989-06-26 | 2005-04-01 | Unilever N.V. | ENZYMATIC DETERGENT COMPOSITIONS. |
DE69033388T2 (en) * | 1989-08-25 | 2000-05-11 | Henkel Research Corp | ALKALINE PROTEOLYTIC ENZYME AND METHOD FOR PRODUCING THE SAME |
DK164074C (en) * | 1989-08-25 | 1992-09-28 | Poul Ole Fanger | METHOD OF ASSESSING AIR POLLUTION AND APPARATUS FOR EXERCISING THE PROCEDURE |
DE4023458A1 (en) * | 1989-08-31 | 1991-03-07 | Kali Chemie Ag | NEW HIGH ALKALINE PROTEASES |
US5352603A (en) * | 1989-08-31 | 1994-10-04 | Kali-Chemie Ag | Highly alkaline proteases |
DK246290D0 (en) * | 1990-10-12 | 1990-10-12 | Novo Nordisk As | NEW ENZYM |
DE4106525A1 (en) * | 1991-03-01 | 1992-09-10 | Solvay Enzymes Gmbh & Co Kg | METHOD FOR IMPROVING THE STABILITY OF HIGH ALKALINE PROTEASES |
DK58591D0 (en) * | 1991-04-03 | 1991-04-03 | Novo Nordisk As | HIS UNKNOWN PROTEAS |
EP0995801A1 (en) * | 1991-07-27 | 2000-04-26 | Genencor International GmbH | Process for increasing the stability of enzymes and stabilized enzymes |
JPH0763368B2 (en) * | 1991-10-09 | 1995-07-12 | 大阪府 | Heat-resistant alkaline protease and method for producing the same |
DE69333463D1 (en) * | 1992-05-18 | 2004-05-06 | Genencor Int | Bacteria producing alkaline proteases, and process for producing these alkaline proteases |
DE4218448A1 (en) * | 1992-06-04 | 1993-12-09 | Solvay Enzymes Gmbh & Co Kg | Alkaline proteases from Bacillus pumilus |
DE4219104A1 (en) * | 1992-06-11 | 1993-12-16 | Solvay Enzymes Gmbh & Co Kg | Alkaline protease from Bacillus sp. MF12, a process for their preparation and their use |
AU682314B2 (en) * | 1992-07-17 | 1997-10-02 | Genencor International, Inc. | High alkaline serine proteases |
DE4304161A1 (en) * | 1993-02-12 | 1994-08-25 | Solvay Enzymes Gmbh & Co Kg | Improved highly alkaline proteases |
DE4411223A1 (en) * | 1994-03-31 | 1995-10-05 | Solvay Enzymes Gmbh & Co Kg | Use of alkaline proteases in commercial textile washing processes |
US6599730B1 (en) * | 1994-05-02 | 2003-07-29 | Procter & Gamble Company | Subtilisin 309 variants having decreased adsorption and increased hydrolysis |
-
1994
- 1994-03-31 DE DE4411223A patent/DE4411223A1/en not_active Withdrawn
-
1995
- 1995-03-27 AT AT95913164T patent/ATE269404T1/en not_active IP Right Cessation
- 1995-03-27 EP EP95913164A patent/EP0753058B1/en not_active Expired - Lifetime
- 1995-03-27 DE DE59510341T patent/DE59510341D1/en not_active Expired - Lifetime
- 1995-03-27 EP EP95104454A patent/EP0686692B1/en not_active Expired - Lifetime
- 1995-03-27 DK DK95913164T patent/DK0753058T3/en active
- 1995-03-27 BR BR9507237A patent/BR9507237A/en not_active Application Discontinuation
- 1995-03-27 US US08/716,293 patent/US6190904B1/en not_active Expired - Lifetime
- 1995-03-27 JP JP7525398A patent/JPH10505741A/en active Pending
- 1995-03-27 AU AU20731/95A patent/AU710223B2/en not_active Ceased
- 1995-03-27 DK DK95104454T patent/DK0686692T3/en active
- 1995-03-27 CA CA002186764A patent/CA2186764C/en not_active Expired - Lifetime
- 1995-03-27 WO PCT/EP1995/001141 patent/WO1995027049A1/en active IP Right Grant
- 1995-03-27 CN CN95193076A patent/CN1148406A/en active Pending
- 1995-03-27 DE DE59510914T patent/DE59510914D1/en not_active Expired - Lifetime
- 1995-03-27 AT AT95104454T patent/ATE222947T1/en not_active IP Right Cessation
- 1995-03-27 NZ NZ282821A patent/NZ282821A/en unknown
- 1995-03-29 AU AU16175/95A patent/AU705385B2/en not_active Ceased
- 1995-03-30 FI FI951520A patent/FI116681B/en not_active IP Right Cessation
- 1995-03-31 CA CA002146063A patent/CA2146063C/en not_active Expired - Lifetime
- 1995-03-31 US US08/413,724 patent/US5880080A/en not_active Expired - Lifetime
- 1995-03-31 JP JP7076618A patent/JPH07286194A/en active Pending
- 1995-03-31 BR BR9501401A patent/BR9501401A/en not_active Application Discontinuation
-
1996
- 1996-09-25 FI FI963829A patent/FI120739B/en not_active IP Right Cessation
-
1997
- 1997-05-08 US US08/853,494 patent/US6165960A/en not_active Expired - Lifetime
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |
Effective date: 20150327 |