CA2395734A1

CA2395734A1 - Nucleic acids, proteins, and antibodies

Info

Publication number: CA2395734A1
Application number: CA002395734A
Authority: CA
Inventors: Craig A. Rosen; Steven C. Barash; Steven M. Ruben
Original assignee: Human Genome Sciences Inc
Current assignee: Individual
Priority date: 2000-01-31
Filing date: 2001-01-17
Publication date: 2001-08-02
Also published as: WO2001055368A8; WO2001055318A2; AU2001241415A1; CA2392757A1; AU2001241417A1; WO2001055328A3; WO2001055367A1; WO2001055203A8; WO2001055200A1; CA2395724A1; CA2393618A1; AU2001241413A1; CA2393652A1; CA2395666A1; WO2001055200A8; CA2398877A1; WO2001055316A8; WO2001055304A8; WO2001055302A8; AU2001241414A1

Abstract

The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Al so provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to thes e novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

Description

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Nucleic Acids, Proteins, and Antibodies [1] This application refers to a "Sequence Listing" that is provided only on electronic media in computer readable form pursuant to Administrative Instructions Section 801 (a)(i).
The Sequence Listing forms a part of this description pursuant to Rule 5.2 and Administrative Instructions Sections 801 to 806, and is hereby incorporated in its entirety.

[2] The Sequence Listing is provided as an electronic file (PTZ15PCT
seqList.txt, 1,891,228 bytes in size, created on January 13, 2001) on four identical compact discs (CD-R), labeled "COPY l," "COPY 2," "COPY 3," and "CRF." The Sequence Listing complies with Annex C of the Administrative Instructions, and may be viewed, for example, on an IBM-PC machine running the 1VIS-Windows operating system by using the V viewer software, version 2000 (see World Wide Web URL: http://www.fileviewer.com).
Field of the Invention [3] The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are -vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention.
The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
Background of the Invention [4] The Hurnan genome is estimated to contain roughly 100,000 genes, each of which plays an important function in sustaining life. Each of these roughly 100,000 genes encodes for a corresponding protein which can be classified based upon its structure and/or function.
Some proteins are secreted, while other proteins reside either as membrane associated proteins or intracellularly. Although protein sequences vary substantially, many patterns and overall properties are shared, such as, for example, amino-terminal signal sequences.

[5] Some proteins, for example secreted proteins, contain an amino-terminal signal sequence which facilitates protein transport. This amino-terminal signal sequence directs, or targets, the protein from its ribosomal assembly site to a particular cellular or extracellular location. Transport may involve any combination of several of the following steps: contact with a chaperone, unfolding, interaction with a receptor and/or a pore complex, addition of energy, and refolding. Moreover, an extracellular protein may be produced as an inactive precursor. Once the precursor has been exported, removal of the signal sequence by a signal peptidase activates the protein. Examples of some protein families that contain signal sequences include cytokines (chemokines) and hormones (growth and differentiation factors).
Computer algorithms can be generated to identify amino-terminal signal sequences.
Examples of computer programs designed to identify amino-terminal signal sequences include hidden Markov models (HMMs), statistical alternatives to FASTA and Smith Waterman algorithms, which have been used to find shared patterns, specifically consensus sequences (Pearson, W.R., and D.J. Lipman, PNAS, 85:2444-48 (1988); Smith, T.F., and M.S. Waterman, J. Mol. Biol., 147:195-97 (1981)). These algorithms are quite flexible in that they incorporate information from newly identified sequences to build even more successful patterns.

[6] Other families of proteins exist as membrane associated proteins. Examples of some of these membrane associated protein families include receptors (nuclear, transmembrane, G protein coupled, and tyrosine kinase), protein kinases, phosphatases, neuropeptides and vasomediators, G proteins, ion channels (calcium, chloride, potassium, and sodium), proteases, transporter/pumps (amino acid, sugar, protein, metal and vitamin;
calcium, phosphate, potassium, and sodium), matrix molecules (adhesion, cadherin, extracellular matrix molecules, integrin, and selectin), and regulatory proteins. Again, computer programs can aid in the discovery of these molecules. For example, Klein et al.
have developed a method ("ALOM", also called as KKD) to detect potential transmembrane segments in polypeptides (Klein, P., et al., Biochim. Piophys. Acta., 815:468 (1985)). It attempts to identify the most probable transmembrane segment from the average hydrophobicity value over a range of amino acid residues. It predicts whether the segment is a transmembrane segment (INTEGRAL) or not (PERIPHERAL), and thus can suggest membrane association of a polypeptide.

[7] Furthermore, some proteins function intracellularly, and can be identified by their structure and/or function. Computer algorithms can be adapted to aid in the identification of novel members of intracellular protein families. Examples of intracellular proteins include transcription factors, various classes of enzymes, Mitochondrial proteins, and signal transduction molecules.

[8] Descriptions of some of these proteins (e.g., receptors, hormones, and matrix proteins) and diseases associated with their dysfunction follow.
Summary of the Invention [9] The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention.
The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

Detailed Description Tables [10] Table 1A summarizes some of the polynucleotides encompassed by the invention (including cDNA clones related to the sequences (Clone ID NO:Z), contig sequences (contig identifier (Contig ID:) and contig nucleotide sequence identifier (SEQ ID
NO:X)) and further summarizes certain characteristics of these polynucleotides and the polypeptides encoded thereby. The first column provides the gene number in the application for each clone identifier. The second column provides a unique clone identifier, "Clone ID
NO:Z", for a cDNA clone related to each contig sequence disclosed in Table 1A. The third column provides a unique contig identifier, "Contig ID:" for each of the contig sequences disclosed in Table 1A. The fourth column provides the sequence identifier, "SEQ ID
NO:X", for each of the contig sequences disclosed in Table 1A. The fifth column, "ORF (From-To)", provides the location (i.e., nucleotide position numbers) within the,polynucleotide sequence of SEQ ID NO:X that delineate the preferred open reading frame (ORF) that encodes the amino acid sequence shown in the sequence listing and referenced in Table 1A
as SEQ ID
NO:Y (column 6). Column 7 lists residues comprising predicted epitopes contained in the polypeptides encoded by each of the preferred ORFs (SEQ ID NO:Y).
Identification of potential immunogenic regions was performed according to the method of Jameson and Wolf (CABIOS, 4; 181-186 (1988)); specifically, the Genetics Computer Group (GCG) implementation of this algorithm, embodied in the program PEPTIDESTRUCTURE
(Wisconsin Package v10.0, Genetics Computer Group (GCG), Madison, Wisc.). This method returns a measure of the probability that a given residue is found on the surface of the protein.
Regions where the antigenic index score is greater than 0.9 over at least 6 amino acids are indicated in Table 1A as "Predicted Epitopes". In particular embodiments, polypeptides of the invention comprise, or alternatively consist of, one, two, three, four, five or more of the predicted epitopes described in Table IA. It will be appreciated that depending on the analytical criteria used to predict antigenic determinants, the exact address of the determinant may vary slightly. Column 8, "Tissue Distribution" shows the expression profile of tissue, cells, and/or cell line libraries which express the polynucleotides of the invention. The first number in column 8 (preceding the colon), represents the tissue/cell source identifier code corresponding to the key provided in Table 4. Expression of these polynucleotides was not observed in the other tissues and/or cell libraries tested. For those identifier codes in which the first two letters are not "AR", the second number in column 8 (following the colon), represents the number of times a sequence corresponding to the reference polynucleotide sequence (e.g., SEQ ID NO:X) was identified in the tissue/cell source. Those tissue/cell source identifier codes in which the first two letters are "AR" designate information generated using DNA array technology. Utilizing this technology, cDNAs were amplified by PCR and then transferred, in duplicate, onto the array. Gene expression was assayed through hybridization of first strand cDNA probes to the DNA array. cDNA probes were generated from total RNA extracted from a variety of different tissues and cell lines.
Probe synthesis was performed in the presence of 33P dCTP, using oligo(dT) to prime reverse transcription.
After hybridization, high stringency washing conditions were employed to remove non-specific hybrids from the array. The remaining signal, emanating from each gene target, was measured using a Phosphorimager. Gene expression was reported as Phosphor Stimulating Luminescence (PSL) which reflects the level of phosphor signal generated from the probe hybridized to each of the gene targets represented on the array. A local background signal subtraction was performed before the total signal generated from each array was used to normalize gene expression between the different hybridizations. The value presented after "[array code]:" represents the mean of the duplicate values, following background subtraction and probe normalization. One of skill in the art could routinely use this information to identify normal and/or diseased tissues) which show a predominant expression pattern of the corresponding polynucleotide of the invention or to identify polynucleotides which show predominant and/or specific tissue and/or cell expression. Column 9 provides the chromosomal location of polynucleotides corresponding to SEQ ID NO:X.
Chromosomal location was determined by finding exact matches to EST and cDNA sequences contained in the NCBI (National Center for Biotechnology Information) UniGene database.
Given a presumptive chromosomal location, disease locus association was determined by comparison with the Morbid Map, derived from Online Mendelian Inheritance in Man (Online Mendelian Inheritance in Man, OMIMTM. McKusiclc-Nathans Institute for Genetic Medicine, Johns Hopkins University (Baltimore, MD) and National Center for Biotechnology Information, National Library of Medicine (Bethesda, MD) 2000. World Wide Web URL:
http://www.ncbi.nlm.nih.gov/omim/). If the putative chromosomal location of the Query overlaps with the chromosomal location of a Morbid Map entry, an OMIM
identification number is disclosed in column 10 labeled "OMIM Disease References)". A key to the OMIM reference identification numbers is provided in Table 5.

[11] Table 1B summarizes additional polynucleotides encompassed by the invention (including cDNA clones related to the sequences (Clone ID NO:Z), contig sequences (contig identifier (Contig ID:) contig nucleotide sequence identifiers (SEQ ID NO:X)), and genomic sequences (SEQ ID NO:B). The first column provides a unique clone identifier, "Clone ID
NO:Z", for a cDNA clone related to each contig sequence. The second column provides the sequence identifier, "SEQ ID NO:X", for each contig sequence. The third column provides a unique contig identifier, "Contig ID:" for each contig sequence. The fourth column, provides a BAC identifier "BAC ID NO:A" for the BAC clone referenced in the corresponding row of the table. The fifth column provides the nucleotide sequence identifier, "SEQ
ID NO:B" for a fragment of the BAC clone identified in column four of the corresponding row of the table.
The sixth column, "Exon From-To", provides the location (i.e., nucleotide position numbers) within the polynucleotide sequence of SEQ ID NO:B which delineate certain polynucleotides of the invention that are also exemplary members of polynucleotide sequences that encode polypeptides of the invention (e.g., polypeptides containing amino acid sequences encoded by the polynucleotide sequences delineated in column six, and fragments and variants thereof).

[12] Table 2 summarizes homology and features of some of the polypeptides of the invention. The first column provides a unique clone identifier, "Clone ID
NO:Z", corresponding to a cDNA clone disclosed in Table 1A. The second column provides the unique contig identifier, "Contig ID:" corresponding to contigs in Table 1A
and allowing for correlation with the information in Table 1A. The third column provides the sequence identifier, "SEQ ID NO:X", for the contig polynucleotide sequence. The fourth column provides the analysis method by which the homology/identity disclosed in the Table was determined. Comparisons were made between polypeptides encoded by the polynucleotides of the invention and either a non-redundant protein database (herein referred to as "NR"), or a database of protein families (herein referred to as "PFAM") as further described below.
The fifth column provides a description of the PFAM/NR hit having a significant match to a polypeptide of the invention. Column six provides the accession number of the PFAM/NR
hit disclosed in the fifth column. Column seven, "Score/Percent Identity", provides a quality score or the percent identity, of the hit disclosed in columns five and six.
Columns 8 and 9, "NT From" and "NT To" respectively, delineate the polynucleotides in "SEQ ID
NO:X" that encode a polypeptide having a significant match to the PFAM/NR database as disclosed in the fifth and sixth columns. In specific embodiments polypeptides of the invention comprise, or alternatively consist of, an amino acid sequence encoded by a polynucleotide in SEQ ID
NO:X as delineated in columns 8 and 9, or fragments or variants thereof.

[13] Table 3 provides polynucleotide sequences that may be disclaimed according to certain embodiments of the invention. The first column provides a unique clone identifier, "Clone ID", for a cDNA clone related to contig sequences disclosed in Table 1A. The second column provides the sequence identifier, "SEQ ID NO:X", for contig sequences disclosed in Table 1A. The third column provides the unique contig identifier, "Contig ID:", for contigs disclosed in Table 1A. The fourth column provides a unique integer 'a' where 'a' is any integer between 1 and the final nucleotide minus 15 of SEQ ID NO:X, and the fifth column provides a unique integer 'b' where 'b' is any integer between 15 and the final nucleotide of SEQ ID NO:X, where both a and b correspond to the positions of nucleotide residues shown in SEQ ID NO:X, and where b is greater than or equal to a + 14.
For each of the polynucleotides shown as SEQ ID NO:X, the uniquely defined integers can be substituted into the general formula of a-b, and used to describe polynucleotides which may be preferably excluded from the invention. In certain embodiments, preferably excluded from the invention are at least one, two, three, four, Eve, ten, or more of the polynucleotide sequences) having the accession numbers) disclosed in the sixth column of this Table (including for example, published sequence in connection with a particular BAC
clone). In further embodiments, preferably excluded from the invention are the specific polynucleotide sequences) contained in the clones corresponding to at least one, two, three, four, five, ten, or more of the available material having the accession numbers identified in the sixth column of this Table (including for example, the actual sequence contained in an identified BAC
clone).

(14] Table 4 provides a key to the tissue/cell source identifier code disclosed in Table 1A, column 8. Column 1 provides the tissue/cell source identifier code disclosed in Table 1A, Column 8. Columns 2-5 provide a description of the tissue or cell source.
Codes corresponding to diseased tissues are indicated in column 6~ with the word "disease". The use of the word "disease" in column 6 is non-limiting. The tissue or cell source may be specific (e.g. a neoplasm), or may be disease-associated (e.g., a tissue sample from a normal portion of a diseased organ). Furthermore, tissues and/or cells lacking the "disease"
designation may still be derived from sources directly or indirectly involved in a disease state or disorder, and therefore may have a further utility in that disease state or disorder. In numerous cases where the tissue/cell source is a library, column 7 identifies the vector used to generate the library.

[15] Table 5 provides a key to the OMIM reference identification numbers disclosed in Table 1A, column 10. OMIM reference identification numbers (Column 1) were derived from Online Mendelian Inheritance in Man (Online Mendelian Inheritance in Man, OMIM.
McKusick-Nathans Institute for Genetic Medicine, Johns Hopkins University (Baltimore, MD) and National Center for Biotechnology Information, National Library of Medicine, (Bethesda, MD) 2000. World Wide Web URL: http://www.ncbi.nlm.nih.gov/omim/).
Column 2 provides diseases associated with the cytologic band disclosed in Table 1A, column 9, as determined using the Morbid Map database.

[16] Table 6 summarizes ATCC Deposits, Deposit dates, and ATCC designation numbers of deposits made with the ATCC in connection with the present application.

[17] Table 7 shows the cDNA libraries sequenced, and ATCC designation numbers and vector information relating to these cDNA libraries.

[18] Table 8 provides a physical characterization of clones encompassed by the invention. The first column provides the unique clone identifier, "Clone ID
NO:Z", for certain cDNA clones of the invention, as described in Table 1A. The second column provides the size of the cDNA insert contained in the corresponding cDNA clone.
Definitions [19] The following definitions are provided to facilitate understanding of certain terms used throughout this specification.

[20] In the present invention, "isolated" refers to material removed from its original environment (e.g., the natural environment if it is naturally occurring), and thus is altered "by the hand of man" from its natural state. For example, an isolated polynucleotide could be part of a vector or a composition of matter, or could be contained within a cell, and still be "isolated" because that vector, composition of matter, or particular cell is not the original environment of the polynucleotide. The term "isolated" does not refer to genomic or cDNA
libraries, whole cell total or mRNA preparations, genomic DNA preparations (including those separated by electrophoresis and transferred onto blots), sheared whole cell genomic DNA preparations or other compositions where the art demonstrates no distinguishing features of the polynucleotide/sequences of the present invention.

[21] As used herein, a "polynucleotide" refers to a molecule having a nucleic acid sequence encoding SEQ ID NO:Y or a fragment or variant thereof; a nucleic acid sequence contained in SEQ ID NO:X (as described in column 3 of Table 1A) or the complement thereof; a cDNA sequence contained in Clone ID NO:Z (as described in column 2 of Table 1A and contained within a library deposited with the ATCC); a nucleotide sequence encoding the polypeptide encoded by a nucleotide sequence in SEQ ID NO:B as defined in column 6 of Table 1B or a fragment or variant thereof; or a nucleotide coding sequence in SEQ ID
NO:B as defined in column 6 of Table 1B or the complement thereof. For example, the polynucleotide can contain the nucleotide sequence of the full length cDNA
sequence, including the 5' and 3' untranslated sequences, the coding region, as well as fragments, epitopes, domains, and variants of the nucleic acid sequence. Moreover, as used herein, a "polypeptide" refers to a molecule having an amino acid sequence encoded by a polynucleotide of the invention as broadly defined (obviously excluding poly-Phenylalanine or poly-Lysine peptide sequences which result from translation of a polyA tail of a sequence corresponding to a cDNA).

[22] In the present invention, "SEQ ID NO:X" was often generated by overlapping sequences contained in multiple clones (contig analysis). A representative clone containing all or most of the sequence for SEQ ID NO:X is deposited at Human Genome Sciences, Inc.
(HGS) in a catalogued and archived library. As shown, for example, in column 2 of Table 1A, each clone is identified by a cDNA Clone ID (identifier generally referred to herein as Clone ID NO:Z). Each Clone ID is unique to an individual clone and the Clone ID is all the information needed to retrieve a given clone from the HGS library.
Furthermore, certain clones disclosed in this application have been deposited with the ATCC on October 5, 2000, having the ATCC designation numbers PTA 2574 and PTA 2575; and on January 5, 2001, having the depositor reference numbers TS-l, TS-2, AC-1, and AC-2. In addition to the individual cDNA clone deposits, most of the cDNA libraries from which the clones were derived were deposited at the American Type Culture Collection (hereinafter "ATCC").
Table 7 provides a list of the deposited cDNA libraries. One can use the Clone ID NO:Z to determine the library source by reference to Tables 6 and 7. Table 7 lists the deposited cDNA libraries by name and links each library to an ATCC Deposit. Library names contain four characters, for example, "HTWE." The name of a cDNA clone (Clone ID) isolated from that library begins with the same four characters, for example "HTWEP07". As mentioned below, Table 1A correlates the Clone ID names with SEQ ID NO:X. Thus, starting with an SEQ ID NO:X, one can use Tables 1, 6 and 7 to determine the corresponding Clone ID, which library it came from and which ATCC deposit the library is contained in.
Furthermore, it is possible to retrieve a given cDNA clone from the source library by techniques known in the art and described elsewhere herein. The ATCC is located at 10801 University Boulevard, Manassas, Virginia 20110-2209, USA. The ATCC deposits were made pursuant to the terms of the Budapest Treaty on the international recognition of the deposit of microorganisms for the purposes of patent procedure.

[23] In specific embodiments, the polynucleotides of the invention are at least 15, at least 30, at least 50, at least 100, at least 125, at least 500, or at least 1000 continuous nucleotides but are less than or equal to 300 kb, 200 kb, 100 kb, 50 kb, 15 kb, 10 kb, 7.Skb, 5 kb, 2.5 kb, 2.0 kb, or 1 kb, in length. In a further embodiment, polynucleotides of the invention comprise a portion of the coding sequences, as disclosed herein, but do not comprise all or a portion of any intron. In another embodiment, the polynucleotides comprising coding sequences do not contain coding sequences of a genomic flanking gene (i.e., 5' or 3' to the gene of interest in the genome). In other embodiments, the polynucleotides of the invention do not contain the coding sequence of more than 1000, 500, 250, 100, 50, 25, 20, 15, 10, 5, 4, 3, 2, or 1 genomic flanking gene(s).

[24] A "polynucleotide" of the present invention also includes those polynucleotides capable of hybridizing, under stringent hybridization conditions, to sequences contained in SEQ ID NO:X, or the complement thereof (e.g., the complement of any one, two, three, four, or more of the polynucleotide fragments described herein), the polynucleotide sequence delineated in columns 8 and 9 of Table 2 or the complement thereof, and/or cDNA sequences contained in Clone ID NO:Z (e.g., the complement of any one, two, three, four, or more of the polynucleotide fragments, or the cDNA clone within the pool of cDNA clones deposited with the ATCC, described herein), and/or the polynucleotide sequence delineated in column 6 of Table 1B or the complement thereof. "Stringent hybridization conditions"
refers to an overnight incubation at 42 degree C in a solution comprising 50% formamide, Sx SSC (750 mM NaCI, 75 mM trisodium citrate), 50 mM sodium phosphate (pH 7.6), Sx Denhardt's solution, 10% dextran sulfate, and 20 ~.g/ml denatured, sheared salmon sperm DNA, followed by washing the filters in O.lx SSC at about 65 degree C.
[25j Also contemplated are nucleic acid molecules that hybridize to the polynucleotides of the present invention at lower stringency hybridization conditions. Changes in the stringency of hybridization and signal detection are primarily accomplished through the manipulation of formamide concentration (lower percentages of formamide result in lowered stringency); salt conditions, or temperature. For example, lower stringency conditions include an overnight incubation at 37 degree C in a solution comprising 6X
SSPE (20X SSPE
= 3M NaCI; 0.2M NaH2P04; 0.02M EDTA, pH 7.4), 0.5% SDS, 30% formamide, 100 ug/ml salmon sperm blocking DNA; followed by washes at 50 degree C with 1XSSPE, 0.1%
SDS.
In addition, to achieve even lower stringency, washes performed following stringent hybridization can be done at higher salt concentrations (e.g. 5X SSC).
[26] Note that variations in the above conditions may be accomplished through the inclusion and/or substitution of alternate blocking reagents used to suppress background in hybridization experiments. Typical blocking reagents include Denhardt's reagent, BLOTTO, heparin, denatured salmon sperm DNA, and commercially available proprietary formulations.
The inclusion of specific blocking reagents may require modification of the hybridization conditions described above, due to problems with compatibility.
[27] Of course, a polynucleotide which hybridizes only to polyA+ sequences (such as any 3' terminal polyA+ tract of a cDNA shown in the sequence listing), or to a complementary stretch of T (or U) residues, would not be included in the definition of "polynucleotide," since such a polynucleotide would hybridize to any nucleic acid molecule containing a poly (A) stretch or the complement thereof (e.g., practically any double-stranded cDNA clone generated using oligo dT as a primer).
[28] The polynucleotide of the present invention can be composed of any polyribonucleotide or polydeoxribonucleotide, which may be unmodified RNA or DNA or modified RNA or DNA. For example, polynucleotides can be composed of single-and double-stranded DNA, DNA that is a mixture of single- and double-stranded regions, single-and double-stranded RNA, and RNA that is mixture of single- and double-stranded regions, hybrid molecules comprising DNA and RNA that may be single-stranded or, more typically, double-stranded or a mixture of single- and double-stranded regions. In addition, the polynucleotide can be composed of triple-stranded regions comprising RNA or DNA or both RNA and DNA. A polynucleotide may also contain one or more modified bases or DNA or RNA backbones modified for stability or for other reasons. "Modified" bases include, for example, tritylated bases and unusual bases such as inosine. A variety of modifications can be made to DNA and RNA; thus, "polynucleotide" embraces chemically, enzymatically, or metabolically modified forms.
[29] The polypeptide of the present invention can be composed of amino acids joined to each other by peptide bonds or modified peptide bonds, i.e., peptide isosteres, and may contain amino acids other than the 20 gene-encoded amino acids. The polypeptides may be modified by either natural processes, such as posttranslational processing, or by chemical modification techniques which are well known in the art. Such modifications are well described in basic texts and in more detailed monographs, as well as in a voluminous research literature. Modifications can occur anywhere in a polypeptide, including the peptide backbone, the amino acid side-chains and the amino or carboxyl termini. It will be appreciated that the same type of modification may be present in the same or varying degrees at several sites in a given polypeptide. Also, a given polypeptide may contain many types of modifications. Polypeptides may be branched, for example, as a result of ubiquitination, and they may be cyclic, with or without branching. Cyclic, branched, and branched cyclic polypeptides may result from posttranslation natural processes or may be made by synthetic methods. Modifications include acetylation, acylation, ADP-ribosylation, amidation, covalent attachment of flavin, covalent attachment of a heme moiety, covalent attachment of a nucleotide or nucleotide derivative, covalent attachment of a lipid or lipid derivative, covalent attachment of phosphotidylinositol, cross-linlcing, cyclization, disulfide bond formation, demethylation, formation of covalent cross-links, formation of cysteine, formation of pyroglutamate, formylation, gamma-carboxylation, glycosylation, GPI anchor formation, hydroxylation, iodination, methylation, myristoylation, oxidation, pegylation, proteolytic processing, phosphorylation, prenylation, racemization, selenoylation, sulfation, transfer-RNA mediated addition of amino acids to proteins such as arginylation, and ubiquitination.
(See, for instance, PROTEINS - STRUCTURE AND MOLECULAR PROPERTIES, 2nd Ed., T. E. Creighton, W. H. Freeman and Company, New Yorlc (1993);
POSTTRANSLATIONAL COVALENT MODIFICATION OF PROTEINS, B. C. Johnson, Ed., Academic Press, New York, pgs. 1-12 (1983); Seifter et al., Meth.
Enzymol. 182:626-646 (1990); Rattan et al., Ann. N.Y. Acad. Sci. 663:48-62 (1992)).
[30] "SEQ ID NO:X" refers to a polynucleotide sequence described, fox example, in Tables lAor 2, while "SEQ ID NO:Y" refers to a polypeptide sequence described in column 6 of Table 1A. SEQ ID NO:X is identified by an integer specified in column 4 of Table 1A.
The polypeptide sequence SEQ ID NO:Y is a translated open reading frame (ORF) encoded by polynucleotide SEQ ID NO:X. "Clone ID NO:Z" refers to a cDNA clone described in column 2 of Table 1A.
[31] "A polypeptide having functional activity" refers to a polypeptide capable of displaying one or more known functional activities associated with a full-length (complete) protein. Such functional activities include, but are not limited to, biological activity, antigenicity [ability to bind (or compete with a polypeptide for binding) to an anti-polypeptide antibody], immunogenicity (ability to generate antibody which binds to a specific polypeptide of the invention), ability to form multimers with polypeptides of the invention, and ability to bind to a receptor or ligand for a polypeptide.
[32j The polypeptides of the invention can be assayed for functional activity (e.g.
biological activity) using or routinely modifying assays known in the art, as well as assays described herein. Specifically, one of skill in the art may routinely assay human polypeptides (including fragments and variants) of the invention for activity using assays as described in the examples section below.
[33] "A polypeptide having biological activity" refers to a polypeptide exhibiting activity similar to, but not necessarily identical to, an activity of a polypeptide of the present invention, including mature forms, as measured in a particular biological assay, with or without dose dependency. In the case where dose dependency does exist, it need not be identical to that of the polypeptide, but rather substantially similar to the dose-dependence in a given activity as compared to the polypeptide of the present invention (i.e., the candidate polypeptide will exhibit greater activity or not more than about 25-fold less and, preferably, not more than about tenfold less activity, and most preferably, not more than about three-fold less activity relative to the polypeptide of the present invention).
[34] Table 1A summarizes some of the polynucleotides encompassed by the invention (including contig sequences (SEQ ID NO:X) and clones (Clone ID NO:Z) and further summarizes certain characteristics of these polynucleotides and the polypeptides encoded thereby.

_ __ _ _ __ U
r ., O ~

O cti y.~

U

.--a ,-~ M

''*'.' ,--i ,-, N ~ ~ ~ ~
~ M

v d' ,--i oo d~ O
OWn I~

,-~d a; o ~ ~ rx a -., a ~ ~ ,-~ o n -d o ~ ~ r M
~ N ~ M M N ' ~-, ~ x ~ d.

H O ,-i .. ~
e~ y N '"~ ''.'' ,.Q

~ N N ~

Ha rx xaooo xyo cxa xx~ a M
N gyp" ~ ~p oo N"
~ ,--r r.i ~p s~ ~ ~ ~D ~p pp s:
, ~ , ~ N Q, ,--i s., ~ f., p ~ O
a~

~ a~,~ Gh p-o" a~ C7 c~
rr~ H v~ o E-~ P-.
p_, o o o 0 0 0 0 0 0 0 ~ 0 0 .r ,,.,~ .,.yes ~ .'J '~ ~
pp Oi~' V1 "{ M Vl O
.-, ~ '~ . N ~ V1 M 00 D1 '~ ~O

O ~ ~ ' O j O ,~
.,~ O 'n ~ N

Q, C7, P~ C'7 ~
C7 x ~ Q, H ~ ~n C7 fi, U

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[35] The first column in Table 1A provides the gene number in the application corresponding to the clone identifier. The second column in Table IA provides a unique "Clone ID NO:Z" for a cDNA clone related to each contig sequence disclosed in Table 1A.
This clone ID references the cDNA clone which contains at least the 5' most sequence of the assembled contig and at least a portion of SEQ ID NO:X was determined by directly sequencing the referenced clone. The reference clone may have more sequence than described in the sequence listing or the clone may have less. In the vast majority of cases, however, the clone is believed to encode a full-length polypeptide. In the case where a clone is not full-length, a full-length cDNA can be obtained by methods described elsewhere herein.
[36] The third column in Table 1A provides a unique "Contig ID" identification for each contig sequence. The fourth column provides the "SEQ ID NO:" identifier for each of the contig polynucleotide sequences disclosed in Table 1A. The fifth column, "ORF (From-To)", provides the location (i.e., nucleotide position numbers) within the polynucleotide sequence "SEQ ID NO:X" that delineate the preferred open reading frame (ORF) shown in the sequence listing and referenced in Table 1A, column 6, as SEQ ID NO:Y.
Where the nucleotide position number "To" is lower than the nucleotide position number "From", the preferred ORF is the reverse complement of the referenced polynucleotide sequence.
[37] The sixth column in Table 1A provides the corresponding SEQ ID NO:Y for the polypeptide sequence encoded by the preferred ORF delineated in column 5. In one embodiment, the invention provides an amino acid sequence comprising, or alternatively consisting of, a polypeptide encoded by the portion of SEQ ID NO:X delineated by "ORF
(From-To)". Also provided are polynucleotides encoding such amino acid sequences and the complementary strand thereto.
[38] Column 7 in Table 1A lists residues comprising epitopes contained in the polypeptides encoded by the preferred ORF (SEQ ID NO:Y), as predicted using the algorithm of Jameson and Wolf, (1988) Comp. Appl. Biosci. 4:181-186. The Jameson-Wolf antigenic analysis was performed using the computer program PROTEAN (Version 3.11 for the Power Macintosh, DNASTAR, Inc., 1228 South Park Street Madison, WI). In specific embodiments, polypeptides of the invention comprise, or alternatively consist of, at least one, two, three, four, five or more of the predicted epitopes as. described in Table 1A. It will be appreciated that depending on the analytical criteria used to predict antigenic determinants, the exact address of the determinant may vary slightly.

[39] Column 8 in Table 1A provides an expression profile and library code:
count for each of the contig sequences (SEQ ID NO:X) disclosed in Table 1A, which can routinely be combined with the information provided in Table 4 and used to determine the tissues, cells, and/or cell line libraries which predominantly express the polynucleotides of the invention.
The first number in column 8 (preceding the colon), represents the tissue/cell source identifier code corresponding to the code and description provided in Table 4.
For those identifier codes in which the first two letters are not "AR", the second number in column 8 (following the colon) represents the number of times a sequence corresponding to the reference polynucleotide sequence was identified in the tissue/cell source.
Those tissue/cell source identifier codes in which the first two letters are "AR" designate information generated using DNA array technology. Utilizing this technology, cDNAs were amplified by PCR and then transferred, in duplicate, onto the array. Gene expression was assayed through hybridization of first strand cDNA probes to the DNA array. cDNA probes were generated from total RNA extracted from a variety of different tissues and cell lines.
Probe synthesis was performed in the presence of 33P dCTP, using oligo(dT) to prime reverse transcription.
After hybridization, high stringency washing conditions were employed to remove non-specific hybrids from the array. The remaining signal, emanating from each gene target, was measured using a Phosphorimager. Gene expression was reported as Phosphor Stimulating Luminescence (PSL) which reflects the level of phosphor signal generated from the probe hybridized to each of the gene targets represented on the array. A local background signal subtraction was performed before the total signal generated from each array was used to normalize gene expression between the different hybridizations. The value presented after "[array code]:" represents the mean of the duplicate values, following background subtraction and probe normalization. One of skill in the art could routinely use this information to identify normal and/or diseased tissues) which show a predominant expression pattern of the corresponding polynucleotide of the invention or to identify polynucleotides which show predominant and/or specific tissue and/or cell expression.
[40] Column 9 in Table 1A provides a chromosomal map location for certain polynucleotides of the invention. Chromosomal location was determined by finding exact matches to EST and cDNA sequences contained in the NCBI (National Center for Biotechnology Information) UniGene database. Each sequence in the UniGene database is assigned to a "cluster"; all of the ESTs, cDNAs, and STSs in a cluster are believed to be derived from a single gene. Chromosomal mapping data is often available for one or more sequences) in a UniGene cluster; this data (if consistent) is then applied to the cluster as a whole. Thus, it is possible to infer the chromosomal location of a new polynucleotide sequence by determining its identity with a mapped UniGene cluster.
[41] A modified version of the computer program BLASTN (Altshul et al., J.
Mol.
Biol. 215:403-410 (1990); and Gish and States, Nat. Genet. 3:266-272 (1993)) was used to search the UniGene database for EST or cDNA sequences that contain exact or near-exact matches to a polynucleotide sequence of the invention (the 'Query'). A
sequence from the UniGene database (the 'Subject') was said to be an exact match if it contained a segment of 50 nucleotides in length such that 48 of those nucleotides were in the same order as found in the Query sequence. If all of the matches that met this criteria were in the same UniGene cluster, and mapping data was available for this cluster, it is indicated in Table 1A under the heading "Cytologic Band". Where a cluster had been further localized to a distinct cytologic band, that band is disclosed; where no banding information was available, but the gene had been localized to a single chromosome, the chromosome is disclosed.
[42] Once a presumptive chromosomal location was determined for a polynucleotide of the invention, an associated disease locus was identified by comparison with a database of diseases which have been experimentally associated with genetic loci. The database used was the Morbid Map, derived from OMIMTM (supra). If the putative chromosomal location of a polynucleotide of the invention (Query sequence) was associated with a disease in the Morbid Map database, an OMIM reference identification number was noted in column 10, Table 1A, labelled "OMIM Disease References)". Table 5 is a key to the OMIM
reference identification numbers (column 1), and provides a description of the associated disease in Column 2.

Clone ID SEQ ID CONTIG BAC ID: SEQ ID EXON
A

NO:Z NO:X ID: NO:B From-To 4697-544.0 HWDAF~LO 199 947007 AC008917 739 1-107 HTTHF'21 213 921596 AC013264. 759 1-527 HNSMB24 235 971537 AC015555 766 1=61 [43) Table 1B summarizes additional polynucleotides encompassed by the invention (including cDNA clones related to the sequences (Clone ID NO:Z), contig sequences (contig identifier (Contig ID:) contig nucleotide sequence identifiers (SEQ ID NO:X)), and genomic sequences (SEQ ID NO:B). The first column provides a unique clone identifier, "Clone ID
NO:Z", for a cDNA clone related to each contig sequence. The second column provides the sequence identifier, "SEQ ID NO:X", for each contig sequence. The third column provides a unique contig identifier, "Contig ID:" for each contig sequence. The fourth column, provides a BAC identif er "BAC ID NO:A" for the BAC clone referenced in the corresponding row of the table. The fifth column provides the nucleotide sequence identifier, "SEQ
ID NO:B" for a fragment of the BAC clone identified in column four of the corresponding row of the table.
The sixth column, "Exon From-To", provides the location (i.e., nucleotide position numbers) within the polynucleotide sequence of SEQ ID NO:B which delineate certain polynucleotides of the invention that are also exemplary members of polynucleotide sequences that encode polypeptides of the invention (e.g., polypeptides containing amino acid sequences encoded by the polynucleotide sequences delineated in column six, and fragments and variants thereof).

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,~ . O _ -[44] Table 2 further characterizes certain encoded polypeptides of the invention, by providing the results of comparisons to protein and protein family databases.
The first column provides a unique clone identifier, "Clone ID NO:", corresponding to a cDNA
clone disclosed in Table 1A. The second column provides the unique contig identifier, "Contig ID:" which allows correlation with the information in Table 1A. The third column provides the sequence identifier, "SEQ ID NO:", for the contig polynucleotide sequences.
The fourth column provides the analysis method by which the homologylidentity disclosed in the Table was determined. The fifth column provides a description of the PFAM/NR hit identified by each analysis. Column six provides the accession number of the PFAM/NR
hit disclosed in the fifth column. Column seven, score/percent identity, provides a quality score or the percent identity, of the hit disclosed in column five.
Comparisons were made between polypeptides encoded by polynucleotides of the invention and a non-redundant protein database (herein referred to as "NR"), or a database of protein families (herein referred to as "PFAM"), as described below.
[45] The NR database, which comprises the NBRF PIR database, the NCBI GenPept database, and the SIB SwissProt and TrEMBL databases, was made non-redundant using the computer program nrdb2 (Warren Gish, Washington University in Saint Louis). Each of the polynucleotides shown in Table 1A, column 3 (e.g., SEQ ID NO:X or the 'Query' sequence) was used to search against the NR database. The computer program BLASTX
was used to compare a 6-frame translation of the Query sequence to the NR
database (for information about the BLASTX algorithm please see Altshul et al., J. Mol.
Biol. 215:403-410 (1990); and Gish and States, Nat. Genet. 3:266-272 (1993). A description of the sequence that is most similar to the Query sequence (the highest scoring 'Subject') is shown in column five of Table 2 and the database accession number for that sequence is provided in column six. The highest scoring 'Subject' is reported in Table 2 if (a) the estimated probability that the match occurred by chance alone is less than 1.0e-07, and (b) the match was not to a known repetitive element. BLASTX returns alignments of short polypeptide segments of the Query and Subject sequences which share a high degree of similarity; these segments are known as High-Scoring Segment Pairs or HSPs. Table 2 reports the degree of similarity between the Query and the Subject for each HSP as a percent identity in Column 7. The percent identity is determined by dividing the number of exact matches between the two aligned sequences in the HSP, dividing by the number of Query amino acids in the HSP

and multiplying by 100. The polynucleotides of SEQ ID NO:X which encode the polypeptide sequence that generates an HSP are delineated by columns 8 and 9 of Table 2.
[46] The PFAM database, PFAM version 2.1, (Sonnhammer et al., Nucl. Acids Res., 26:320-322, 1998)) consists of a series of multiple sequence aligmnents; one alignment for each protein family. Each multiple sequence alignment is converted into a probability model called a Hidden Markov Model, or HMM, that represents the position-specific variation among the sequences that make up the multiple sequence alignment (see, e.g., Durbin et al., Biological sequence analysis: probabilistic models of proteins and nucleic acids, Cambridge University Press, 1998 for the theory of HMMs). The program HMMER
version 1.8 (Sean Eddy, Washington University in Saint Louis) was used to compare the predicted protein sequence for each Query sequence (SEQ ID NO:Y in Table 1A) to each of the HMMs derived from PFAM version 2.1. A HMM derived from PFAM version 2.1 was said to be a significant match to a polypeptide of the invention if the score returned by HMMER 1.8 was greater than 0.8 times the HMMER 1.8 score obtained with the most distantly related known member of that protein family. The description of the PFAM family which shares a significant match with a polypeptide of the invention is listed in column 5 of Table 2, and the database accession number of the PFAM hit is provided in column 6.
Column 7 provides the score returned by HMMER version 1.8 for the alignment.
Columns 8 and 9 delineate the polynucleotides of SEQ ID NO:X which encode the polypeptide sequence which show a significant match to a PFAM protein family.
[47] As mentioned, columns 8 and 9 in Table 2, "NT From" and "NT To", delineate the polynucleotides of "SEQ ID NO:X" that encode a polypeptide having a significant match to the PFAM/NR database as disclosed in the fifth column. In one embodiment, the invention provides a protein comprising, or alternatively consisting of, a polypeptide encoded by the polynucleotides of SEQ ID NO:X delineated in columns 8 and 9 of Table 2.
Also provided are polynucleotides encoding such proteins, and the complementary strand thereto.
[48] The nucleotide sequence SEQ ID NO:X and the translated SEQ ID NO:Y are sufficiently accurate and otherwise suitable for a variety of uses well known in the art and described further below. For instance, the nucleotide sequences of SEQ ID NO:X
are useful for designing nucleic acid hybridization probes that will detect nucleic acid sequences contained in SEQ ID NO:X or the cDNA contained in Clone ID NO:Z.
These probes will also hybridize to nucleic acid molecules in biological samples, thereby enabling immediate applications in chromosome mapping, linkage analysis, tissue identification and/or typing, and a variety of forensic and diagnostic methods of the invention. Similarly, polypeptides identified from SEQ ID NO:Y may be used to generate antibodies which bind specifically to these polypeptides, or fragments thereof, and/or to the polypeptides encoded by the cDNA clones identified in, for example, Table 1A.
[49] Nevertheless, DNA sequences generated by sequencing reactions can contain sequencing errors. The errors exist as misidentified nucleotides, or as insertions or deletions of nucleotides in the generated DNA sequence. The erroneously inserted or deleted nucleotides cause frame shifts in the reading frames of the predicted amino acid sequence. In these cases, the predicted amino acid sequence diverges from the actual amino acid sequence, even though the generated DNA sequence may be greater than 99.9%
identical to the actual DNA sequence (for example, one base insertion or deletion in an open reading frame of over 1000 bases).
[50] Accordingly, for those applications requiring precision in the nucleotide sequence or the amino acid sequence, the present invention provides not only the generated nucleotide sequence identified as SEQ ID NO:X, and a predicted translated amino acid sequence identified as SEQ ID NO:Y, but also a sample of plasrnid DNA
containing cDNA
Clone ID NO:Z (deposited with the ATCC on October 5, 2000, and receiving ATCC
designation numbers PTA 2574 and PTA 2575; deposited with the ATCC on January 5, 2001, and having depositor reference numbers TS-l, TS-2, AC-l, and AC-2;
and/or as set forth, for example, in Table 1A, 6 and 7). The nucleotide sequence of each deposited clone can readily be determined by sequencing the deposited clone in accordance with known methods. Further, techniques known in the art can be used to verify the nucleotide sequences of SEQ ID NO:X.
[51] The predicted amino acid sequence can then be verified from such deposits.
Moreover, the amino acid sequence of the protein encoded by a particular clone can also be directly determined by peptide sequencing or by expressing the protein in a suitable host cell containing the deposited human cDNA, collecting the protein, and determining its sequence.
RACE Protocol For Recovery of Full Lehgth Geues [52] Partial cDNA clones can be made full-length by utilizing the rapid amplification of cDNA ends (RACE) procedure described in Frohman, M.A., et al., Proc. Nat'l.
Acad.

Sci. USA, 85:8998-9002 (1988). A cDNA clone missing either the 5' or 3' end can be reconstructed to include the absent base pairs extending to the translational start or stop codon, respectively. In some cases, cDNAs are missing the start codon of translation, therefor. The following briefly describes a modification of this original 5' RACE
procedure. Poly A+ or total RNA is reverse transcribed with Superscript II
(Gibco/BRL) and an antisense or complementary primer specific to the cDNA sequence. The primer is removed from the reaction with a Microcon Concentrator (Amicon). The first-strand cDNA
is then tailed with dATP and terminal deoxynucleotide transferase (Gibco/BRL).
Thus, an anchor sequence is produced which is needed for PCR amplification. The second strand is synthesized from the dA-tail in PCR buffer, Taq DNA polymerase (Perkin-Elmer Cetus), an oligo-dT primer containing three adjacent restriction sites (Xhol, SaII and CIaI) at the 5' end and a primer containing just these restriction sites. This double-stranded cDNA is PCR
amplified for 40 cycles with the same primers as well as a nested cDNA-specific antisense primer. The PCR products are size-separated on an ethidium bromide-agarose gel and the region of gel containing cDNA products the predicted size of missing protein-coding DNA
is removed. cDNA is purified from the agarose with the Magic PCR Prep kit (Promega), restriction digested with XhoI or SaII, and ligated to a plasmid such as pBluescript SI~II
(Stratagene) at XhoI and EcoRV sites. This DNA is transformed into bacteria and the plasmid clones sequenced to identify the correct protein-coding inserts.
Correct 5' ends are confirmed by comparing this sequence with the putatively identified homologue and overlap with the partial cDNA clone. Similar methods known in the art andlor commercial kits are used to amplify and recover 3' ends.
[53] Several quality-controlled kits are commercially available for purchase.
Similar reagents and methods to those above are supplied in lcit form from GibcoBRL
for both 5' and 3' RACE for recovery of full length genes. A second kit is available from Clontech which is a modification of a related technique, SLIC (single-stranded ligation to single-stranded cDNA), developed by Dumas et al., Nucleic Acids Res., 19:5227-32 (1991). The major differences in procedure are that the RNA is alkaline hydrolyzed after reverse transcription and RNA ligase is used to join a restriction site-containing anchor primer to the first-strand cDNA. This obviates the necessity for the dA-tailing reaction which results in a polyT stretch that is difficult to sequence past.
[54] An alternative to generating 5' or 3' cDNA from RNA is to use cDNA
library double-stranded DNA. An asymmetric PCR-amplified antisense cDNA strand is synthesized with an antisense cDNA-specific primer and a plasmid-anchored primer. These primers are removed and a symmetric PCR reaction is performed with a nested cDNA-specific antisense primer and the plasmid-anchored primer.
RNA Ligase Protocol FoN Gehe~atihg The 5' o~ 3' End Seque~zces To Obtain Full Length Genes [55] Once a gene of interest is identified, several methods are available for the identification of the 5' or 3' portions of the gene which may not be present in the original cDNA plasmid. These methods include, but are not limited to, filter probing, clone enrichment using specific probes and protocols similar and identical to 5' and 3' RACE.
While the full length gene may be present in the library and can be identified by probing, a useful method for generating the 5' or 3' end is to use the existing sequence information from the original cDNA to generate the missing information. A method similar to 5' RACE
is available for generating the missing 5' end of a desired full-length gene.
(This method was published by Fromont-Racine et al., Nucleic Acids Res., 21(7):1683-1684 (1993)).
Briefly, a specific RNA oligonucleotide is ligated to the 5' ends of a population of RNA
presumably containing full-length gene RNA transcript and a primer set containing a primer specific to the ligated RNA oligonucleotide and a primer specific to a known sequence of the gene of interest, is used to PCR amplify the 5' portion of the desired full length gene which may then be sequenced and used to generate the full length gene. This method starts with total RNA isolated from the desired source, poly A RNA may be used but is not a prerequisite for this procedure. The RNA preparation may then be treated with phosphatase if necessary to eliminate 5' phosphate groups on degraded or damaged RNA which may interfere with the later RNA ligase step. The phosphatase if used is then inactivated and the RNA is treated with tobacco acid pyrophosphatase in order to remove the cap structure present at the 5' ends of messenger RNAs. This reaction leaves a 5' phosphate group at the 5' end of the cap cleaved RNA which can then be ligated to an RNA
oligonucleotide using T4 RNA ligase. This modified RNA preparation can then be used as a template for first strand cDNA synthesis using a gene specific oligonucleotide. The first strand synthesis -reaction can then be used as a template for PCR amplification of the desired 5' end using a primer specific to the ligated RNA oligonucleotide and a primer specific to the known sequence of the gene of interest. The resultant product is then sequenced and analyzed to confirm that the 5' end sequence belongs to the relevant gene.

[56] The present invention also relates to vectors or plasmids which include such DNA sequences, as well as the use of the DNA sequences. The material deposited with the ATCC (deposited with the ATCC on October 5, 2000, and receiving ATCC
designation numbers PTA 2574 and PTA 2575; deposited with the ATCC on January 5, 2001, and receiving ATCC designation numbers TS-l, TS-2, AC-l, and AC-2; and/or as set forth, for example, in Table 1A, Table 6, or Table 7) is a mixture of cDNA clones derived from a variety of human tissue and cloned in either a plasmid vector or a phage vector, as described, for example, in Table 7. These deposits are referred to as "the deposits" herein.
The tissues from which some of the clones were derived are listed in Table 7, and the vector in which the corresponding cDNA is contained is also indicated in Table 7. The deposited material includes cDNA clones corresponding to SEQ ID NO:X described, for example, in Table 1A (Clone ID NO:Z). A clone which is isolatable from the ATCC Deposits by use of a sequence listed as SEQ ID NO:X, may include the entire coding region of a human gene or in other cases such clone may include a substantial portion of the coding region of a human gene. Furthermore, although the sequence listing may in some instances list only a portion of the DNA sequence in a clone included in the ATCC Deposits, it is well within the ability of one skilled in the art to sequence the DNA included in a clone contained in the ATCC Deposits by use of a sequence (or portion thereof) described in, for example Tables lAor 2 by procedures hereinafter further described, and others apparent to those skilled in the art.
[57] Also provided in Table 7 is the name of the vector which contains the cDNA
clone. Each vector is routinely used in the art. The following additional information is provided for convenience.
[58] Vectors Lambda Zap (U.S. Patent Nos. 5,128,256 and 5,286,636), Uni-Zap XR
(U.S. Patent Nos. 5,128, 256 and 5,286,636), Zap Express (U.S. Patent Nos.
5,128,256 and 5,286,636), pBluescript (pBS) (Short, J. M. et al., Nucleic Acids Res. 16:
7583-7600 (1988);
Aping-Mees, M. A. and Short, J. M., Nucleic Acids Res. 17.9494 (1989)) and pBK
(Alting-Mees, M. A. et al., Strategies 5:58-61 (I992)) are commercially available from Stratagene Cloning Systems, Inc., 11011 N. Torrey Pines Road, La Jolla, CA, 92037. pBS
contains an ampicillin resistance gene and pBK contains a neomycin resistance gene.
Phagemid pBS
may be excised from the Lambda Zap and Uni-Zap XR vectors, and phagemid pBK
may be excised from the Zap Express vector. Both phagernids may be transformed into E. coli strain XL-I Blue, also available from Stratagene.

[59] Vectors pSportl, pCMVSport 1.0, pCMVSport 2.0 and pCMVSport 3.0, were obtained from Life Technologies, Inc., P. O. Box 6009, Gaithersburg, MD 20897.
All Sport vectors contain an ampicillin resistance gene and may be transformed into E.
coli strain DH10B, also available from Life Technologies. See, fox instance, Gruber, C.
E., et al., Focus I5: 59- (1993). Vector lafmid BA (Bento Soares, Columbia University, New York, NY) contains an ampicillin resistance gene and can be transformed into E. coli strain XL-1 Blue. Vector pCR~2.1, which is available from Invitrogen, 1600 Faraday Avenue, Carlsbad, CA 92008, contains an ampicillin resistance gene and may be transformed info E. coli strain DHlOB, available from Life Technologies. See, for instance, Clark, J.
M., Nuc. Acids Res. 16:9677-9686 (1988) and Mead, D. et al., BiolTechnology 9: (1991).
[60] The present invention also relates to the genes corresponding to SEQ ID
NO:X, SEQ ID NO:Y, and/or the deposited clone (Clone ID NO:Z). The corresponding gene can be isolated in accordance with known methods using the sequence information disclosed herein. Such methods include preparing probes or primers from the disclosed sequence and identifying or amplifying the corresponding gene from appropriate sources of genomic material.
[6I] Also provided in the present invention axe allelic variants, orthologs, and/or species homologs. Procedures known in the art can be used to obtain full-length genes, allelic variants, splice variants, full-length coding portions, orthologs, and/or species homologs of genes corresponding to SEQ ID NO:X or the complement thereof, polypeptides encoded by genes corresponding to SEQ ID NO:X or the complement thereof, and/or the cDNA contained in Clone ID NO:Z, using information from the sequences disclosed herein or the clones deposited with the ATCC. For example, allelic variants and/or species homologs may be isolated and identified by making suitable probes or primers from the sequences provided herein and screening a suitable nucleic acid source for allelic variants and/or the desired homologue.
[62] The polypeptides of the invention can be prepared in any suitable manner.
Such polypeptides include isolated naturally occurring polypeptides, recombinantly produced polypeptides, synthetically produced polypeptides, or polypeptides produced by a combination of these methods. Means for preparing such polypeptides are well understood in the art.
[63] The polypeptides may be in the form of the secreted protein, including the mature form, or may be a part of a larger protein, such as a fusion protein (see below). It is often advantageous to include an additional amino acid sequence which contains secretory or leader sequences, pro-sequences, sequences which aid in purification, such as multiple histidine residues, or an additional sequence for stability during recombinant production.
[64] The polypeptides of the present invention axe preferably provided in an isolated form, and preferably are substantially purified. A recombinantly produced version of a polypeptide, including the secreted polypeptide, can be substantially purified using techniques described herein or otherwise known in the art, such as, for example, by the one-step method described in Smith and Johnson, Gene 67:31-40 (1988). Polypeptides of the invention also can be purified from natural, synthetic or recombinant sources using techniques described herein or otherwise known in the art, such as, for example, antibodies of the invention raised against the polypeptides of the present invention in methods which are well known in the art.
[65] The present invention provides a polynucleotide comprising, or alternatively consisting of, the nucleic acid sequence of SEQ ID NO:X, and/or the cDNA
sequence contained in Clone ID NO:Z. The present invention also provides a polypeptide comprising, or alternatively, consisting of, the polypeptide sequence of SEQ
ID NO:Y, a polypeptide encoded by SEQ ID NO:X or a complement thereof, a polypeptide encoded by the cDNA contained in Clone ID NO:Z, and/or the polypeptide sequence encoded by a nucleotide sequence in SEQ ID NO:B as defined in column 6 of Table 1B.
Polynucleotides encoding a polypeptide comprising, or alternatively consisting of the polypeptide sequence of SEQ ID NO:Y, a polypeptide encoded by SEQ ID NO:X, a polypeptide encoded by the cDNA contained in Clone ID NO:Z, and/or a polypeptide sequence encoded by a nucleotide sequence in SEQ ID NO:B as defined in column 6 of Table 1B are also encompassed by the invention. The present invention further encompasses a polynucleotide comprising, or alternatively consisting of, the complement of the nucleic acid sequence of SEQ ID NO:X, a nucleic acid sequence encoding a polypeptide encoded by the complement of the nucleic acid sequence of SEQ ID NO:X, and/or the cDNA contained in Clone ID NO:Z.
[66] Moreover, representative examples of polynucleotides of the invention comprise, or alternatively consist of, one, two, three, four, eve, six, seven, eight, nine, ten, or more of the sequences delineated in Table 1B column 6, or any combination thereof.
Additional, representative examples of polynucleotides of the invention comprise, or alternatively consist of, one, two, three, four, five, six, seven, eight, nine, ten, or more of the complementary strands) of the sequences delineated in Table 1B column 6, or any combination thereof. In further embodiments, the above-described polynucleotides of the invention comprise, or alternatively consist of, sequences delineated in Table 1B, column 6, and have a nucleic acid sequence which is different from that of the BAC
fragment having the sequence disclosed in SEQ ID NO:B (see Table 1B, column 5). In additional embodiments, the above-described polynucleotides of the invention comprise, or alternatively consist of, sequences delineated in Table 1B, column 6, and have a nucleic acid sequence which is different from that published for the BAC clone identified as BAC
ID NO:A (see Table 1B, column 4). In additional embodiments, the above-described polynucleotides of the invention comprise, or alternatively consist of, sequences delineated in Table 1B, column 6, and have a nucleic acid sequence which is different from that contained in the BAC clone identified as BAC ID NO:A (see Table 1B, column 4).
Polypeptides encoded by these polynucleotides, other polynticleotides that encode these polypeptides, and antibodies that bind these polypeptides are also encompassed by the invention. Additionally, fragments and variants of the above-described polynucleotides and polypeptides are also encompassed by the invention.
[67] Further, representative examples of polynucleotides of the invention comprise, or alternatively consist of, one, two, three, four, five, six, seven, eight, nine, ten, or more of the sequences delineated in column 6 of Table 1B which correspond to the same Clone ID
NO:Z (see Table 1B, column 1), or any combination thereof. Additional, representative examples of polynucleotides of the invention comprise, or alternatively consist of, one, two, three, four, five, six, seven, eight, nine, ten, or more of the complementary strands) of the sequences delineated in column 6 of Table 1B which correspond to the same Clone ID
NO:Z (see Table 1B, column 1), or any combination thereof. In further embodiments, the above-described polynucleotides of the invention comprise, or alternatively consist of, sequences delineated in column 6 of Table 1B which correspond to the same Clone ID
NO:Z (see Table 1B, column 1) and have a nucleic acid sequence which is different from that of the BAC fragment having the sequence disclosed in SEQ ID NO:B (see Table 1B, column 5). In additional embodiments, the above-described polynucleotides of the invention comprise, or alternatively consist of, sequences delineated in column 6 of Table 1B which correspond to the same Clone ID NO:Z (see Table 1B, column 1) and have a nucleic acid sequence which is different from that published for the BAC clone identified as BAC ID NO:A (see Table 1B, column 4). In additional embodiments, the above-described polynucleotides of the invention comprise, or alternatively consist of, sequences delineated in column 6 of Table 1B which correspond to the same Clone ID NO:Z (see Table 1B, column 1) and have a nucleic acid sequence which is different from that contained in the BAC clone identified as BAC ID NO:A (see Table 1B, column 4). Polypeptides encoded by these polynucleotides, other polynucleotides that encode these polypeptides, and antibodies that bind these polypeptides are also encompassed by the invention.
Additionally, fragments and variants of the above-described polynucleotides and polypeptides are also encompassed by the invention.
[68] Further, representative examples of polynucleotides of the invention comprise, or alternatively consist of, one, two, three, four, five, six, seven, eight, nine, ten, or more of the sequences delineated in column 6 of Table 1B which correspond to the same contig sequence identifer SEQ ID NO:X (see Table 1B, column 2), or any combination thereof.
Additional, representative examples of polynucleotides of the invention comprise, or alternatively consist of, one, two, three, four, five, six, seven, eight, nine, ten, or more of the complementary strands) of the sequences delineated in column 6 of Table IB
which correspond to the same contig sequence identifer SEQ ID NO:X (see Table 1B, column 2), or any combination thereof. In further embodiments, the above-described polynucleotides of the invention comprise, or alternatively consist of, sequences delineated in column 6 of Table 1B which correspond to the same contig sequence identifer SEQ ID NO:X
(see Table IB, column 2) and have a nucleic acid sequence which is different from that of the BAC
fragment having the sequence disclosed in SEQ ID NO:B (see Table 1B, column 5). In additional embodiments, the above-described polynucleotides of the invention comprise, or alternatively consist of, sequences delineated in column 6 of Table IB which correspond to the same contig sequence identifer SEQ ID NO:X (see Table 1B, column 2) and have a nucleic acid sequence which is different from that published for the BAC clone identified as BAC ID NO:A (see Table 1B, column 4). In additional embodiments, the above-described polynueleotides of the invention comprise, or alternatively consist of, sequences delineated in column 6 of Table 1B which correspond to the same contig sequence identifer SEQ ID
NO:X (see Table 1B, column 2) and have a nucleic acid sequence which is different from that contained in the BAC clone identified as BAC ID NO:A (See Table IB, column 4).
Polypeptides encoded by these polynucleotides, other polynucleotides that encode these polypeptides, and antibodies that bind these polypeptides are also encompassed by the invention. Additionally, fragments and variants of the above-described polynucleotides and polypeptides are also encompassed by the invention.

[69] Moreover, representative examples of polynucleotides of the invention comprise, or alternatively consist of, one, two, three, four, five, six, seven, eight, nine, ten, or more of the sequences delineated in the same row of Table 1B column 6, or any combination thereof. Additional, representative examples of polynucleotides of the invention comprise, or alternatively consist of, one, two, three, four, five, six, seven, eight, nine, ten, or more of the complementary strands) of the sequences delineated in the same row of Table 1B
column 6, or any combination thereof. In preferred embodiments, the polynucleotides of the invention comprise, or alternatively consist of, one, two, three, four, five, six, seven, eight, nine, ten, or more of the complementary strands) of the sequences delineated in the same row of Table 1B column 6, wherein sequentially delineated sequences in the table (i.e.
corresponding to those exons located closest to each other) are directly contiguous in a 5' to 3' orientation. In further embodiments, above-described polynucleotides of the invention comprise, or alternatively consist of, sequences delineated in the same row of Table 1B, column 6, and have a nucleic acid sequence which is different from that of the BAC
fragment having the sequence disclosed in SEQ ID NO:B (see Table 1B, column 5). In additional embodiments, the above-described polynucleotides of the invention comprise, or alternatively consist of, sequences delineated in the same row of Table 1B, column 6, and have a nucleic acid sequence which is different from that published fox the BAC clone identified as BAC ID NO:A (see Table 1B, column 4). In additional embodiments, the above-described polynucleotides of the invention comprise, or alternatively consist of, sequences delineated in the same row of Table 1B, column 6, and have a nucleic acid sequence which is different from that contained in the BAC clone identified as BAC ID
NO:A (see Table IB, column 4). Polypeptides encoded by these polynucleotides, other polynucleotides that encode these polypeptides, and antibodies that bind these polypeptides are also encompassed by the invention.
[70j In additional specific embodiments, polynucleotides of the invention comprise, or alternatively consist of, one, two, three, four, five, six, seven, eight, nine, ten, or more of the sequences delineated in column 6 of Table 1B, and the polynucleotide sequence of SEQ ID
NO:X (e.g., as defined in Table 1B, column 2) or fragments or variants thereof.
Polypeptides encoded by these polynucleotides, other polynucleotides that encode these polypeptides, and antibodies that bind these polypeptides are also encompassed by the invention.

[71] In additional specific embodiments, polynucleotides of the invention comprise, or alternatively consist of, one, two, three, four, five, six, seven, eight, nine, ten, or more of the sequences delineated in column 6 of Table 1B which correspond to the same Clone ID
NO:Z (see Table 1B, column 1), and the polynucleotide sequence of SEQ ID NO:X
(e.g., as defined in Table 1A or 1B) or fragments or variants thereof. In preferred embodiments, the delineated sequences) and polynucleotide sequence of SEQ ID NO:X correspond to the same Clone ID NO:Z. Polypeptides encoded by these polynucleotides, other polynucleotides that encode these polypeptides, and antibodies that bind these polypeptides are also encompassed by the invention.
[72] In further specific embodiments, polynucleotides of the invention comprise, or alternatively consist of, one, two, three, four, five, six, seven, eight, nine, ten, or more of the sequences delineated in the same row of column 6 of Table 1B, and the polynucleotide sequence of SEQ ID NO:X (e.g., as defined in Table 1A or 1B) or fragments or variants thereof. In preferred embodiments, the delineated sequences) and polynucleotide sequence of SEQ ID NO:X correspond to the same row of column 6 of Table 1B.
Polypeptides encoded by these polynucleotides, other polynucleotides that encode these polypeptides, and antibodies that bind these polypeptides are also encompassed by the invention.
[73] In additional specific embodiments, polynucleotides of the invention comprise, or alternatively consist of a polynucleotide sequence in which the 3' 10 polynucleotides of one of the sequences delineated in column 6 of Table 1B and the 5' 10 polynucleotides of the sequence of SEQ ID NO:X axe directly contiguous. Nucleic acids which hybridize to the complement of these 20 contiguous polynucleotides under stringent hybridization conditions or alternatively, under lower stringency conditions, are also encompassed by the invention. Polypeptides encoded by these polynucleotides and/or nucleic acids, other polynucleotides and/or nucleic acids that encode these polypeptides, and antibodies that bind these polypeptides are also encompassed by the invention. Additionally, fragments and variants of the above-described polynucleotides, nucleic acids, and polypeptides are also encompassed by the invention.
[74] In additional specific embodiments, polynucleotides of the invention comprise, or alternatively consist of, a polynucleotide sequence in which the 3' IO
polynucleotides of one of the sequences delineated in column 6 of Table IB and the 5' IO
polynucleotides of a fragment or variant of the sequence of SEQ ID NO:X are directly contiguous Nucleic acids which hybridize to the complement of these 20 contiguous polynucleotides under stringent hybridization conditions or alternatively, under lower stringency conditions, axe also encompassed by the invention. Polypeptides encoded by these polynucleotides and/or nucleic acids, other polynucleotides and/or nucleic acids encoding these polypeptides, and antibodies that bind these polypeptides are also encompassed by the invention.
Additionally, fragments and variants of the above-described polynucleotides, nucleic acids, and polypeptides are also encompassed by the invention.
[75] In specific embodiments, polynucleotides of the invention comprise, or alternatively consist of, a polynucleotide sequence in which the 3' 10 polynucleotides of the sequence of SEQ ID NO:X and the 5' 10 polynucleotides of the sequence of one of the sequences delineated in column 6 of Table 1B axe directly contiguous. Nucleic acids which hybridize to the complement of these 20 contiguous polynucleotides under stringent hybridization conditions or alternatively, under lower stringency conditions, are also encompassed by the invention. Polypeptides encoded by these polynucleotides and/or nucleic acids, other polynucleotides and/or nucleic acids encoding these polypeptides, and antibodies that bind these polypeptides are also encompassed by the invention.
Additionally, fragments and variants of the above-described polynucleotides, nucleic acids, and polypeptides are also encompassed by the invention.
[76] In specific embodiments, polynucleotides of the invention comprise, or alternatively consist of, a polynucleotide sequence in which the 3'. 10 polynucleotides of a fragment or variant of the sequence of SEQ ID NO:X and the 5' 10 polynucleotides of the sequence of one of the sequences delineated in column 6 of Table 1B are directly contiguous. Nucleic acids which hybridize to the complement of these 20 contiguous polynucleotides under stringent hybridization conditions or alternatively, under lower stringency conditions, are also encompassed by the invention. Polypeptides encoded by these polynucleotides and/or nucleic acids, other polynucleotides and/or nucleic acids encoding these polypeptides, and antibodies that bind these polypeptides are also encompassed by the invention. Additionally, fragments and variants of the above-described polynucleotides, nucleic acids, and polypeptides, are also encompassed by the invention.
[77] In further specific embodiments, polynucleotides of the invention comprise, or alternatively consist of, a polynucleotide sequence in which the 3' 10 polynucleotides of one of the sequences delineated in column 6 of Table 1B and the 5' 10 polynucleotides of another sequence in column 6 are directly contiguous. Nucleic acids which hybridize to the complement of these 20 contiguous polynucleotides under stringent hybridization conditions or alternatively, under lower stringency conditions, are also encompassed by the invention. Polypeptides encoded by these polynucleotides and/or nucleic acids, other polynucleotides and/or nucleic acids encoding these polypeptides, and antibodies that bind these polypeptides are also encompassed by the invention. Additionally, fragments and variants of the above-described polynucleotides, nucleic acids, and polypeptides are also encompassed by the invention.
[78] In specific embodiments, polynucleotides of the invention comprise, or alternatively consist of, a polynucleotide sequence in which the 3' 10 polynucleotides of one of the sequences delineated in column 6 of Table 1B and the 5' 10 polynucleotides of another sequence in column 6 corresponding to the same Clone ID NO:Z (see Table 1B, column 1) are directly contiguous. Nucleic acids which hybridize to the complement of these 20 lower stringency conditions, are also encompassed by the invention.
Polypeptides encoded by these polynucleotides and/or nucleic acids, other polynucleotides and/or nucleic acids encoding these polypeptides,. and antibodies that bind these polypeptides are also encompassed by the invention. Additionally, fragments and variants of the above-described polynucleotides, nucleic acids, and polypeptides are also encompassed by the invention.
[79] In specific embodiments, polynucleotides of the invention comprise, or alternatively consist of, a polynucleotide sequence in which the 3' 10 polynucleotides of one sequence in column 6 corresponding to the same contig sequence identifer SEQ ID
NO:X (see Table 1B, column 2) are directly contiguous. Nucleic acids which hybridize to the complement of these 20 contiguous polynucleotides under stringent hybridization conditions or alternatively, under lower stringency conditions, are also encompassed by the invention. Polypeptides encoded by these polynucleotides and/or nucleic acids, other polynucleotides and/or nucleic acids encoding these polypeptides, and antibodies that bind these polypeptides are also encompassed by the invention. Additionally, fragments and variants of the above-described polynucleotides, nucleic acids, and polypeptides are also encompassed by the invention.
[80] In specific embodiments, polynucleotides of the invention comprise, or alternatively consist of a polynucleotide sequence in which the 3' 10 polynucleotides of one of the sequences delineated in column 6 of Table 1B and the 5' 10 polynucleotides of another sequence in column 6 corresponding to the same row are directly contiguous. In preferred embodiments, the 3' 10 polynucleotides of one of the sequences delineated in column 6 of Table 1B is directly contiguous with the 5' 10 polynucleotides of the next sequential exon delineated in Table 1B, column 6. Nucleic acids which hybridize to the complement of these 20 contiguous polynucleotides under stringent hybridization conditions or alternatively, under lower stringency conditions, are also encompassed by the invention. Polypeptides encoded by these polynucleotides and/or nucleic acids, other polynucleotides and/or nucleic acids encoding these polypeptides, and antibodies that bind these polypeptides are also encompassed by the invention. Additionally, fragments and variants of the above-described polynucleotides, nucleic acids, and polypeptides are also encompassed by the invention.
[81] Many polynucleotide sequences, such as EST sequences, are publicly available and accessible through sequence databases and may have been publicly available prior to conception of the present invention. Preferably, such related polynucleotides are specifically excluded from the scope of the present invention. Accordingly, for each contig sequence (SEQ ID NO:X) listed in the fourth column of Table 1A, preferably excluded are one or more polynucleotides comprising a nucleotide sequence described by the general formula of a-b, where a is any integer between 1 and the final nucleotide minus 15 of SEQ
ID NO:X, b is an integer of 15 to the final nucleotide of SEQ ID NO:X, where both a and b correspond to the positions of nucleotide residues shown in SEQ ID NO:X, and where b is greater than or equal to a + 14. More specifically, preferably excluded are one or more polynucleotides comprising a nucleotide sequence described by the general formula of a-b, where a and b are integers as defined in columns 4 and 5, respectively, of Table 3. In specific embodiments, the polynucleotides of the invention do not consist of at least one, two, three, four, five, ten, or more of the specific polynucleotide sequences referenced by the Genbank Accession No. as disclosed in column 6 of Table 3 (including for example, published sequence in connection with a particular BAC clone). In further embodiments, preferably excluded from the invention are the specific polynucleotide sequences) contained in the clones corresponding to at least one, two, three, four, five, ten, or more of the available material having the accession numbers identified in the sixth column of this Table (including for example, the actual sequence contained in an identified BAC clone).
In no way is this listing meant to encompass all of the sequences which may be excluded by the general formula, it is just a representative example. All references available through these accessions are hereby incorporated by reference in their entirety.

SEQ

ID EST Disclaimer Clone NO: ContigRange ID of a Range of b NO: Z X ID: Accession #'s HE2KJ64 12 906019I - 913 15 - AA16466I, AI962647, AAI64645, AA096157, T77033, AI656439, T69166, 244826, 855232, AA164782, AA496160, AA247800, AA091213, AC020570, and AC020570.

HAGDV32 13 11786261 - 188915 - AL049128, AA398117, 854194, 1903 AA394218, AA081522, AA247129, and AF061936.

HLICC37 14 8569581 - 624 15 - AA203242, AL365356, AL365356, 638 and AL365356.

HAJCQ63 16 8238501 - 777 15 - AA902808, AI002049, AF082556, 791 and AF082557.

HLMMV66 17 11539031 - 738 15 - AW084519, AI244442, AA,614014, 752 AI808637, AA903338, AI342240, AI962752, AI717991, AW 139714, AI921541, AI660761, D20168, AW138271, AI219797, AI041118, F19235, AI798637, F16699, AI201892, T29020, AI792451, AIOS4048, AW393736, AW393737, AA748165, AA918804, AA811883, AW271140, AW207518, AAS25796, AW393733, and D30758.

HLWAR08 18 10963891 - 519 15 - _ 533 AA078617, AJ133128, and AF160798.

HBGTT76 19 11523271 - 816 15 - AI284640, AL046409, AW419262, 830 AI963720, AI613280, AW193265, AI431303, AI305766, AI801482, AI334443, AA581903, AL119691, AI345654, AI270117, AI281881, AA587604, AW327868, AL037683, AW439558, AI708009, AL045053, AW303196, AI133164, AW274349, AW301350, AL041690, AW408717, AI110770, AA569471, AL046205, AA610491, AI076616, AL138455, AW021583, AI754253, AW265393, AL138265, AW276827, AI312309, AW028429, AA491814, AI350211, AL044940, AA490183, AI754658, AA526787, AI064864, AW238278, AI696962, AA720702, AW438643, AI799642, AI270559, F36273, AA521323, AI345681, AI345675, AI610159, AI969436, AA394271, AI679782, AL042753, AI469968, AW088846, AI619997, AA468022, AI064952, AW406162, AI754336, AI305547, AI341664, AW268300, AI623720, AI473943, AI345518, AA164251, AA521399, AI149478, AI798473, AW265009, AW407578, AI192631, AI289067, AI133102, AI633390, AI368256, AI471481, AI249997, AA491284, AA613345, AI821271, AI061334, AW083402, AI732865, AW004911, AW270270, AW073470, AI688846, AL079645, AW410400, AA857486, AI871722, AW029038, AA584201, AI570261, AI355206, AW302013, AW193432, AA533333, AI053672, AW162049, AI962050, AI345157, AI929531, AI307201, AA649642, AI801591, AI624142, AW103758, AI744995, AW148792, AW021207, AA551552, AI375710, AA126051, AA126035, AL134972, AW304584, AW131249, AI370094, AI339850, AA507824, H71429, AI379719, AI801600, AW338086, AI344844, AI298710, AW301809, AI559705, AA468131, AI370074, AL038785, AI567076, AA846935, AI805363, AI340453, AI457397, AA877817, AW167372, AI499503, AA623002, AI246119, AI696955, AI286356, AI246796, AA610271, AI792287, AI653886, AA503258, AW261871, AI368745, AA847499, AI376I00, AL042853, AW410354, AI921649, AI281697, AI053790, AA584145, AL120687, AA533036, AI587565, AA587256, AI538433, AA713815, AA621858, C75026, AL046457, AL048626, AI564496, AA488746, AI085719, AI358571, AI499134, AL038703, AW339568, AL121235, AW166815, AI623898, AI148277, AA493471, AA631507, AA503473, 824887, AL135405, AW269488, AW276435, AL038705, AA703820, AL038474, AA780515, AA502I55, AI674873, AI635818, AI499938, AI625244, AI688928, AI538852, AI357288, AA806796, AA758934, AI890918, AI918421, AI017415, AA084070, AI281903, AI860020, AW406447, AA49183I, AL009179, AP000513, D83989, AF015147, AF077058, AC006138, M37551, AF015151, X75335, U57006, U57007, AF015149, AF015I56, AF015157, U18394, X54180, U18391, U18392, X55925, U57005, X54176, U57009, U18396, 297205, X54181, X54178, X53550, U18395, U57008, AL096775, I51997, U18393, AL022238, X55926, U18399, 297200, 270688, AJ229041, AF015148, X54175, X55931, X55924, U18387, AC006251, AC005251, X54179, U18390, AL034419, AC005486, AC008249, AF015153, U67221, 298742, U18398, U67801, AC005914, AP000455, AC002526, AL035455, AL049829, AC006476, AC003102, AC005211, AC004477, X55923, AC004895, AL021392, AL050342, AC005962, AC004217, AC005154, AC005180, AC005859, ALI10292, X55927, AF134726, AF027390, AC010175, AC006004, AC004890, U18400, AC004234, X74558, AL049795, U91326, AL132985, U67231, AC005144, AC005921, AC007226, AC005005, AC010197, AC010200, AF015160, AC005829, AC005296, AF085913, X55922, 222650, AC005664, AL031257, X55932, AC006511, AC016026, 543650, U12580, AC007043, AL022163, AC006088, AC004987, AC007682, U67233, AC007I93, AL109628, 269666, AL117256, AC006353, X88791, AP000692, AF109907, AC005815, AL023883, AC004986, AL133371, ALI09984, AC007546, AC004861, AC005632, AC007845, AF015166, AF015167, AC005295, AC004490, AC006213, 286061, AF015150, U67222, AF124523, AF001549, AC004712, ' AC005089, AL031985, U07562, 282210, AC002119, AL008709, AC010072, AC005288, AC006157, AC004638, U6783I, U12584, AL023882, AC004381, AL023755, AC006153~, AC002347, 270042, AL136295, AC004253, AF015158, AC005909, AC007099, AC004858, ALI21603, Z9805I, AC004514, 249816, S7520I, U66059, L81648, X55930, AL031311, AC004111, AF146367, U67229, AC006160, AC000353, AL050097, U72787, AC007050, AL031054, AC004931, AP000431, AC002564, AC003980, AL121652, AC004686, AL121591, X76629, AL022318, AC007114, AC005597, AC005737, U67832, AC006344, AC005784, AC004650, AF015155, AL136297, AC004940, AC003085, AP000555, AL03I734, AC007384, AFOI5154, AL031281, AC006128, AF123462, AB020859, AC002507, AC002430, AC006292, AC004016, AL031777, AL008728, X54156, U94788, AL008716, AC006207, AC007298, AL021546, 268287, AL096861, AC007237, 286062, U67226, AC007590, AL008723, AC007488, AC004945, AL049845, AL049699, AL121915, AF001298, AC004626, AL022315, 268869, A39972, U95739, AC002429, 275741, 299716, AL031594, AC006960, 298752, AC005901, AC004883, and AC006155.

HMCF024 20 9246471 - 572 15 - AA354491, and AL133087.

HBIOM94 21 9731371 - 112815 - AW369756, AW062278, AA452837, AA452978, AI767361, AI005282, AI263850, AW016065, N62955, AA514551, AI674818, and AA885328.

HBJLRI 22 10124651 - 105515 - AW406595, AW407230, AW405242, l 1069 AW406935, W75960, AA280941, AW404229, AI127571, AI083668, AI762839, AI479026, AI880750, AI659971, AI418465, AI871470, AI40I5I1, AI884848, AA744459, AA744457, AI033897, AA744029, and AI814201.

HLTER04 23 5909901 - 160215 - AI080277, AI985856, AI811944, 1616 AI792263, AA503208, AA947957, H39200, AI222195, AI078373, N40065, AI572864, AA612717, AI159887, AW136999, W76131, AA724067, AI219932, AA677397, 854201, 854208, , AW195855, 812887, AA364711, AA923230, F06179, W72906, AI818758, AA853060, AA853062, AA765276, H99593, AI885955, AA669080, AA853061, AA361288, AA853065, 818216, AA853063, AA853064, 842154, AI608615, AA382148, AA336625, AW192034, AA036871, T95989, 841281, F02451, AI207644, AL121330, M61984, H39201, AA307662, AI908083, AA525750, AI198566, AW197911, AA036872, H38407, AA868442, AI215851, AA508495, AA410479, AI697792, AI125914, AI457418, Y13350, AJ001309, AF011793, AB028853, U95727, AF088046, AL035079, AC007338, AC007338, AC018845, and AC018845.

HMSMU30 24 10506011 - 609 15 - 623 AA374213, AW088077, AA346367, and AA346368.

H2MBY83 25 7521241 - 517 15 - 531 AI203647, W44356, AA757210, AI193047, AA524479, AI130814, AI344478, AA582236, AA316493, AI288858, AI146994, AI148643, AA730161, W45709, AI168644, AA927666, AI750017, AA453739, AA491660, AA453820, AA557746, AA652628, AI685002, AI141208, AI190610, AI610804, AA490862, AI859485, AA025400, AI475353, AA346812, AA300676, AI859458, AA356638, AC017104, and AC017104.

HBUAH93 26 11647391 - 161415 - 1628AA247840, 893421, 806351, 806293, AB023163, AF161412, and AF049612.

HMZAD58 27 9753041 - 334115 - 3355N26584, W94986, N38905, AI075815, AI367921, AI184158, AA830019, AI033601, N54995, AA83002I, N27197, AA918808, AI539580, AI273730, AI262545, AA587088, AA779942, AA262747, AA676908, AA730411, W86602, H16056, AA287348, AA303482, AW179318, W91912, AA670033, AA705754, AW300038, AA887595, AA703588, AL038837, AL039074, AL037051, AL036725, AL039564, AL039108, AL039156, AL039085, AL039659, AL039109, AL039625, AL039648, AL039128, AL038531, AL039629, AL039678, AL039150, N46479, AL045337, AL040992, AI219099, AL037726, AL039423, AL042909, AL0394I0, AL045353, AL036973, AL044407, AA312749, AL039538, AL039924, AL039386, AL037526, AL037639, AL038821, AL036196, AL044530, 299396, AL038851, AL037615, AL037082, AL036418, AL039566, AL036924, AL038025, AL036767, AL036190, AL043441, AL043445, AL039509, AA903850, AL036238, AL036117, AL036679, AL045341, T24119, AL036733, T24112, H00069, AL043422, T23947, AL045794, AL043423, AL037601, AL037027, AL037178, AL036191, AI535783, AW013814, 847228, AW452756, AL037054, AI535983, AL036158, D80253, AW451070, AL036998, AL036964, T23659, AL036858, AL036765, D51250, AL037077, AA495756, AL037177, D59787, AL036174, D59275, AL037021, D80043, AL037643, D80219, AA351345, AL038447, T48598, AL036268, 225782, AL036132, AL036139, AA514190, AL036167, T02921, AL037600, D80227, AA631969, D80240, AL036900, D80134, AL036719, D51423, AL037085, T11051, AL036999, D80210, AL036808, 225783, D59619, AL036953, AW450376, H00072, AL036227, AA287308, AL037016, AW451932, AL037094, AW197479, C14227, _ AL037002, AA887468, D80193, AL037569, D80196, AL036207, AW135155, D59927, D80168, AW392670, D80366, AL037047, AL039440, AL038509, U46347, C75259, AW384394, AL134I53, AW363220, AL119484, AL038520, AL043003, AW372827, AL119457, AL037679, AL119497, AL119319, AL119324, AL119439, AL119391, AL119443, U46350, AI557751, AL119522, U46351, AL119483, AL119363, C14389, AL119355, D63482, AF124491, AF112366, A9721I, A95051, D88984, AR031374, A49700, AR031375, A58521, AR020969, AR062871, II8371, AR025207, X68127, AR017907, A38214, A44171, I56772, I95540, AR018924, A63067, A51047, A63064, AR018923, A63072, AR068507, AR068506, AR015960, AR000007, AR015961, A25909, AR036905, AJ244003, AJ244004, AJ244005, A67220, X73004, A98767, I19516, A93963, A93964, I66495, I66494, I60241, I60242, I66498, I66497, I66496, I66486, I66487, A02712, A95052, AR043602, AR043603, AR043601, A95117, A85477, A18053, I06859, A48774, A18050, A23334, A75888, I70384, A60111, A23633, AR007512, A85396, A23998~

A48775, A84772, A84776, A84773, A84775, AR062872, A84774, AR062873, AR067731, AR037157, AR067732, A86792, A58522, A91750, Z96I42, I92483, AR038286, I00074, A58524, A58523, AR054109, I63120, A20702, A43189, A43I88, A20700, A92133, D34614, A64081, A24783, A24782, I03665, A81878, I03664, A15078, E00523, D14548, I03343, AF156296, E13740, AR036903, D28584, AR022240, A11245, A02710, E12615, AR035193, E14304, A07700, A13392, AI3393, I19517, A27396, A76773, A22413, AR027100, I28266, E16590, I21869, I13349, E16678, AR008430, AF156294, S70644, A70040, A82653, E16636, A35536, A35537, A02135, A04663, A02136, A04664, I01992, I25027, I26929, I44515, I26928, I26930, I26927, A58525, I08051, I25041, YI1923, A93016, V00745, A91754, A49045, AJ230933, ABOI2117, AF118808, Y11926, I44516, AR000006, X58217, AR038762, AR064706, I49890, AF019720, I00077, I68636, A92636, U87250, A58526, A91753, A60957, I00079, A51384, I84554, E03165, E0222I, EOI6I4, E13364, I84553, A60968, Y11449, AR066482, A60985, A60990, A60987, A10361, D44443, AF096793, AR035975, AR035974, AR035977, AR035976, AR035978, X15418, AB007195, A97221, AF096810, A18722, A10363, Y17188, I08250, E04616, AF130655, .

AF156299, X73003, Y11447, AF156302, S83538, M32676, AF156303, I07888, AR063812, Y11920, S65373, I07429, I03663, A02711, A04448, A04447, A04442, A04441, AR060234, AR051692, I12420, 578798, I19525, A80951, A91965, AR066494, E03018, X13220, I69350, AR023813, Y11458, I02343, A20701, AC078916, AC078916, AC022305, AC002518, AC072032, and AC072032.

HGHNH17 28 9753781 - 100815 - AW340658, AI830575, AI970997, 1022 AI375239, AI955746, W52045, AA452348, AA505698, AA452125, AW403701, AI742513, AI199971, AI338181, AI338219, AA926692, AA938400, AA644138, AW402946, AI344126, AI186703, AI183773, AI675706, AA156689, AI300753, AA884026, W60021, W38892, N95054, AI148098, H01993, AA954291, W44927, AI751818, AA805553, AW170013, W39574, AW 150567, AI864148, AA280408, AI494112, H04586, 827968, AI193848, AI078102, AI936538, H39712, AI198333, AA194406, AA094826, H02089, AA363376, AA642334, 828221, T94680, AI373118, AA280407, AA994085, AI352072, H13826, AI818830, AA918331, AA554306, AI093632, AI276589, AA447655, AI273430, N30561, H28693, AA134664, AI278504, AW341382, H13182, AI934888, W24049, H13867, AA919107, AF169284, and AC026236.

HNJCE31 30 11523461 - 125215 - AI018173, AI760388, AW300938, 1266 AI199891, AI933017, AI346277, AI951521, AI274896, AI347966, AA668791, AA782661, AI026785, AW405280, AI001012, AA458453, H40863, AI589680, T68710, AA824434, M78791, AA303076, AA2803I3, AA303075, AA280557, AA897610, AI222091, AW167599, AI971179, AB032972, AF156777, and AFI55352.

HKAIU14 31 9195381 -1564 15 - AA452443, AA748492, AA281066, AI038581, AI042300, AA448716, AA588218, W24345, T74435, N95542, AA448626, AA603589, AA243343, AA452281, AA824559, AA371584, T50615, AA243539, F12392, AI524537, AA281191, T50481, F10009, AI004I87, AA810738, 814413, AW385047, T63277, C01253, AA876044, and AI557234.

HCE4I12 32 9115861 - 382 15 - AA013102.

HFOYI18 33 9264881 - 984 15 - AI655769, AI056895, AI808132, 998 AA056028, AI333033, AI373246, AI982973, AA352349, AI918693, AA324259, AI369511, AW026758, AA662463, AA767509, AA056046, ' AI417153, and AA226846.

HHEDM89 34 9450551 - 106615 - AL120995, AA599042, and AL109865.

HFXKW18 35 9452881 - 232415 - T19088, T03269, AI905856, 2338 AW178893, D58283, D59859, AW179328, AW177440, D80022, C14331, D80166, D80195, D80193, ' D59927, D59467, D51423, D59619, D80210, D51799, D80391, D80164, D59275, D80240, D80253, D80043, D59787, D80227, D59502, D81030, D80212, D80196, D80188, D80219, AA305409, C15076, AW378532, D80269, D57483, D80038, D80366, C14429, D50979, D50995, D59889, C14389, D80024, D59610, D80378, AW178775, AW352117, AW178762, D80045, D80241, AW177501, D51060, AW177511, D80134, AW366296, AW352158, D51022, D51097, C14014, AW360811, C75259, AW176467, AW375405, AA305578, AW377672, AW377671, D80251, AW360844, AW360817, D81026, AW375406, D80248, AW378534, AW179332, AW179023, AW178905, AA514188, D58253, D80522, AW352171, AW377676, AW352170, AW 177731, AW 178907, D80132, AW 179019, AW 179024, AA514186, D80133, AW 178906, AW378528, AW 177505, AW 179020, AW 178909, AW 177456, AW 179329, AW 178980, AW 177733, AW 178908, AW 178754, AW 179018, AW 178911, D80268, AW179004, AW178914, AA553357, AW367967, D80302, AW178774, AW352174, AW177723, D80439, D80247, T48593, AW178983, D51103, AW378533, AW367950, AI535850, C14975, AW178986, C06015, D45260, X82626, A84916, A67220, D89785, A62300, A62298, Y17188, A78862, D34614, D26022, D88547, AJ132110, AR018138, X67155, A25909, AR025207, AB012117, AF058696, Y12724, AR008278, A85396, I19525, AR066482, A44171, A85477, AB028859, A86792, X93549, A94995, D88507, AR008443, I18367, I50126, I50132, I50128, I50133, AR066488, AF135125, A82595, U87250, AR016514, D50010, AR060138, A45456, A26615, AR052274, AR066490, D13509, Y09669, AR060385, AB033111, AB002449, AR066487, U87247, A43192, A43190, AR038669, A30438, AB023656, AR008408, X93535, AR060133, U79457, and AR008382.

HBIMF04 36 9516011 - 138515 - AI922958, AI972432, AW391908, 1399 AI922949, AI961967, AA568658, AA484955, AW207083, AW139687, AW296274, AW195438, H55661, AW294860, 887853, AL119220, H61275, H52133, H38451, H52024, 890897, 887771, 887761, 888865, 887838, AL022328, AL022328, AL022328, a_nd AL022328.

HDPKI66 38 8238541 - 142115 - 1435AW207698, AA927827, AA931212, AW183281, AB033075, AF112886, AF075461, U92478, and AF075462.

HOCQD08 39 9729811 - 701 15 - 715 AA314782, AA121597, AW179125, AA307196, AW410914, AA315619, AA151174, AA221000, F12658, AA205790, AA148973, W42974, T74241, AA353399, AA209384, AA385968, AA421728, AA377635, N40506, W44995, AA339272, AA249242, W07625, W05068, AB026125, AC018568, and AC018568.

HDPRP54 40 12282831 - 244315 - 2457AI392846, AI565035, AA430988, AA811609, AI754385, AA130556, AW268863, AA906509, AI698734, AW007245, AI092244, AW 118314, AA337522, AA383461, AI537049, AA861761, AA782718, AA130S93, AA928445, AW050550, AW438768, AA459681, D63077, AW273355, N51495, AI698391, AI621341, AI699823, AW051088, AI610446, AI270183, AI590043, AI866090, AW022682, AI277008, AI583578, AI537187, AI554821, AI802695, AI670015, AI612913, AI587156, AI624293, AI468872, AI696570, AI247193, AI589428, AI500514, AI685517, AI537677, AI432570, AI613038, AW 192687, AI571439, AI800341, AW020397, AL042944, AI538850, AW132107, AI564290, AI445620, AI623941, AI687568, AW410259, AI802542, AI884459, AI434731, AI927233, AW172982, AI540674, AI889189, AI445611, AL046466, AW170725, AW 129616, AW089233, AW007555, AI249389, AI446046, AI628325, AW023338, AA916133, AI679550, AI798456, AI289310, AI819014, AW087199, AW080746, AI567769, AI670009, AI433157, AI702073, AI690748, AI590423, AA806757, AW 129659, AW128834, AW089844, AI633125, AI591228, AW079572, AI538564, AW006032, AI915291, AW152182, AI368579, AI499963, AI923989, AI638644, AI254731, AI866469, AI561356, AI536685, AW166870, AI884318, AI452560, AI802240, AI266643, AI475371, AI554516, AI539847, AI673363, AI345688, AL045349, AI682968, AI669864, AI625464, AI359787, AW162194, AI422688, AW050850, AI245008, AI819202, AI912434, AL046944, AI887389, AI648458, AW029566, AI096481, AI638798, AI537837, AI797538, AI919500, AI610402, AI818353, AI570807, AI499581, AI758309, AI499570, AI366900, AW 118518, AI301046, AI619662, AI679266, AW022584, AI446511, AL046595, AI891102, AI250627, AW168875, AI433611, AL036638, AI932794, AL138399, AI687168, AI917963, W74529, AW029611, AI471429, AA806719, AI678688, AI963625, AI097137, AI859991, AL039390, AI499890, AI635851, AI923370, AI961589, AW148423, AI470648, AL043152, AI474646, AI699011, AI440239, AI680221, AIS87121, AI376872, AI933992, AI819976, AI818980, AW0512S8, AI971615, AW026882, AI244249, AI439745, AL039716, AW198075, AI590020, AI582932, AI890574, AI589134, AI095003, AA019328, AI824576, AA8I4990, AI525669, AW083572, AI473536, AI954080, AI282346, AI609236, AW054964, AI401697, AL037582, AI690687, AW084425, AL037602, AI869765, AI500714, AW167083, AI241744, AI491710, AI678446, AW024594, AI890223, AIS97758, AI536601, AW262S52, AL045413, AW152459, AW083778, AL119863, AI619777, AI679506, AW150794, AI540458, AW197005, AI570056, AI566670, AI306610, AI564259, AI950892, AI868204, AI912356, AI890507, AW088628, AI814S94, AI956086, 257391, 257390, I89947, 297214, I48978, AJ005690, X72889, AB025103, U35846, AR034821, S36676, AL137480, AF090903, AL117587, A77033, A77035, AR038854, AL133640, AL110296, AL137550, AL080148, AL137271, AL133637, I48979, AF111849, AF177401, X79812, E01314, AF061795, AF151685, I32738, A07588, AL137530, AL137574, Y16645, I09499, AF113019, I33392, AL133016, AL137533, U80742, A65340, AF069506, ALI37529, 568736, A6534I, AF111851, AF061981, L04849, AF113694, AL137478, AF026124, U77594, AL137292, AL137479, AF113677, X66871, 582852, AL122050, AL080159, 213966, AL133062, 583440, AF090901, AL080126, AL133619, AL110280, AL122110, X82434, AL049339, AL137557, AF159615, AF047716, A58545, AF044323, AL133606, AL133112, I00734, AF026816, AL050277, E00617, E00717, E00778, U73682, A08910, A08909, AF079763, AL137488, AL117435, AJ012755, A21103, AF087943, U53505, AL122100, AL110221, AL117648, A08916, AF017790, AF090900, U57352, A08913, U96683, L04504, AF008439, AL137463, A18777, AB016226, X66862, AF067728, A08908, AF031147, A08912, A12297, XS3587, A15345, U75932, S61953, Y10655, AF017437, AL049283, AF115392, AF183393, AL137711, U87620, AL050149, AL096744, E02221, AF102578, AL050366, U49908, A76335, AL117416, AF106697, AL137548, S76508, AF100781, AF028823, Y10823, AL050024, AL133557, AF185576, AL110159, AL080124, AL049314, AF094480, AL023657, AL110218, AR020905, I89931, S78453, AF126247, AF145233, X70685, AF141289, X89102, AL110222, AL110225, X99971, AL133049, AF057300, AF057299, I49625, X80340, 282022, U86379, Y14314, AL122118, AL133113, AL050138, AL137665, X63162, AL137558, AL137547, AL137658, AL122093, X65873, I89934, AL133560, X98066, AL137627, A08907, AL049324, S63521, AF118094, Y11587, AL049382, AL050170, AR011880, AF078844, AL117460, AF112208, AL080154, AL137459, E06743, 237987, AF090886, AF117657, AF158248, AF039138, AF039137, M92439, A58524, A58523, AF067790, A57389, U92068, I17544, AL122098, AL117457, AF106657, E01614, E13364, L04852, AF153205, E07108, AL050155, E01573, E02319, AF115410, 575997, AF118090, AF118092, U58996, AL050092, AL137641, A23630, AL080163, AF119336, E05822, Y11254, AL049347, Y10936, AL049430, AF132676, A52563, AF061836, I03321, AL137471, AF199027, AL133665, A03736, AF111112, AL050172, AF192557, AJ238278, and AL137554.

HE2BW32 41 6094681 - 272 15 - 286 AA262522, F06472, AA295016, AA366764, AA523700, AA296800, AW246977, AA482405, AL037121, AA127877, AI929496, AW328197, 892273, AA447905, AA033682, H71644, AI346910, N34110, AA428825, AA166921, AW250621, AI702323, AA418151, N34715, AI814423, AI347153, W40205, N49047, AA406476, AA406516, AC006238, AF057358, AF086627, AF044670, AC005318, AF115503, AF157497, and AF086630.

HAJAU21 42 6706061 - 354 15 - 368 AAS 13506, AB015317, Y12226, X54424, AJ224114, and AJ224113.

HE8DL23 43 6936411 - 487 15 - 501 W78996, AW172850, AW169307, AW401638, AA399131, AA251893, AI361767, AB015318, AF068706, AF068707, AL135999, and AL135999.

HFTCM92 44 9288511 - 769 15 - 783 AI589776, AI057117, AW272585, AI246523, AA767227, AI625485, AA873003, AI239712, AI955774, AW296331, AI479753, AI741538, F32315, AI674694, AI932376, AA804789, AA044610, AA9935I0, AA243346, F369I4, N55553, AA262732, AI961836, AI684523, AI127216, AI927868, AA720891, AA324979, AA953487, 886959, AA039578, AA487796, AI886998, AA485892, AI685404, 805274, AA912800, F18062, C00227, AA747721, 805331, and AA326305.

HE6BQ76 45 7756161 - 353 15 - 367 AA099543, AA669197, AA127290, 818710, H08922, W79474, AW118919, AW304022, N41498, AA213595, W86555, H51174, 225317, AA304745, AI609937, H57648, AF083033, AR028451, AF072860, 284477, and AF083032.

HAMFP60 46 7150971 - 493 15 - 507 AW451560.

HHFHY84 47 7150981 - 375 15 - 389 AW451560.

HE6FD03 48 11509001. - 15 - AA431537, AW404444, AI283081, 932 946 AI355127, AA431213, AI025060, AI241247, AI017479, AI276732, AA700252, AA737782, AI351906, AI564874, AA861742, AI051964, 240548, AI864024, AA976182, AI363484, AI350761, AA688143, AI160881, AI028241, AA662752, 884964, AI332354, F08983, AI471267, 878868, AA670442, AI920956, AA312704, AA229532, AW411050, AA420758, AA830333, AC006547, AC000083, AC000097, AC003060, AC005664, AJ236691, 568736, A93016, A91160, and AL133565.

HDTFT90 49 11653381 - 685 15 - AI623819, AI799883, AI814412, 699 AI952039, AI972947, AI826075, AL045697, AW337996, AA167742, AW167132, AW264027, AA209462, AI394192, AI458169, AI289432, AI863491, AI620722, AW440580, AI984766, AI758979, AI610824, AI287482, AI289435, AW002172, AA648408, AI634183, AI125609, AA150039, T65400, AW207026, W93405, AI949306, AA150203, AI659678, AA741391, AI951377, H09775, AW 166423, H24845, AI453490, 801203, AI631154, AA258738, 862398, T54772, AI434048, AA744971, AI857358, C00469, AA258877, AI949348, AI469756, F09546, AA449685, AI299480, 862397, AI672560, AW089174, AI690289, AA514475, AI078116, AA456139, AI91291 S, AA093121, AA954932, AW025809, AW305231, AI224855, AI093059, AI341411, AI479298, AA718988, AI734889, AI827201, N95744, AI830516, AW303777, AA846245, AW014387, AI869379, N25902, AI042513, W94876, AA081121, AA152265, N63437, F21778, AW298184, AA150155, AI241692, AA988159, AA594584, W20340, AA709203, AI699865, AI677796, AI433157, AI702073, AW163834, AA225339, AW026882, AL079963, AL038605, AL119863, AI619502, AI312428, AI918449, AI587121, AI340603, AI802542, AI923989, AI627988, AW198090, AL036274, AI569583, AL120695, AI568132, AW022808, AI538259, AI801325, AW268067, AI349645, AI569945~

AW268253, AI926790, AI815232, AI620284, AL048656, AA470491, AW161156, AA640779, AL045500, AI348854, AW 129106, AW302992, AI537677, AI348897, AI868204, AW 161579, 836271, AI284517, AI670009, AA572758, AI952217, AI815855, AL041772, AL036403, AI564719, AW089572, AL036631, AI538885, AW151136, AI349226, AI439452, AI874166, AW169604, AL110306, AI473536, AI627360, AL048323, AI783504, AI929I08, AL048340, AW163823, AL120853, AI433384, AI249497, AW022682, AI890833, AW193134, AL036980, AL045774, AI446538, AI589267, AI886753, AI309401, AI500523, AW074993, AI349614, AI343112, AL121286, AI689420, AW301300, AI349598, AI312152, AI345735, AW075084, AI590686, AI349937, AW 104724, AI554245, AW 149076, AI500061, AI307708, AW072719, AL040241, AI890507, AL036802, AI313320, AI571439, AI340627, AW302965, AL036361, AL047344, AI783530, AI859991, AW238730, AI872423, AI445025, AI312146, AW051088, AI537244, AI312339, AI306613, AI345745, AI345258, AW169653, AW268072, AL045620, AI340519, AA908294, AI345608, AW162194, AW020693, AI334893, AL036673, AA580663, AW300889, AL041150, AW118518, AL138457, AL036664, AI269862, AI570807, AI635067, AI611348, AI812107, AI310575, AI923370, AI567128, AI868931, AI866798, AL036396, AI431424, AI343030, AW148363, AW073270, AA420722, AB029022, AF125948, AL117457, I48978, ALI22093, AF146568, AL023657, AF090903, I89947, 578214, AL096744, A08916, AJ000937, I48979, AF061943, AF090900, AL133560, AL1221I0, AL122050, AF087943, AF113699, AL110225, U42766, A77033, A77035, AL050277, AF125949, AL133640, AF113690, AL110196, A08913, AF097996, AF111849, AL133565, A08910, I89931, AL049430, AL050116, AL080124, I49625, AL050149, A08909, X82434, AF162270, AL049452, AL137459, AF017437, Y16645, L31396, L31397, AL117435, AL117460, I03321, AL137538, AR059958, AL117649, E07108, AF177401, 568736, AF100931, AF113677, AL137271, AF113013, AR038969, X96540, U88966, AR038854, AL050024, AF026124, Y14314, AF158248, AF111851, AJ238278, AL133075, AL133016, AF090901, A08912, AF026816, AL110280, AL122123, A58524, A58523, AF091084, AF090943, AF118064,.

AL137557, AL049283, E05822, Y11587, AL133080, AR011880, U68387, A03736, AF113019, A65341, AL137550, E12747, AF061573, E02349, AF017152, AF111112, AF078844, AR013797, AF118094, Y11254, AF079763, AL110221, AF113691, AL049464, AL133067, AF090934, AL080159, I33392, AF183393, AL050146, AL050393, AL133606, AF079765, X63574, X72889, AR000496, AL049382, U39656, AL133557, AL133568, AL122121, AB019565, AF113689, AL049314, U58996, L30117, AL133093, X84990, AL050108, AF118070, AL117583, AF185576, AF090896, U80742, AL117394, AL137488, AF106862, AF113694, E04233, 282022, AL137648, AJ242859, AL117585, U00763, X65873, U35846, AJ012755, AL080060, X70685, 272491, AF210052, AF176651, AL080137, AF104032, I09499, AL049466, A18777, AL137478, AL133665, A93350, AF113676,,AL137533, Y07905, D83032, E03348, A90832, Y09972, AL133113, I68732, AL137463, S61953, AB016226, X87582, AF153205, AL122098, AL050138, I00734, AL137480, AL137429, AL137283, AL049938, AF067728, AL137560, 237987, A07647, E00617, E00717, E00778, AL117440, AL137527, AL137294, AL137476, E07361, A93016, AL133104, AF003737, AL137526, U67958, M30514, A12297, AL133072, U91329, AF057300, AF057299, X98834, AL080127, AL080148, AL137479, AL122049, AL049300, AL110I97, A45787, AL080074, L19437, AL050172, E15569, U72620, AF119337, I26207, I42402, A08908, X93495, AL117432, AL137521, AL137556, I09360, AL133081, AL133098, D16301, U96683, AL133077, AL133014, E08263, E08264, AF118090, U78525, AJ006417,'X62580, E06743, AL122106, AL122118, X06146, A18788, AF126247, and AF132676.

HPJCU63 50 10824581 - 884 15 - AW016133, AI935230, C04161, 898 AA680307, AA947457, AI765980, AA889263, and AI146454.

HFITE38 51 7932031 - 412 15 - AW401574, AW411042, AW391980, AA852415, W61124, AL138163, AI313133, AI554624, AA331917, W76458, AI909669, AA357067, D55453, AW361222, T08329, AA035103, AA371686, AA378552, AAl 16099, N45490, AA452303, 815571, AA310762, AA613412, AW360837, AA478499, 808104, T84898, AA551115, AA894909, AA328222, AA654947, AW088409, AI951963, W23225, AI205283, AA657656, C18294, T32049, AA225936, AF126181, U92544, AF128528, AF128527, and 298046.

HDPDH64 52 7965091 - 506 15 - AI929457, AW249044, AI739490, 520 AB020706, X14972, X53773, X14971, and 266177.

HFKKS58 53 11588001 - 144115 - AW246359, AW246572, AA827562, AA514488, AL135673, AI539185, AA459956, AI190270, AA778031, AA083889, AI539830, AL134250, AA255533, AA460045, AA083888, AA532881, F19104, AA384265, AA749416, AI972095, AA247961, AA702934, N66268, AA364111, N79931, AI630888, AA255505, AW438881, AA729375, AA334602, AW363733, T06791, AF116910, and AW662264.

HE8CM38 54 11979031 - 154315 - AW341277, AA449052, AA677433, AI375482, AI393099, AA649052, AI913346, AI859698, AI417958, AI373524, AI769760, AA442905, AW271751, AI685790, AI684073, AW243463, AA470724, AI670074, AI344642, N76222, AA701021, AA758141, AW029224, AI040528, AI376742, AA693735, AW296327, H42313, H12220, AA835707, AA464605, AA121186, T26462, N54520, AA758284, AA430532, AI470967, AA121187, N50674, AI565321, AW193102, T26463, H30000, AA885708, AW079408, 240783, AA887660, AA373205, C05171, AA918565, F07717, H43079, T99533, 820437, H30001, AW020286, N50763, AA66S044, H46108, T99427, 843557, AI913702, AI915506, AI368375, T17007, AL045626, AI500061, AI288285, AI963846, AW083573, AI623941, AI690813, AA911767, AL041150, AA641818, AI802542, AW161156, AL135024, AI765469, AI696611, AI345416, AI345612, AI345415, AI473536, AI699865, AL037582, AL037602, AI434453, AL038445, AL119863, AI874166, AW198090, AI538885, AI567582, AI354998, AI571439, AI241923, AW130534, AI673363, AL119791, AI890214, AI866127, AI491842, AI611810, AI419650, AL110306, AI648408, AI288050, AI913452, AI929108, AI254727, AI554818, AI335426, AI348777, AI890907, AI950729, AW059828, AI470293, AL041772, AL037454, AA908294, AL040449, AW 152000, AW 196078, AI274508, AL039086, AI358701, AI866770, AI933589, AW078650, AI355779, AL043981, AI921746, AW078818, AI863191, AI432040, AI538850, AA805434, AI445992, AI568138, AI591407, AI581033, AL036274, AI432085, AI887381, AI474146, AII74394, AI868931, AI973152, AW 118518, AI452993, AW268122, AI499986, AI537677, AI521560, AI678357, AI796743, AI923370, AW 130930, AW130356, AW160376, AI446373, AI469505, AW051059, AIS38008, AW104141, AA761557, AW078800, AI648458, AI500523, AI918449, AI335208, AW029294, AI872423, AL045500, AL134830, AI802826, AI866469, AI125884, AW 167086, AI886123, AI620284, AW301409, AA640779, AI434468, AI445990, AW300782, AL036638, AL036673, v AI866780, AI471361, AI281867, AI300294, AI612750, AW300889, AIS40674, AI073952, AW149925, AI537261, AI499285, AI590686, AI539071, AI623682, AW163834, AI340519, AI699011, AI884318, AI340603, AI624293, AI680389, AL037030, AI961589, AI433157, AI702073, AW131999, AI690426, AI373914, AI873644, AI680377, AI570966, AI783504, AI553645, AL079963, AI824576, AI554343, AI263331, AI863321, AI281757, AI859991, AI572096, AI923989, AI284517, AI434741, AW051088, AI571529, AI249946, AI633125, AI567360, AL046618, AI365256, AI698391, AA456793, AI815232, AI538564, AA502794, AW265004, AL036361, D79994, AL035461, AF110520, AL133665, AL1I7435, AL080I24, A65341, AL133640, AF104032, I48978, I89947, AL137533, E12747, AB007812, X93495, AJ012755, AL122110, AL049382, AF026816, I26207, X84990, A08913, A08916, A08912, AL122093, AF067790, A03736, AF111112, AL133645, AR038854, X82434, E02221, AL122121, AL122050, Y14314, AF106657, U35846, AF032666, AJ238278, AL117585, AL117457, A08910, A08909, X79812, Y11254, I42402, A08908, 282022, AL122118, AL137488; AF090934, A77033, A77035, AF026124, AL133075, AF090900, AF177401, X06146, AF030513, AL137276, AF113690, I33392, AL137271, AL122100, AL050149, AF185576, I48979, AL133010, X65873, I89931, AL137478, AF087943, AFI83393, AF090903, AF090896, AF008439, I49625, AF081197, AF081195, AL137476, AF091084, A18777, AF100931, AF017437, Y16645, AL117460, E07108, AL023657, AL096751, AROI1880, AL050277, YI0655, AF126247, AF215669, AL133016, AF113013, AL133606, AF118094, AL137538, AL133565, AF106862, U95114, AL049938, Y11587, AJ242859, U78525, ALI33113, X83508, 576508, A21103, AF078844, L19437, AL110196, E06743, AL049452, AL137550, AF159615, A93350, AL110221, AF061795, A07647, AF151685, AL096744, AF090901, AF079765, AL080074, AL133104, AF067728, AL050024, AL133080, AF113699, X80340, AF069506, E02349, ALi 17416, AL137459, 237987, AL080127, AL133568, AL050393, 297214, AL133560, A08911, AL049300, AL049283, I03321, AR029490, AL050172, AF079763, D16301, D83032, I09499, 578214, AL137705, AL050I55, Y07905, AL137480, AL137292, AJ005690, X72889, I89944, I89934, X63410, AF113694, AR013797, AL117583, AL137529, E03348, A86558, AL049466, AF118090, X81464, S36676, A65340, AL133558, U58996, Y10080, AR059958, AL117649, AL050116, 579832, AL050092, AF022363, U72620, AL110218, AL137539, AF162270, AR020905, AF113019, AF113677, AL137523, AL080154, AF153205, AL133557, AF125948, AF139986, AB019565, A08907, AF113689, AL049430, AF132676, AF061836, AL133624, AF111849, Y09972, AL122045, AF125949, A12297, AL137521, A18788, S61953, X62580, AL122111, AF210052, AF176651, AF158248, A08915, AF146568, U72621, U42766, AL080163, AL080060, AF119337, AL133067, AL137556, I80064, E05822, AC002467, I17544, M96857, AF000301, I66342, AF113691, AL137548, AJ006417, AL137463, S75997, E04233, U67958, AJ000937, AL080159, E03349, AR000496, U39656, 272491, L30117, AF031147, AL117440, and AL110225.

HAJBU67 55 8569221 - 717 15 - AA314478, AA380939, AW239035, AA380937, AF132951, AC008910, AC008910, AC026230, AC026230, and AC026230.

HHEHD10 56 12046961 - 158915 - AI952147, AA827782, AI523970, 1603 AW008938, AA236865, AI673370, AW043829, AI143323, N36986, AA306716, AI361743, AA460666, AW080829, AI914077, AI214786, AA862831, AI963652, AI805253, AI423188, AI003936, AA994686, AA130868, AI913070, AA533231, AI358965, AI873692, AA569719, AA865951, AI272308, AI445569, AA644481, AAI79075, AA968581, AI418685, AI669710, AA130923, C00906, 885067, AA502585, AI088486, N46300, AA176755, AA847433, AL048511, AL122098, AA436168, AA436295, AI445942, and AI224003.

HE8EQ22 58 10319601 - 801 15 - AA306763, AA471282, 860471, 815 AA355988, 897538, AI984936, AA164607, AA284002, T55524, 854342, AF156778, and AF155354.

HSACD83 59 9115881 - 543 15 - AA910780, AA374903, U44096, 557 and AB028997.

HHGB053 60 10917141 - 899 15 - AA130923, AA847433, AL048511, 913 and AL122098.

HE8FD82 61 11547851 - 132815 - AI768630, AA706436, AW157621, 1342 AI078119, AA524776, H30754, AW150289, AA532707, AW139797, AW021449, AI621272, AI016209, AI860138, AW135889, AA657976, 813815, AI918682, AI968824, AI206287, AA374031, H81740, 888478, AA077298, AA779405, AA135075, AA364727, AA015913, AA371202, AI394720, T07862, AA825944, AF147198, C14420, AI971484, AI340575, and AI052382.

HOHAS44 62 9148101 - 809 15 - AL035953, AI124738, AW401606, AA523304, AW402591, AW401458, AW367481, W39252, AW401461, AW361591, T08548, AW361667, AW361610, AA136313, AW361658, AW361482, F11247, AW361674, W61067, AA374706, H08891, F08026, AA361745, AA351469, N88445, H14875, AW392259, N88487, 228364, F12897, 814296, AL138414, AA828798, AA319125, W63585, 829411, T07869, W52703, N89245, AI752182, AI133443, AA460616, AA205396, AW378459, AA774792, N30042, N86188, AA095400, N40686, N85070, AA351168, AA465136, AA037173, AW379721, T74738, D21260, U31757, J03583, and AA829032.

HE8OF42 63 11178571 - 533 15 - 219388, and AA329822.

HSKHS71 64 11547981 - 712 15 - H71659, AW300749, AI829537, 726 AI005241, AC005208, AC005736, AC007993, AC007151, AC004216, AC005088, AC004491, AC005105, AC005482, AC005104, AP000252, AC005011, AP000212, AP000134, AC004167, AP000031, AF024533, AC004656, and AP000564.

HISBT75 65 11810201 - 850 15 - 864 AI589776, AI057117, AW272585, AI246523, AA767227, AI625485, AA873003, AI239712, AI955774, AW296331, AI479753, AI741538, F32315, AI674694, AI932376, AA804789, AA044610, AA993510, AA243346, F36914, N55553, AI961836, AA262732, AI927868, AII27216, AA720891, AA953487, AA324979, 886959, AI684523, AA039578, AA487796, AI886998, AA485892, AI685404, 805274, AA912800, F18062, C00227, AA747721, 805331, and AW512952.

HFVKF77 66 9309641 - 377415 - 3788AI150873, AI189373, AL042988, AA632159, AI346260, AI523411, AI024354, AA808543, AA854033, AW088247, AI758696, AW073231, AI815545, AI418920, AI825902, AL035953, AL037320, AA579628, AW151081, AA587235, AW189155, AA576880, W63585, AI954477, AW338975, AI828607, AW085567, AW130637, AI623663, AI983431, AI620641, AA133366, AI583234, AA576375, AI445524, AA774792, AA771885, AA507864, AI124738, AW401606, AA723567, AA523304, AW188638, AI752181, AI469475, AA743810, AI625556, AI520737, AI692845, AI291738, AW401458, AA460616, AW402591, AW440557, AW264616, AW378459, AI797318, AA877897, AI453366, W52703, AA062675, AI348108, AA431305, AA744898, AI096834, AI568940, AA598662, N42214, AI829306, AI689212, AA588710, AI364980, W92760, AA707687, AA737920, AI362019, AW367481, AA662924, AA648800, AI146983, AI360896, AI335953, AI335738, AA693465, AW243835, AI355350, AA513467, AA653209, AI799692, AI537502, AA024674, AA844498, AW401461, AI174402, AI087241, AI124681, N35697, AA974150, AA971015, AI249769, AI816487, AI289906, AI087251, AA069996, AI348606, AI268906, AW339188, W39252, AA720740, AA653122, AI077988, AA126442, W56132, W59975, AI299885, AA954634, AI143573, W07025, AI095842, AI251001, AI342779, AA620496, AW373167, AA962293, N33870, AW022463, T23553, AI752182, AI061217, AA610153, AI635496, AI088481, AI049998, AA351429, AA729067, AI954294, AW382249, AA775247, D57958, AA461543, AA025033, AW361591, AI039984, AA775965, AI869140, AA962136, AA890566, AI335637, T08548, W15283, AW361667, AI275152, AA074800, AI362481, AW361610, AA351469, AL042411, W01330, AI537138, AA086189, AA487036, N63087, T08547, AA024458, H82140, AA136313, AA100413, W77960, AW361482, AW068048, AA037112, AA665530, AA693343, AW361658, AA775356, H02897, AI720119, AA074736, F11247, N25237, H82046, H50116, AW024379, AA587794, AA860622, L44395, AA026360, AW068306, AW361674, N66965, H50163, AW022745, AA126549, F12897, AI866095, AA055152, AA058324, AA351168, N42394, F06129, H54288, AW382152, W72216, AI566615, AW402774, W61067, AI335581, D57693, AA723091, AA465091, AA069826, AA379771, W93158, F02395, AA886695, AA146865, H14875, AA374706, AA325364, 228364, T28891, AA037173, AA100909, AA852560, H08891, AI267577, AW075341, AA342585, AA036923, 881778, F08026, AI950628, 863151, H81959, W65373, D31495, T62798, AA351428, AA365809, AA037496, H27815, AA321416, AA852559, AA319588, F00686, W61068, T62946, AI813324, D21260, U31757, J03583, AR032006, 814296, 840246, 840246, 881525, H03798, H04689, H08813, H14828, H27755, H29769, H67694, H81958, N25912, N30042, N50736, N79530, N80063, AA025106, AA034371, AA037438, AA055035, AA058328, AA082649, AA146864, AA492000, AA748093, D45298, AI088785,1,49069, N86188, N88445, N88487, N89245, 829411, AA095400, AA205396, D12334, AA585371, AA585388, 221212, 221347, 221351, F04266, F08910, F10505, AI245150, AI264614, AI371863, and AI669288.

HJABW64 67 9314021 - 451 15 - 465 AA310521, AA314039, AA232595, AA223451, AA081255, C16722, and AA188117.

HCEMY90 68 9329271 - 592 15 - 606 AA324130, AA361570, 812848, AF214633, AF214633, AC024242, and AC024242.

HHFLF63 69 9338541 - 772 15 - 786 AA280252, AI693282, AA170809, and AC023295.

HSKAN19 70 9352291 - 157915 - 1593AW007702, AI564551, AI924539, AW007297, AW262796, AW419073, AW004917, AI650277, AA122325, AI653276, AA127688, AI114823, AI800389, AI798176, AA127787, AI283151, AA151029, AW024375, AI654070, AA806020, AI082416, AA131394, AI147624, AW001184, AA532361, AI690703, AA316383, AA628956, H49147, AA218613, N44016, AA218738, AA179610, AW169382, T25520, AI888971, AI911536, AA622966, AA227688, AW275250, AA150922, AA131553, AI698898, N34949, C14182, AI363988, AI337382, AI444966, and N50769.

HE9SE88 71 I 1522401 - 127815 - 1292AA306657, AA363705, AI65I
100, AI824886, AI651101, AI978581, and AC004527.

HDTDG41 72 9424901 - 166015 - 1674AW450923, AL135736, AW192703, AI655462, AW337165, AI741321, AW193820, AW338706, AL135737, AI088424, AI657039, AI148466, AI493987, AI373846, AI862037, AI240315, AW237808, AI277357, AI370866, AA330080, AW002412, AI927071, AI913035, AI828398, N67239, AI089278, AW385367, AI278393, D62202, AA058336, T60482, AA653554, AI445780, D62655, D62632, D79382, D62164, AA037746, AA039256, AA329280, N75385, AA482447, AW242180, AI493154, AA093789, C04500, D61803, AA127836, D79428, D79850, AA054489, D79371, D79874, AA328211, D79432, D79746, D62383, AA63I896, AA135605, AA127830, N77278, AA091731, H75799, AL137848, and AL137848.

HTEPX32 73 8706981 - 134915 - 1363AI217947, AW237109, AI918745, AI968403, AA934788, and X84693.

HEGAB84 74 11283201 - 463 15 - 477 AI222155, AA305409, AC007040, and Y12724.

HTEKQ12 75 12137461 - 262815 - 2642AI655698, AI913638, AI917717, AI640777, AI650912, AA579656, AW294581, AI125546, AI244551, 816227, AA127442, AI220551, AA781390, AL045671, AA913470, AI024395;

AA316404, AI652678, AA127441, AA585439, AA585440, AL044201, AL037341, AA889244, 840605, AW083791, AL040768, AL044015, AL046147, AL042245, AL049007, AL043950, AL043468, AL042700, AL038532, AL036500, AW299612, AL046994, AL042712, AL040414, AL040571, AL046097, AL044771, AL134123, AL037435, 840606, AL044258, AA585434, AL041577, AL046150, AL037371, 228355, AL037335, AI535639, AA994975, AL040856, AL043848, AI014240, AL043570, AL046914, AI525556, AI541510, AL046850, AA585453, AL037323, AL041459, AI546855, AI525316, AL044029, AL043814, AL048647, AL043128, AL044064, AL039316, AL043201, AL043923, AL079876, AI525328, AL039338, AI541374, AL043935, AL040252, AL045994, AL037727, AL045991, AL043537, AI541514, 615189, AI541523, AL037343, AL047593, AI556967, 230131, AL044377, AI526180, AI546999, AL043936, AL043845, AI525306, AI541534, AL044199, AL043903, AI557807, AA585101, AL041374, AL040329, AI541317, AL037443, AL040082, AW002446, AI541509, AI526140, AL043604, AI541017, AI525431, AI546828, AL040263, AA585356, AI526194, AI541365, AL042096, C16300, 240910, AI547039, AI526196, AL040148, AL043627, AI541535, AL041523, AL044583, AL038983, AL041730, AI546945, AL046392, AI540967, AL044272, AI557799, AI557731, AI541508, AL042135, AL040090, AI541307, T11028, AI526144, AL040052, AL044274, AI546899, AI535660, D61254, 829445, AL040294, AI525653, AI546884, AI557787, 828735, AL040458, AL041186, AL040510, AL040625, AL045817, AL041142, AL041238, AL041133, AL041131, AL046330, AL040322, AL047183, AL041051, AL041292, AL047036, AL040119, AL047170, AL047057, AL047219, AL041227, AL040463, AL039915, AL043612, AL041197, AL040155, AL041346, AL040529, AL041096, AL047012, AL041358, AL041277, AL041163, AL041098, AL040621, AL043538, AL041324, AL040464, AL044162, AL043496, AL041086, AL041296, AL041233, AI557262, AL043467, AL041159, AL045725, AL044186, AL041140, AL040193, AL044037, AL040168, AL040091, AL040128, AL040255, AL040342, AL040285, AL040332, AL040617, AL040553, AL045684, AI536138, AL040745, AL040370, AL043677, AL046442, AL040839, AL041752, AL040149, AL043775, AL044165, AL043492, AL041602, AL045920, AL041278, AL038838, AL040253, AL044074, AL041635, AL045990, AL044187, AI525320, T23985, AW373267, AL040576, AI142134, AL045753, AI546891, AL079878, AL049018, AL040444, AL039744, AL045857, AI557796, AI546875, U09874, AB027570, AR017907, I66495, I66494, I66487, I66498, I66497, I66496, I66481, I66486, I66488, I66489, A83642, A83643, I66485, I66490, I66491, I66492, I66493, A83151, I66482, I66483, I66484, I13349, A91965, I05488, I61310, A60977, A91752, I08196, A92133, A60961, AR027319, A91751, AR027318, A68112, A68104, I63560, A06419, A21892, I63561, I63563, A23997, A68114, A21895, A25909, AR067731, AR037157, AR054109, AR067732, A05160, A08030, A20502, A86792, A58522, I19516, AR028564, A47368, A84772, A20702, AR062872, I19517, AR009152, AR009151, AR062873, A84776, A84773, A84775, A43189, A43188, A84774, A64973, A60985, A60990, A58524, A89633, A89634, A58523, A60987, AR002333, A76773, A22413, A98767, I15353, A93963, A93964, A38214, I56772, I95540, A91750, A20700, A58521, A91754, AR031375, AR020969, A32110, AR031374, A49700, A29109, A32111, AR062871, E14304, I08776, A81878, I25027, I26929, I44515, I26928, I26930, I26927, I44516, E16678, I25041, X81969, A95096, A95106, A95105, AF082186, I07249, AR068508, AR068510, AR068509, A63954, I91969, I58322, I58323, AR003585, AR038762, AR035975, AR035974, AR035977, AR035976, AR035978, I08051, E12584, A63067, A51047, A63064, A63072, AR068507, AR068506, AR036903, I01987, A90655, AR038855, AJ244004, AR008429, D78345, A85395, A85476, I18895, I44681, AJ244005, AJ244003, A98420, A98423, A98432, A98436, A98417, A98427, A92666, A92668, A92667, A92665, X12660, Y16359, I63120, X83865, A18053, M28262, AJ244007, I15717, I15718, E03627, I49890, I48927, A02712, A77094, A77095, I84553, A9505I, I84554, A18050, A23334, A75888, I70384, A60111, A23633, AR007512, I08396, I00682, A60212, A60209, A60210, A11624, A11623, E00609, A60211, E13740, A11178, E01007, A10361, A35537, A35536, A02136, A04664, A02135, A04663, I08395, I06859, AR043601, A11245, I03331, E12615, A02710, AR035193, A07700, A13393, A13392, I62368, AR031488, I13521, I52048, A27396, AR027100, I44531, I28266, I21869, A70040, A82653, E16636, A93016, A24783, A24782, A95117, AF149828, I01995, AR031566, I60241, I60242, AR038066, A20699, E00696, E00697, E03813, AR027099, I19525, AR051652, Y09813, T66686, and 805668.

HNTSX71 76 12211171 - 180315 - 1817H25971, H45756, AI417586, AA230146, W44525, H25938, AW084173, T40629, AL133035, and 284465.

HFCFH75 77 9512021 - 789 15 - 803 AA209338, AA209404, AA2992I6, and AA314039.

HEOQY55 78 12046931 - 213815 - 2152AI740584, AW002002, AI985800, AI762576, AI798477, AA534961, H15320, AW081499, AI889034, AI278720, 852194, 816209, 882785, AA314880, AI918168, AI824664, AI926177, 816208, F04683, N76763, T84274, W92215, 817096, T87269, AA302483, T78575, W92216, T79785, H41133, 817095, T79354, T78491, T87183, 811236, AA377828, 241900, 811184, T91358, AI822090, T91445, T85160, F01406, AW150480, T50809, AW090340, U90728, AW002004, 853223, H41178, AB008793, AB012254, and AF147342.

HPJDQ48 79 9521851 - 143715 - 1451AA828379, AA837189, AA721432, AI826972, and AW451560.

HTTCB17 80 11748651 - 295715 - 2971AI499419, AI820049, AW070938, AL042008, AA984061, AA781142, AL042032, AL041636, AL043672, AA52I
I50, AI090248, AA533251, AW183150, AW090185, AA236580, AI986141, AA234444, T64870, AI039274, AA761405, AA688276, AA285153, H58691, AI025833, AI283608, AA454934, AI223971, AA421748, AI025468, RS8865, AA740862, AA836810, AA911678, T40471, AA157675, H23351, AF012373, N53133, AI698072, T67438, AI912060, AI220192, AA284019, AL043673, AA224471, T39198, AA829259, T99670, AA215781, H23240, AA056347, AI698363, T99070, AL046440, AL046465, AI968320, T69471, AA652360, AW265609, AA626470, AA428563, AI557751, T11417, D80043, D58246, AA809122, C14227, C14331, D80064, AA514184, D80258, D80014, D59503, AI535686, D80195, D80251, D58283, D80253, D80188, D80247, D80366, D80391, D59787, D80157, C06015, D59859, D80522, D80439, D80248, D80166, D59927, C03092, D51423, D59619, D80210, D51799, D80240, AW178893, AA305409, D80196, C14389, D45260, D57483, D81030, D59467, D50979, D59610, D80212, D80268, AA305578, D80219, D80022, D51022, D80164, D59275, AA514186, D80038, D80227, D59502, H67854, AI53S959, F13647, D81026, D50995, C14014, D59889, D80269, D80133, AW360834, D80193, X84692, AC007172, U07155, AR018138, A30438, A84916, A62298, X68127, A82595, Y17187, AR008277, AR008281, AR008278, A62300, AB028859, AJ132110, AR060385, AF058696, Y17188, I50126, U46128, I50132, I50128, I50133, I14842, AR054175, AR016691, AR016690, AB002449, A70867, AR062872, AR016514, AR066488, Y09669, X67155, AR060138, A45456, A94995, D26022, AR066487, A26615, AR052274, A43192, Y12724, A63261, A43190, AR038669, A25909, A67220, D89785, A78862, D34614, A64136, A68321, AF123263, AR008443, D88547, D50010, and AW779867.

HE2SY09 81 9538281 - 633 15 - 647 AW249044, AI929457, AL042867, X14971, AB020706, and AC006942.

HFEBN52 82 8104291 - 438 15 - 452 AW025309, AW304444, AW084572, AI436722, AI373537, AA335976, AW024833, AW269191, AA700625, E15324, E15326, AL136001, AL136001, AL359399, and AL359399.

HHSDM19 84 9560451 - 183515 - 1849AA461035, AI672417, AI922318, AA455380, AA207253, AW073828, AI656613, AI015897, AA081097, AI354270, AA223211, AA187149, AA207246, W07268, N79769, AA453976, AA765863, AF114029, AA456020, AA382282, AI287653, AA648749, 841461, AI535793, AI536006, D61645, AA992075, 858462, AA564978, AA204953, AA232403, AA382281, AA209404, 264530, and 264529.

HDTIT49 85 9569171 - 841 15 - 855 AL138392, AA427786, T70793, AL138393, and AB0330S1.

HTLGW19 86 11630721 - 194815 - 1962AA523383, AI742620, AI761443, AI952075, AW058000, AW051868, AI003892, AI963321, AI12S092, AA740995, AA505650, AA458975, AA459191, AW292537, 836885, T09140, AA814793, 812123, AA307344, AI678050, AI371536, W42803, T03560, AI141992, AI640208, AI940309, AI247362, AI874238, AI470119, AI860445, AA961156, W42715, AA430202, AI796167, and ' AA430309.

HJPCA88 87 9589421 - 686 15 - AW245543, and AW245988.

HE9TA54 88 9602531 - 184715 - AI978973, AW369076, AW370703, AA534881, AW378876, AW369110, AI804249, AW327458, AW135792, AW369167, AA453172, AA310335, AI090260, AI754244, AI479778, AI191452, AI754645, W49847, AI147878, AA315343, AA449642, AA204775, AI460118, AW020839, AI904759, AA643726, AI922592, AA452494, AI274979, AI087146, AI635048, AI635041, AA113120, AA629855, AA644499, AI78451I, AA306559, AI312811, AI445708, AA779358, AA449479, AI190399, AW369088, AA229791, AI246414, 278389, AI433738, N94029, AI272914, AI378550, D60918, AA713577, AA501589, AW025696, AI590682, AA669450, AA584300, AI289061, N68360, AA748622, AW194963, AI630019, AA831867, AA502188, 868043, H18960, 852950, AI350618, AA429958, AA379878, T80097, 823764, AA333242, AI401408, AA356163, C04569, C04581, AA306800, 853735, AW027179, 837182, AA262222, AA112441, AA331867, AW105576, C16683, N87167, H62030, AA937229, AA206893, AA463653, T07391, AA092767, AI129491, AI591277, AI590460, D19876, AW023484, AI343133, AI345777, AI349943, AI318121, AF083246, and AF031483.

HCFCD40 89 9637561 - 456315 - AI003504, AI978786, AI942472, 4577 AW157102, AI923428, AW305224, AI337325, AL043698, AI949346, AA779822, AA902404, AA247183, AW450949, AI183371, AI422983, AI085398, AI624398, AA653306, AI12999I, AA702436, AW408332, AW166329, W73118, AL118913, AA308483, AI088358, AI095015, AI146768, AI718426, AI002387, AA310294, AI268360, N51414, AI754081, AW177065, AW238419, AA779348, AI950139, W86275, AI263017, AI094353, W31856, AI439425, AI057081, AI248226, AA699336, AI370781, AI805789, AA284436, AA234679, AA490361, AA889342, AL043697, W77820, W73138, H82394, AW263912, N80171, N34343, W78224, 899060, AA962061, AA807778, AW368126, W39284, AA678399, AW368120, W86309, N42811, C04873, AA225086, AW368023, AA679450, AI473702, AA628546, AI909121, T34767, H30308, H08335, AW175578, AW182966, AA768970, T23851, T08453, T16462, AI743061, AA234752, AA225217, 862711, T35501, 859446, W72185, AA358369, AA362699, H17164, AI028580, AW444986, AW002495, AI088059, AI334137, AW 175689, AI367965, AI432305, AI803106, AI367964, AW304421, AW104041, 859387, AI378977, AA296134, AI034255, AI684123, AA853740, 899257, 844755, 899245, AA099272, AI830449, AW088296, AI968631, T33541, T56948, 863669, AI151401, W81632, 852397, AI375778, 899049, T30054, AI088406, AI446077, AI933597, AI302303, AI140293, AW387233, AA917412, AA056449, AA301282, AA810276, AW363137, R14831~, AI160952, AA532412, N50861, AW080680, AA090589, AA642583, AI745558, 852396, W03638, W81516, AI241010, AI800855, AA978275, AI769864, AW378894, F06155, AA054691, AI266732, T35240, H12819, AI803688, AA093937, AA095746, N56371, AI783666, W70334, AI588883, AA781204, AA292712,, AW163071, AA811471, AI915047, AA825759, AA831866, AI889870, F05792, AW193572, 238714, AA709427, D43951, D87078, and AC007041.

TT~EN77 90 11897201 - 118815 - AW044467, F36391, F24585, 1202 F32675, AA280314, F25326, F28193, F28533, F28615, F19619, F24152, AW237359, F29659, F22107, F29073, AI684954, AI936300, F18281, AI202754, AA346025, F25534, F32185, AA345800, F24544, F29939, F35657, F37193, AA179959, F34439, F30682, F34910, AA31I094, AW292728, F35448, F26754, and AJ011118.

HHESP66 91 11546411 - 103615 - AI125852, AA259012, AA224099, AW087456, AA326934, AA326933, AC005188, AC006291, and AF028722.

HAHHQ37 92 9674421 - 222615 - AW401851, W07754, AA806378, 2240 AA947309, AI921808, AI654857, AA310232, AW 176705, AI651405, AI660075, H14527, AI431898, H26800, N35426, 846681, AI631881, C17310, AI672616, C16874, AI624730, AW 182813, AI460327, AI624728, AA620869, AI025529, AA720646, F35365, AA650038, T40637, AI201217, AF053356, and AR016407.

HAMAA10 93 9687491 - 958 15 - AI971343, AW380724, AA195950, AA192963, AI620346, AW449825, F21243, 224852, T30560, AW380723, 217422, AA176595, AA176955, F00172, AA195854, AA192662, AA194350, and U76618.

HHFMH12 94 9693241 - 388215 - AI096627, AI750041, AI589918, 3896 AI870013, AI431911, AW071873, AI567485, AI492558, AW082735, AI493768, AI971206, AW068564, AI494149, AA158252, AI422826, AI363488, AI460100, AW104306, AA100840, AI755276, AA476207, AI992015, AW026405, AI1902I7, AA67883I, AI376927, AI738539, AI439206, AA037160, AI418906, AI361483, AI038534, AA877117, AI356122, AA425180, AI372673, D80801, AA160849, AI499098, N77542, AI359937, AA349465, W88956, AA325211, N62261, AW150270, N94717, AA043409, D80800, AA355373, AI084962, AI372674, H63354, AA313505, AA789304, AA351821, AI937868, AA102488, AA349466, AA158399, AW339965, AA330631, AW083453, AA156068, AW075493, AA161281, AA654017, AA350488, AI094530, AI205125, AI686221, H41345, W89039, AA548969, AI334361, AW338483, AA102489, AI961671, AI570099, AA367255, AA351820, T98883, AA301787, AA631107, T18598, AA102418, AI926390, AA143489, AW189862, AA02702I, AA702382, AA904590, D31580, AI590590, AW082999, AA376185, AL042199, W88756, AW134571, AW009324, AI811883, AW003196, D29325, D29337, AA043408, 845887, AI702386, H50462, AI198157, AI858384, and AI624949.

HDTIE58 95 9713391 - 250215 - 2516AF150174, AI417513, AI698235, AL119457, AL1I9399, AL119324, AL042544, 856970, AA471187, AL134524, 299396, AL121306, AL119443, AW392670, AL119464, AL134920, AW372827, AA572761, AR035224, AR019098, I25027, AR054109, I44515, I26928,126930, I26927, I25041, I44516, I85513, AR009152, AR009151, AR027099, AR020199, AR001287, AR064321, AR020200, A94046, A94054, AR020198, I05393, A10617, AR028792, AR020197, A01324, A01323, AR019094, AR034783, I63120, A92666, I89986, AR067733, A92668, I49890, A92667, AR064322, AR064323, AR064320, A94048, A94061, A92665, A32110, AR038321, AR038307, AR029418, AR067734, AR067731, A49045, AR067732, AR029417, A83642, A83643, A70359, I05430, AR028791, AR028793, AB026436, A91752, AR060234, AR066494, A46343, A46342, AR032878, A92081, A92080, A92077, A92078, A92079, A91751, A81671, AR054110, and AL049423.

HIBCN93 96 9736791 - 149215 - 1506AI056401, AW072652, AI885072, AW205916, AI879122, AI885524, N34233, AI953626, AI768363, AI500165, AI887770, AI651798, AA393235, N35730, AW297174, AI802927, AW271854, 856346, AA249118, AI377463, AW070857, AI824909, N53527, AA9483I0, AI20686I, AA572777, AA570002, AA814424, N25635, AA255602, AI478500, N25539, AA634056, H07018, N28490, AA416965, N34136, N34013, AA902860, AA255576, AW029208, AI690664, AI198003, H99526, H05467, N49189, AI190195, AI864484, N30121, H99763, AI024777, AA379362, AA262183, AI191172, 886778, AA721016, AA350164, 813979, AI963889, AA339761, 817378, N49183, AA262707, T33288, 842616, H99527, T16329, AI423712, AI952318, D62700, AI267479, N92737, W20356, AA385524, T28424, AA370138, AA279758, N24571, 840039, AI351820, AI674497, AA864521, T35226, D57142, 856257, N50244, AI124956, and AF143235.

HSWAP86 97 11653861 - 783 15 - AI057117, AW272585, AI589776, 797 AI246523, AA767227, AI625485, AA873003, AI239712, AI955774, AW296331, AI741538, AI479753, F32315, AI674694, AI932376, AA804789, AA044610, AA993510, AA243346, F36914, N55553, AA262732, AI961836, AI927868, AI127216, AA324979, AA953487, AA720891, 886959, AA039578, AA487796, AI886998, AA485892, AI685404, 805274, AI684523, AA912800, F18062, C00227, AA747721, 805331, AL134110, AL134524, AL045327, AL038878, AL045328, AL047163, AL042898, AI318479, AL037295, AL038838, AL037343, AL048677, AL038651, AI547295, AL038983, AI142134, D29033, AL037436, AL037335, AL037323, U46344, AL037727, AL037443, AL038532, . AL038822, AL038761, AL037435, AL135012, AL040472, AL043941, AL039432, AL044125, AL043923, AL043814, AL047012, AL041238, AL044186, AL040617, AL043845, AL041347, AL038024, AL045494, AL040576, AL040193, AL045753, AL042523, AL041955, AL040463, AL047170, AL048657, AL044037, AL041635, AL040294, AL044064, AL041459, AL041577, AL044162, AL040464, AL0472I9, AL040625, AL045684, AL041752, AL046850, AL040768, AL045671, AL046994, AL046914, AL048714, AL039360, AL038745, AL040052, AL043496, AL040444, AL043538, AL040621, AL0405I0, AL043467, AL043677, AL040839, AL043492, AL041602, AL044074, AL041730, AL041523, AL043627, AL041374, AL043848, AL043570, AL047183, AL042135, AL046442, AL041324, AL042420, AL041133, AL039643, AL039316, AW363350, AL041098, AL040322, AL046392, AL045891, AL040119, AL044272, AL044258, AL037341, AL038040, AL041096, AL042096, AL042655, AL042519, AL045817, AL042468, AL041168, AL049018, AL079852, AL041163, AL041159, AL045920, AL040148, AL047057, AL042741, AL038041, AL040458, AL044187, AL045990, AL039338, AL079878, AR066494, AJ238010, A93923, A939I6, D17247, A93931, AR064707, A85203, AL133053, AL122101, AL133074, AL133049, AR023813, and AL133082.

HHSGI32 98 12165491 - 262215 - AW341277, AA449052, AA677433, AI375482, AI393099, AI913346, AA649052, AI859698, AI417958, AI373524, AI769760, AA442905, AW271751, AI685790, AL045906, AW243463, AI684073, AI670074, AA470724, AI344642, N76222, AA701021, AA758141, AW029224, AI040528, AI376742, AA693735, H423I3, AW296327, H12220, AA464605, AA835707, N54520, T26462, AA121186, AA758284, AA430532, AI470967, AA121187, AI565321, N50674, AW193102, AA885708, H30000, T26463, AW079408, AA864717, T17007, AA761856, 240783, AA887660, AA373205, 005171, AA918565, F07717, H43079, T99533, 820437, H30001, AA371324, AW020286, N50763, AA665044, H46108, T99427, 843557, AI368375, AI915506, AI913702, 895437, AA374682, D79994, AL035461, and L10617.

HAJBH69 99 8121641 - 311 15 - AL038926, AL038950, AW408001, AW391591, H55315, AF190862, AL035496, AL110219, D63876, and AL035496.

HAGFN07 100 9536061 - 122415 - AW249532, AI813508, AI823915, 1238 AI342400, N37069, AA568252, AA947519, AI150772, AI677789, AI037990, AI688701, AI016445, AI143732, AA533883, AI565693, AA639295, AI083663, AA621146, N27680, AA831223, AA132974, AA057865, AW245927, N20843, AA918001, AI368438, AA121653, AA057158, AI078660, F36772, AA064652, AA602087, AW083290, AI685603, F28422, W46636, AI673324, AA564277, N75480, AA056990, AA602067, AA195380, AA056931; F32570, AA862954, F20800, AI688690, AA502303, T82852, AA373896, AA741294, AW083609, AA635261, AI056552, AA627771, AI032312, AI953435, AI480060, N30051, AI423931, AI265981, AW360851, AA421701, AA708457, ' AA670135, AA532823, T77227, AW058031, H73306, AA584493, AA584183, AI003123, AF161387, AC005480, AC005914, AF165926, AF111168, L44140, AC005566, AC004686, AC004685, AC005821, U91326, AC004448, AC005736, AC005778, AC002045, U9I321, AFI96969, AL022326, AC002544, AL031281, AC005585, 284466, AC004876, AL133246, AL049569, AC004526, AC003042, AC002072, AC005391, AC006312, AL049776, U95742, AC005082, AC007226, AC010205, AC002369, AF111169, AC005409, 293017, AC002350, AL024498, AC002126, 283844, AC005520, AC006273, 295114, AL135744, AC005565, 298051, and AC007285.

HMAER78 102 7027351 - 258 15 - 272 AC074333.

HKAAV49 103 11797131 - 232415 - 2338AI799049, AI817763, AI858292, AI760537, AI765842, AI420944, AA251693, AA486025, AI473693, AA312702, AA886700, AA994059, AW131318, AI829801, AA504162, AW381909, AA694610, AA282359, AI906052, AW293269, AI818103, 841095, AI857294, AA488643, AI744493, AA826123, AI684375, AA749198, AI422295, AI809857, AI494356, AW241550, AW340230, AA345053, AA961472, AA865761, AW291047, AW 169873, AA836393, AW379702, AW149767, AW293108, AI493451, AA251293, AW444604, AI684607, AI798963, AA811232, AA282239, AA806298, AI826070, AA927651, AW296764, AA027336, AW451802, AW084424, AW363396, AI358492, AW296453, AI741498, AA765031, N79797, AA588465, AI952176, AI248480, AA635240, AA527689, AI023395, AI394251, AA563855, AI201310, AI299742, T62220, AA989547, AI453478, AI361852, AW328273, AI361088, AA534434, AI698315, AI089866, AI201017, AW022967, AA586932, AW043580, AI150585, AI816772, AI040272, AI379533, AA554854, AW411504, AW268671, AI702328, C21347, AA765074, AI393879, AI037874, AI919086, 816122, D25647, AI184722, AI095412, AI370571, AI458842, AA569975, D57706, AI479367, AW 189870, AI310479, AA226696, D57993, AI707799, AI223264, AW338591, AI587380, AI582086, AI301338, AW273757, AI952041, AI796665, AA687975, F36849, AI240389, W84553, 832337, AI601274, AA360214, AA326781, AI685411, AI983171, AA009712, AI858644, AI423714, AI264456, AI707658, AA455918, AI274115, AI718515, AI720566, AA995995, AI752880, AA187492, AI709267, AA083781, AA009518, AA009605, AA857434, AA187493, AA733076, AI803597, AI263960, AI376377, W96223, AA041372, AI350163, AI144406, AI308932, AI288655, AA679555, AI127377, AI346738, AI000041, W93998, AA256978, AI276726, AW302468, AI633656, AA558214, AI887048, AA973779, AA583257, AA443217, AI336629, AA922486, AI263444, AA501596, AI679621, AA723834, AI633571, AI749034, AA534316, AA729899, AA679404, AI354810, N92309, AI417142, AA625398, AI224534, AA583151, AA444051, AA922429, N91164, F24871, AI206667, AA838247, AA011173, F15777, AA640113, AI349555, AA995062, AA722750, AA418468, AA588110, AI952192, AA617727, T85282, AA0248I
1, AI185033, AW272752, AI003158, AI086164, AI749144, C05933, AI263502, AA765610, AA622630, AI400678, AI299597, AA010745, AI749536, AI383391, AI969224, AA424677, AA634592, AI791420, AI142475, AA847361, AA614429, AW452846, AI090953, AI720507, AW130221, AA256979, AA069984, N20916, AI749974, AI828097, AA971799, AA009822, H03360, AW 182234, H45259, C00609, AA253088, H88975, AA092475, AA581362, AW090671, AF121775, M77198, M81457, and M38591.

HAPQS74 I04 8555381 - 761 15 - AI401739, AI743497, AI198899, 775 AI807434, AA040087, AI288962, AA158618, AA918798, AA969724, AW293072, AI493380, AA412433, AA781779, AI207883, AA122226, AA978278, AI970236, AW087431, AA040134, AA282679, AA412432, N27578, and AF136450.

HTEPM33 105 8705611 - 816 15 - AA824347, AA889787, AI425084, AA868962, AI190895, AL132776, AF083394, AL132776, AL132776, and AL132776.

HLTES49 106 8722621 - 381 15 - 821493, AW247091, AA318712, 395 W69555, AA373044, W03593, W81335, AA156841, AA150985, AA151036, AA025956, AA526626, AA341135, W81261, W38490, AA344784, N42066, W05636, AW404642, AA458523, AA355413, H22398, AW051303, AI160442, N36565, T20101, AI949608, AI808171, AI126861, AI147464, AI188724, AI417410, AI675163, AI149310, W88848, AII93857, AI333419, AA987272, AA889985, AI159779, AI203946, AA772316, AI190133, AI088553, AI148793, AI147633, AA723186, and AC004707.

HDTEJ81 107 9198731 - 790 15 - AW051303, AI160442, AI675163, 804 AI417410, AA779534, AI949608, AI147464, AI188724, AI808171, AI193857, AI149310, W05636, AII26861, N36565, AA987272, W81261, AA772316, AAI56841, AI333419, AI203946, AI159779, AA458523, AI190133, AI088553, AI147633, AI148793, AA151036, N67749, AA723186, AA025956, AA150985, AA889980, AW136090, AI128528, AA150928, AA813501, AA150938, W81335, AI091251, AI494503, AW273369, AA525973, AW404642, AI015920, AI347389, W69555, AW247091, AA526626, N80199, AA716232, W03593, AA806495, AW265401, AI160615, AA536057, AA025768, AI023538, AI022607, AA730333, AI004543, AA373044, AA962262, AA516362, AA503958, AA774485, AI635460, AI022762, W69266, AA641289, AA341135, W88848, W81336, N32922, AA318712, T30218, AA992404, AI675588, AI636840, W38490, AI283855, AI262717, AA344784, F35937, 842876, AI185384, AA513218, AA579739, N77883, W88752, AW079571, 821493, N42066, T16491, AA543048, W81193, AI269143, T05161, AA355413, AI572961, AI674400, H22398, F34997, AA973177, AA889985, AI702406, AI699857, AI349772, AI499463, AI758437, AI433976, AW162071, AL047042, AL121270, AL135661, AI349004, AW268253, AT064830, AI868831, AI349933, AW117882, AW301409, AL036146, AI568870, AW274192, AW071349, AI340582, AL036396, AI906328, AW103371, AI678302, AL121365, AI567351, AI687728, AI500077, AL045500, AI250293, AI815383, AW074993, AI5387I6, AW195957, AI440426, AI312152, AI345735, AI349937, AI281779, AI633419, AL119791, AI686926, AI521012, AI349645, AI613017, AI433157, AI436456, AI687376, AI697137, AL046849, AW071417, AW089572, AL036802, AI679724, AI863014, AI439087, AW169653, AW303152, AL038605, AI275175, ALI19049, AI608667, AL047763, AW238730, AI590128, AI343112, AI635461, AI873731, AI497733, AI349256, AA640779, AA613907, AI282655, T20101, AA572758, AI475371, AI564719, AI500553, AI620284, AI673256, AI498579, AI889203, AI702433, AI636456, AW068845, AI610645, AI349614, AI866608, AI445432, AL036980, AI625079, AI690751, AL120736, AI631107, AI800453, AI800433, AI800411, AI568854, AI857296, AL038778, AI540832, AI818683, AI499393, AI567632, AI207510, AI249257, AL040243, AI285735, AI366549, AW148320, AI348897, AI583316, AL120854, AL036240, AL119748, AI345744, AI282903, AI690835, AI920968, AI687375, AI349598, AI609592, AL036759, AI597918, AI610307, AI469532, AA938383, AW080838, AI597750, AI580190, AI969601, AI934036, AW 166645, AI866002, AL036274, AI907070, AI753683; AI475134, AI919058, AW235035, AI813914, AI281773, AI801213, AI680113, AC004707, AL050393, I48979, AL133016, AF125949, L31396, AF113691, L31397, AF104032, AF118064, S78214, AJ242859, AL133640, AF090943, AL117457, AF113676, Y11587, AL049452, AF090900, AF118070, A93016, AL080060, AF113694, I89947, AF113013, AF090934, AF078844, AL050146, AF090901, AL137527, AL110221, AF090903, AFI13689, ALI33606, AR059958, S68736, AF113690, AL049938, AL117460, AL110196, AF090896, AF106862, AL133075, AL050149, I89931, AL050108, A08916, AL049466, X84990, AL122050, AL050116, U42766, AB019565, A08913, AF113019, AF113677, AL049314, AF113699, AF017152, AL080137, AL122093, E03348, AL050277, AL137283, AL080124, AL096744, AL133557, AR011880, AF158248, X63574, AL122121, AL133565, AL049430, AL133093, Y16645, I48978, AL133080, Y11254, AL117394, AL122123, AL137557, AL137459, E07361, AF146568, AJ000937, AF111851, AF091084, U91329, AF097996, AF125948, AL050138, X82434, AF177401, AL117585, AL110225, AF079765, AJ238278, 149625, AF017437, E07108, AL049464, U00763, ALI33560, AL117583, S6I953, AL137550, AL049300, AF067728, A65341, A08910, AL049382, E02349, AL122098, A08912, AL117435, AL050024, X70685, A03736, AC007390, AC002467, AFI 18094, U80742, AF183393, A08909, I33392, AF091512, AL096776, 282022, AL133113, A58524, A58523, AC006371, AC004690, AL122110, E05822, A77033, A77035, AC004987, X96540, AL049283, AC006336, ALI37538, AL080I27, U72620, X72889, AL137648, AC005295, AL137271, AL137521, AF087943, AL137463, AF061943, A12297, I03321, I09360, AC004686, X93495, I26207, U3S846, AC007298, Y09972, AL110197~ X65873, U67958, AL035067, I42402, AL080159, AL022147, AC004385, AC007392, AC004093, I17767, ALI33072, AC007172, AF026124, AL035587, AC006112, AL133077, AL133104, M30514, I66342, X98834, AC004883, E04233, E15569, AC005291, U95739, AL137523, L13297, AL078602, AL133445, AJ012755, L78810, E08263, E08264, AF042090, AL031346, AC006840, AL137533, AL133568, AF162270, AF111112, AC010077, AC006039, AC005488, AC004707, and AC004707.

HTLCY21 108 9102121 - 851 15 - 888948, H51012, H30614, 885182, 865 015076, D80164, D59467, 014389, D59502, D59275, D81026, D80195, D59619, D81030, D80210, D80240, D50979, D80227, D58283, D80022, D80166, DS1799, D59859, D80219, D80193, D59787, D80391, D51423, D80253, D80043, D80269, D59610, D80212, D80038, D80196, D80188, D59927, 014331, D57483, AA305409, D80366, D59889, D50995, D80045, D8024I, D80251, D80378, AW177440, D80024, 014429, D51022, AA305578, D51060, T03269, 014014, D80522, AW178893, AW378532, 075259, AA514188, D52291, AW179328, D80248, D51250, AW369651, D80134, AA514186, D58253, AW 178762, AW 178775, AW 177501, AW177511, D80133, AW176467, AW360811, AW352158, D80268, 005695, T11417, 014077, F13647, AW352117, AW375405, AW377671, AI910I86, 014407, D80I32, AW378540, AW366296, D80302, AW360844, D59373, AW360817, AW375406, AW378534, AW179332, AW377672, AW179023, AW178905, D51103, 006015, AI905856, 221582, D80439, AW352171, AW377676, AW178906, AW352170, AW177731, D80247, AW 178907, AW 179019, AW
179024, AW177505, AW360841, AW179020, D59627, AW 178909, AW 177456, AW
179329, AW178980, AW177733, AW378528, AW 178908, AW 178754, AW
179018, AW360834, AW352174, AI557751, D80014, AW 179004, AW 179012, AW
178914, AW378525, D51213, D51097, AA285331, D80157, AW177722, AW367967, D59503, AW177728, D81111, AW179009, D51759, AW178774, AW178911, AW378543, AW352163, D80258, H67854, D58246, AW178983, AW352120, AW178781, T48593, D59653, 014227, AW177734, D58101, AI535850, AW177723, T02974, AI557774, AW177508, D45260, 003092, AI525923, AI535686, 014975, AW367950, AW378533, AA809122, D59551, H67866, T03116, D80064, AW177497, AW178986, D59317, AI525925, D45273, AI525917, D51221, 014973, D80168, 014344, AI525920, D59474, D60010, 014957, AA514184, D60214, AI525227, T03048, 014046, D59695, AI525242, AI525235, AI535961, D80949, D51079, AI525912, AW378542, AI525215, 014298, AW378539, AI525237, 016955, 005763, 233452, D31458, AI525222, AF135415, U89343, 571659, AJ132110, A84916, AR018138, A62300, A62298, AF058696, A25909, AB028859, X67155, Y17188, D26022, AR008278, A67220, D89785, A78862, D34614, D88547, I82448, X82626, Y12724, A82595, AR025207, AB002449, AR060385, A94995, AR016808, AR008443, AB012117, I50126, I50132, I50128, I50133, X68127, A85396, AR066482, A44171, AR066488, AR016514, A85477, AR060138, A45456, I19525, A26615, AR052274, A86792, U87250, X93549, Y09669, A43192, A43190, AR038669, AR054175, I14842, AR066487, AR066490, A30438, I18367, D88507, D50010, Y17187, A63261, I79511, AR008277, AR008281, AR008408, AR062872, A70867, AR016691, AR016690, U46128, D13509, AF135125, A64136, A68321, AR060I33, AB023656, 282022, U79457, AF123263, AB033111, AR032065, AR060382, X93535, and AR008382.

HKAKF45 109 10909881 - 826 15 - 840 AW381241, AL117504, AB023174, and AL096678.

HMWDF88 110 9067691 - 349 15 - 363 H94922, 878249, AA448990, 814119, and N47060.

_H_HFCU86111 9450621 - 692 15 - 706 AW068821, AA179850, AA347950, and AF 132937.

HTPHO01 112 11524241 - 117615 - AA045042, AA843152, AA156920, 1190 N93318, AI336321, AA156748, AA9I9I07, W72463, AA830277, AA037135, AI080539, AA156724, AW054682, AA412716, AI214531, AA156830, AI268319, AI192613, AI089320, AI129828, AA744675, AW054721, AI368693, N30238, AI056447, W37283, AI582210, AA401901, AA832431, AA722658, AI338219, AA505698, W67440, AI972030, AI139094, AA926692, W32525, AI375239, AI742513, AI344126, AW026339, AI338181, AI970997, AI074233, AI139159, AA452I25, AI300753, AA731 I54, N95054, AA928924, AI830575, AI494078, AA644138, AI751817, AI183773, AI675706, AI148098, AA995310, W60021, AA954291, W44927, AI199971, AA130261, 848544, AI991339, AA911327, AI359933, W67441, AI285066, AA884026, AI095687, AI203669, AI559949, AA805553, AI192137, H01993, W44501, W76019, 864418, AA482591, AW 170013, AA035330, AW150567, AI291185, AI264416, AA194283, AI300238, H28315, AI864148, W25141, AW340658, 868955, AA938400, AA135790, W37796, AA772619, AI494112, N57130, AI9S5746, AI363456, AA280408, H43891, 827968, AI307177, 868838, AI376902, AI888544, AI936538, AI198333, C17813, 832608, AI337473, AA894852, W24433, AA194406, N76141, H43929, H28314, AI300609, AA094826, AI655355, AA363376, N93111, AA149447, AI186703, W23603, 863811, AA642334, 848631, N94620, AA960954, AA988685, AI352072, AA866053, AA135746, W05645, W32641, AA156689, H39712, AA452348, H13826, AA918331, AA612832, AI193848, AA554306, AI093632, AI276589, AA447655, AI273430, N30561, H28693, AA134664, AI373118, H04586, AI278504, AA095991, AI587139, AW341382, AI818830, AA994085, F23391, AA039759, H13182, AI934888, W24049, 832498, AI078102, and AF169284.

HFXKR90 113 9483991 - 575 15 - AA453713, AW058431, AI796911, 589 AI800218, AI346281, and AL117551.

HDPBQ32 114 9491911 - 290615 - AL041780, AA447233, W63594, 2920 AI479623, AL120043, AI862014, AW370548, AW370546, AA833890, AA528106, AW342135, AA767439, AI884921, AA810497, AI479859, AW246967, AI598172, AA316311, AI862137, AA808946, AW438512, AW250167, AW014235, N48194, N31847, AAS65004, AI147687, AI42 I 531, W94723, AA709397, AI041972, AI860296, AW029341, AI311132, AI097206, AI124091, AI363367, AI093332, AW273088, AIOI7231, AA658369, AA669438, AA488942, W94478, AA436731, AI439831, AI986078, W26165, AI864954, AI866181, AA648310, AW274809, AA635499, HI0274, AA630795, AW316730, AW440901, W04336, AL041779, AA658353, AA767423, AW105681, AW002817, AA976719, H386I0, AA452736, W88618, AI573056, AI017009, AI192454, T33808, AA042879, AA878793, AI818364, AI435523, AA485399, AI280334, AI669596, N23334, AI630924, AI349078, AA086333, AL135653, AI360950, AW262423, AI374697, AI568362, AA782533, AI908446, AA581018, T69944, AA262554, N23946, AA366444, AA027924, AA452551, AA358621, F37326, AL134964, 811755, AA761233, AA358622, AI206778, AW262418, 823435, H37936, AW298228, H86266, AW272102, AA100347, AA626778, H38589, N64738, T06960, T53997, AI814020, AA988901, H11262, T64797, AI033988, C00287, F27815, AA215782, 817275, F05786, AW079229, AI525067, 807905, T24060, AA299962, H10218, W27761, F12185, AI352630, D56196, 812465, N91751, AA193243, AI018166, 807852, AA424815, H38851, AA370279, T82106, 851860, T81790, 241898, F11035, F02033, AA093862, AA918426, AA043004, AA371442, N24549, AA351515, H86265, AA805378, 841949, T55253, T72550, AA485560, H11263, 837351, 844220, F01399, T93582, 841392, AW238018, AA027858, AW088974, T70019, AA918403, AA356909, AA034107, N74170, AA832430, N53341, AW070570, AA632032, AW238023, N87429, AL040495, 854254, T10580, AI828485, W26617, AA495855, AW137399, 224796, AI873580, F00149, AW024740, AA192580, AI086408, AI7999I0, AA585140, W27789, AW131985, AW406062, AA629234, N63605, AA639515, AA885541, N56490, AA377723, AA583734, AA627268, AI908889, AI371383, and N83787.

HNTAR73 115 9492891 - 363 15 - AA453713, AW058431, AI346281, 377 AI796911, AI920904, AI276048, AW 196781, AI264211, AI022218, AI201482, AI583539, AI955668, AI911743, AA526367, AI924093, AI766300, AI983710, AW026429, AI800218, AI623560, AA922838, AI565141, AW299693, AI306731, and AL117551.

HHEGC16 116 9507781 - 148315 - AI074147, AI249752, AI991117, 1497 AA573289, AI744674, AW372737, AW383987, AI951269, AW372734, AW372745, AI097133, AW081142, AA121349, AI560208, AI160271, AW388634, H69344, AI309528, . AI310351, AW073286, AI222028, AW372735, AA121301, AW170797, N31288, AW372730, AA278853, H47623, AA742972, AW363751, AW372731, AA864447, AW372736, AA173309, H47925, AW372742, AA278420, AI476011, AI572193, AW372739, AW372744, AW188877, H38254, H69345, AA278794, N22901, AW372740, AW372786, AW372738, AA769896, AL040673, AL044623, AI445886, AI431235, and AF 132937.

HSIGE72 117 9522751 - 253715 - AI927678, AA232725, AI633723, 2551 AI333470, AA779999, AI816902, AI022001, AI434446, AI056039, AI925006, AI288255, H29661, N47100, AI124781, AA206869, N34544, HI5466, AI674776, AI479295, AI419277, AI246156, AI375207, N62861, AA315242, AI250185, AI861879, AI184068, AA325690, AW016675, AI283674, AW304435, T79977, H50315, AI266406, W26725, F01086, 869275, H29577, T83389, AA657840, T8I576, W24823, AI084936, AA905914, AA736793, 869161, 812256, F05440, T97379, AI627522, AW300235, AA885377, AI419677, AA206868, F00267, AI425106, D56584, 816708, T97268, H15410, AI904285, N67285, 839343, AA308742, F05501, F01702, AA236518, AI804415, X66366, AF174130, AL049835, AL117667, and AL049779.

HCGMG56 118 9536601 - 694 15 - W81261, AW051303, AI160442, 708 AA156841, W05636, AI949608, AA458523, N36565, AI188724, AI147464, AI808171, AI193857, AI675163, AI417410, AI149310, AI126861, AA151036, AI333419, AA025956, AI159779, AA987272, AI203946, AA150985, AA772316, AA779534, AI088553, AI190133, AI147633, AI148793, W81335, AA723186, AW404642, AI128528, AA889980, W69555, AW247091, AI091251, AA525973, AW273369, N80199, AA813501, AA526626, W03593, AI494S03, AI015920, AI347389, AW136090, AA150938, AA150928, N67749, W81336, AA373044, AA716232, N32922, W88848, AI160615, AA025768, AA730333, AA536057, AI023538, AA341135, W69266, AI022607, AA318712, AA641289, AI004543, W38490, AA806495, AW265401, AA962262, AA774485, AA516362, AA503958, AA344784, AI022762, AI635460, T30218, AA992404, AI675588, AI283855, AI636840, AI262717, F35937, N77883, N42066, 821493, W88752, AI185384, AA513218, AA579739, 842876, AA355413, W81193, T16491, AA543048, H22398, AW079571, T05161, F34997, AA889985, AI269143, T20101, AI674400, AA973177, AC004707, AC004707, and AC004707.

HNGBQ66 119 9660011 - 194015 - AW239349, AA075198, AW089835, AI249014, U56656, AA602491, AA602490, AA148805, AA375315, AI248362, AA355780, AA857449, AA857800, AI625310, T93052, AA046175, AI355290, AI246624, AI952649, AA910993, AA705614, AA213680, AA640285, AI435S92, AA256651, AA213638, AI983332, AI310880, AA876950, AA742759, T49744, AL117554, AF123534, AF194371, AF069782, AF053232, AF 161469, and AC009069.

HTXPY09 120 9660131 - 114415 - 1158AI435592, U56656, AA148805, AA046175, AA075198, AF194371, AF069782, AF053232, AF123534, AL117554, and AF161469.

HCHAS12 121 9666261 - 137515 - 1389AI539386, AI190303, AA868538, AI219986, AI345954, AA988977, AI309975, AI200426, AI338679, AI720044, AI148589, AI827995, AI829710, AI807471, AW268605, AI202768, AA932930, AI808710, N37092, AI091541, W74439, AI436105, AI332422, AI222787, AA865258, AA883578, AI830140, AI536845, AA435561, AI476645, AA436117, AI393567, AI742423, AI991280, AI040961, AA976254, AI911731, AI204236, AI684261, AI807161, AI798704, AI091532, AW001083, AA776717, AA906270, AI286196, AW084515, AA884285, AA884231, AW195890, AI203679, AA843421, AI142135, AA393148, AI149711, AI167652, AA917965, AA758038, AA846787, AA923373, AA740667, AI936554, AW043785, AA994527, AA725406, AI243219, AI083755, AI200425, AI291760, AW269733, AA456074, AW391262, AI833323, AI311479, AW304042, AI243370, AA777492, AI694334, AI027967, AA910051, AI167246, AI031908, AA757222, AI025986, W58740, AI091504, AI679583, AI688130, AA758549, AI935008, AI318065, AA972041, AA962659, AI083851, N29346, AW188625, AA897637, N40362, AA996162, AA748637, AI241349, AI150116, AI799122, AW166483, AA971938, AA884703, AI807973, AI243421, AI347903, AI024835, AI025228, AW183835, AI798180, AI858097, W79084, AA875'917, AI276559, AI493367, AA410432, AA905015, AW371415, AA904368, AI284271, AA505880, AI743644, AA305510, AA938552, N26589, N27547, AI911350, AI377383, 823891, AI187351, AI214377, AW082764, AA843427, AA954722, AA954270, W00472, AA4123I7, AA740333, AA455577, AI971480, AA305179, AI216245, AW085014, AA977877, AI689289, 865987, AI220007, AA099550, 876814, 865986, AA815444, AI698618, AA835882, AA969436, 883423, AI198119, AA861386, AI168675, AI160545, AA815351, AI269132, AI243242, AI223152, H02479, H72396, AA970621, AI762065, 871169, AI289227, AA952918, AA999722, AA305134, AI205806, 823890, AI215980, AW082794, AA927156, D60944, AW137925, AA928243, AA912408, D6I030, AA890I54, AA758323, AA932728, 863480, H01351, AA972542, AI216504, 863278, AW135447, AA885425, H12460, AA628621, AI272123, 889052, AI749504, AA724803, H59895, H72421, AA775373, AA877346, H01218, 875983, 802720, 873757, 873969, F37219, AA970616, AI826276, AI189999, 876229, AA295914, H02478, 876230, H03862, 831547, 837557, AI001978, AA853105, AA548419, N39659, AA588892, AA885048, AW104374, AA483809, 873670, 873883, ' H00834, AI784120, 863227, AI885432, AI149979, AA442745, 831066, 826664, H17430, 876442, AA832163, 825112, AA833569, 879832, H03308, 836714, AI417747, 823710, AA579968, AF151810, AF039696, T85666, 825111, 872440, 876443, 879639, H03307, H12509, N57044, N72191, AA099077, AA159464, AA501911, AA512970, AA516390, AA534533, AA541583, AA577436, AA885823, AA928429, AA705903, AA709286, AA812583, AA860558, AA883844, AA907332, AA939048, AA953782, AI301012, AI391496, AI559375, AI148978, AI187988, AI239820, AI697358, AI867664, AI924417, and AI951457.

H6EDI12 122 11540531 - 836 15 - 850 AA722724, AI972007, AI284131, AI636619, AI540606, AI624304, AW074274, AI797794, AI886206, AI955906, AW029349, AI473451, AI888621, AI291973, AW084097, AW168709, AI886192, AI683590, AI698401, AI860691, AI568060, AI521244, AW088903, AI446405, AI874151, AI452556, AI683463, AI632033, AI378123, AI498579, AW118332, AW026425, AI092027, AI281867, AA493923, AI580674, AW195969, AI868163, AI859880, AW058279, AW078805, AI345347, AI571699, AA494167, AI499986, AI784230, AI798501, AW151136, AW089689, AA468418, AW081255, AI343059, AI885989, AI349933, AI345608, AW007939, AI890057, AI345253, AI953438, AW148320, AI690751, AW403717, AI446003, AW 196105, AI521476, AI860897, AI336503, AI922577, AI348854, AI345471, AA449768, AI678446, AI679728, N22406, AI6I9754, AW128945, AI272116, AI697321, AW183601, AW088134, AW089006, AI702301, AI636719, AI433384, AI916419, AI571873, AW082600, AW168503, AI799195, AW058233, AI627880, AI872423, AI805688, AI625237, AW082088, AI348917, AW I6I202, AI249946, AA019646, AW148590, AI933780, AA635382, AI564426, AI434020, AI929108, F26535, AW080723, AI873638, AW409931, AI565172, AW089275, AW193911, AI623736, AI570056, AI349957, AI500662, AI927755, AW082033, AI559619, AI345005, AI784214, AW263569, H89138, AL036718, AI537837, AI620093, AI282743, AW162189, AI252813, AI582871, AI923357, AW006270, AI073952, AW089572, AW088560, AL037030, AI932949, AI917963, AI679550, AW131288, AI828568, AI539153, AI357316, AI419650, AI633419, AI799674, AW129171, AI281660, AI686926, AI590423, AI473528, AA848053, AI619737, AI366992, AI470293, AL040011, AI670790, AI866307, AL040694, AL036772, AI446373, AI539771, AI591080, AL036396, AI961589, AI573026, AW261842, AI472536, AI633297, AI453413, AI933992, AW087193, AW085721, AI348897, AI610645, AI917252, AI801213, AI144266, AI684053, AI345224, AI357599, AI917154, AW008090, AI076761, AI648408, AI612750, AI358456, AI34309I, AI345677, AI553645, AI953765, AI280561, AI874109, AI311892, AI872091, AI886055, AW082623, AA908294, AI554487, AI445131, AA580663, AI951076, AW167469, AI963209, AI345370, AI783504, AL043052, AW054972, AI479165, AI309306, AI635067, AL040586, AI242736, AL038529, AI802244, AW074702, AI55961I, AI554484, AI886594, AI367210, AI827311, AI274745, AI680498, AI434242, AI801325, AI554343, AW168802, AI524671, AA769433, AI590635, AW073898, AI254597, AI648567, AI249877, AA740450, AI933001, AI587153, AI671651, N72726, AI890806, AI589267, AW161579, T99953, AW081383, AW044029, AI865116, W33163, AL110306, AI744923, ALI37547, X81464, I48978, AL137292, AJ242859, I89947, AL117585, A08916, AF162270, A08913, 577771, U67958, D83989, A08912, A08910, A18777, A08909, E15569, AF158248, A08908, A21101, 576508, AL050172, L30117, AF159615, A27171, AF113689, I89931, AF210052, I89934, I49625, AF113676, AR038854, AL080086, Y11587, X93495, X65873, AF061943, AL080110, AF113019, AL133016, AL080127, A08907, 213966, L19437, AF081197, AF081195, AL117416, AL117629, A52563, AL137641, AC002467, AF003737, AL122049, AR000496, U39656, I03321, AR059958, ALI10221, A45787, AF146568, AL050393, E15582, E03348, E03349, AL080154, S78214, I48979, A21103, AF090934, AL137557, AF118090, AF031147, AF183393, AL137538, E15324, AL117649, AL117578, E07108, AF039138, AF039137, AL080137, AL137488, 579832, AF022363, AF106862, I89944, AF012536, AJ001838, AL133075, AF061795, AF151685, U49434, A23630, AL080060, AF118070, AL133645, AL122098, U96683, AF205861, AL137656, AL137273, AL050092, AL050138, Y08769, A03736, AL050170, AL050277, AF069506, AF067728, AL080074, U58996, AL137665, AF100931, AL133640, AR029490, AL049466, AF094480, AB007812, U68233, I92592, AF026124, AL137574, U87620, L31396, AL117440, AL117432, AL133565, E02221, L31397, A08911, AC004987, AL137539, Y10080, AL117648, AF119337, AF110329, AL133067, AL137556, AF114170, Y16645, AL049300, X79812, AL110196, I26207, AL137640, AL049382, I42402, X52128, AL133624, 569510, AF090900, U68387, AF079765, U80742, AF061573, AL122121, M92439, AL137476, AL122123, I00734, AL080124, AL049464, AL137429, AF207750, AF036941, 578453, A86558, AF065135, AF107847, U57715, AL122106, I46765, J05032, Y14314, AL096744, E00617, E00717, E00778, AJ003118, AL133077, A08915, AL137527, AL096751, AL133072, AL137548, AL133112, U88966, A93016, A15345, AF104032, AL110171, Y10655, AF113690, X87582, AL080159, D89079, E02349, AF111851, AF114818, X84990, AL133557, AL137558, AF199027, AL080140, AL050146, AF030513, AL137294, U77594, U35846, E01614, E13364, AF032666, AJ012755, AF028823, AL050149, AF215669, AF113699, AL137560, AF132676, AF061836, AL080158, E06743, E08631, AF106697, AL133014, U78525, AL110224, AF137367, AL133665, AL137300, AL049465, AL137537, E12747, AL133560, AF169154, AF111112, AF067790, AL122110, 575997, AL110225, A57389, AL049339, X56039, A65340, L13297, A65341, E05822, E02253, and E04233.

HE8MI76 123 9114741 - 947 15 - AA313731, AI752306, H29716, 961 AL042709, AA360323, AI082737, 220973, AA332646, AI052306, AW305203, AL119510, AL119412, AB018271, and AL137008.

HHSAD81 125 6028541 - 594 15 - AI590557, 868404, and AC004622.

HCEEZ56 126 11716921 - 172615 - AA283155, AI041082, AA282986, 1740 AI082687, AW403360, 853658, T16349, AA677984, 853547, AI264476, AA345142, AI498326, 836905, AA227450, AA918259, AF196968, and AW614362.

HE8TT33 127 11894551 - 351815 - AW409918, AA555102, AI003522, AL043031, AA630416, AI948578, AW337170, AW167070, AW273765, AA594053, AI569275, AW273196, AI831256, AW305101, AI687711, AI831600, AI1385S8, AA496831, AI720563, AA862433, AI313149, AW078880, AA533096, AA779221, AW067833, AA948345, AW273465, W58044, AI937816, AI281213, AI679632, AI952028, AI760519, AI865162, AW246361, AI302423, AI343733, AA706415, AI123673, AI760685, AI440246, N40557, AI281253, AA313629, AA831725, AI086766, AA961667, AL046656, AA716744, AA496873, AA847610, 'AA484227, AW190441, AA946987, AA12897i, AA973226, N40313, H42150, N73331, H42149, AI350245, AI368945, AI475499, AA977358, T28751, H84038, N32942, AA085404, AW183573, N42612, AA128970, H77931, AI140887, H73041, AA837673, C02304, H43391, W27688, AA872296, AI241610, AA190948, H43336, 867613, AA961909, AA524847, T03450, AI350294, AA380114, F12338, AA383474, AI190656, AA191759, H47534, H45269, AI492862, AA931139, AA082891, H45339, AI355469, T64817, AA501558, AA814534, AI750497, 867612, 886074, AI459505, N46601, AA335464, AA361053, AI909884, AA357114, AA355688, AI336599, AL134295, F09959, T15538, AI025690, AA088237, AA911691, AW246574, AA522480, AA836961, AA379298, AW264621, N53833, AA574323, AA355779, H47535, AA355194, AI909872, AI569324, H84039, AA884453,.

AA353547, AI909354, AI422492, AI186316, AA938697, AA380307, AW207459, AI126767, AI040461, AW243462, AA093799, AI700607, AI650403, AA903783, AI700585, AI140020, AI863592, AA045775, AI185719, AI458991, AA040588, W58356, AI089011, AA348299, AA521227, T63406, AA634111, AI984854, AA833567, AW339171, AW067885, AI202083, D21163, U97079, AB038021, AB038022, AW467708, AW511944, AW516364, AW589630, AW769094, AW769284, AW769934, and AW771689.

HAGBX32 128 9513511 - 624 15 - 638 W29095, H04905, H11833, AF100346, and AC004125.

HLWEE80 129 12025341 - 136315 - 1377AI609398, AI278617, AA621655, AA868455, AI081552, AI290739, AI608719, AI567964, AA421224, AA421214, AW193527, AW009516, AI754809, AI022091, AA868840, AW001133, AI376946, AI735188, AI689150, AI743002, AA993670, AW009876, AA911941, AA888156, AA830904, AI277633, AA602889, AA579086, N40529, AA449842, AA843194, AI241348, AA873585, AI273254, AA947889, AA830858, AI090471, AA425965, AA989498, AI300301, AA612762, AI284299, AA550844, AA488241, AA602504, AI026923, AII90110, AA993166, AA421945, AA429053, AA622170, AW250093, AA468742, AA610770, AA078825, AW250846, AI018058, AA410582, AA421946, AI301856, AA683333, AA402945, AI350362, AI753847, AI080736, AA216765, AW403534, AA443534, AA460139, AA847314, AA468762, AA662376, AA476292, AA429082, AI268605, AA581663, AA155589, T70058, AI47I315, AW247558, AAb86337, AW245161, AW248397, N63003, W94599, AA076631, AA468553, AA449898, 869521, AI269128, F36072, AW406807, AI160438, AI880407, AA857872, H23088, N90006, AA460736, AA099847, AA316956, AI872357, AA351368, AW402201, AA864547, W95828, 887220, AA693504, AA258525, AA837812, AA078793, AA3099I0, AA349834, AI688327, AA587426, AI364726, HI4233, AI879829, H30244, AA405877, N79911, AA379651, AW014579, F09159, 887285, AA857088, AA455853, AA654151, H30633, AA364138, 228833, T34731, H87247, AA405186, W00489, F37916, T36108, F36790, H96271, AA665325, 884553, T74871, M62217, AA335313, 887446, AA429249, AA364554, F00281, AA102601, AA887570, AI343791, AI244591, 845183, 820760, AA758410, AA243274, AW247954, N3I446, F32088, 241560, H23087, W05255, AA778048, WI9804, AA085433, AA844795, AL037768, H87295, AA365385, AA773338, F02045, AI005580, AA974346, F11498, AW152260, AA280940, AA323312, AI474244, AA370531, AI524279, AA988319, N98909, AA100352, AI58I582, F34288, AA301073, AA093258, AA382483, AI417506, AI973107, AA384134, D20373, AA365451, AW059596, AA463916, N85692, AA983218, AA371673, T83115, F08593, AA911791, H49168, AA991819, D54442, AA248261, AI143752, AA514249, AA09I531, AA642283, N53896, AA351369, AA053001, AI910138, AA085173, 885162, AI351795, F05797, AI564786, AA055276, AW151136, AI923989, AI630927, AI9164I9, AI581033, AL037454, N29277, AI573026, AI473451, AI590423, AW021717, AI310575, 869938, AL047422, AI815239, AI538764, N63128, AL036705, AL039086, AW020693, AI340533, AW020397, AW162194, AI623941, AW151979, AI345567, AL036396, AW023338, 575463, L38995, X84694, L38996, Y11796, E02349, AL133565, AF039137, I48978, X06146, AF079763, ALI37555, AL110218, I89947, EI5324, AL117460, AR038854, AL080110, ALI33112, AL137547, A08910, A08909, Y09972, AL13303I, A08908, AL133645, A08913, AF114168, AF201468, AF183393, X84990, A08912, S77771, AF061943, AF022813, AJ000937, AL133640, M96857, AL137548, J05277, AL133560, A18777, A08907, A76335, AR054987, ALl'37479, E04233, AL117626, AR038969, A12297, L13297, AFI13699, AFOI7790, E06743, Y07905, 565585, X72387, AF113691, I89931, AL137429, ALIZZI2I, 576508, I89934, I49625, AF106827, AF142672, X86693, A08916, AL050116, X56039, AL049283, 146765, AL137529, AL096744, A21101, AC004200, AL137537, Y10080, AL050277, I33392, A08911, AF026816, AR013797, AL049996, AL133637, 578453, AF111849, AF125948, AL137488, L04504, AF061573, AF102578, AJ012755, AL110280, AL035458, AF111112, AB019565, AF126247, X70685, ALI22I 1 I, AF200464, AB007812, AL122100, AJ003118, U72621, AL117435, U35846, X96540, S78214, AL080118, E01573, E02319, I41145, AL049324, I09360, AL133558, AL050024, AL133557, AL110225, AF090901, AL122093, AL096751, A03736, AJ005690, I48979, U88966, U49908, AL110222, AF207750, AF118094, AF069506, 272491, AL080158, AL137658, AF090896, AF079765, U91329, AL133665, M80340, AF017437, AL137478, AL137271, AF026124, AL1377I1, A07647, AL023657, AF185576, U80742, AL133606, AF043642, AR068466, AF032666, X57961, A23630, A58524, A58523, AF091084, AB016226, AF090934, Y16645, 536676, AF065135, AF090903, AL137533, AL080140, AFI58248, AL050155, X72889, D83032, T89944, AF090943, AL049430, AL133098, X52128, AF153205, E12579, E12580, AL080139, AL133016, E01963, AF146568, D16301, I09499, D55641, AL110159, AL137539, U53505, U54559, LI0353, Yi 1254, AL110196, AL133080, AF087943, Y10936, AL133081, AL050172, A93350, X92070, AF090886, AL117457, U66274, AL136842, AF177401, x32738, U42766, AL137480, X87224, AR011880, AF057300, I00734, E12747, AF057299, X63410, AL117648, AF113690, AF113677, AR029490, AL110296, I26207, AL080234, AF106697, M27260, AF090900, AF047443, AL137284, X99717, E00617, E00717, E00778, AF194030, AF039138, E15582, U78525, AF139986, AL049452, U58653, X63574, A18788, X81464, L04849, AL122110, AR020905, AL136884, AF003737, AF113019, AL133067, L04852, and AF 114170.

HMEFI81 130 12267391 - 415915 - AI073560, AI201459, AA527879, 4173 AA700382, AA777810, AA286925, AA151678, AA418754, AI637549, AA778792, AA983573, W80620, AW103826, AA932949, AA418693, AI829622, AA703112, AA151758, AI131357, AA846135, AI568518, AI124085, W04420, H54635, AA583784, AA960837, AA585439, T87505, W78994, AI200626, M79159, N76001, H53519, H53520, 816415, H54636, AA585453, AI535639, AA585440, AI525556, F11222, N90636, AA442473, AA312406, AI538798, AI525316, AI541510, 228355, AI546855, F08885, AI541374, C15189, AA585434, 802437, AI525328, AI541514, AI556967, 230131, AI541523, AA585356, AI526180, AI546999, AI525306, AI541534, AA585101, 802334, AL044771, AL134123, AL043950, AL036500, AI541509, AI525431, AI541017, AL044029, AI526140, AI557807, AL049007, AL043468, AI541365, AL042245, AI526194, AL045671, AL046147, AL044015, AL040768, AI557731, AL042700, AL046994, AL042712, AL040414, AL040571, AI546828, AL046097, C16300, AL043201, AI526196, AL037341, AI547039, D61254, AI540967, AL040252, AI546945, AL079876, AI557799, AI541535, AI526I44, AI541508, AI557262, AI535813, AI541307, AL048647, AI525653, AL047593, AA585438, AL046914, AL045991, T11028, AL044377, AI535660, AI546899, 829445, AL043604, AI557082, AI557787, 828735, AI536138, AL040510, AL040625, AL045817, AL041142, AL041238, AL041133, AL047183, AL040322, AL041131, AL046330, AL041051, AL041292, AL040119, AL047036, AL047170, AL047057, AL047219, AL041227, AL040463, AL039915, AL043612, AL041197, AL040155, AL041346, AL040529, AL041096, AL047012, AL041358, AL041277, AL041163, AL041098, AL040621, AL043538, AL041324, AL040464, AL044162, AL041086, AL043496, AL041296, AL041233, AL043467, AL041159, AL045725, AL044186, AL041140, AL040193, AL044037, AL040168, AL040091, AL040128, AL040255, AL040285, AL040342, AL040332, AL040617, AL040553, AL045684, AL040745, AL040370, AL043677, AL046442, AL040839, AL041752, AL040149, AL043775, AL044165, AL043492, AL041602, AL045920, AL041278, AL038838, AL040253, AL044258, AL044074, AL041635, AL045990, AL040458, AL044199, AL044187, AL040263, AL040090, AL040294, AL040329, AL040082, AL044272, AL041186, AL040148, AL041730, AL041523, AL043627, AL046392, AL041374, AL040052, AL043845, AL043537, AL039338, AL042135, AL044064, AL039316, AL043923, AL038983, AL043814, AL043848, AL041459, AL043570, AI525320, AL041577, AL044201, AL046850, AL038532, AL037727, T23985, AL040576, AI142134, AL045753, AL044274, AL079878, AL049018, AL044583, AL040444, AL039744, AL045857, AI546891, AL040856, AR017907, I13349, A91965, X81969, AR038855, AR062871, I66485, I66487, I66498, I66495, I66494, I66497, I66496, I66481, I66486, A83642, A83643, I66488, I66489, I66490, I66491, I66492, I66493, A83151, I66482, I66483, I66484, AR062872, AR062873, AR008429, A25909, A20702, A20700, A43189, A43188, A85395, A85476, I18895, AJ244004, AF082186, AJ244005, AJ244003, I44681, A58522, A84772, AR067731, A84776, A84773, A84775, AR067732, A84774, AR037157, A91750, AR054109, A98420, A98423, A98432, A98436, A98417, A98427, I63120, A98767, A93963, A93964, E12584, Y16359, I19525, AR038762, D78345, X83865, A58524, A58523, A86792, A18053, M28262, I15717, II5718, E03627, AJ244007, I49890, I48927, A93016, A02712, A77094, A77095, I84553, A81878, A95051, I84554, A18050, A23334, A75888, I70384, A64973, A60111, A23633, AR007512,108396, I00682, A11624, A11623, E00609, E13740, Al 1178, E01007, A10361, A60212, A60209, A60210, A60211, A35537, A35536, A02136, A04664, A02135, A04663, I08395, I06859, AR043601, A11245, I62368, E12615, A02710, AR035193, E14304, A07700, A13393, A13392, AR031488, I13521, I52048, A27396, AR027100, I44531, I28266, I21869, A70040, A82653, E16636, I03331, Y09813, A24783, A24782, A92133, A95117, I44516, A90655, AF149828, I01995, I08051, A91752, AR031566, I25027, I26929, I44515, I26928, I26930, I26927, E16678, I60241, I60242, A62298, AR038066, A20699, E00696, E00697, A32110, E03813, AR009151, AR027099, AR051652, U94592, I05488, I61310, A60961, A60977, AR051651, A68112, A68104, A06419, A21892, A23997, A68114, A89633, A89634, I08196, A21895, AR027319, A91751, AR027318, AR028564, A60985, A60990, 232836, A47368, A60987, I19516, I19517, D50010, A76773, A22413, AR002333, I63560, AR009152, I63561, I63563, A05I60, A08030, A20502, AJ230935, A95096, A95106, A95105, I07249, I08776, A38214, AR068508, AR068510, AR068509, A63954, I91969, I56772,195540, I58322, I58323, AR003585, I25041, I15353, AJ230902, I05558, A62300, A84916, AR035975, AR035974, AR035977, AR035976, AR035978, A29109, A32111, AJ230972, U87250, AJ230951, A22738, I08389, AJ231009, X07299, D13316, A70872, A58521, A91754, AA994060, AI222259, and AW473454.

HOUHW83 131 11999421 - 269015 - AL042853, N88564, AI270117, 2704 AW274349, AL046409, AI431303, AI284640, AI963720, AA521323, AI732865, AI696962, AW419262, AL044940, AL119691, AW303196, AW193265, AI281881, AW301350, AI613280, AI334443, AA521399, AL046205, AL138455, AW410400, AI110770, AA720702, AL041690, AA491284, AL138265, AA610491, AI254615, AA828704, AA526787, AI754658, AA665330, AI799642, AA581903, AI064864, AI133164, AA908687, AW265393, AI623720, F36273, AI350211, AL037683, AW020340, AA468022, AI355206, AW276827, AI679782, AW407578, AW00491I, AI889781, AI865905, AA631507, AW238278, AI076616, AL039958, AW072587, AA490183, AA649642, AI341548, AW028429, AI561060, AI370074, AI473943, AL042756, AA164251, AI801591, AW270382, AI149478, AI587583, AL045053, AI587565, AI289067, AA682912, AA723017, AW276435, AI821271, AW302013, AI559705, AA8778I7, AA101689, AL048626, AI368745, AL119649, AW169151, AI358501, AI499938, AW085740, AI270559, AI821714, AI792133, AI791913, AI370094, AI085719, AI471481, N53150, AW438643, AI969436, AA394271, AA832181, AA456976, AW072923, AI709365, AA847499, AI345157, AA613345, AI344812, AA469451, AI192631, AI619997, 824205, AW408717, AW088202, AI570261, AI358571, AI830390, AW265170, AW103758, AI814735, AW083402, AW131249, AI499503, AA126051, AI053672, AA126035, AW406447, AI798473, AI733755, AI801482, AW338086, AW162049, AA579179, AI871722, AA947360, AA583955, AI929531, AA402129, AI654588, AA515224, AW070892, AW073470, AW029038, AA613203, AA613227, AA455483, AI564284, AW020992, AI376100, AI821785, AI708009, AI921649, AW245747, AL042420, AI379719, AA584167, AI653636, AI305766, AI801600, AL038474, AW406755, AA469327, AI633025, AI624142, AW270270, AA178953, AW023672, AA192740, AL119984, AA482711, AI625244, AW148792, AA491814, AI453383, AW439558, C06327, AI161293, AA719292, AA594145, AA502103, AW406162, AA515909, AL044858, AL038785, AL045077, AI860020, AI281903, AL048925, L14684, AF015149, U18395, AC006561, U95742, U18398, X55925, U18393, I51997, AC007216, U57005, AF077058, AC004066, AC004741, U18392, D83989, AF015147, AC007237, AF015157, 284718, X55931, X55924, U18387, X53550, AC007848, X75335, AF015148, U57008, AF001549, U95740, U67231, U57006, AF090940, M37551, U02531, U18391, AF067844, AF227510, AC002039, U02532, AF015156, AP000165, U57009, U18394, X54175, AL035681, AL035425, AL035448, AC006538, AC006288, AF015151, U75931, X54179, AC002470, U91326, X54181, AC002565, 298742, AC005291, AC002544, AC005353, AF015155, AL109799, AC004478, U67801, AP000351, AP000128, AP000206, AC006160, AC004848, AF020503, AC005839, AL121603, AL035411, AC004626, X55926, AL031733, AL033533, AP000352, AF015153, AL00918I, X54177, AC008040, 269666, L78833, AC010197, AL031123, 284486, AF111169, X76629, AL122003, U57007, AC010175, X54178, X54176, AL034351, AC007043, U80017, X54180, AC004638, AC004987, AL035458, 286062, AL033543, AC005066, AC009516, U18390, AC003007, AL078638, 298884, AC002119, AC006292, AL023882, AC012599, AF111168, AC005081, S43650, AC004019, AC004650, AC004861, U67221, AL031257, AC006079, AC006001, AC005411, AF038667, AC004814, X55923, AP000245, AP000315, AL035405, AC007437, AC007151, AC002314, AC005632, AL118497, AL022397, AP000354, AP000474, AL136295, AL049759, AC005488, AL035665, AC006141, AL049562, AC002530, AF015158, AC007536, AC007324, D84394, AL035447, AP000228, AL008728, AC008044, AC004040, AP000270, U51560, AL021395, D88270, AC004493, AC005050, AL133399, AC004921, U67222, 293016, AC003085, U89335, AL008627, AC006960, AC005330, AC002984, AC005939, D87675, U18399, AC003964, 222650, AC006480, AC005250, AP000056, AP000124, AC005913, AC005815, AP000140, AC004841, AC007384, AC005786, AC006213, AC002549, AC004990, AL049647, 269706, AL021453, AF015167, AC005246, AC008079, AL117256, AP000049, AL034545, 269918, AF012654, AP000555, AC007068, AC005901, AL031848, 280896, AC008115, AC004808, 282976, AC005324, AC007919, AB020859, AC004854, AL021546, AL132994, AL049544, AP000088, AC004686, AL008634, AC002400, AC006511, AC004522, AC008122, AC004466, AC002564, AL034420, U12584, U66059, AL121591, AL031985, AC005412, AL031054, 282244, AC002543, AC006132, AC002430, AC008064, AC005962, AL133485, AC000118, AC005387, AC003119, AC007021, AC005154, AP000952, AC002072, AC006251, AL031447, AC005768, AF123462, and AC007565.

HSLCB60 132 I 1930501 - 153715 - AW062391, and A14709.

HSLFG64 133 12281451 - 297615 - AI526148, arid L29346.

HWAER24 135 9346931 - 270615 - AI073560, AI201459, AA527879, 2720 AA700382, AA151678, AA777810, AA286925, AA418754, AI637549, AA778792, AA983573, AW103826, W80620, AA932949, AI829622, AA418693, AA703112, AA151758, AI568518, AI131357, AI124085, AA846135, W04420, H54635, AA583784, W78994, AA960837, T87505, AI200626, M79159, H53519, N76001, H53520, 816415, H54636, F11222, N90636, AA442473, AI538798, F08885, 802437, 802334, AA994060, AI247499, AA436664, and AI222259.

HKMAC08 136 11218651 - 710 15 - AW160584, AW162850, AF175406, AF063825, AF063824, AF063823, AF063822, and X99792.

HBGOT10 138 9634571 - 423 15 - E01360.

HWMEQ37 140 9495681 - 853 15 - D31382, AI927431, AI380837, 867 AF2I6312, and E13203.

HFRBX44 141 11078981 - 220915 - U59490.

HRDDR74 142 11033621 - 106615 - T69052, AI557293, W32034, 1080 AW360811, AW177440, T03269, AW375405, AW178893, D59275, AWI79332, AW366296, C14389, AW179328, AW375406, AW378534, D58283, AW377672, AW179023, AW178905, D59859, D80022, C14331, D80166, AWI77731, D80195, D80193, D59927, D59467, D51423, D59619, D80210, D51799, D80391, D80164, D80240, D80253, D80043, D59787, D80227, D59502, AW378532, AA305578, D80038, AW377676, AA305409, AW352170, AW 178907, AW 178762, AW 178908, 'AW179019, AW178906, AW178911, T48593, D80439, D80247, AW378528, D80132, D80134, AW378533, C06015, D45260, ' C03092, AA285331, AA514184, AI525913, AJ238764, AF051852, AF155663, Y07744, AJ132236, A84916, A67220, D89785, A62300, A62298, YI7188, AB028859, A78862, D34614, D26022, AJ132110, AR018138, AR008278, X67155, Y12724, AF058696, A25909, I50132, D88547, I50126, I50128, I50133, A94995, AR066488, X82626, A82595, AR016514, AR060138, A45456, A26615, AR052274, AR008443, Y09669, AR060385, AR025207, AB002449, D50010, AR066487, A43192, A43I90, AR038669, A30438, Y17187, D13509, A63261, A70867, AR060133, AR008408, AR062872, AR016691, AR016690, U46128, A64136, and A68321.

HTTER50 145 12205861 - 126815 - 1282890889, AA322680, N91406, and AF077032.

HUFBV44 146 12205851 - 249815 - 2512AW237290, AI016073, AI633654, AI480414, AI741813, AI694646, AI870003, AA741322, N49686, AA001286, AA195332, AW24I614, AW 105043, AW440337, AA987206, N50814, AA001142, AW340366, AI383472, AI040221, AI857324, H97009, AI440186, AI362748, AW293I40, AA001923, AA812049, AA355299, N69378, W78919, AA769267, AA490844, H66481, AW338758, H08410, AI571634, H08409, AW295825, AI141531, N62515, AAI95333, T98178, W78825, H61192, AA641777, AA001947, T98177, AW081085, N49789, T90989, AI560764, N50467, 810846, 801438, H65509, AI276915, AI559361, 801437, N79412, H66482, T79031, W94269, AL037558, AW473166, AW571578, AW572241, and AW612505.

HWMJR63 148 11524291 - 990 15 - 1004AW340658, AI830575, AI970997, AI375239, AI955746, AA452348, AA505698, AA452125, AW403701, W52045, AI742513, AI199971, AI338181, AI338219, AA926692, AA938400, AA644138, AW402946, AI344126, AI186703, AI183773, AI675706, AA156689, AI300753, AA884026, W60021, W38892, N95054, AI148098, H01993, W44927, AI751818, AA805553, AW170013, AA954291, AW150567, W39574, AI864148, AA280408, AI494112, H04586, 827968, AI193848, AI078102, AI936538, H39712, AI198333, AA194406, AA094826, H02089, AA363376, AA642334, 828221, T94680, AI373118, AA280407, AA994085, AI352072, H13826, AI818830, AA918331, AA554306, AI093632, AA447655, AI276589, AI273430, N30561, H28693, AA134664, AI278504, AW341382, H13182, AI934888, W24049, H13867, AA919107, and AF169284.

HTLAA37 151 7546411 - 329 15 - 343 AC005546.

HRGDD16 153 8771171 - 377 15 - 39I AI9050I4, AL040212, and AC005546.

HNSAB28 154 8812861 - 112815 - 1142AL118633, AW175806, AI909009, AA033651, AW391350, AA287796, 801351, AA032243, AA515416, Y08565, AJ133523, AC010188, and AC010188.

HTTEP70 155 9177291 - 948 15 - 962 AW249443, AA682998, AW404364, AI961145, AA349769, 017472, AA350606, AA377837, AA380720, AW024225, AI498715, AA360525, AL040211, 242503, AA176150, AC005546, AC005546, and AC005546.

HMSII43 I56 946985I - 657 15 - AI8078I7, AI24I225, AI4979I6, 671 F06544, D31247, N56216, AA428123, AA339686, AA287075, AA410717, T78145, W69382, W69383, AII67280, H75982, F05840, D31349, AA419308, AA404625, N41831, AI344817, AI282326, AW403717, AI696626, AI274769, AA225339, N80094, AI251205, AI619716, AA427700, AI318280, AL039086, AI309401, AL036214, AI343112, AL036980, AI349598, AW023590, AI345735, AI340582, AI699011, AW161579, AI252023, AL120853, AW302988, AI343059, AW102785, AWI03893, AI561299, AI476109, AI923768, AI635464, AI608676, AI446003, AI349933, AI888953, AI868831, AI250663, AI886124, AI689175, AW084219, AI933785, AI633419, AI554218, AI866002, AI431909, AI433976, AI828731, AW079159, AI687065, AI612759, AW089I79, AI610645, AW151729, AI269696, AI867042, AI696819, AI344928, AW 103371, AI280661, AI537617, AI680498, AI919345, AW088899, AW089518, AI366549, AI362637, AI636719, AI539153, AW 150578, AI648663, AI866608, AI611743, AW082594, AW083804, AI589993, AW238730, AL119791, F37471, AI800433, AI498579, AI445165, AI963216, AA814407, AW149227, AI284131, AI097248, AI648684, AI344933, AW190042, AI922676, AI590120, AI922901, AW068845, AI249962, AI610115, AW074993, AI494343, AI349614, AW268220, AW073994, AI468872, AI889953, AI334450, AI364788, AW088903, AI829327, AI520702, AI680162, AW051107, AW268253, AI888944, AW088134, ~ AW 162071, AI312152, AL041772, AW235745, AI539771, AL038605, AI859464, AI554245, AI348897, AW081255, AI307708, AI251830, AL036631, AL040241, AW082040, AL079794, AI620287, AI929108, AI446373, AW 169634, AI916419, AA640779, AI349937, AI349645, AW071417, AI537677, AI491798, AI590423, N71180, AI370390, AA493923, AW059713, AI312428, AL045266, AI572418, AW075084, AA494167, AI921176, AI539028, AL036403, AI345608, AI554427, AI345224, AI569583, AI269862, AL038445, AI313320, AL045163, AW263979, AI648502, AI336575, AI799199, AL038565, AI862144, AI284509, AL121328, AI345471, AI873644, AI805638, AI366992, AL036215, AL120854, AI811 I68, AI499652, AI564719, AI281772, AI572892, AI889376, AI567351, AI800453, AL046926, AA287231, AI524671, AI608936, AI521012, AW059837, AW051258, AI812015, AI569309, AI921248, AI924971, AI922577, AW151785, AI611738, AI207510, AI571909, AI619502, AI677796, AI478123, AI632408, AI802542, AI627880, AI308032, AL036274, AL041150, AI499285, AI886753, AI174394, AW169653, AW026882, AI224992, AI344785, AI783504, AI869367, AL079963, AW148320, AI620284, AI784252, AL040243, AL119863, AW075413, AI570781, AI500077, AI538085, AW302992, AI874166, AI591316, I48979, 148978, AF017437, A08916, I89947, A08913, AF017152, AF125948, AL133093, AF125949, AL133557, I89931, A08910, A93016, I49625, A08909, AL137538, AL133077, AF113013, AL122123, AL110196, I42402, AL117583, AL137527, A12297, AL122098, AL122093, AL137648, X63574, AL080124, AB019565, AF113019, AL049314, U00763, AJ242859, AF113676, AL110225, 568736, AL133565, AL117457, AF104032, AF113690, Y16645, AL080137, AF106862, AF118064, AF061943, AL050277, AFI58248, AFI13677, AF118070, E02349, AL117585, AL133016, AL050393, AL080060, AJ000937, AL122050, AL049430, AF111851, 578214, X84990, AL122I21, AF113694, AF090934, I09360, U67958, AL049382, AL080127, AL110221, AL050138, AF079765, AR011880, AL049452, AF097996, AL137557, E07108, AL133075, AL096744, AL050146, AL050108, AF090896, ALI33606, AL133080, AF113699, E15569, AF113691, AF090900, AL133072, X98834, U72620, AL049466, AL137283, A65341, AL133640, AR059958, AF090901, AF078844, AF090943, AL137550, Y11254, AL049464, AL137459, AJ238278, AL117460, AL133560, AF146568, AL137463, U42766, AF091084, X82434, E03348, AF113689, AF118094, Y11587, AL080159, AF090903, AL050149, AL050116, AF177401, U80742, AL117394, AL133113, X93495, AL122110, L31396, I26207, L31397, A58524, A58523, U35846, AL050024, I33392, AL117435, A03736, I03321, X70685, AF183393, X65873, AL049938, A77033, A77035, AF087943, AR000496, U39656, AL137271, 282022, AL137521, X96540, X72889, E07361, AF067728, U91329, AJ012755, AF111112, A08912, AF119337, AL049300, A93350, AL137560, AL122049, AL133014, AL137526, AL049283, AL110197, AL133104, AF026816, E08263, E08264, AL137556, AL050172, AF026124, Y14314, A90832, AF003737, AL133645, S61953, 272491, AL110280, AR038969, U78525, AF162270, AF153205, U96683, AL133568, AF057300, AF057299, AL117440, AL133098, A45787, AF185576, AL137476, AL133067, E05822, AL137523, I00734, AF081197, E04233, E00617, E00717, E00778, AR013797, AR038854, E08631, L30117, AF079763, A07647, X87582, M30514, Y09972, AL080074, AL122111, AL137300, AJ006417, I96214, U58996, U68387, Y07905, AF081195, X92070, 237987, AL0236S7, AF210052, AL137480, L19437, AF051325, AF106827, I17767, AF111849, AL137533, AL137273, E02221, AF008439, AL117432, U49908, AF067790, X62580, AL133081, AF061573, AL080086, AL137478, AF132676, AF061836, AL122118, AL137292, X53587, I41145, AL080158, I09499, and AL137294.

HMADVl 157 9207701 - 416 15 - 430 HNTCK35 158 12262011 - 384515 - 3859AA196347, AI972907, AI798906, AW006190, AI951558, AI521165, AI937074, W72702, AA609417, AI791375, AI564706, AI142337, AI143225, AW303829, AI146777, AA829913, H17764, AI161337, AI192949, AA862277, AA688099, AI090807, AI948438, AW175962, AW263020, AI859167, AA948215, AI826140, AA854164, AI192234, AI360480, AA558454, AI598133, AA130443, H06325, AA603668, AI288828, AI220002, W52518, AA112031, 853537, W49527, AI267289, AA478207, AI017662, T59701, AI219669, W77942, AA057465, W49528, AA130442, AI580291, AA668787, AA193008, AI698736, H20710, AI266704, AA192624, 859691, H57299, AI214274, AI247660, AI888165, 225084, H06279, 859631, AI076244, H93660, W20416, AA046167, AA678302, H15989, 853648, AI081111, 224882, H10591, AA731842, AA932849, AA603080, AI127430, H93661, AA782406, AI290516, T51584, AIS36630, AI245065, AI473591, AI795819, F30895, H57300, 242230, AA863278, F31510, AI795811, AA523927, AA045850, F33254, AI147328, F35916, AI924270, 228618, AA413403, 836809, AI024519, AA883966, F25758, AW380084, F29690, AA782858, AC005523, AF064447, AC005048, AL022147, AL110197, 249258, 237987, AC007392, and Y17327.

HTPGQ16 159 10277811 - 878 15 - 892 AI962647, T69166, AA585439, 228355, AI541374, AI546855, AI525556, AI541510, AI541514, 230131, AI546999, AA247800, AI525306, AA585101, AA585453, AI541534, AI541523, AI546828, AI526140, AI525316, AI556967, AA58S434, AI535639, AI541509, AI525431, AI541017, C15189, AI526194, AI656439, AI547039, C16300, AA585440, AI546945, AI557799, AI541365, AI557807, AI540967, T11028, AI541535, AI541307, AI557731, AI546899, AI526180, D61254, AI557787, 829445, 828735, AI526196, AL040510, AL040625, AL045817, AL041142, AL041238, AL041133, AL047183, AL040322, AL041131, AL046330, AL041051, AL041292, AL040119, AL047036, AL047170, AL047057, AL047219, AL041227, AL040463, AL039915, AL043612, AL041197, AI557796, AL040155, AL041346, AL040529, AL04I096, AL047012, AL041358, AL041277, AL041163, AL041098, AL040621, AL043538, AL04I324, AL040464, AL044162, AL041086, AL043496, AL041296, AL041233, AL043467, AL041159, AL045725, AL044186, AL041140, AL040193, AL044037, AI546891, AL040091, AL040128, AL040168, AL040255, AL040285, AL040342, AL040332, AL040617, AL040553, AL045684, AI525320, AL040745, AL040370, AL043677, AL046442, AL040839, AL041752, AL040149, AL043775, AL944165, AL043492, AL041602, AI546875, AL045920, AL041278, AL038838, AL040253, AI526184, AL044074, AL041635, AI557262, AL045990, AL040458, AL044199, AL044187, AL040090, AL040263, AL040294, AL040329, AL040082, AL044272, AL041186, AL040148, AL041730, AL041523, AL043627, AL046392, AL041374, AI540920, AL040052, AL043845, AL043537, AL039338, AL042135, AL044064, AL038983, AL039316, AL043923, AL043814, AL043848, AL041459, AL043570, AL041577, AL044258, AL044201, AL046850, AL038532, AL040768, AL037727, AI541508, T23985, AL040576, AL046994, AL040414, AL040571, AL046914, AI142134, AL045753, AL044274, AL079878, AL049018, AL040444, AL039744, AL045857, AA585356, AA585476, AL038822, AL045671, D57491, AL046327, AL041168, AL049069, AI541013, AL043444, AL041246, AL040472, AL040238, AL041955, AL041347, C16305, T23957, AL038761, AL040075, AI525328, T41289, AI541345, AI525203, AJ239433, AI526187, 829177, AL080031, AL045989, AI526073, AL046147, AL042096, AI557802, AI541415, AL044529, AL037436, AL039643, AL039360, AL037435, AI541390, AI525321, AI557279, 829218, AI541205, D55233, AL044125, AI54I506, T23888, AA174I70, AI535660, AL079852, AI557238, AI526195, AI525653, AI525339, AA585155, AI535813, AL045211, AI536138, AI557082, AI557155, AI557727, 845895, D61185, AL041210, AI557734, AL037341, AI540882, AI547071, AL037323, AR017907, I13349, A25909, A91965, AR062871, AR038855, I18895, A85395, A85476, AR062872, AR062873, AF082186, AJ244004, AR037157, AJ244005, AJ244003, A20702, A20700, A43189, A43188, X81969, 163120, AR008429, A98767, A93963, A93964, AR038762, A98420, A98423, A98432, A98436, A98417, A98427, Y16359, 144681, D78345, X83865, A84772, A84776, A84773, A84775, A84774, AR054109, AR067731, A86792, AR067732, A58522, A91750, AJ244007, A18053, M28262, A60212, A60209, A60210, A60211, I15717, I15718, E03627, I49890, I48927, A02712, A77094, A77095, I84553, A81878, A95051, 184554, A18050, A23334, A75888, I70384, A64973, A60111, A23633, AR007512, 108396, I00682, A11623, A11624, E00609, E13740, A11178, E01007, A10361, A35536, A35537, A02135, A04663, A02136, A04664, 106859, I08395, AR043601, A11245, I03331, A02710, E12615, AR035193, E14304, A07700, A13392, A13393, I62368, AR031488, I13521, I52048, A27396, AR027100, I44531, I28266, I21869, I44516, A70040, E16678, A82653, E16636, A93016, A24783, A24782, A92133, A95117, A58524, A58523, A90655, AF149828, I01995, AR038066, I08051, AR031566, I25027, I26929, I44515, I26928, I26930, I26927, I6024I, I60242, A20699, E00696, E00697, E03813, I66482, AR009151, I66485, I66483, I66484, I66498, I66497,166496, AR027099, I66487, I66486, AR051652, AR051651, U94592, 232836, Y09813, AJ230935, D50010, I66495, I66494, AJ230902,166481, A83642, A83643,166488, I66489, I66490, I66491, I66492, I66493, A83151, I05558, AJ230972, AJ230951, A70872, X07299, AJ231009, I19525, A22738, I08389, AR035975, D13316, AR035977, A70869, D13509, AB025273, I18302, AR051957, E12584, AR035974, AR035976, AR035978, AJ231028, A32110, E17098, AC005913, A22734, AR022273, AR064707, AJ230867, AR054723, AJ230845, I36244, X55486, AR051864, U87250, X82786, AR051865, A06631, 560422, AR009152, AJ231011, A91752, AR028564, AR027319, A91751, AR027318, A68112, A68104, A06419, A21892, A23997, A68114, A89633, A89634, A21895, A05160, A08030, A20502, I15353, AR063812, X87559, I05488, I61310, A60961, A60977, AR002333, A60985, A60990, A47368, A60987, I19516, I19517, I07249, I08776, and A38214.

HOCMS18 160 12275941 - 372015 - AA115295, AI983849, AA873315, 3734 AL049024, N36273, AA625435, AA780019, W44645, AI926527, AA551576, AW149789, AA873307, W84522, AW303776, AI355170, N31714, AW069314, AA599312, AA969227, AA534678, AA676593, AI338244, AI460358, N31721, AI366135, N42400, AI127202, AW021988, AI753611, AI926969, W44644, AA056181, N33197, AA115270, AI357402, AW083323, AA493560, AA426326, AW073382, AI571515, AI628677, AA426325, AA427844, AA894546, AA233420, AA992123, W79889, AA046428, AA429402, AA954743, AI214877, 888205, AI142383, AW117398, AI911337, AA425133, AA233622, AI475634, AA213391, AI287696, AI147373, AI701411, AW275286, AA213392, 888096, AA693897, AA622262, T88771, N24819, AI4195I6, AA505746, AI350967, AW337337, N33426, N63079, AI083596, W74274, AW020877, AI832767, AA864950, H72333, AA487895, H71599, T94091, AI005421, AA195578, AI184310, H71470, AA029095, N52803, AA908660, W84510, AI350791, AI275186, AW069414, AI954381, AW241382, AI368443, N57625, AA426011, AI473104, AA194897, AA515528, AW014339, AA346752, AA488007, AA449380, AA782901, AA358274, AI305169, 245942, F04796, AA300764, AA485787, F20248, N44732, AA367342, AI832109, AI282589, AA449253, T94173, AA377697, T53312, N42376, AA299914, AI570082, AW072984, AI492474, 217418, AA919076, N88248, AL117489, C01927, AA485660, and AW474331.

HE8AM58 161 12049361 - 159715 - AA331573, D49658, AJ000338, 1611 AB007596, AB007595, AB007590, AF220000, and AB007594.

HUSGZS 162 9555421 - 420 15 - AW410914, AA314782, AA315619, AA307196, W42974, AA221000, F12658, AA148973, AA121597, AW179125, AA205790, T74241, AA353399, AA151174, N40506, AA339272, AA209384, AB026I25, AC018568, and AC018568.

HELEQ48 163 9608661 - 486 15 - AI591223, AW025351, AW243247, AW 148715, AW206432, 843019, M79245, AI768009, AI282406, AA297699, AI566825, T31578, H30370, AI873011, AI468048, and AB002361.

HOFOE03 164 12262511 - 370215 - AF150275, N32051, AI249187, 3716 AF002216, AI133188, AI539493, N42445, N21001, N25798, H99881, AL079717, H79945, H80726, H83090, AI565587, H82871, H80725, AW075744, AJ133831, AI338158, N36506, N28567, AW385286, and AB002377.

HNFFR23 165 5852891 - 346 15 - AC008751.

HOGCC57 166 12055111 - 803 15 - AA411425, H58696, AI817007, 817 AI419471, H58306, AA931895, AA885801, AL042606, AA770619, AA877086, AI086358, AA558122, AI247400, AI198553, AI142274, AI147991, and AR044120.

HFOZC96 167 9266851 - 698 15 - AI589776, AI057117, AW272585, 712 AI246523, AA767227, AI625485, AA873003, AI239712, AI955774, AW296331, AI741538, AI479753, F32315, AI674694, AI932376, AA804789, AA044610, AA993510, AA243346, F36914, N55553, AA262732, AI961836, AI927868, AA324979, AI127216, AA953487, 886959, AA720891, AA039578, AI684523, AA487796, AI886998, AA485892, AI685404, 805274, AA912800, F18062, C00227, AA747721, 805331, and AF238376.

HOHBK44 168 8238721 - 514 15 - 528 AI133188, AL079717, AF002216, AJ133831, AI338158, AW385286, and AB002377.

HHERB37 169 7084771 - 444 15 - 458 AI146685, AA085407, AI745120, AI262886, F06929, F30111, F35773, F07397, AA090959, W05535, F21145, N87462, F12448, AA243832, T74070, 857608, AF088982, AF088983, AF092536, AC005259, and AL355377.

HEGAW40 170 7106521 - 674 15 - 688 AW006873, AA627973, AI138661, AA741125, AA749030, AI685305, AA813972, AA748557, H99202, AA227998, AI796325, W02040, AW 137937, AA227824, AA768499, AA215600, and W32239.

HDTDQS1 171 11522641 - 150415 - 1518AI016714, AW391661, AA847865, AISS4330, AA483400, AA483411, AI051725, N66755, AI825794, N62194, AW327616, AA902896, AA725234, AI769182, 860056, AA594900, AA933624, H05474, T16298, AA977118, 860119, H07025, AI671131, AA054722, AA650410, AA469117, AI815393, AA740290, 843427, N76491, AA761969, AW327262, AA716570, AA916000, T34734, AA112320, N29491, AI435962, AA478943, AA443197, AW377345, N31578, AW377295, N99049, AA029980, AI263863, AW377378, AW377297, AW377218, AW377231, AA805766, AI499056, T90105, AA659890, AA054669, AA342241, AA81I545, AI091066, AW393506, F03954, and T82929.

HOVCC60 173 7189181 - 792 15 - 806 T66088, 820466, H28845, F11782, 836030, 854148, 817605, H19122, 244635, 242554, 817616, and N50384.

HMVAC92 174 7317321 - 4S4 I5 - 468 C18294, AA115838, W76458, T32095, T30710, AA378552, AW360837, 808104, W23225, T35980, N45490, AI554624, T35790, AI313133, T84898, AW391980, 220579, AA357067, T35190, AA310762, AA328222, 815571, AI205283, AA03S 103, AA448769, AA214347, W38702, N56257, AA116099, AW401574, AW411042, AA371686, AA452303, AI570120, AA613412, W61124, AA093588, T63232, AW368742, AA868496, AW338692, AW 167217, AI954547, AI955639, AA079294, AA478499, W24470, 870678, AA657656, AA166897, AA453225, AA341741, AI697147, T16000, AI921707, AA894909, AAS51115, AF128527, AF126181, AF128528, U92544, 298046, AB029037, and A75460.

HWGAF89 175 7420531 - 736 15 - 750 AL135068, AA461053, AA460486, T67180, AI628805, AC007041, and D87078.

HHBEG78 176 9691061 - 444 15 - 458 AA194446, AAI94603, and U76618.

HPMJT61 177 11524221 - 136715 - I38IAW409700, AI333316, AA456955, AI970049, AI381634, AI741903, AI420038, N76926, AI674975, AW444456, 842051, AA680112, AW023699, AA358453, N55540, H50735, AW020342, AA457064, H50647, AA479171, 820871, AI468658, and H56974.

HKAED89 178 8275731 - 527 15 - 541 AI830569, AI689270, AW339088, AW 137765, AI660157, AW206080, AW139670, AA747810, AI066685, AA741078, AA593017, AI364910, AA743755, AI214128, AF038458, and AF038458.

HHAMA35 179 8502721 - 132715 - 1341AA648933, AA742244, AI739536, AA393227, AA812029, AA424400, AW368992, AA424474, AA724544, AA416925, AA261812, AW390517, AA100143, AA372643, W23989, AW403227, H94816, AA313329, AI829684, W58474, AL043108, AA165152, AA091310, T10404, W52177, W48807, AA843784, T28111, and A93912.

HRADJ08 180 1179715I - 248315 - 2497AW341277, AA442905, AA449052, AA677433, AI375482, AI393099, AA649052, AI913346, AI859698, AI417958, AI373524, AI769760, AW271751, AI685790, AW243463, AI684073, AI670074, AA470724, AI344642, H12220, N76222, AA701021, AA758I41, AW029224, AI040528, AI376742, AA693735, AW296327, H42313, AA464605, AA835707, T26462, N54520, AA121186, AA758284, AA430532, AI470967, AI565321, AA121I87, N50674, AW193102, AA885708, AW079408, H30000, T26463, T17007, 240783, AA887660, AA373205, C05171, AA9I8565, F07717, H43079, T99533, 820437, H30001, AW020,286, AA665044, N50763, H46108, AA374682, T99427, 843557, AI368375, AI915506, AI913702, 895437, D79994, AL035461, and L10617.

HLYAN64 181 8673661 - 199215 - 2006AI821213, AI821209, AI807218, 851319, AI983657, AI937338, W07708, AW444958, AA805535, H41438, AI732196, AI344897, AI144038, AI807212, AA582540, AA600981, AI349626, AA707347, AI589436, AI140382, 851431, 849133, 836051, AI732193, AA745702, AA468776, AW271143, N80586, AA976044, AA468630, AI865638, AA838544, AA077645, H51527, AA326999, AA295306, AA337557, AI053787, AW271014, AI800018, AA338692, AI567011, AI312040, AI744268, AI863002, AI499570, AW008226, AA767177, AW079640, AI817492, AI249877, AI540179, AI633125, AI804531, AI653402, AI473536, AI250852, AW410416, T69241, AI247293, AW089844, AI539690, AI561228, AI620864, AWI63554, AI633061, AI635634, AI696714, AI678446, AI568967, AT689096, 881679, AI915291, AI590043, AI288050, 820540, AA503384, AI571909, AI469425, AI783825, AI357049, AI932739, AI280732, AI524179, AI567305, AI884318, AI538686, AI638644, AA019328, AI579901, AI620944, AIS38564, AI819326, AI658566, AI590755, AI670002, AW152182, AA825548, AI696583, AI651840, AW078735, AL120676, AI240978, AI701097, AL120446, AI360195, AI582932, AI679771, AI866469, AI368579, AI696603, AW004606, AW265127, AI961414, AW 191844, AA808175, AW084233, AI583032, AI571439, AI280082, N25033, AI570056, AI289791, AI475331, AI440399, AI688854, AW083572, AI762739, AI433611, AW025279, AI524654, AA761557, AI972112, AI866419, AI866801, AI698391, AI540350, AI635851, AI635032, AI819545, AA481053, AI440133, AW195253, AI637584, AA916133, AI670009, F34309, AI954721, AI568293, AW058304, AA831948, AI282688, W45039, AI561231, AI536638, AI628325, AI583578, AI275609, AI889189, AW051088, AW104141, AW020397, AI819976, AI953767, AI818980, AW084881, AW130088, AI811344, AI419826, AI796743, AL046466, AW131294, AI829893, AI688858, AI678409, N21402, AL046200, AW 104827, AI370623, AI491710, AI610307, AW236186, AI421662, AI872154, AI538259, AI539800, AI687362, AI824748, AI868175, AW190297, AI475139, AI445829, AW081383, AL043073, AW192363, AI589428, AI884528, AI302590, AA001397, AI500714, AI884303, AI382313, AI355779, AL134712, AW168452, AW 149311, AW 166722, AI868680, AA648402, AI522052, AI610714, AI308037, AI884469, AI499161, AW131065, AI699823, AI352514, AI345415, AI625256, W74529, AI499325, AI824688, AW087336, AI679098, AI401697, AI580190, AW148882, AI679261, AI499285, AI432644, AI719817, AW410306, AI689470, AI817363, AI357273, AI359787, AW 198090, AI439903, AI125015, AW075382, AL138420, AI811603, AI468622, AA830709, AI281687, AW148363, AI440239, AI656270, AI888480, AI343325, AF161413, AF061981, AF032666, AL122104, AL133665, A18777, AF102578, AL080159, AL049460, 554890, AL117587, D44497, AL050149, AJ005690, 213966, U37359, AL137550, I33392, 582852, A58545, AF061573, 297214, A93350, AFI95092, I32738, AR038854, A08907, Y11587, AL133049, AL117460, AL137627, 536676, E02349, X57084, X66113, AF044323, AL080150, AF106657, AR034821, A15345, A32826, A30330, A32827, A30331, AL050155, AL137562, A77033, A77035, X80340, AL133619, AL122098, AR050959, AF113019, A08913, 577771, X99971, X06146, AF106945, AL133084, Y13350, 282022, A31001, AF153205, AF126488, AF047716, E01314, AF090903, A08912, AL050116, U57352, Y14634, AL133113, X67813, AJ012755, AL110280, D83032, AL133623, A08911, AL133637, I80062, AL137459, AL080148, AC002471, AC005374, U89906, AF118070, Y14314, I34395, I18358, AF030513, S76508, A08910, X53587, A60092, A60094, AF031572, A08909, I89947, AJ005870, AF026008, I48978, E12747, A08908, AF145233, AL117416, I09499, U73682, AR068466, AF026816, AF000167, X82434, A07588, E12579, AF118092, AF183393, AL137292, 573498, AF118558, AF124728, AL110224, AF002672, AF116573, AF000145, 230970, AF180525, A18788, AL133560, AF126247, X66871, AR029490, AL137271, AF115392, U58996, AL110296, AL137538, 568736, S83440, U80919, E01614, E13364, AR066486, AL137537, AR020905, AL049996, AF119336, AL117463, I33391, AF111849, AL122100, I26207, AL133062, X78627, U35846, AL133061, M19658, A86558, I22020, AF000301, AL023657, AF205861, X83508, 235309, AF179633, I29004, X66417, AF167995, I79595, AL137463, AF002985, AF126372, AL133558, A65341, AF215669, AJ000937, AL137530, AL133081, X89102, S59519, AF200464, AJ242859, AL133557, AL080139, E00984, I04527, AL137711, AL110158, AF090900, AF058921, AL137256, AL137488, AF090901, AF106862, AL050366, AL080074, AF113691, D55641, A76337, A44314, AL137554, AF094480, A45787, AF004162, AL122118, U80742, AL050138, AL137480, U51587, S69381, U78525, AF077051, A21103, X63410, AL049465, AF098484, X87582, AL080146, AF089818, X63162, U67082, M86826,117544, AB007812, AL117578, ALI33075, AF067790, AL136884, AF14I315, AL137557, AF038847, AL133080, E03168, X84990, AF185614, AF036268, AF177401, . AL031984, AL117443, AF144082, L04504, and AL137479.

HTLHP64 182 8831201 - 101515 - AA243884, 855643, 855421, 1029 H42362, and N75418.

HNTCI60 183 8907541 - 796 15 - AL046248, AL046015, N92391, 810 W24708, AA130104, AI905673, AI905674, and AC020663.

HUCMU74 184 8997511 - 786 15 - 299396, AL038837, AL037051, 800 AL036725, AL036418, AA631969, AL039074, AL039085, AL039564, AL036858, AL039156, AL039108, AW392670, AL038509, AL039109, AL039128, AL036924, AL037094, AW384394, AL039659, AL038531, AW372827, AL036196, AW363220, AL119443, AL039625, AL039648, AL045337, AL036767, AL037082, AL119497, AL037526, AL036190, AL037639, U46341, AL039678, AL039629, AL039423, AL036238, AL038447, AL039150, AL119319, AL040992, AL119457, AL042909, AL119324, AL119363, AL119496, AL119396, AL119418, AL119483, AL119484, AL119341, AL119391, AL119355, AL037077, AL119335, U46350, AL119522, AL042965, U46349, U46351, AL038520, AL037726, AL039410, AL038851, AL134538, AL039386, AL036268, U46347, U46346, AL119399, AL037085, AI798092, AL119444, AL036998, AL036733, AL037615, AL134528, AL042614, AL037205, AL119439, AL037178, AL042975, AL119488, AL134518, AL037027, U46345, AL036679, AL042542, AL042984, AL042551, AL134527, AL036765, AL043029, AL036191, AL042970, AL036719, AL134532, AL042450, AL042544, AL043019, AI142134, AL043003, AL037021, AL037054, AL119464, AL036774, AL036836, AL036158, AL036886, AL036999, AL036964, AB033020, AR060234, AR066494, A81671, AR023813, AR064707, AR069079, AR054110, and AB026436.

HWWGT02 185 9080171 - 815 15 - 829 AI554691, AI159923, W57638, AW182099, AI819209, AI003931, AI805914, AC004188, AB014086, AP000516, AB014086, AB014086, AC004188, and AC004188.

HSKDU47 186 11547971 - 730 15 - 744 AA431523, AA171452, AW138802, AI738771, AI809942, AI826110, AW452200, AA745516, AW002570, AA908687, AI341458, AI284640, AL119691, AW270382, AA351056, AA828749, AW028392, AA491831, AW075948, AI554718, AI473943, AA737432, H56509, AL042853, AI281881, AW238278, AW021207, AI567832, AI633025, AA724333, AA662225, AA808877, AA531186, AA577959, AI377567, AI377556, AA713891, AI377505, AI754336, AA788982, AW103758, AA938105, AA640772, AA652764, AA679532, AA679936, AA486559, F29184, AA525892, AA661814, AA630362, AA847952, AI537077, AA578391, AI932599, AA594145, F27407, AI873852, AI873761, AA491284, AL137614, X55931, X54180, AL031390, X55923, 293017, U49740, AL035455, AP000298, AL031295, AC004099, AL049569, AC006063, AL035671, AF039907, AC005295, 284469, AC004884, AC002984, AL133245, AC007226, AC005237, AP000044, AC005253, AL109829, AC004650, AL022324, AC006350, 297196, AC005387, AF001549, AL023575, AL035425, U91323, AL096701, AC007216, AC005324, 285987, AC006000, AC007066, AC006505, AL022328, AC004686, AL031118, AF010238, AC007790, AL133445, AC005332, AL133353, AF196969, AC005839, AC010170, AL03I584, X78673, AC005821, AL050341, AC002045, AC003007, AL031666, AC004447, AJ011930, AC004638, U73648, U95742, AC005180, AC000052, 282976, AP000112, AC007666, AL096791, AL110120, AC006064, AB014079, AC006960, AC004955, U95740, AC005378, AC004019, AL021707, AC005778, 293783, AL031848, AF157623, L49046, AC004804, AC004522, AC005632, AC006139, AL049760, AP000301"
AP000514, AL031054, AC004987, AC002120, AC006285, AL031775, AL035448, AC004584, AL109748, AC006042, AL031659, 298946, U95739, AL133249, AP000459, AC005863, AL035089, 298742, AB023056, AD000092, AP000114, AL109865, 298051, AC007032, AP000349, 269705, AC007308, AC005902, AC005694, AL049844, AC002425, AC007528, AL121603, AC002377, AL022315, AL03I432, AC004799, AF064863, AL035608, AC005531, AL031311, AL023882, AC005829, AC005545, AF190465, AL022476, AC006213, AC005803, AC005932, AC005921, AC005300, AC004754, AC003986, AC005783, AL031662, 284480, AC005154, AL035587, AC009178, AC008125, AL022302, AL096712, AC005261, AP001059, AL031281, AC004400, AC006450, 269714, AL096765, AC005914, AC004034, AL049691, AF111169, AL031273, AC006075, AL035458, AC006057, AC005755, AC005355, AC006315, AL008710, AC004381, 295115, 269917, AP000501, AP000045, D00591, 292846, AL096711, AC006277, AC006251, AC003087 249237, and AC004470.

HODFI03 187 9180081 - 139215 - AL036125, AI925441, AW363137, AW238419, AL043697, AL043698, 899060, AA781204, AI588883, AL135068, 899049, 862711, AA853740, AI337325, D87078, AC007041, D43951, AC007041, AC007041, and AC007041.

HWHHR02 188 9191691 - 884 15 - AI453533, AW003844, AI797910, 898 AA161335, AA833762, W49529, AI356252, AI863269, W49530, AI422074, AI087203, AI348189, AI080077, AI292023, AI359963, AI278825, AI700817, AW452178, AI223214, AA861082, AI494222, AI424097, AI685699, AI423758, W93516, AA765993, AA662451, AW016106, AA437126, AI26I516, AA969280, AA909645, AA704629, AI217567, AI964021, AA253458, W56681, AI583564, AW264194, AI268910, T84925, AW341371, AI183764, AI933190, AI240846, AA777656, T05444, AA250913, AL138376, AI245120, AF053356, AF053356, AF053356, and AF053356.

HSVBQ03 189 9248501 - 340 15 - 224798, AI984000, AI376738, 354 AA853182, H57665, AI801497, AA889345, AW269830, AW385653, AI469976, AI951239, AW385674, AI470014, W70229, AI090780, AI460I94, W44651, AA913912, AI352112, AI277888, AI277222, W70230, W44650, AI299070, AI147785, AI141926, H58505, AB037938, AC004477, and AC004477.

HSLCQ10 190 11539141 - 104515 - AW079850, N34064, N64316, 1059 AA346933, 863682, 862727, AI525343, AA206737, AA418089, and AA249010.

_H_K_A_CQ38191 9753821 - 157815 - AI589776, AI057117, AW272585, 1592 AI246523, AA767227, AI625485, AA873003, AI239712, AI955774, AW296331, AI684523, AI741538, AI479753, AI674694, F32315, AA804789, AI932376, AA993510, AA044610, AA243346, F36914, N55553, AI961836, AA262732, AI927868, AI127216, AA720891, AA953487, AA324979, AA262814, 886959, AI862200, AA039578, AA487796, AI886998, AA243547, AA485892, AA042797, AI685404, 805274, AA326305, AA912800, N76938, 875748, F18062, C00227, AA747721, 805331, AI554396, N29277, AW303152, AI345778, AW132056, AL079963, AI659795, AL135517, AL120853, AI932953, 836271, AL036631, AI312428, AL039086, AI340519, AI340603, AI627988, AI801325, AW020693, AI611743, AI537677, AI633125, AL048656, AL110306, AI348854, AI696819, AW022682, AI929I08, AL038605, AI364788, AI559619, AL041772, AI345740, AA814407, AI700159, AA658033, AW300889, AI344785, AL042377, AW023338, AI445992, AA420722, AI953562, AL036638, AI345370, AI288285, AL121286, AI620284, AI345608, AW303089, AL036980, AI499986, AI494201, AL036274, AI334450, AW403717, AI500523, AL037454, AW302965, AW020419, AI340627, AI609128, AA640779, AL036403, AI468872, AL119863, AW081143, AW238730, AA613907, AI436576, AW083804, AA572758, AL038505, 299428, AI916419, AI254727, AI336575, ALI 18781, AI476376, AI249497, AL037030, AL045500, AI269862, AI309401, AA579232, AW068845, AA635382, AI567582, AI815232, AI610645, AI783504, AW162194, AI349645, AW302992, AI923989, AI284517, AI500061, AI871697, AI254226, AI866770, AI343059, AI961589, AL040243, AI440263, AI690748, AL119828, AI624548, AI349933, AL121270, AL134259, AW081797, AI349957, AI954422, AI433157, AI702073, AL040241, AI538885, AL036802, AW059713, ALI20854, AI866573, AI345005, AW268067, AI446373, AI537837, AW 161156, AI623941, AW051059, AI609580, AI580290, AI500662, AA493923, AI345471, AI345347, AW059828, AI280607, AI698391, AL040827, H89138, AA494167, AL036396, AW020406, AI343112, AI473799, AI582932, AL036214, AI670009, AW301300, AI521560, AI889189, AI349598, AI868204, AW075207, AI343037, AW161579, AW151136, AI345735, AW268072, AI888661, AW148408, AW302988, AI889147, AI500706, AA572872, AI873644, AL036780, AI307210, AL043055, AL119791, AI282504, AI805762, AI340511, AI366992, F27438, AI313320, AI251221, AI313352, AI887389, AI382670, AI280661, AI699011, AI680498, AI537617, AI874166, AI919345, AW088903, AL038565, AI345688, AW074869, AI345416, AL040277, AI345612, AW268293, AI349266, AI334452, AL038076, AW243886, AW081255, AI312146, AI312339, AI309431, AI251830, I48978, I48979, AF132676, AF061836, AL137479, AL117457, AF113677, AL137429, Y11254, A08916, A08910, AL049283, A08909, I89947, AL050108, I00734, AL122110, AL049430, A08913, E00617, E00717, E00778, AJ000937, AF090943, AF113694, AL110221, AF079765, AR411880, AF100931, U42766, AL133606, I89931, AF097996, AJ238278, AL137529, AB016226, I49625, AL122050, AL137538, AL137533, AF177401, A58524, A58523, AL049300, AL110196, S78214, AL122093, AL137550, AR059958, AF017152, AL110225, AJ006417, AL122121, AL080074, AL133560, X81464, AF113690, AF090934, AF087943, AL049314, AF111851, AL117435, A18777, AL133081, AL137648, AL133075, X93495, AL122123, AF028823, AL133080, AL050172, AF058921, AF158248, AF113019, AL049466, U72620, I33392, AL133640, AL137271, AF183393, AL117460, AF090903, U68387, AL137658, AF090901, AL137294, AF106862, Y10655, Y16645, AL137459, AF026124, AF125948, ALI37656, A08912, A03736, U00763, AR038854, I89934, U90884, AF078844, E03348, AL137283, I03321, A08908, AL117585, AF146568, AF113013, AF061573, AF091084, AR013797, A65341, X62580, U96683, AL096744, AF090896, AL050393, X65873, AF026816, AL080060, AFI13689, Y11587, AL049382, AF079763, AL050116, AL133113, X82434, AR038969, U67958, E02349, I42402, AL122098, E07I08, AL133016, AL133077, AF104032, AL137539, AL080124, X63574, A18788, AF100781, X72889, AL137526, AL137557, M30514, AF210052, X52128, AF159615, AF111849, AL050149, I09499, AL050146, AL137488, E02221, AL137480, AL137521, X96540; U88966, AL050277, AL133557, AF090900, AL137705, AR020905, AF017437, AF126247, AL122111, A90832, U58996, X92070, M96857, AL080127, AF125949, AL080137, AF118094, AL133558, E05822, A77033, A77035, AR000496, AL049452, U39656, AL117394, 282022, X84990, 237987, Y07905, AL133072, U35846, AL133565, X98834, AL122049, AL133093, AL050024, E06743, AF113699, AF069506, AL117583, AL049465, Y09972, AL122118, AL080148, A12297, AF102578, AF081197, E12747, A93016, I89944, AF118070, AF106827, AJ242859, AL133665, AF113676, L31396, AJ003118, L31397, D83032, E01573, E02319, AF118064, AF051325, X70685, 272491, Y10080, AF061795, AF151685, 568736, AL049464, AL137463, U91329, AB019565, A21103, AL080086, I09360, E04233, AL137478, U55017, M86826, E08631, E15569, U80742, U78525, AL137527, AL050092, and AL050138.

HE9GZ52 192 9645791 - 440 15 - 454 AI372490, AB020640, 298884, AL359881, 298884, and 298884.

HSYBD55 193 11973481 - 619 15 - 633 857737, AI375137, C03950, and AF116826.

IiTAJM37194 11524231 - 882 15 - 896 AI863425, AW005342, AA916533, AI932220, AI564040, AA953376, AI985590, N69484, AI439698, N90977, AL041573, AL121286, AL079963, AI815855, AI570861, AL110306, AI929108, AI698391, AI802542, AL036638, AA225339, AL037582, AL037602, AI554344, AI537677, AI174394, AA427700, AI475371, AL119863, AL040456, AI590686, AW087445, AI798456, AI824576, AI499285, AW083573, AW022682, AI632408, AI920782, AW169604, AL119791, AA287231, AL121365, AI890223, AL037454, AW189802, AA572758, AL045620, AI635067, AI521012, AI281867, AL038445, AI801325, AI251221, AI802654, AW238730, AW167918, AI554821, AI683492, AL047172, AI565128, AI445990, AI564723, AI274745, AI832245, AI439762, AI934035, AL036631, AW148970, AI635492, AI468872, AI270183, AL138457, AI570807, AW243741, AI254731, AW 152000, AI866780, AI679211, AI866770, AA464027, AL135661, AI699011, AI345416, AI345612, AI497733, AI619716, AA493923, AI470651, AI873644, AW269097, AI334445, AW059828, AA640779, AI445992, AW072588, AI345415, AI874166, AWI29230, AI627893, AI554245, AI796743, AI567612, AI288305, AW118518, AI689702, AI886753, AI933589, AW026882, AW169653, AI955906, AI923370, AI627988, AI336495, AI073952, AI783504, AI620284, AL120300, AA908294, AW162194, AL042628, AI499986, AL119399, AI500061, AI670009, AW243886, AW169634, AW103371, AL045500, AI590423, AI433157, AI702073, AW023590, AA848053, AI174591, AI500523, AA470491, AW020419, AI536574, AL036980, AW198090, AI648473, AI580674, AI802240, AL036673, AI284484, AI254226, AI521560, AW 198075, AI207656, AI633125, AI312428, AI784230, AI915291, AW302965, AI340519, AI281782, AL039132, AW05I226, AI582932, AW074869, AI889189, AI584140, AW128945, AI440263, AW029329, F27788, AL036396, AL041562, AI311892, AW163834, AI307736, AI590830, AW088903, AW089405, AL036804, AI494201, AL036274, AI673363, AI952145, AW079572, AL040241, AW190042, AW050578, AI587156, AI345347, AI567582, AL041772, AI915243, AI873604, AI432040, AW161156, AI872910, AI888953, AI241763, AI818574, AI805688, AW071349, AI536685, AI922689, AL041150, AI969641, AI689640, AL036802, AW168485, AI830029, AI561254, AA833760, AWI67448, AW073697, 881679, AW074993, AW072484, AI349614, AL036403, AL042382, AI343112, AW406529, AW150578, AI963846, AL040243, AL079794, AI590415, AI685211, AW301409, AI687689, AW021588, AI648663, AI282355, AW301300, AW051088, AI349598, AI349256, AL036664, AW075207, AI473799, AW059713, AI184903, AI312152, AI343037, AI702406, AW089689, AI345735, AW075084, AW148536, AW074009, AI349933, AI382670, AA614183, AL120853, AL133087, E05822, AF090934, AL137527, A77033, A77035, I48979, 578214, Y16645, AL122050, AF183393, AL050393, I89947, AJ012755, AL137550, I48978, A08910, A08909, AR034830, I96214, AL096744, AF017437, AJ000937, AL133568, AF090900, AL122118, AL049382, AL049465, AF090901, AL122123, A08916, A08913, U35846, AL110280, X63574, AF113677, 568736, AF104032, X72889, AL117435, AF106862, AL133075, AF057300, AF057299, AL050024, AL117460, Y14314, AF177401, AF113690, AF118070, AL137560, AL133557, AL117457, AF158248, X65873, AR013797, AF097996, AL133098, AL133113, A03736, AF061943, AL133093, AL049283, I89931, AL133080, U68387, AL137521, AL050277, I49625, AJ238278, AF026124, AL117432, AR038854, X80340, AL133016, AF126247, AF118064, AF090896, AL122121, S36676, Y11587, AL110196, X62580, AL133640, U58996, 282022, AF017152, AFI25948, AFI I3013, X93495, AL133565, AF061573, S61953, AL137526, Y11254, AL049314, AR059958, AB007812, AL080158, AF090903, AL137488, AR011880, AF113019, AL049938, A90832, AF087943, AF113699, AL137271, M30514, AF125949, AR038969, A18777, A65341, I33392, U00763, AL110221, A58524, A58523, AL080060, A93016, AL122110, AL122049, M86826, X84990, E07108, AF061795, AL050116, AF151685, AL117394, AL133606, AF079765, U72620, AF078844, AF100931, AF067728, AL137558, AL133014, AL122093, AL080148, A08912, U42766, AL080124, I03321, X70685, AF079763, X92070, AL080127, AL050149, L31396, AL137273, A12297, L31397, AF113694, AL137557, AF051325, A08908, AL122045, AL133072, U91329, AL133560, AF026816, X98834, U88966, U67958, AF132676, E02349, AF061836, AF111851, AL110197, AL133665, AF153205, AF111849, A93350, U96683, AL110225, X96540, AL080086, AF091084, I26207, AL049466, AL049300, AF090943, AR000496, U39656, AJ242859, U80742, AL050138, E02221, AL137463, I41145, E03348, Y10080, AL137459, AF162270, X52128, A07647, AF113676, AF113691, U49434, AL133104, AL080159, AF118090, AL049464, AB019565, I80064, AF003737, AL133067, X82434, AF113689, AL049452, 272491, AL050172, AL117585, AL122098, AL133077, ALI10222, AF067790, I09360, AL049430, AL117583, AF159615, AL050146, AL080137, AL050092, I00?34, AJ006417, AL137429, AF118094, X87582, AL133081, AL122111, Y09972, E00617, E00717, E00778, AL050108, AF146568, AF106657, AL137300, X81464, AF1I1112, AL137556, L19437, AL137478, AL133645, I42402, AF210052, L30117, and AL137538.

HSDJH63 195 9411201 - 138515 - AA741118, AW451491, AA252360, AA252405, AC006252, AC006252, AC006252, AC012224, and AC044892.

HNNAG23 196 11376911 - 495 15 - U46349, AW392670, U46346, 509 AL119355, AL119341, AL119319, AL119457, AL119483, U46351, AL119324, AW372827, AW363220, U46350, 299396, U46347, AW384394, AL119443, AL119484, AL119363, AL119391, AL119444, AL119497, AL119439, U46341, AL119335, AL119522, AL119418, AB026436, AR054110, AR060234, AR066494, and A81671.

HYAAL21 197 9431351 - 189015 - AW328507, AI655972, AA523409, AA009534, AI809237, AW137703, W92392, AI377032, AI872211, AA523391, R9513I, W56565, AI217725, AI381901, AI248517, H67840, AW328508, AI150552, AI241274, AA334258, AA620439, AA609120, W92335, AW194863, 808496, AA580479, N76255, AI142666, AI912966, 225384, AW243314, AA531424, W56787, F17380, AI217148, AW057531, and AI825787.

HPBCF69 198 9464691 - 676 15 - 690 AA298316, AA431938, and AL022101.

HWDAE40 199 9470071 - 216615 - 2180AF150174, AI417513, AI698235, 856970, AA471187, AC008917, AC008917, and AC016605.

HUVHH77 200 9483771 - 155015 - 1564AL119101, 860392, T85035, H07958, AI751941, 855083, AA330057, T91983, AL132641, AB007865, AF169676, AL132641, AL132641, and AL132641.

HTLIT03 201 9668701 - 890 15 - 904 AA886893, AA862723, AA470745, AA928557, AC004531, AC004531, AC004531, AC009077, AC009077, and AC009077.

HUJDA09 202 9515261 - 767 15 - 781 AI133670, W26633, AW375605, AA318069, AA853744, AI174232, AA521255, AA024888, N46555, 858116, AA447471, H77993, 858328, T47555, AI205304, T81235, W25885, 833242, AA349799, 220968, AA206898, AW380305, AA852419, AA355036, AW352357, AA486937, T80568, AA350303, AW138906, AA533322, W22449, AI372724, AI751908, AL133628, AF124440, AJ133038, and AB029448.

HTEPU67 203 11522621 - 155615 - 1570AL046221, AI971610, 872491, AI399742, AA426607, 881472, AI828470, AA247827, AL049014, AL041370, AL041369, and AB033049.

HULFJ52 204 9529281 - 106915 - 1083AW248392, AW269526, AW007505, AA873566, AA77763I, AA868719, AI095590, AW044220, AA935632, AI017929, AW166336, AA310175, AI889052, AI598144, AW328519, AW328518, AA831482, AA417135, N33459, AA618021, AA313368, AA868795, AA993399, AI083718, AI016702, AA459170, AI302612, AI160021, AA600754, AA447569, AA961682, AI285263, AI720708, AA860514, AI220450, AI469794, AI014825, AI301635, AI248971, AI128630, AA833995, AA875886, AI161342, AA936142, AI873496, AA476531, N35132, AA508601, AA883939, AI032546, N35532, AI581853, AA689457, AI520938, AA150058, AA507444, N26481, AW073092, AI863340, AA868027, AA909159, AA983159, AA829435, AI469742, AA136946, N35190, AA909264, AA587029, AA729752, AA886275, AA448553, F25329, AA917976, AW139387, F24032, D54530, AA152181, AI281705, N94436, AA723449, AA729741, F36770, N42432, AI609646, AI352654, AA872218, F18960, AW379804, AW204886, T78714, AA878640, AA152029, AI525049, AI686214, AA885866, AA632370, AA936986, AA639717, AA152103, AI815674, N86284, T78330, AA416980, AA508567, AA046681, AA508645, AI581953, AI417261, AA689510, D80791, AA642285, 805838, AA321232, AI708646, AI193213, AA827419, AA994079, AI758801, AA906828, D20172, AA766875, AI204124, AA417762, AA953345, AA082003, AA075950, AI479726, AI567451, AI192424, AA602743, AI630533, AA643709, AA047323, AA644356, AA902839, AI381206, AA873293, AI168779, AI056836, T67155, AA074065, AA262030, AI718619, AA573420, AA877485, 880525, AA046792, AI377046, AA101110, W30783, AA780251, D19766, N23403, AF087660, AC002400, and X61997.

HTEPV02 205 11522631 - 143215 - 1446AI204272, AI017771, AW297920, AA902816, and AA909581.

HFVIH16 207 11646311 - 158215 - 1596AW401441, T05017, M85838, AC003658, AC005620, AL008634, and AL133245.

HTJAB35 208 4912731 - 507 15 - 521 AA504694, AW372019, AL133355, AC005484, AC007151, AC005527, AF053356, AL049872, AC005529, AC016026, U95742, AL049795, AC005295, U91321, AC007845, AC002365, AC002404, AC004675, AC006101, 298051, 298941, AC007842, AF088219, AC013256, AL096701, AC005664, AP000501, AC004895, AL031595, 293023, and AC005102.

HRABP94 209 9704811 - 159015 - 1604AI952147, AA827782, AI523970, AW008938, AA236865, AI673370, AW043829, AI143323, N36986, AA306716, AI361743, AA460666, AW080829, AI914077, AI214786, AA862831, AI963652, AI913070, AI805253, AI423188, AI003936, AA994686, AA130868, AA533231, AI358965, AI873692, AA569719, AA865951, AA644481, AI272308, AI445569, AA130923, AI418685, AI669710, C00906, 885067, AA847433, AA502585, AA968581, AI088486, N46300, AA176755, AL048511, AA179075, AW163823, AW162071, AI274452, AL042488, AI799540, AI961393, AA904283, AI290128, F35031, AI582822, AA088789, AA829775, AI270039, AI679800, AW262565, AL042515, AI918424, AI884459, AA807326, AL122098, 568736, A57389, AL137562, AF158248, U72071, X79812, AL049959, AF070632, U92068, AJ131955, AF169154, AF030165, 230970, AL096709, 249258, AC006561, AL022396, AC007370, AL049540, U94316, AP000250, AP000133, AP000211, AF162270, I80845, AF107018, U77594, AL080074, AR029580, AL359711, AL359711, AL359711, AL109947, AL109947, AL109947, AL136222, and AL 136222.

HWAGC08 210 9581391 - 537 15 - AA133438, AI904808, AA447236, 551 AL048981, and AC005071.

HRDET35 211 9453501 - 179815 - AA603325, AI123244, AI742610, 1812 AW451297, AW 167511, AI869312, AA522674, AI122654, AI638539, AA693938, AI085752, AI922008, AI521658, AI913241, AI288451, AI432336, AI925715, AI394394, AI243319, AW30I143, AI417213, AI056464, AA937953, AI827213, AI963292, AI094469, N94395, AA736786, AW444808, AA984628, H14735, AI425075, AA968590, AI445367, AI866676, AA627433, H25970, AI356146, AI742621, H27088, AI194056, AI803734, AI872656, AI420510, 869552, T73549, AI222629, H45935, 238818, AI547263, H25733, 242656, AI656165, H25937, AI557864, AI525500, AI541356, . T18597, AI557262, D59436, AI557I55, AI525316, AI541205, AI525556, AI541365, AI547250, AI557731, D59751, AA585098, AI535813, AI541321, AI557408, AI526078, 845895, AI546971, AA585325, D57491, 015737, AI557084, 829657, AI541346, AI541034, AA585101, AI557602, 828967, 232887, AI535639, AI557317, 828735, 829445, 232822, AI547196, AA585439, AI557808, AI546921, 828892, AI540974, AI547039, AI536138, AI535660, AI526140, D61185, 228355, 828965, AA585155, AI541517, AI557740, T11028, 829218, AI547006, D60844, AI541027, AI557727, AA585476, AI546829, 016305, 828895, AI541535, AI526184, AI541506, AA283326, AI557238, AI546875, AA585329, AI525656, AI557763, D61254, AI546999, AI526113, AI557734, 016293, AI557082, 230131, AI557787, AI557039, AI526194, D53472, D55233, D60765, AI525306, 016300, AA170832, AI541374, AI540903, AI557533, AI541383, 015069, AI546945, AI525431, AI541013, AI541523, 233559, AI557809, AA585453, D53161, AI525856, AI541307, AJ239433, AI557807, 829177, AI546996, 015406, AI546891, AA359427, AA514191, 016296, AI557285, D54897, D57186, AI540967, 014208, AI557041, 829179, T41289, AI525320, AA883608, AI526186, AI526187, 829262, AI541056, AI54i048, AI541075, 829172, AI557279, D53447, AI525339, 014391, 015120, 016315, 016292, AI547202, AA585378, AI556967, AI526016, 015762, AI547137, AI526195, AA585356, AI526180, AI526073, AI557718, AA174170, AA585434, AI541527, 016294, AI525653, D52835, AI557852, 014322, AI526191, D30843, AI557758, AI526146, AI546828, AI541415, AI557264, D59458, D60730, AI540944, AI557799, T41329, 014723, AI541422, AA585440, AI541514, AI525286, AI546855, T19407, AI557312, C06219, AI541345, AI526205, AI541390, C16290, AI524891, Y09813, U94592, AR062871, A25909, AR038855, 232836, A70869, AR038762, A85395, A70872, A85476, X81969, Y16359, AJ244005, AF082186, D50010, D13509, AJ244004, A20702, AR062872, AR062873, A20700, A43189, A43188, AR037157, AR017907, AJ244003, D78345, AR054723, AC005913, AF006072, A98420, A98423, A98432, A98436, A98417, A98427, A98767, A93963, A93964, I63120, X82786, U87250, 230183, A62298, I08389, AR050070, A82595, A82S93, I19525, I44681, X55486, X83865, X76012, I08396, A84772, A86792, A84776, A84773, A8477S, AJ243486, A84774, AR054109, AR067731, A58522, AR067732, A91750, AR035975, AR035977, AR031358, AR031365, A18053, A93016, I13349, AJ244006, AB025273, I05558, A60212, A60209, A60210, A60211, A35536, A35537, A02135, A04663, A02136, A04664, I84553, I84554, A62300, I05845, A22739, E03627, I48927, A90655, D13316, E17098, A02712, A77094, A77095, A81878, A95051, I06859, A18050, A23334, A75888, I70384, A64973, A60111, A23633, AR007512, AR017826, AR031566, I00682, I62368, A11245, A11623, E00609, A11624, E13740, A11178, E01007, A10361, A16035, AR043601, X82834, AR003381, AR063812, M28262, I26929, I26928, AF149828, Y14219, AJ231028, I15718, I03331, S60422, I01995, A02710, E12615, AR035193, A92133, E14304, A07700, A13392, A13393, AR031488, I13521,152048, A27396, I25027, AR027100, I49890, I44531, I28266, I21869, I44515, I26930, I26927, A9I965, I44516, A70040, A82653, I08051, E16636, I15717, A22738, A22734, I33632, U45328, A24783, A24782, A95117, A58524, AF213384, AJ230935, AJ230972, A58523, A06631, E16678, E03654, AB005666, AR035974, AR035976, AR035978, AJ230845, I08395, AR038066, AJ131952, AF135243, AJ230902, I66495, I66494,160241, I60242, I66498, I66497, I66496,166486, I66487, AJ230951, AJ231009, I03669, I03668, L36913, AJ230867, AR051957, A20699, E00696, E00697, E03813, I66482, AR009151, I66485, I66483, I66484, AR027099, AJ230996, A05993, A05991, AR051651, AR051652, and AR025466.

HGBIA24 212 11538901 - 111015 - AL042041, W40130, AW179228, 1124 AI807061, AB002377, U04847, AR036413, and Y17126.

HTTHF21 213 9215961 - 798 15 - AA699339, AC074092, AC074092, AC013264, and AC013264.

HWHJZ40 214 9641531 - 127715 - N47207, AI971441, and AL122104.

HJMBN52 215 9662261 - 104915 - AL079758, AI288028, AW135082, 1063 AI081066, AA806585, AA282088, AI799780, AI623497, AI918288, AL07995I, AA535036, AI932410, 241770, AI990083, H11909, AI561356, AI538692, AW025279, AW192300, AI679550, AI812015, AW084056, AI348901, AI309306, AI783792, AI560679, AA575874, AW080076, AW168451, AI677797, AI678409, AI537677, AI669639, AI690961, AW 150762, AI433611, AI096771, AI251221, AL040694, AW 162194, AW 150326, AI370623, AI570966, AW004886, AI623835, AI922315, AI225000, AI927233, AI589428, AI242246, AI887163, AI491710, AI784387, AI866573, AI345415, AI419440, AI537991, AI819202, AA190918, AI43473I, AI270183, AW059568, AI886123, AW081255, N25033, AI915295, AI934035, AI539800, AW190297, AW085786, AI886355, AI284060, AW 148303, AW020693, AW 148738, AI918408, AW075382, AW020381, AA835966, AL048351, AI648458, AI572021, AI537643, AI554484, AI826225, AI560545, AI524I79, AL036265, AI680369, AWOI9985, AI636456, AL043091, AI554485, AW189126, AI919147, AI859464, AI537187, AA654165, AW051088, AW087877, W31910, AI630877, AW079572, AW168828, AI554402, AI933992, AW084447, AI758652, AI627714, AI114703, F35299, AW075936, AW089405, AW080746, AI889180, AI698391, AI040725, AL042191, F33257, AI886055, AI866040, AI567866, AI590043, AI923989, AI619820, AA464027, AI926593, AI859644, AI536685, AW152067, AL036638, AW195253, AI433206, AI280661, AA857847, AW051048, AI434242, AL046454, AI276358, AL046466, AI648699, AI590999, AI863665, AI961589, AI540606, AI537516, AI953803, AW071689, AW078710, AI336644, AI863241, AI224373, AW194185, AW118417, AI926041, AW118353, AI474646, AI669864, AI254727, AW082532, AI689614, AI683939, AI538342, AA493109, AL041220, AI699823, AI863455, AI888621, AI564448, AI365256, AI312428, AI873638, AI432644, AI249877, AW194014, AI917331, AI802240, AI352326, AI688854, AW088882, AI499279, AI571529, AW151283, AW168875, AI250627, AW128931, AA464646, AW239367, AW022084, W81248, AI625516, AL048871, AA760851, AW022636, AW 191844, AI573167, AI245008, AI357599, AI282268, AI539771, AI554444, AI471429, AL046931, AI802654, AI537863, AW173633, AI633061, AI814087, AL041230, AW410177, AW022584, AA908294, AI446646, AI700159, AI862144, AI628325, AA748682, AL040241, AI678446, AI888317, F34698, AI434134, AW082623, AW029197, AL135047, AI636619, AI620866, AI933903, AI581033, AI310606, AI564765, AI872722, AI540458, AW023871, AW327527, AW088560, AI954422, AI634919, AW302990, AI925164, AI473536, AI469516, AI758309, AI282346, AI811785, AI344935, AW079432, AI345612, AI800155, AA687471, D63484, AF109906, AL137480, AC005815, AL137665, AL050170, AL096751, I48978, U77594, I09499, E04233, M92439, I89947, AF026008, E06743, AR068466, AF067790, AF113019, X66862, X98834, AF180525, AF114168, A91160, A91162, AL110218, A18777, A08913, AL133560, U86379, Y09972, AF177767, A08912, A08910, A08911, A08909, AL122098, U35846, AF032666, I00734, AL031984, AF113694, A08907, X76228, U92068, A08908, AL137529, U87620, S69510, AL133016, E00617, E00717, E00778, AR034821, 576508, AF028823, I48979, AF111112, D44497, AF017790, X99226, AL078630, I89931, AF161699, AF112208, S77771, AL133072, I49625, AL133080, X61399, AF109905, X57084, AL110224, AF002672, X62773, AR038854, S75997, A57389, AL049339, AL080159, AF001215, AF069506, AL122100, AF015958, 568736, AL096728, U80742, AL133112, AF055917, I89934, AR068753, AF126247, X60786, AL049314, AL133081, AL050172, AL137459, I30339, I30334, S83440, 579832, AL110222, AF022363, U51587, E01314, AL080086, L13297, AF182215, A23630, AF113691, AL050310, AF118070, X83544, AL117583, AL137294, A52563, Y11435, AF119336, X66871, AL133558, E02253, I33392, AF210052, X52128, AF109155, AL133054, AL137658, AL1221I8, AL133619, E02221, AR053103, A08916, AL080118, AF151109, X92070, AF026124, E12579, AF179633, AF200464, D55641, AL080124, A21103, AC002464, AL122110, E02152, A08456, 578453, I42402, AR038969, AF111849, U62807, AF177401, AF106657, U72620, AF113013, AC003032, AC004686, AL137463, X81464, X82434, AF013249, AF016628, AC004213, AL122104, AL137271, AF031147, AL137711, AL133049, E01614, E13364,189944, AF169154, AF061573, E0863I, U54559, AF162270, AF132676, AF061836, U58996, A07647, AL050149, AF026030, AL137547, AF044323, AL133014, AL137488, AF106934, AF090901, AL080148, U42766, AL137521, X63574, X53777, U88966, A58524, A58523, AL034417, AF082526, AL137662, A65340, L40363, I26207, 582852, AF126488, AL137574, AF145233, AL110221, E06788, E06790, AL136842, E06789, AF039138, AF039137, AL137641, AF102578, AL122121, 297214, A21101, AF104032, D16301, AFI13690, 563521, YI0080, Y10823, A07588, U67958, A83556, AR000496, AF113699, AL049382, U39656, AF118090, AR060156, AF090886, AL133075, AF061795, A58545, AL117457, AL050116, AF151685, AF199027, AF158248, AL096720, AL133568, AL080126, AC024049, and AF276758.

HUFCN47 2I6 11979271 - 259615 - AI760194, AI927898, AI336201, 2610 AI927907, AA584317, AW295934, AI9I3591, AA779893, AI927508, AI651559, AI829397, W87653, AA776800, AA776850, AI761887, AA778340, AA137050, AA129545, AW268410, AW369793, AI291466, AW172272, AI033092, AI122659, AA825180, AA779164, AW1S0144, AI499117, W72249, AI478286, AW022740, N23572, AI811636, AA393829, AA595168, AA393828, AI689567, AI828403, AI151409, AA678034, AI650760, AI671401, AA122104, AI679454, AA934S08, AI624260, AW140004, AI373049, H98850, AW168229, AA558970, AA452648, AI311851, AI623111, W87654, AI221442, W86674, W76334, AI368965, AI186444, AAI36524, AA137122, AA429808, AA861331, H99223, AI138483, AA789253, N29659, AA931521, AA938437, N56614, 861734, AA644I26, W86530, AI017369, W56880, H13339, AI023729, AA322817, AA370677, AI989760, AA416684, N68604, T71029, 866190, 242947, AI985238, 859589, AA370676, AA301141, AI695321, W60230, F06078, AI273943, AI865027, AA724462, H22960, AI521700, T79145, F10189, AI537308, 861735, N26340, AA007246, T79226, AI363800, 867070, T99989, AA057869, AI391674, AI096493, AA905436, AA394311, AA122103, T35380, AI659488, AL047735, AI569343, H1620I, AA249553, W25579, H16200, AA056994, T34602, AA972578, H85574, AA703249, AI718301, H84136, AI769144, AA446I45, T19228, AI912488, H84137, AA007247, AW026302, AI150909, W60229, AA543012, AA805360, AI923763, AI808053, AI923755, AI038549, AI299392, AA525242, AI363317, AI423070, AW074268, AI004762, AI142528, AI366824, AW 189200, AI809295, AI422905, AI581719, AA435552, AI049778, AI434072, AW340472, AA720972, AA285270, AI298865, 884798, AA682274, AA825825, AW074622, AI299364, 898981, AI653505, AI653497, . AI005389, AW3786S1, AW378652, AA778203, H38182, AA594432, AI686562, 220432, AA605010, AI903936, AW376259, H47520, AA937921, AI251939, T67636, AI368176, AA972687, AAS63913, AA772536, and A74394.

HHEUC31 2I7 I09I624I - 772 15 - AAI32827, and AI905590.

HUSAL47 218 11979281 - 284815 - AI160081, AI240596, AI804003, 2862 AA459487, AA742366, AA972891, AA280738, AA612844, AA578562, AW182249, AW449085, AA665027, N44566, D81704, AA748357, D60753, H58990, 866624, H78860, and AA195537.

_H_HFGD38219 1153892I - 111515 - AI675967, AI972614, AA463221, 1129 AI022794, AI424263, AA001733, AL036043, AA463220, AA247152, AA670278, AA331577, AC010385, AF042089, and AL137717.

HVAOGIl 220 11522751 - 105415 - N25812.

HUVDR03 221 9746841 - 324215 - AA768846, AI671768, AI961239, 3256 AI884699, AA514474, AI521280, AA156958, AI679628, AI239530, AI885479, AI336225, AI735075, AI186828, AI626081,~AI494518, AI275985, AA749446, AI914010, AI130746, AI921928, AA993271, AW207720, AI130728, AI299980, AA976621, W69667, AA742981, AA229014, AI279330, AA156866, 819745, AI216523, AA255782, AI8I1823, 884393, AA488821, AI419263, AA489068, AA229863, AA701250, AA705638, N47318, AA229731, AW271763, AA687125, AA862901, AW372345, AW272381, AA939081, AL044304, W73428, AI478491, AW089880, AA702739, AW021871, AA765337, AA977247, F06156, W73367, AI141957, W45513, AA127066, AI283582, 884392, AI985183, AW439593, AI560741, AI186368, AI687916, AI203537, AA047572, W69666, H66133, AI081094, AA453238, AA463404, AA356896, AW294792, AA318684, H66549, AL046248, AA373158, AA011074, AL046015, 225224, AA480226, AW292636, H43300, AI222506, W24708, AA492470, AA579885, T47922, T47923, AA348753, T05906, AA455850, H43299, AW292633, AI419633, AA011075, D61430, AI587496, AA772416, AA147480, N92391, AA378964, 845164, AA714016, AA130104, AI560507, AW272813, AW376847, AI471022, H16I72, AI568064, 868334, AI567645, AW376809, W45654, AA256004, AA280280, AL133683, AA378963, AA341472, AA887264, AA147880, AA704633, AA429202, AI905673, AI216605, AW168495, C14179, AI963999, AC020663, AF108453, U70255, L06564, X89268, and AF005380.

HUDAE29 222 6898111 - 275 15 - AI191415.

HIBCJ89 223 9546811 - 251615 - AL039924, AA633985, W76256, 2530 W72063, W58499, AL045794, AL044364, AW013814, AA349955, AL036630, AA349954, AW450335, T02921, AL044412, W58534, T24112, T24119, AL039459, AL036650, AA778891, AL039476, AL042334, AL040992, AL039109, AL038531, AL037726, AL039629, AL039659, AL039625, AL039648, AL038837, AL039074, AL039566, AL039678, AL039108, AL039538, AL039564, AL039509, AL039156, H00069, AL042909, AL039128, AL044407, AL036973, AL045341, AL045337, AL037051, AL045353, AL039386, AL039423, AL039410, AL039150, AL038025, AL038821, AL044530, AL036725, AL039521, AL043445, AL043422, F25532, AI535983, F18362, AL043586, T23947, AL043423, AL044413, AL043441, AL036196, F34438, AL037639, AL037615, AW451070, AL036767, AL036117, AI535783, AL039085, AL043613, AL037526, AL043585, AL036238, 847228, AL036679, AW452756, AI655417, AW297822, AL037601, AL039576, AL044178, ' AL039504, AL036158, AL036733, AL039842, AL036964, AL037027, D51250, AL043840, AL039550, AL036924, AL036765, AL037054, T23659, AL040947, AL037I77, AL03885I, AL036998, T23658, AL037643, AL036133, AL036418, AL036227, AL036163, AL037047, AW293068, AL037082, D80253, AL036207, AL037124, AL036167, AL039472, AL036191, AL036132, AL037021, AL044354, AL037049, D59787, AL037600, AL036190, AL037679, AL036139, D59275, AL036152, D80043, D80219, T48598, AL036900, T23656, AL037178, AA514190, AL048425, AW451416, AL039555, D80227, AL037085, 225782, AL036174, AL036953, D80240, AL036808, D80134, AL037569, D51423, 299396, T11051, AL036150, D80210, AW450376, H00072, D59619, AL036268, AL038043, C14227, AL044447, D80193, AL037077, D80196, AI557751, AL037002, AL039417, D80168, 225783, AW 135155, D59927, D80366, AL036858, C75259, C14389, AL037016, AL036229, D59889, AL034408, A95051, A18050, AR007512, A18053, AR036905, AR062871, AR043601, A23334, A75888, I70384, A60111, A23633, AR017907, AR062872, A84775, AR062873, A84772, A84776, A84773, I06859, A84774, AR067731, AR067732, A91750, A20702, A58522, A43189, A43188, A20700, E12615, AR035193, A92133, I60241, I60242, AR027100, I28266, AR043602, AR043603, E13740, A98767, A25909, A23998, A95052, A93963, A93964, A38214, A10361, A95117, AR037157, A44171, I56772, I95540, AR018924, A63067, A51047, A63064, AR03I374, AROI8923, A48774, A63072, A49700, A48775, AR068507, AR068506, I63120, AR054109, AR015960, AR000007, AR015961, I03343, A5852I, A86792, AR022240, AR020969, A81878, A58524, A58523, E14304, A24783, A24782, A27396, E16678, A49045, A82653, A93016, E16636, I25027, I26929, I4451S, I26928, I26930, I26927, A58525, AR038762, I49890, I44516, AR031375, AR000006, A58526, A91753, X68127, AJ244003, A85396, A85477, A13038, A29289, I62368, AR031488, I13521, I52048, I44531, I18371, AR067733, AR029418, AR029417, AR017908, A68112, A68104, AR067734, A98467, I15353, AR028669, AR028668, AR028667, AR028670, A84746, AR028672, AR038066, A17115, A18079, I50882, I66495, I66494, I66498, I66497, I66496, I66487, I66486, AF156296, A71440, I13349, E06034, A07699, A71435, E08322, I74623, A60109, AR025207, A98420, A98423, A98432, A98436, A98417, A98427, AR028564, AR051651, AR051652, A83643, A83151, I01968, A13388, A28163, AR005163, E00974, A02228, AR005154, E00954, E00952, AR005157, AR005160, E00953, E00955, I08049, AR005I53, A49989, I43960, AR021440, E03165, E02221, E13364, AR005165, A49701, A10360, E02679, E02104, A95096, E02098, A92666, I31848, E02001, AR060673, E01718, E02003, AR060676, E02102, E03550, E02100, E01997, A58998, E02291, E02292, E02293, E01999, E02396, E02327, A95106, E01563, E02431, E01693, E01696, A92668, A95105, A91965, I09250, A92667, A70040, A94048, A94061, E01024, AR050583, AR050584, E02430, E01148, A94046, A94054, E12527, I63560, E01503, E12523, A49428, I63561, I63563, E02432, I84556, A20357, A62009, E01216, I84555, I77211, A99078, A28084, A75741, I70974, I31847, A80476, A39734, E02096, E01324, and I08638.

HIBEG40 224 5041581 - 389 15 - 403 AA351313, and AA351814.

HWBEG33 225 11958061 -2298 15 -2312 AA195189, AI872284, AI970956, AA195225, AW081553, AI087990, AW4S0597, AI813529, AA196805, AW341108, AI989416, AA76I908, AA1926I9, AA196388, AA907918, AI005370, AI125962, AA180234, AI692710, F33759, F30952, 217874, AA180852, AA196665, AA490979, AA363184, F36186, AI681453, AA768364, AL137735, AF155353, AF159164, AL132642, AW510603, AW770570, and AW770858.

HWHKD22 226 11508781 - 791 15 - 805 AI829903, AI633646, AI986119, AI769747, AI984540, AW337994, AI769807, AI610118, AI354761, AW014492, AI696473, AI815233, AA205305, AA811626, AA418029, AA808125, N70046, AI825035, AI371756, AI680927, AI632886, H39858, AW302373, N25678, AI915190, AA810844, 886213, AA846497, AA442702, AI298620, AI916429, AI299340, H28050, AA633452, AA496038, and AA418089.

HE9SE46 228 9445111 - 212615 - AA195155, AI268255, AW419341, 2140 AI824127, AI797143, AI300923, AI292148, AI70340I, AI268439, AI292153, AW 137704, AI831208, 835403, AW137395, AI379414, AI379109, AI277432, AA057594, AI432198, AI300400, AI300976, AI300968, AW138254, AA862254, AA978306, AAI36742, AAi87853, AA411758, AW139302, AA418285, AI697655, AA136133, AI299234, W44727, AW135673, AA933000, AA195026, AW134622, AI336837, AI214619, AW388217, AA406572, AI342824, AW388179, AI222659, AI378218, AW370464, AA878171, AA825160, 825577, AI871540, AW388239, AA985538, AI468745, AW206391, T10355, AA424539, T75128, AA418322, 805548, AA976873, AA363106, F11165, H09479, AA114288, F12796, AA346579, AA112328, AA917973, 242588, 818424, AA424606, AA781256, AA625611, AI633662, AA331566, N90086, AA055551, C18803, AI695403, AI741622, AW378385, AA995638, N63577, F05973, AA455944, AAI90723, AA904239, AA436288, AI752009, and AI305270.

HTLDW37 229 8642761 - 110415 - AW025605, AW025604, AA862436, AA375852, AI732328, AA371876, AI033275, and AB014607.

HWAFG54 230 12271381 - 374415 - AI760827, AW408019, AI253155, 3758 AI349366, AI356482, AA814034, AW075920, AW407984, AI760691, AA251937, AI766650, AA352825, AA243541, AI934100, AA352840, H72208, H72106, AW193021, AL035530, and AW664438.

HKAFS73 231 8104331 - 396 15 - N80779.

HTXJD74 232 9211751 - 109715 - AA030013, W04200, T96295, 1111 AA348729, AW369326, AI817745, AI902506, AI740457, AA303510, AI902496, AW298344, AA843339, AI902495, AI902509, W19941, AW452907, AI902510, AI610042, AF151638, AF114430, U21660, 250026, AF151639, AF040261, AF114436, 250024, AF114437, AF114431, AF114434, AF114432, AF114433, AF114435, and AF040266.

HSIGQ50 233 9324481 - 133215 - AW361379, AA131062, AC015551, AC019214, and AC019214.

HWWDY4 234 9326071 - 713 15 - AA451973, AW044300, AI925874, AC002064, and AC006153.

HNSMB24 235 9715371 - 671 15 - AI978874, AI469095, AP001623, 685 AP001623, AC015555, and AC015555.

HWLOU63 236 9468621 - 709 15 - AI074147, AI249752, AA573289, 723 AI744674, AW081142, AI951269, AI560208, AI309528, AI097133, AI310351, AI222028, AW073286, AA121301, AI160271, AI991117, AW170797, AA278853, H47623, AA742972, AA864447, AI572193, AA173309, AW188877, H69345, AA121349, AW363751, AW383987, AW372736, AI476011, AW372731, AW372739, AW372742, AW372744, N22901, AA769896, AW372786, AW372740, AW388634, AW372738, AW372734, AW372745, AW372735, AW372737, H69344, and AF132937.

Code Description Tislue Organ ell DiseaseVector Line AR022a Heart a Heart AR023a Liver a Liver AR024a mammary Qlanda mammar land AR025a Prostate a Prostate AR026a small intestinea small intestine AR027a Stomach a Stomach AR028Blood B cells . Blood B
cells AR029Blood B cells Blood B cells activated activated AR030Blood B cells Blood B cells resting restin AR031Blood T cells Blood T cells activated activated AR032Blood T cells Blood T cells restin restin AR033brain brain AR034breast breast AR035breast cancer breast cancer AR036Cell Line CAOV3Cell Line AR037cell line PA-1 cell line AR038cell line transformedcell line transformed AR039colon colon AR040colon (9808co65R)colon (9808co65R) AR041colon (9809co15)colon (9809co15) AR042colon cancer colon cancer AR043colon cancer colon cancer (9808co64R) (9808co64R) AR044colon cancer colon cancer 9809co14 9809co14 .

AR045corn clone 5 com clone AR046corn clone 6 com clone AR047corn clone2 corn clone2 AR048corn clone3 corn clone3 AR049Corn Clone4 Corn Clone4 ARO50Donor II B CellsDonor II
24hrs B Cells 24hrs AR051Donor II B CellsDonor II
72hrs B Cells 72hrs AR052Donor II B-CellsDonor II
24 hrs. B-Cells hrs.

AR053Donor II B-CellsDonor II
72hrs B-Cells 72hrs AR054Donor II RestingDonor II
B Cells Resting B
Cells ARO55Heart Heart AR056Human Lung (clonetech)Human Lung (clonetech) AR057Human Mammary Human Mammary (clontech) (clontech) AR058Human Thymus Human Thymus (clonetech) (clonetech) AR059Jurkat (unstimulated)Jurkat (unstimulated) AR060Kidne Kidne AR061Liver Liver AR062Liver (Clontech)Liver (Clontech) AR063Lymphocytes Lymphocytes chronic lymphocytic chronic lymphocytic leukaemia leukaemia AR064Lymphocytes Lymphocytes diffuse large B cell lymphomadiffuse large B cell lym homa AR065Lymphocytes Lymphocytes follicular 1 m homa follicular 1 m homa AR066normal breast normal breast AR067Normal Ovarian Normal Ovarian (4004901) (4004901) AR068Normal Ovary Normal Ovary AR069Normal Ovary Normal Ovary AR070Normal Ovary Normal Ovary AR071Ovarian Cancer Ovarian Cancer AR072Ovarian Cancer Ovarian Cancer (97026001) (97026001) AR073Ovarian Cancer Ovarian Cancer (97076029) (97076029) AR074Ovarian Cancer Ovarian Cancer (98046011) (98046011) AR075Ovarian Cancer Ovarian Cancer (98066019) (98066019) AR076Ovarian Cancer Ovarian Cancer (98076017) (98076017) AR077Ovarian Cancer Ovarian Cancer (98096001) (98096001) AR078ovarian cancer ovarian cancer AR079Ovarian Cancer Ovarian Cancer AR080Ovarian Cancer Ovarian Cancer AR081Ovarian Cancer Ovarian Cancer AR082ovarian cancer ovarian cancer AR083Ovarian Cancer Ovarian Cancer AR084Ovarian Cancer Ovarian Cancer AR085Ovarian Cancer Ovarian Cancer AR086ovarian cancer ovarian cancer AR087Ovarian Cancer Ovarian Cancer AR088Ovarian cancer Ovarian cancer 3rd C00 3rd AR089Prostate Prostate AR090Prostate (clonetech)Prostate (clonetech) AR091rostate cancer rostate cancer AR092prostate cancerprostate #15176 cancer #15176 AR093prostate cancerprostate #15509 cancer #15509 AR094prostate cancerprostate #15673 cancer #15673 AR095Small IntestineSmall Intestine (Clontech) (Clontech) AR096S Teen S Teen AR097Thymus T cells Thymus T
activated cells activated AR098Thymus T cells Thymus T
resting cells restin AR099Tonsil Tonsil AR100Tonsil geminal Tonsil geminal center center centroblast centroblast AR101Tonsil germinalTonsil germinal center B center B
cell cell AR102Tonsil 1 m h Tonsil lym node h node AR103Tonsil memory Tonsil memory B cell B
cell AR104Whole Brain Whole Brain AR105Xeno raft ES-2 Xeno raft AR106Xeno raft SW626Xeno raft H0002Human Adult Human Adult Heart Uni-ZAP
Heart Heart XR

H0004Human Adult Human Adult Spleen Uni-ZAP
Spleen S leen XR

H0007Human CerebellumHuman CerebellumBrain Uni-ZAP
XR

H0008Whole 6 Week Uni-ZAP
Old XR
Emb o H0009Human Fetal Uni-ZAP
Brain XR

H0012Human Fetal Human Fetal Kidney Uni-ZAP
Kidne Kidne XR

H0013Human 8 Week Human 8 WeekEmbryo Uni-ZAP
Whole Old XR
Embryo Emb o H0014Human Gall BladderHuman Gall Gall Bladder Uni-ZAP
Bladder XR

H0015Human Gall Bladder,Human Gall Gall Bladder Uni-ZAP
fraction II Bladder XR

H0016Human Greater Human Greaterperitoneum Uni-ZAP
Omentum Omentum XR

H0018Human Greater Human Greaterperitoneum Uni-ZAP
Omentum, Omentum XR
fII remake H0023Human Fetal Uni-ZAP
Lun XR

H0024Human Fetal Human Fetal Lun Uni-ZAP
Lun III Lun XR

H0026Namalwa Cells Namalwa B-Cell Lambda Line, EBV ZAP II
immortalized H0028Human Old OvaryHuman Old Ovary pBluescript Ovary H0030Human Placenta Uni-ZAP
XR

H0031Human Placenta Human PlacentaPlacenta Uni-ZAP
XR

H0032Human Prostate Human ProstateProstate Uni-ZAP
XR

H0033Human Pituita Human Pituita Uni-ZAP
XR

H0036Human Adult Human Adult Small Uni-ZAP
Small Small Int. XR
Intestine Intestine H0037Human Adult Human Adult Small pBluescript Small Small Int.
Intestine Intestine H0038Human Testes Human TestesTestis Uni-ZAP
XR

H0039Human Pancreas Human PancreasPancreas diseaseUni-ZAP
Tumor Tumor XR

H0040Human Testes Human TestesTestis diseaseUni-ZAP
Tumor Tumor XR

H0041Human Fetal Human Fetal Bone Uni-ZAP
Bone Bone XR

H0042Human Adult Human Adult Lung Uni-ZAP
Pulmonary Pulmonar XR

H0046Human EndometrialHuman EndometrialUterus diseaseUni-ZAP
Tumor Tumor XR

H0047Human Fetal Human Fetal Liver Uni-ZAP
Liver Liver XR

H0048Human Pineal Human Pineal Uni-ZAP
Gland Gland XR

H0050Human Fetal Human Fetal Heart Uni-ZAP
Heart Heart XR

H0051Human HippocampusHuman Brain Uni-ZAP
Hi ocam us XR

H0052Human CerebellumHuman CerebellumBrain Uni-ZAP
XR

H0056Human UmbilicalHuman UmbilicalUmbilical Uni-ZAP
Vein, Vein Endothelialvein XR
Endo. remake Cells H0057Human Fetal Uni-ZAP
S leen XR

H0058Human Thymus Human ThymusThymus diseaseLambda Tumor Tumor ZAP II

H0059Human Uterine Human UterineUterus diseaseLambda Cancer Cancer ZAP II

H0063Human Th mus Human ThymusTh mus Uni-ZAP
XR

H0064Human Right Human Brain,Brain Uni-ZAP
Hemisphere right XR
of Brain hemis here H0068Human Skin TumorHuman Skin Skin diseaseUni-ZAP
Tumor XR

H0069Human ActivatedActivated Blood Cell Uni-ZAP
T-Cells T-Cells Line XR

H0070Human Pancreas Human PancreasPancreas Uni-ZAP
XR

H0071Human Infant Human InfantAdrenal Uni-ZAP
Adrenal Adrenal Glandland XR
Gland H0075Human ActivatedActivated Blood Cell Uni-ZAP
T-Cells T-Cells Line XR
(II) H0079Human Whole Human Whole Embryo Uni-ZAP
7 Week 7 XR
Old Emb o (II) Week Old Emb o H0081Human Fetal Human Fetal Skin Uni-ZAP
Epithelium Skin XR
(Skin) H0083HUMAN JURKAT Jurkat Cells Uni-ZAP
MEMBRANEBOUND XR

POLYSOMES

H0085Human Colon Human Colon Lambda ZAP II

H0086Human epithelioidEpithelioid Sk Muscle diseaseUni-ZAP
XR

sarcoma Sarcoma, muscle H0087Human Thymus Human Thymus pBluescript H0090Human T-Cell T-Cell LymphomaT-Cell diseaseUni-ZAP
Lymphoma XR

H0097Human Adult Human Adult Heart pBluescript Heart, Heart subtracted H0098Human Adult Human Adult Liver Uni-ZAP
Liver, Liver XR

subtracted H0099Human Lung Cancer,Human Lung Lung pBluescript Cancer subtracted HO100Human Whole Human Whole Embryo Uni-ZAP
Six Week Six XR

Old Embryo Week Old Embryo H0101Human 7 Weeks Human Whole Embryo Lambda Old 7 ZAP II

Emb o, subtractedWeek Old Embr o H0102Human Whole Human Whole Embryo pBluescript 6 Week Six Old Embr o (II),Week Old subt Embr o H0103Human Fetal Human Fetal Brain Uni-ZAP
Brain, Brain XR

subtracted HOI09Human Macrophage,Macrophage Blood Cell pBIuescript Line subtracted H0111Human Placenta,Human PlacentaPlacenta pBluescript subtracted H0116Human Thymus Human ThymusThymus pBluescript Tumor, subtracted Tumor H0119Human PediatricHuman PediatricKidney Uni-ZAP
Kidney XR

Kidne HOI22Human Adult Human SkeletalSk Muscle Uni-ZAP
Skeletal XR

Muscle Muscle H0123Human Fetal Human Fetal Brain Uni-ZAP
Dura Mater Dura XR

Mater H0124Human Human Sk Muscle diseaseUni-ZAP
XR

Rhabdom osarcomaRhabdom osarcoma H0125Cem cells cyclohexamideCyclohexamideBlood Cell Uni-ZAP
Line XR

treated Treated Cem, Jurkat, Ra'i, and Su t H0130LNCAP untreatedLNCAP Cell Prostate Cell Uni-ZAP
Line Line XR

H0134Raji Cells, CyclohexamideBlood Cell Uni-ZAP
cyclohexamide Line XR

treated Treated Cem, Jurkat, Ra'i, and Su t H0135Human Synovial Human SynovialSynovium Uni-ZAP
Sarcoma XR

Sarcoma H0136Supt Cells, CyclohexamideBlood Cell Uni-ZAP
cyclohexamide Line XR

treated Treated Cem, Jurkat, Ra'i, and Su t H0141Activated T-Cells,Activated Blood Cell Uni-ZAP
12 hrs. T-Cells Line XR

H0144Nine Week Old 9 Wk Old Embryo Uni-ZAP
Early Early XR

Sta a Human Stage Human H01497 Week Old EarlyHuman Whole Embryo Uni-ZAP
Stage 7 XR

Human, subtractedWeek Old Emb o H0150Human E idid E idid mis Testis Uni-ZAP
mus XR

HO15IEarl Sta a HumanHuman Fetal Liver Uni-ZAP
Liver Liver XR

H0152Early Stage Human Fetal Liver Uni-ZAP
Human Liver, Liver XR

fract(II) HO155Human Thymus, Human ThymusThymus pBluescript subtracted Tumor H0156Human Adrenal Human AdrenalAdrenal diseaseUni-ZAP
Gland XR

Tumor Gland Tumor Gland H0161Activated T-Cells,Activated Blood Cell Uni-ZAP
24 hrs., T-Cells Line XR

1i ation 2 H0163Human S novium Human S noviumS novium Uni-ZAP
XR

H0164Human Trachea Human TracheaTrachea diseaseUni-ZAP
Tumor XR

Tumor H0165Human Prostate Human ProstateProstate diseaseUni-ZAP
Cancer, XR

Stage B2 Cancer, stage H0166Human Prostate Human ProstateProstate diseaseUni-ZAP
Cancer, XR

Sta a B2 fractionCancer, sta a B2 H0169Human Prostate Human ProstateProstate diseaseUni-ZAP
Cancer, XR

Sta a C fractionCancer, sta a C

H017012 Week Old Twelve Week Embryo Uni-ZAP
Early Stage Old XR

Human Earl Sta a Human H017112 Week Old Twelve Week Embryo Uni-ZAP
Early Stage Old XR
.

Human, II Early Stage Human H0173Human Cardiomyopathy,Human Heart diseaseUni-ZAP
XR

RNA remake Cardiom o ath H0178Human Fetal Human Fetal Brain Uni-ZAP
Brain Brain XR

H0179Human Neutro Human NeutroBlood Cell Uni-ZAP
hil hil Line XR

H0181Human Primary Human PrimaryBreast diseaseUni-ZAP
Breast XR

Cancer Breast Cancer H0187Restin T-Cell T-Cells Blood Cell Lambda Line ZAP II

H0188Human Normal Human NormalBreast Uni-ZAP
Breast XR

Breast H0194Human Cerebellum,Human CerebellumBrain pBluescript subtracted H0196Human Cardiomyopathy,Human Heart Uni-ZAP
XR

subtracted Cardiom o ath H0197Human Fetal Human Fetal Liver Uni-ZAP
Liver, Liver XR

subtracted H0198Human Fetal Human Fetal Liver Uni-ZAP
Liver, Liver XR

subtracted, os. clon H0199Human Fetal Human Fetal Liver Uni-ZAP
Liver, Liver XR

subtracted, neg clone H0200Human Greater Human Greaterperitoneum Uni-ZAP
Omentum, XR

fract II remake,Omentum H0204Human Colon Human Colon Colon pBluescript Cancer, subtracted Cancer H0207LNCAP, differentialLNCAP Cell Prostate Cell pBluescript Line Line ex ression H0208Early Stage Human Fetal Lung pBluescript Human Lung, Lung subtracted H0212Human Prostate,Human ProstateProstate pBluescript subtracted H0213Human Pituitary,Human Pituitary- Uni-ZAP
XR

subtracted H0214Ra'i cells, C clohexamideBlood Cell Bluescri c clohexamide Line t treated, subtractedTreated Cem, Jurkat, Raji, and Su t H0216Supt cells, CyclohexamideBlood Cell pBluescript cyclohexamide Line treated, subtractedTreated Cem, Jurkat, Ra'i, and Su t H0217Supt cells, CyclohexamideBlood Cell pBluescript cyclohexamide Line treated, differentiallyTreated Cem, Jurkat, ex ressed Ra'i, and Su t H0225Activated T-Cells,Activated Blood Cell Uni-ZAP
l2hrs, T-Cells Line XR

differentiall ex ressed H0228C7MCF7 cell C7MCF7 Cell Breast Cell Uni-ZAP
line, Line, Line XR

estro en treatedestro en treated H0230Human Cardiomyopathy,Human Heart diseaseUni-ZAP
XR

diff ex Cardiom o ath H0231Human Colon, Human Colon Bluescri subtraction t H0235Human colon Human Colon Liver pBluescript cancer, metaticized Cancer, metasticized to liver, subtraction to liver H0239Human Kidney Human KidneyKidney diseaseUni-ZAP
Tumor XR

Tumor H0242Human Fetal . Human FetalHeart pBluescript Heart, Heart Differential (Fetal-S ecific) H0244Human 8 Week Human 8 WeekEmbryo Uni-ZAP
Whole Old XR

Emb o, subtractedEmb o H0246Human Fetal Human Fetal Liver Uni-ZAP
Liver- Liver XR

Enzyme subtraction H0247Human Membrane Human MembraneBlood Cell Uni-ZAP
Bound Line XR

Polysomes- EnzymeBound Polysomes Subtraction H0249HE7, subtractedHuman Whole Embryo Uni-ZAP
by 7 XR

hybridization Week Old with E7 Embryo cDNA

H0250Human ActivatedHuman Monocytes Uni-ZAP
XR

Monocytes H0251Human ChondrosarcomaHuman Cartilage diseaseUni-ZAP
XR

Chondrosarcoma H0252Human OsteosarcomaHuman Bone diseaseUni-ZAP
XR

Osteosarcoma H0253Human adult Human Adult Testis Uni-ZAP
testis, large Testis XR

inserts H0254Breast Lymph Breast LymphLymph Uni-ZAP
node cDNA Node Node XR

library H0255breast lymph Breast LymphLymph Lambda node CDNA Node Node ZAP II

Libra H0261H. cerebellum, Human CerebellumBrain ' Uni-ZAP
Enzyme XR

subtracted H0263human colon Human Colon Colon diseaseLambda cancer ZAP II

Cancer H0264human tonsils Human TonsilTonsil Uni-ZAP
XR

H0265Activated T-CellT-Cells Blood Cell Uni-ZAP
Line XR

( l2hs)/Thiouridine IabelledEco H0266Human MicrovascularHMEC Vein Cell Lambda Line ZAP II

Endothelial Cells, Tract.
A

H0267Human MicrovascularHMEC Vein Cell Lambda Line ZAP II

Endothelial Cells, fract.
B

H0268Human UmbilicalHUVE Cells UmbilicalCell Lambda Vein Line ZAP II

Endothelial vein Cells, fract.
A

H0270HPAS (human Human PancreasPancreas Uni-ZAP
pancreas, XR

subtracted) H0271Human Neutrophil,Human NeutrophilBlood Cell Uni-ZAP
- Line XR

Activated Activated H0272HUMAN TONSILS, Human TonsilTonsil Uni-ZAP
XR

H0282HBGB"s differentialHuman PrimaryBreast Uni-ZAP
XR

consolidation Breast Cancer H0286Human OB MG63 Human Bone Cell Uni-ZAP
treated Line XR

(10 nM E2) fractionOsteoblastoma I

MG63 cell line H0288Human OB HOS Human Bone Cell Uni-ZAP
control Line XR

fraction I Osteoblastoma HOS

cell line H0290Human OB HOS Human Bone Cell Uni-ZAP
treated Line XR

( 1 nM E2) fractionOsteoblastoma I HOS

cell line H0292Human OB HOS Human Bone Cell Uni-ZAP
treated Line XR

( 10 nM E2) Osteoblastoma fraction I HOS

cell line H0294Amniotic Cells Amniotic Placenta Cell Uni-ZAP
- TNF Cells - Line XR

induced TNF induced H0295Amniotic Cells Amniotic Placenta Cell Uni-ZAP
- Primary Cells - Line XR

Culture Prima Culture H0298HCBB"s differentialCAMAlEe CellBreast Cell Uni-ZAP
Line XR

consolidation Line H0305CD34 positive CD34 PositiveCord Blood ZAP Express cells (Cord Cells Blood) H0306CD34 depleted CD34 DepletedCord Blood ZAP Express Buffy Coat (Cord Blood) Buffy Coat (Cord Blood) H0309Human Chronic Synovium, Synovium diseaseUni-ZAP
Synovitis Chronic XR

Synovitis/

Osteoarthritis H0316HUMAN STOMACH Human StomachStomach Uni-ZAP
XR

H0318HUMAN B CELL Human B CellLymph diseaseUni-ZAP
Node XR

LYMPHOMA Lymphoma H0320Human frontal Human FrontalBrain Uni-ZAP
cortex XR

Cortex H0321HUMAN SCHWANOMASchwanoma Nerve diseaseUni-ZAP
XR

H0327human corpus Human CorpusBrain Uni-ZAP
colosum XR

Callosum H0328human ovarian Ovarian CancerOv diseaseUni-ZAP
cancer XR

H0329DermatofibrosarcomaDermatofibrosarcomSkin diseaseUni-ZAP
XR

Protuberance a Protuberans H0331Hepatocellular HepatocellularLiver diseaseLambda Tumor ZAP IT

Tumor H0333HemangiopericytomaHemangiopericytomBlood diseaseLambda ZAP
vessel II

a H0334Kidney cancer Kidney CancerKidne diseaseUni-ZAP
XR

H0340Corpus CallosumCorpus Collosum- Uni-ZAP
XR

H0341Bone Marrow Bone Marrow Bone MarrowCell Uni-ZAP
Cell Line Cell Line XR

(RS4;11) Line RS4;11 H0343stomach cancer Stomach Cancer diseaseUni-ZAP
(human) - XR

5383A (human) H0346Brain-medulloblastomaBrain Brain diseaseUni-ZAP
XR

(Medulloblastoma)-H0349human adult Human Adult Liver pCMV Sport liver cDNA Liver 1 libr H0350Human Fetal Human Fetal Liver Uni-ZAP
Liver, mixed Liver, XR

& 14 week mixed 10&14 Week H0351Glioblastoma GlioblastomaBrain diseaseUni-ZAP
XR

H0352wilm"s tumor Wilm"s Tumor diseaseUni-ZAP
XR

H0354Human Leukoc Human LeukocBlood Cell CMVS ort tes tes Line 1 H0355Human Liver Human Liver, pCMVSport normal Adult H0356Human Kidne Human Kidne Kidne CMVS ort H0357H. Normalized Human Fetal Liver Uni-ZAP
Fetal Liver XR

Liver, II

H0361Human rejected Human Rejected diseasepBluescript kidney Kidne H0365Osteoclastoma-normalizedHuman diseaseUni-ZAP
XR

B Osteoclastoma H0369H. Atrophic Atrophic Uni-ZAP
Endometrium XR

Endometrium and myometrium H0370H. Lymph node Lymph node diseaseUni-ZAP
breast with XR

Cancer Met. Breast Cancer H0373Human Heart Human Adult Heart CMVS ort Heart 1 H0375Human Lun Human Lun CMVS ort H0379Human Ton ue, Human Ton S ortl frac 1 ue H0380Human Ton ue, Human Ton S ortl frac 2 ue H0383Human Prostate Human Prostate Uni-ZAP
BPH, re- XR

excision BPH

H0392H. Menin ima, Human Menin brain 5 ortl Ml ima H0393Fetal Liver, Human Fetal Liver Bluescri subtraction Liver t II

H0396Ll Cell line Redd-Sternber ZAP Ex ress cell H0399Human Kidney Human Kidney Lambda ZAP
Cortex, re- II

rescue Cortex H0400Human Striatum Human Brain,Brain Lambda ZAP
II

De ression, Striatum re-rescue De ression H0402CD34 depleted CD34 DepletedCord Blood ZAP Express Buffy Coat (Cord Blood), Buffy Coat re-excision (Cord Blood) H0405Human Pituitary,Human Pituitary pBluescript subtracted VI

H0408Human kidney , Human Kidney pBluescript Cortex, subtracted Cortex H0409H. Striatum Human Brain,Brain pBluescript Depression, subtracted Striatum De ression H0411H Female Bladder,Human FemaleBladder pSportl Adult Adult Bladder H0412Human umbilicalHUVE Cells UmbilicalCell pSportl vein - Line endothelial vein cells, IL-4 induced H0413Human UmbilicalHUVE Cells UmbilicalCell pSportl Vein Line Endothelial vein Cells, uninduced H0415H. Ovarian Tumor,Ovarian Tumor,Ovary diseasepCMVSport II, 2.0 H0416Human Neutrophils,Human NeutrophilBlood Cell pBluescript - Line Activated, re-excisionActivated H0419Bone Cancer, Bone Cancer Uni-ZAP
re-excision XR

H0421Human Bone Marrow,Bone Marrow pBluescript re-excision H0422T-Cell PHA 16 T-Cells Blood Cell S ortl hrs Line H0423T-Cell PHA 24 T-Cells Blood Cell S ortl hrs Line H0424Human Pituit Human Pituita Bluescri , subt IX t H0427Human Adipose Human Adipose, pSportl left hiplipoma H0428Human Ovary Human Ovary Ovary pSportl Tumor H0431H. Kidney Medulla,Kidney medullaKidney pBluescript re-excision H0433Human UmbilicalHUVE Cells UmbilicalCell pBluescript Vein Line Endothelial vein cells, frac B, re-excision H0434Human Brain, Human Brain, pBluescript striatum, re-excision Striatum H0435Ovarian Tumor Ovarian Tumor,Ovary pCMVSport 10-3-95 2.0 H0436Restin T-Cell T-Cells Blood Cell S ortl Libr ,II Line H0437H Umbilical HUVE Cells UmbilicalCell Lambda Vein Line ZAP II

Endothelial vein Cells, frac A, re-excision H0438H. Whole Brain Human Whole ZAP Express #2, re- Brain excision #2 H0441H. Kidney Cortex,Kidney cortexKidney pBluescript subtracted H0444Spleen metasticSpleen, MetasticSpleen diseasepSportl melanoma malignant melanoma H0445Spleen, ChronicHuman Spleen,Spleen diseasepSportl CLL

lymphocytic leukemia H0455H. Striatum Human Brain,Brain pBluescript Depression, subt Striatum De ression H0457Human Eosino Human Eosino S ortl hils hils H0459CD34+cells, CD34 positive pCMVSport II, cells 2.0 H0478Salivary Gland,Human SalivarySalivary pSportl Lib 2 Gland land H0483Breast Cancer Breast Cancer pSportl cell line, Cell MDA 36 line, MDA

H0484Breast Cancer Breast Cancer pSportl Cell line, Cell angiogenic line, Angiogenic, H0485Hodgkin"s LymphomaHodgkin"s diseasepCMV Sport I 2.0 L m homaI

H0486Hodgkin"s LymphomaHodgkin"s diseasepCMVSport II 2.0 Lym homa II

H0487Human Tonsils, Human Tonsils CMVS ort lib I 2.0 H0488Human Tonsils, Human Tonsils CMV S ort Lib 2 2.0 H0489Crohn"s DiseaseIleum Intestine diseaseS ortl H0492HL-60, RA 4h, HL-60 Cells,Blood Cell Uni-ZAP
Subtracted RA Line XR

stimulated for 4H

H0494Keratinoc to Keratinoc CMV S ort to 2.0 H0497HEL cetl line HEL cell HEL pSportl Iine 92.1.7 H0506Ulcerative ColitisColon Colon S ortl H0509Liver, HepatomaHuman Liver,Liver diseasepCMVSport 3.0 He atoma, anent 8 H05I0Human Liver, Human Liver,Liver pCMVSport normal 3.0 normal, Patient # 8 H0518pBMC stimulatedpBMC stimulated pCMVSport w/ poly 3.0 I/C with oly I/C

H0519NTERA2, controlNTERA2, pCMV Sport 3.0 Teratocarcinoma cell line H0520NTERA2 + retinoicN'TERA2, pSportl acid, 14 days Teratocarcinoma cell line H0521Primary DendriticPrimary Dendritic pCMVSport Cells, 3.0 lib 1 cells H0522Primary DendriticPrimary Dendritic pCMVSport 3.0 cells,frac 2 cells H0525PCR, pBMC I/C pBMC stimulated PCRII
treated with oly I/C

H0527Human Liver, Human Liver,Liver pSportl normal,CapFinderO~~normal, Patient # 8 H0529Myoloid ProgenitorTF-1 CeII pCMVSport Cell Line; 3.0 Line Myoloid progenitor cell line H0530Human Dermal Human Dermal pSportl Endothelial Endothelial Cells;

Cells,untreateduntreated H0538Merkel Cells Merkel cellsL m h S ortl node H0539Pancreas Islet Pancreas Pancreas diseasepSportl Cell Tumor Islet Cell Tumour H0542T CeII hel er HeI er T CMV S ort I cell 3.0 H0543T cell hel er Hel er T CMV S ort II cell 3.0 H0544Human endometrialHuman endometrial pCMVSport 3.0 stromal cells stromal cells H0545Human endometrialHuman endometrial pCMVSport 3.0 stromal cells-treatedstromal cells-treated with ro esterone with ro a H0546Human endometrialHuman endometrial pCMVSport 3.0 stromal cells-treatedstromal cells-treated with estradiol with estra H0547NTERA2 teratocarcinomaNTERA2, pSportl cell line+retinoicTeratocarcinoma acid (14 days) cell line H0549H. Epididiymus,Human Uni-ZAP
caput & XR

corpus Epididiymus, caput and co us H0550H. Epididiymus,Human Uni-ZAP
cauda XR

E ididi mus, cauda H0551Human Thymus Human Thymus pCMVSport Stromal 3.0 Cells Stromal Cells H0553Human Placenta Human Placenta CMV S ort 3.0 H0555Rejected Kidney,Human RejectedKidney diseasepCMVSport lib 4 3.0 Kidney H0556Activated T- T-Cells Blood Cell Uni-ZAP
Line XR

cell( 12h)/Thiouridine-re-excision H0559HL-60, PMA 4H, HL-60 Cells,Blood Cell Uni-ZAP
re- PMA Line XR

excision stimulated H0560KMH2 KMH2 CMV S ort 3.0 H0561L428 L428 CMVS ort 3.0 H0562Human Fetal Human Fetal pCMVSport Brain, Brain 2.0 normalized c5-11-26 H0563Human Fetal Human Fetal pCMVSport Brain, Brain 2.0 normalized 50021F

H0570Human Fetal Human Fetal pCMVSport Brain, Brain 2.0 normalized C500H

H0572Human Fetal Human Fetal pCMVSport Brain, Brain 2.0 normalized AC5002 H0574Hepatocellular HepatocellularLiver diseaseLambda Tumor; re- ZAP II

excision Tumor H0575Human Adult Human Adult Lung Uni-ZAP
XR' Pulmonar ;re-excisionPulmona H0576Resting T-Cell;T-Cells Blood Cell Lambda re- Line ZAP II

excision H0579Pericardium Pericardium Heart S ortl H0580Dendritic cells,Pooled dendritic pCMVSport pooled 3.0 cells H0581Human Bone Marrow,Human Bone Bone Marrow pCMVSport 3.0 treated Marrow H0583B Cell I m homaB Cell Lym B Cell diseaseCMVS ort homa 3.0 H0584Activated T-cells,Activated Blood Cell Uni-ZAP
24 T-Cells Line XR

hrs,re-excision H0585Activated T-Cells,l2Activated Blood Cell Uni-ZAP
T-Cells Line XR

hrs,re-excision H0586Healing groin healing groingroin diseasepCMVSport wound, 6.5 3.0 hours post incisionwound, 6.5 hours ost incision - 2l H0587Healing groin Groin-2/19/97groin diseasepCMVSport wound; 7.5 3.0 hours ost incision H0589CD34 positive CD34 PositiveCord Blood ZAP Express cells (cord Cells blood),re-ex H0590Human adult Human Adult Small Uni-ZAP
small Small Int. XR

intestine,re-excisionIntestine H0591Human T-cell T-Cell LymphomaT-Cell diseaseUni-ZAP
XR

lym homa;re-excision H0592Healing groin HGS wound diseasepCMV Sport wound - healing 3.0 zero hr post-incisionproject;
abdomen (control) H0593Olfactory Olfactory pCMVSport epithelium 3.0 epithelium;nasalcavityfrom roof of left nasal cacit H0594Human Lung Cancer;re-Human Lung Lung diseaseLambda Cancer ZAP II

excision H0595Stomach cancer Stomach Cancer- diseaseUni-ZAP
XR

(human);re-excision5383A (human) H0596Human Colon Human Colon Colon Lambda Cancer;re- ZAP II

excision Cancer H0597Human Colon; Human Colon Lambda re-excision ZAP II

H0598Human Stomach;re-Human StomachStomach Uni-ZAP
XR

excision H0599Human Adult Human Adult Heart Uni-ZAP
Heart;re- Heart XR

excision H0600Healing AbdomenAbdomen diseasepCMVSport 3.0 wound;70&90 min post incision H0606Human Primary Human PrimaryBreast diseaseUni-ZAP
Breast XR

Cancer;re-excisionBreast Cancer H0608H. Leukoc tes, H.Leukoc CMVS ort control tes 1 H0613H.Leukocytes, H.Leukocytes pCMVSport normalized 1 cot 5B

H0614H. Leukocytes, H.Leukocytes pCMVSport normalized cot H0615Human Ovarian Ovarian CancerOvary diseaseUni-ZAP
Cancer XR

Reexcision H0616Human Testes, Human TestesTestis Uni-ZAP
Reexcision XR

H0617Human Primary Human PrimaryBreast diseaseUni-ZAP
Breast XR

Cancer ReexcisionBreast Cancer H0618Human Adult Human Adult Testis Uni-ZAP
Testes, Testis XR

Lar a Inserts, Reexcision H0619Fetal Heart Human Fetal Heart Uni-ZAP
Heart XR

H0620Human Fetal Human Fetal Kidney Uni-ZAP
Kidney; Kidney XR

Reexcision H0622Human Pancreas Human PancreasPancreas diseaseUni-ZAP
Tumor; XR

Reexcision - Tumor H0623Human UmbilicalHuman UmbilicalUmbilical Uni-ZAP
Vein; XR

Reexcision Vein Endothelialvein Cells H062412 Week Early Twelve Week Embryo Uni-ZAP
Stage Old XR

Human II; ReexcisionEarl Sta a Human H0625Ku 812F Baso Ku 812F Baso S ortl hils Line hils H0626Saos2 Cells; Saos2 Cell pSportl Untreated Line;

Untreated H0627Saos2 Cells; Saos2 Cell pSportl Vitamin D3 Line;

Treated Vitamin D3 Treated H0628Human Pre-DifferentiatedHuman Pre- Uni-ZAP
XR

Adipocytes Differentiated Adi oc tes H0631Saos2, DexamethosomeSaos2 Cell pSportl Line;

Treated Dexamethosome Treated H0632Hepatocellular HepatocellularLiver Lambda Tumor;re- ZAP II

excision Tumor H0633Lung Carcinoma TNFalpha diseasepSportl A549 activated TNFalpha activatedA549--Lung Carcinoma H0634Human Testes Human TestesTestis diseaseUni-ZAP
Tumor, re- XR

excision Tumor H0635Human ActivatedActivated Blood Cell Uni-ZAP
T-Cells, T-Cells Line XR

re-excision H0637Dendritic CellsDentritic , pSportl From cells from CD34 Cells CD34 cells H0638CD40 activated CD40 activated pSportl monocyte dendridic cellsmonocyte dendridic cells H0641LPS activated LPS activated pSportl derived dendritic cellsmonocyte derived dendritic cells H0642Hep G2 Cells, Hep G2 Cells Other lambda Libra H0643He G2 Cells, He GZ Cells Other PCR libr H0644-Human Placenta Human PlacentaPlacenta Uni-ZAP
(re- XR

excision) H0645Fetal Heart, Human Fetal Heart Uni-ZAP
re-excision Heart XR

H0646Lung, Cancer Metastatic pSportl (4005313 A3): Invasive squamous Poorly cell lung Differentiated carcinoma, Lung poorly di Adenocarcinoma, H0647Lung, Cancer Invasive diseasepSportl (4005163 poorly B7): Invasive, differentiated Poorly Diff. lung Adenocarcinoma,adenocarcinoma Metastatic H0648Ovary, Cancer: Papillary diseasepSportl (4004562 Cstic B6) Papillary neoplasm Serous of low Cystic Neoplasm,malignant Low potentia Mali Qnant Pot H0649Lung, Normal: Normal Lung pSportl (4005313 Bl) H0650B-Cells B-Cells CMVS ort 3.0 H0651Ovary, Normal: Normal Ovary pSportl (9805C040R) H0652Lung, Normal: Normal Lung pSportl (4005313 B1) H0653Stromal Cells Stromal Cells pSportl H0654Lung, Cancer: Metastatic Other (4005313 A3) Invasive Squamous Poorly- cell lung differentiated Carcinoma Metastatic poorly lun adenoc dif H0656B-cells (unstimulated)B-cells pSportl (unstimulated) H0657B-cells (stimulated)B-cells (stimulated) S ortl H0658Ovary, Cancer 9809C332- Ovary diseasepSportl Poorly &

(9809C332): differentiateFallopian Poorly differentiated Tubes adenocarcinoma H0659Ovary, Cancer Grade II Ovary diseasepSportl Papillary (15395A1F): Carcinoma, Grade II Ovary Pa illa Carcinoma H0660Ovary, Cancer: Poorly differentiated diseasepSportl (15799A1F) Poorlycarcinoma, ovary differentiated carcinoma H0661Breast, Cancer:Breast cancer diseasep5portl (4004943 A5) H0662Breast, Normal:Normal Breast-Breast pSportl (400552282) #4005522(B2) H0663Breast, Cancer:Breast CancerBreast diseasepSportl (4005522 -A2) #4005522(A2) H0664Breast, Cancer:Breast CancerBreast diseasep5portl (9806C012R) H0665Stromal cells Stromal cells S ortl 3.88 3.88 H0666Ovary, Cancer: Ovarian Cancer, diseasepSportl (4004332 A2) Sample #4004332A2 H0667Stromal cells(HBM3.18)Stromal cell(HBM pSportl 3.18) H0668stromal cell stromal cell pSportl clone 2.5 clone 2.5 H0669Breast, Cancer:Breast CancerBreast pSportl (4005385 A2) (4005385A2) H0670Ovary, Cancer(4004650Ovarian Cancer- pSportl A3): Well-Differentiated4004650A3 Micropapillary Serous Carcinoma H0671Breast, Cancer:Breast Cancer- pSportl (9802C020E) Sample #

H0672Ovary, Cancer: Ovarian Ovary pSportl (4004576 A8) Cancer(4004576A8) H0673Human Prostate Human ProstateProstate Uni-ZAP
Cancer, XR

Sta a B2; re-excisionCancer, sta a B2 H0674Human Prostate Human ProstateProstate Uni-ZAP
Cancer, XR

Sta a C; re-excissionCancer, sta a C

H0675Colon, Cancer: Colon Cancer pCMVSport 3.0 (9808C064R) 9808C064R

H0676Colon, Cancer: Colon Cancer pCMVSport 3.0 (9808C064R)-total9808C064R
RNA

H0677TNFR de enerateB-Cells PCRII
oli o H0682Serous Papillaryserous papillary pCMVSport 3.0 Adenocarcinoma adenocarcinoma (9606G304SPA3B) H0683 Ovarian Serous Serous papillary pCMVSport Papillary 3.0 Adenocarcinoma adenocarcinoma, sta a 3C
(9804601 H0684 Serous PapillaryOvarian Cancer-Ovaries pCMVSport 3.0 Adenocarcinoma 98106606 H0685 Adenocarcinoma Adenocarcinoma pCMVSport of of 3.0 Ovary, Human Ovary, Human Cell Line, Cell # OVCAR-3 Line, # OVCAR-H0686 Adenocarcinoma Adenocarcinoma pCMVSport of of 3.0 Ovary, Human Ovary, Human Cell Line Cell Line, # SW-626 H0687 Human normal Human normalOvary pCMVSport 3.0 ova (#96106215)ov (#96106215) H0688 Human Ovarian Human Ovarian pCMVSport 3.0 Cancer(#98076017)cancer(#98076017), mRNA from Maura Ru .

H0689 Ovarian Cancer Ovarian Cancer, pCMVSport 3.0 #98066019 H0690 Ovarian Cancer,Ovarian Cancer, pCMVSport # 3.0 97026001 #97026001 H0691 Normal Ovary, normal ovary, pCMVSport 3.0 #97106208 #97106208 H0693 Normal ProstateNormal Prostate pCMVSport 3.0 #ODQ3958EN Tissue #

H0694 Prostate gland Prostate prostate pCMVSport gland, 3.0 adenocarcinoma adenocarcinoma,gland modldiff, leason H0695 mononucleocytesmononucleocytes pCMVSport from 3.0 patient from patient at Shad Grove Hos it N0006 Human Fetal Human Fetal Brain Brain S0001 Brain frontal Brain frontalBrain Lambda cortex cortex ZAP II

S0002 Monoc to activatedMonoc te-activatedblood Cell Uni-ZAP
Line XR

S0003 Human OsteoclastomaOsteoclastomabone diseaseUni-ZAP
XR

50004 Prostate Prostate Prostate Lambda BPH ZAP II

50007 Early Sta a Human Fetal Uni-ZAP
Human Brain Brain XR

S0010 Human Am dala Am dala Uni-ZAP
XR

S0011 STROMAL - Osteoclastomabone diseaseUni-ZAP
XR

OSTEOCLASTOMA

50015 Kidne medulla Kidne medullaKidne Uni-ZAP
XR

S0016 Kidne P ramids Kidne ramidsKidne Uni-ZAP
XR

S0021 Whole brain Whole brain Brain ZAP Ex ress 50026 Stromal cell stromal cellBone marrowCell Uni-ZAP
TF274 Line XR

50027 Smooth muscle, Smooth musclePulmanaryCell Uni-ZAP
serum Line XR

treated artery 50028 Smooth muscle,controlSmooth musclePulmanaryCell Uni-ZAP
Line XR

arter 50031 S final cord S final cords final Uni-ZAP
cord XR

50032 Smooth muscle-ILbSmooth musclePulmanaryCell Uni-ZAP
Line XR

induced arter 50035Brain medulla Brain medullaBrain Uni-ZAP
oblongata XR

oblon ata S0036Human SubstantiaHuman Substantia Uni-ZAP
Nigra XR

Nigra S0037Smooth muscle, Smooth musclePulmanaryCell Uni-ZAP
ILlb Line XR

induced ~ artery S0038Human Whole Human Whole ZAP Express Brain #2 - Brain Oli o dT > l.SKb#2 S0040Adipocytes Human Adipocytes Uni-ZAP
XR

from Osteoclastoma S0042Testes Human Testes ZAP Ex ress S0044Prostate BPH rostate BPH Prostate diseaseUni-ZAP
XR

S0045Endothelial Endothelial endothelialCell Uni-ZAP
cells-control cell Line XR

cell-lun S0046Endothelial-inducedEndothelial endothelialCell Uni-ZAP
cell Line XR

cell-lun S0048Human Hypothalamus,Human diseaseUni-ZAP
XR

Alzheimer"s Hypothalamus, Alzheimer"s 50049Human Brain, Human Brain, Uni-ZAP
Striatum XR

Striatum S0050Human Frontal Human Frontal diseaseUni-ZAP
Cortex, XR

Schizophrenia Cortex, Schizo hrenia S0051Human Human diseaseUni-ZAP
XR

Hypothalmus,SchizophrenHypothalamus, is Schizo hrenia 50052neutro hill human neutroblood Cell Uni-ZAP
control hils Line XR

S0053Neutrophils human neutrophilblood Cell Uni-ZAP
IL-1 and LPS Line XR

induced induced SO110Brain Amygdala Brain diseaseUni-ZAP
XR

De ression S0114Aner is T-cell Aner is T-cell Cell Uni-ZAP
Line XR

S0116Bone marrow Bone marrow Bone marrow Uni-ZAP
XR

SOI26Osteoblasts Osteoblasts Knee Cell Uni-ZAP
Line XR

50132Epithelial-TNFaAirway Epithelial Uni-ZAP
and INF XR

induced 50134A o totic T-cella o totic Cell Uni-ZAP
cells Line XR

SOI40eosino hil-IL5 eosino hil lun Cell Uni-ZAP
induced Line XR

S0142Macrophage-oxLDLmacrophage- blood Cell Uni-ZAP
Line XR

oxidized LDL

treated S0144Macrophage (GM-CSFMacrophage Uni-ZAP
(GM- XR

treated) CSF treated) S0146rostate-edited rostate BPH Prostate Uni-ZAP
XR

50148Normal ProstateProstate rostate Uni-ZAP
~ XR

S0150LNCAP rostate LNCAP Cell Prostate Cell Uni-ZAP
cell line Line Line XR

S0152PC3 Prostate PC3 prostate Uni-ZAP
cell line cell XR

line 50176Prostate, normal,Prostate prostate Uni-ZAP
XR

subtraction I

50182Human B Cell Human B- Uni-ZAP
8866 Cell 8866 XR

50188Prostate,BPH, Human Prostate diseasepSportl Lib 2 BPH

50192Synovial FibroblastsSynovial pSportl Fibroblasts (control) 50194Synovial by S novial 5 ortl oxia Fibroblasts S0196Synovial IL-1/TNFSynovial pSportl Fibroblasts stimulated 50206Smooth Muscle- Smooth musclePulmanaryCell pBluescript HASTE Line normalized arter 50210Messan ial cell,Messan ial S ortl frac 2 cell 50212Bone Marrow Bone Marrow pSportl Stromal Cell, untreatedStromal Cell,untreated 50214Human Osteoclastoma,Osteoclastomabone diseaseUni-ZAP
re- XR

excision 50216Neutrophils human neutrophilblood Cell Uni-ZAP
IL-1 and LPS Line XR

induced induced S0218Apoptotic T-cell,apoptotic Cell Uni-ZAP
re- cells Line XR

excision S0222H. Frontal H. Brain, Brain diseaseUni-ZAP
Frontal XR

cortex,epileptic;re-Cortex, Epileptic excision S0242Synovial FibroblastsSynovial pSportl Fibroblasts (Ill/TNF), subt 50250Human OsteoblastsHuman OsteoblastsFemur diseaseCMVS ort II 2.0 50260S final Cord, S final cords final Uni-ZAP
re-excision cord XR

S0276SynoviaI hypoxia-RSFSynovial Synovial pSportl fobroblasts subtracted (rheumatoid)tissue S0278H Macrophage Macrophage Uni-ZAP
(GM-CSF (GM- XR

treated), re-excisionCSF treated) S0280Human Adipose Human Adipose Uni-ZAP
Tissue, XR

re-excision Tissue S0282Brain Frontal Brain frontalBrain Lambda Cortex, re- cortex ZAP II

excision S0294Larynx tumor Larynx tumorLarynx,vocal diseasepSportl cord S0298Bone marrow Bone marrow Bone marrow pSportl stroma,treated stroma,treatedSB

S0300Frontal lobe,dementia;re-Frontal LobeBrain Uni-ZAP,XR
.

excision dementia/Alzheimer' 's S0306Larynx normal Larynx normal pSportl #10 261-S0310Normal trachea Normal trachea S ortl S0312Human Human diseasep5portl osteoarthritic;fractionosteoarthritic II

cartila a S0314Human r Human diseasepSportl osteoarthritis;fractionosteoarthritic I

cartilage S0316Human Normal Human Normal pSportl Cartila e,FractionCartila a I

S0324Human Brain Brain Cerebellum S ortl S0328Palate carcinomaPalate carcinomaUvula diseaseS ortl S0330Palate normal Palate normalUvula S ortl S0332Pharynx carcinomaPhar nx carcinomaH o h S ortl nx S0340Human OsteoarthriticHuman diseasepSportl Cartilage Fractionosteoarthritic IV cartila a S0342Adipocytes;re-excisionHuman Adipocytes Uni-ZAP
from Osteoclastoma XR

50344Macrophage-oxLDL;macrophage- blood Cell Uni-ZAP
re- oxidized Line XR
excision LDL
treated S0346Human Amygdala;re-Amygdala Uni-ZAP
excision XR

50348Cheek CarcinomaCheek Carcinoma diseasepSportl 50352La nx CarcinomaLar nx carcinoma diseaseS ortl S0354Colon Normal Colon NormalColon S ortl II

S0356Colon CarcinomaColon CarcinomaColon disease5 ortl S0358Colon Normal Colon NormalColon S ortl III

S0360Colon Tumor Colon Tumot Colon diseaseS ortl II

S0362Human GastrocnemiusGastrocnemius pSportl muscle S0364Human Quadrice Quadrice S ortl s s muscle S0366Human Soleus Soleus Muscle S ortl S0370Larynx carcinomaL nx carcinoma diseaseS ortl II

S0372La nx carcinomaLar nx carcinoma diseaseS ortl III

50374Normal colon Normal colon S ortl 50376Colon Tumor Colon Tumor diseaseS ortl 50378Pancreas normalPancreas pSportl PCA4 Normal No PCA4 No 50380Pancreas Tumor Pancreas diseasepSportl PCA4 Tu Tumor PCA4 Tu 50384Ton ue carcinomaTon ue carcinoma diseaseS ortl S0386Human Whole Whole brain Brain ZAP Express Brain, re-excision 50388Human Human diseaseUni-ZAP
Hypothalamus,schizophreHypothalamus, XR
nia, re-excisionSchizo hrenia S0390Smooth muscle, Smooth musclePulmanaryCell Uni-ZAP
control; artery Line XR
re-excision S0398Testis; normal Testis; normal S ortl S0400Brain; normal Brain; normal S ortl 50404Rectum normal Rectum, normal S ortl 50406Rectum tumour Rectum tumour S ortl S0408Colon, normal Colon, normal S ortl S0410Colon, tumour Colon, tumour S ortl S0412Temporal cortex-Temporal diseaseOther Alzheizmer; cortex, subtracted alzheimer 50414Hippocampus, Hippocampus, Other Alzheimer Alzheimer Subtracted Subtracted S0418CHME Cell Line;treatedCHME Cell pCMVSport Line; 3.0 hrs treated 50420CHME Cell CHME Cell S ortl line, Line,untreated untreatetd S0422Mole Cell Line Mole Celt pCMVSport GM-CSF Line 3.0 treated ( I GM-CSF treated ng/ml) (lng/ml) S0424TF-1 Cell Line TF-1 Cell p5portl GM-C5F Line Treated GM-CSF Treated S0426Monocyte activated;Monocyte-activatedblood Cell Uni-ZAP
re- Line XR
excision S0428Neutrophils human neutrophilsblood Cell Uni-ZAP
control; re- Line XR
excision S0430Aryepiglottis Aryepiglottis pSportl Normal Normal S0432Sinus piniformisSinus piniformis pSportl Tumour Tumour S0434Stomach Normal Stomach Normal diseaseS ortl 50436Stomach Tumour Stomach Tumour diseaseS ortl S0438Liver Normal Liver Normal pSportl MetSNo MetSNo 50440Liver Tumour Liver Tumour S ortl Met 5 Tu S0442Colon Normal Colon Normal 5 ortl S0444Colon Tumor Colon Tumour diseaseS ortl S0446Ton ue Tumour Ton ue Tumour S ortl S0448Lar nx Normal L nx Normal 5 ortl S0450Lar nx Tumour L nx Tumour S ortl S0456Tongue Normal Tongue Normal p5portl 50458Thyroid Normal Thyroid normal pSportl (SDCA2 No) 50460Th roid Tumour Th roid Tumour S ortl S0468Ea.h .926 cell Ea.h .926 5 ortl line cell line 50474Human blood Platelets Blood Other platelets latelets 53010Human Blastoc Human Blastoc Other st st 53012Smooth Muscle Smooth musclePulmanaryCell pBluescript Serum arte Line Treated, Norm 53014Smooth muscle, Smooth musclePulmanaryCell pBluescript serum arter Line induced,re-exc 56014H. h othalamus,H othalamus Brain ZAP Ex frac A ress S6016H. Frontal Cortex,H. Brain, Brain diseaseUni-ZAP
E ile tic Frontal XR
Cortex, E
ile tic S6022H. Adipose TissueHuman Adipose Uni-ZAP
Tissue XR

S6024Alzheimers, Alzheimer"s/SpongyBrain diseaseUni-ZAP
spongy than a XR
chap a S6026Frontal Lobe, Frontal LobeBrain Uni-ZAP
Dementia dementialAlzheimer' XR
's S6028Human Manic Human Manic Brain diseaseUni-ZAP
Depression de ression XR
Tissue tissue T0002Activated T-cellsActivated Blood Cell pBluescript T-Cell, Line 5K-PBL fraction T0003Human Fetal Human Fetal Bluescri Lun Lun t SK-T0006Human Pineal Human Pinneal pBluescript Gland SK-Gland T0008Colorectal TumorColorectal diseaseBluescri Tumor t SK-T0010Human Infant Human Infant Other Brain Brain T0023Human PancreaticHuman Pancreatic diseasepBluescript Carcinoma Carcinoma SK-T0039HSA 172 Cells Human HSA172 pBluescript cell SK-line T0040HSC172 cells 5A172 Cells Bluescri t SK-T0041Jurkat T-cell Jurkat T-cell Bluescri G1 hare t SK-T0042Jurkat T-Cell, Jurkat T-Cell Bluescri S base Line t SK-T0048Human Aortic Human Aortic pBluescript Endothelium Endothilium SK-T0049Aorta endothelialAorta endothelial pBluescript cells + cells SK-TNF-a T0060Human White Human White Bluescri Adi ore Fat t SK-T0067Human Thyroid Human Thyroid pBluescript SK-T0068Normal Ovary, Normal Ovary, pBluescript Premeno aural Premeno aural SK-T0069Human Uterus, Human Uterus, pBluescript normal normal SK-T0071Human Bone MarrowHuman Bone pBluescript Marrow SK-T0074Human Adult Human Adult Bluescri Retina Retina tISK-T0078Human Liver, Human Liver, pBluescript normal normal Adult SK-adult T0082Human Adult Human Adult Bluescript Retina Retina SK-T0109Human (HCC) pBluescript cell line SK-liver (mouse) metastasis, remake TO110Human colon pBluescript carcinoma SK-(HCC) cell line, remake T0114Human (Caco-2) pBluescript cell line, SK-adenocarcinoma, colon, remake T0115Human Colon pBluescript Carcinoma SK-(HCC) cell line L0005Clontech human aorta oIyA+ mRNA (#6572) L0021Human adult (K.Okubo) L0040Human colon mucosa L0055Human rom elocyte L0060Human th mus NSTH II

L0065Liver He G2 cell line.

L0105Human aorta aorta polyA+
(TFu'iwara) L0142Human placenta placenta cDNA
(TFujiwara) L0146Human fovea retinal fovea cDNA

L0151Human testis testis (C. De Smet) L0157Human fetal brain brain (TFu'iwara) L0163Human heart heart cDNA

(YNakamura) L0174AP20 melanoma AP20 mRNA

melanom a L0185Human immortalized HS74 and fibroblasts its (H.L.Ozer) SV40-transform ed sublines L0351Infant brain, BA, Ml3-Bento Soares derived L0352Normalized infant BA, MI3-brain, Bento Soares derived L0356S, Human foetal Bluescript Adrenals tissue L0361Stratagene ovary ovary Bluescript SK

(#937217) L0362Stratagene ovarian Bluescript cancer SK-(#937219) L0363NCI CGAP_GC2 erm cell Bluescri tumor t SK-L0364NCI CGAP GC5 erm cell Bluescri tumor t SK-L0366Stratagene schizoschizophrenic Bluescript brain brain SK-S I 1 S-I 1 frontal lobe L0367NCI CGAP_Schl Schwannoma Bluescri tumor t SK-L0368NCI CGAP_SS1 s novial Bluescri sarcoma t SK-L0369NCI CGAP_AAl adrenal adenomaadrenal Bluescri land t 5K-L0370Johnston frontalooled frontalbrain Bluescri cortex lobe t SK-L0372NCI CGAP Col2 colon tumor colon Bluescri t SK-L0373NCI CGAP_Col tumor colon Bluescri l t SK-L0374NCI_CGAP_Co2 tumor colon Bluescri t SK-L037SNCI CGAP_Kid6 kidney tumorkidney Bluescri . t SK-L0376NCI CGAP_Larl larynx larynx Bluescript SK-L0378NCI CGAP_Lul lun tumor lun Bluescri t SK-L0381NCI_CGAP_HN4 squamous pharynx Bluescript cell SK-carcinoma L0382NCI CGAP_Pr25 a ithelium rostate Bluescri (cell line) t SK-L0383NCI CGAP_Pr24 invasive prostate Bluescript tumor (cell SK-line) L0384NCI CGAP_Pr23 rostate tumorrostate Bluescri t SK-L0386NCT_CGAP_HN3 squamous tongue Bluescript cell 5K-carcinoma from base of tongue L0387NCI_CGAP_GCBO germinal tonsil Bluescript center B- SK-cells L0388NCI_CGAP HN6 normal gingiva Bluescript (cell SK-line from immortalized kerati L0393B, Human Liver t1 l tissue L0415b4HB3MA CotB-HAP-Ft Lafmid BA

L0418b4HB3MA-CotI09+10- Lafmid BA

Bio L0435Infant brain, lafmid LLNL array BA
of Dr. M. Soares L0438normalized infanttotal brain brain lafmid brain BA
cDNA

L0439Soares infant whole Lafmid brain 1NIB brain BA

L0443b4HB3MK Lafmid BK

L0455Human retina retina eye lambda cDNA gtl0 randomly primed sublibrar L0462WATMl lambda tll L0465TESTl, Human lambda adult nm1149 Testis tissue L0468HE6W lambda za L0471Human fetal Lambda heart, ZAP
Lambda ZAP Ex Ex ress ress L0475KGl-a Lambda KG1-a Lambda Zap Zap Express cDNA Express library (Strata ene) L0480Stratagene cat#937212 Lambda (1992) ZAP, pBluescript SK(-) L0483Human pancreatic Lambda islet ZAPII

L0485STRATAGENE Humanskeletal leg muscle Lambda skeletal musclemuscle ZAPII
cDNA
Libra , cat.
#936215.

L0493NCI_CGAP_Ov26 papillary ovary pAMPl serous carcinoma L0499NCI CGAP_HSCZ stem cell bone marrow AMPl 34+!38+

L0509NCI_CGAP Lu26 invasive lung pAMPl adenocarcinoma L0513NCI_CGAP_Ov37 early stage ovary pAMPl papillary serous carcinoma L0517NCI CGAP_Prl AMP10 -L0518NCI CGAP_Pr2 AMPIO

L0519NCI CGAP Pr3 AMP10 L0520NCI CGAP_Alvl alveolar ~ pAMPlO
rhabdom osarcoma L0521NCI CGAP Ewl Ewin "s sarcoma AMP10 L0522NCI CGAP Kidl kidne AMP10 L0523NCI CGAP Li li osarcoma AMP20 L0524NCI CGAP Li1 liver AMP10 L0525NCI CGAP Li2 liver AMP10 L0526NCI_CGAP_Prl2 metastatic pAMPlO
prostate bone lesion L0527NCI_CGAP Ov2 ovar AMP10 L0528NCI CGAP Pr5 rostate AMP20 L0529NCI CGAP Pr6 rostate AMP10 L0530NCT CGAP Pr8 rostate AMP10 L0532NCI CGAP Th th roid AMP10 L0533NCI CGAP_HSC1 stem cells bone marrow AMP10 L0534Chromosome 7 brain brain pAMPlO
Fetal Brain cDNA Libr L0539Chromosome 7 placenta pAMPlO
Placental cDNA Librar L0540NCI_CGAP_PrlO invasive prostate pAMPlO
prostate tumor L0541NCI_CGAP_Pr7 low-grade prostate pAMPlO
prostatic neo lasia L0543NCI_CGAP_Pr9 normal prostaticprostate pAMPlO

a ithelial cells L0545NCI_CGAP_Pr4.1 prostatic prostate pAMPlO

intraepithelial neoplasia - high rade L0546NCI CGAP Prl8 stroma rostate AMP10 L0550NCI_CGAP_HN9 normal squamous pAMPlO

epithelium from retromolar txi one L0551NCI_CGAP_HN7 normal squamous pAMPlO

epithelium, floor of mouth L0554NCI CGAP_Li8 liver pAMPlO

L0562Chromosome 7 HeLa pAMPlO
HeLa cell cDNA Library line;

ATCC

L0564Jia bone marrowbone marrow Bluescri stroma stroma t L0565Normal Human Bone Hip pBluescript Trabecular Bone Cells L0581Strata ene liver liver Bluescri (#937224) t SK

L0583Stratagene cDNA pBluescript library Human fibroblast, SK(+) cat#937212 L0584Stratagene cDNA pBluescript library Human heart, SK(+) cat#936208 L0586HTCDLI pBluescript SK(-) L0587Stratagene colon pBluescript (#937221) L0588Stratagene endothelial pBluescript cell SK-L0589Stratagene fetal pBluescript retina SK-L0591Stratagene HeLa pBIuescript cell s3 SK-L0592Stratagene hNT pBluescript neuron SK-(#937233) L0593Stratagene pBluescript SK-neuroepithelium (#937231) L0594Stratagene pBluescript SK-neuroepithelium L0595Stratagene NT2 neuroepithelialbrain pBluescript neuronal cells SK-precursor937230 L ~ Stratagene colon pBluescript L0596colon SK-(#937204) L0598 Morton Fetal cochlea ear Bluescri Cochlea t SK-L0599 Strata ene lun lun Bluescri (#937210) t SK-L0600 Weizmann Olfactoryolfactory nose pBluescript epithelium SK-Epithelium L0601 Stratagene pancreas pancreas ~pBluescript SK-(#937208) L0602 Pancreatic Isletancreatic ancreas Bluescri islet t SK-L0603 Stratagene placenta placenta pBluescript SK-(#937225) L0604 Stratagene musclemuscle skeletal pBluescript muscle L0605 Stratagene fetalfetal spleenspleen pBluescript spleen SK-(#937205) L0606 NCI_CGAP_LymS follicular lymph pBluescript lymphoma node SK-L0608 Stratagene lunglung carcinomalung NCI-H69 pBluescript carcinoma SK-L0612 Schiller oligodendrogliomabrain pBluescript SK-oli odendro (Strata lioma ene) L0615 22 week old pBluescriptII
human fetal liver cDNA librar SK(-) L0617 Chromosome 22 pBluescriptIIKS
exon L0622 HMl pcDNAII

(Invitro en) L0623 HM3 pectoral pcDNAII
muscle (after mastectom (Invitro ) en) L0626 NCI_CGAP_GCl bulk germ pCMV-SPORT2 cell seminoma L0629 NCI_CGAP_Mel3 metastatic bowel pCMV-SPORT4 (skin melanoma rimary) to bowel L0631 NCI CGAP_Br7 breast pCMV-SPORT4 L0632 NCI CGAP_Li5 hepatic adenomaliver pCMV-SPORT4 L0634 NCI_CGAP_Ov8 serous ovary pCMV-SPORT4 adenocarcinoma L0636 NCI_CGAP_Pitl four pooled brain pCMV-SPORT6 pituitary adenomas L0637 NCI_CGAP_Brn53 three pooledbrain pCMV-SPORT6 menin iomas L0638 NCI_CGAP_Brn35 tumor, 5 brain pCMV-SPORT6 pooled (see description) L0639 NCI_CGAP_Brn52 tumor, 5 brain pCMV-SPORT6 pooled (see descri tion) L0640 NCI_CGAP_Brl8 four pooled breast pCMV-SPORT6 high-grade tumors, includin two rima L0641 NCI_CGAP_Col7 juvenile colon pCMV-SPORT6 granulosa tumor L0642 NCI_CGAP_Col8 moderately colon pCMV-SPORT6 differentiated adenocarcinoma L0643 NCI_CGAP_Col9 moderately colon pCMV-SPORT6 differentiated adenocarcinoma L0644.NCI_CGAP_Co20 moderately colon pCMV-SPORT6 differentiated adenocarcinoma L0645 NCI_CGAP_Co21 moderately colon pCMV-SPORT6 differentiated adenocarcinoma L0646 NCI_CGAP_Col4 moderately- colon pCMV-SPORT6 differentiated adenocarcinoma L0647 NCI_CGAP_Sar4 five pooled connective pCMV-SPORT6 sarcomas, tissue including m xoid 1i osarcoma L0648 NCI_CGAP_Eso2 squamous esophagus pCMV-SPORT6 cell carcinoma L0649 NCT_CGAP_GU1 2 pooled genitourinary pCMV-SPORT6 high-grade transitionaltract cell tumors L0650 ' NCI_CGAP_Kidl32 pooled kidney pCMV-SPORT6 Wilms"

tumors, one primary and one metast L0651 NCI CGAP_Kid8 renal cell ~ kidne CMV-SPORT6 tumor L0653 NCI_CGAP_Lu28 two pooled lung pCMV-SPORT6 squamous cell carcinomas L0655 NCI_CGAP_Lyml2 lymphoma, lymph pCMV-SPORT6 node follicular mixed small and lar a cell L0656 NCI_CGAP_Ov38 normal a ova CMV-SPORT6 ithelium L0657 NCI_CGAP_Ov23 tumor, 5 ovary _ pCMV-SPORT6 pooled (see descri tion) L0658 NCI_CGAP_Ov35 tumor, 5 ovary pCMV-SPORT6 pooled (see descri tion) L0659 NCI CGAP_Panl adenocarcinomaancreas CMV-SPORT6 L0661 NCI_CGAP_Me115 malignant skin pCMV-SPORT6 melanoma, metastatic to lymph node L0662 NCI_CGAP_Gas4 poorly differentiatedstomach pCMV-SPORT6 adenocarcinoma with si net r L0663 NCI_CGAP_Ut2 moderately- uterus pCMV-SPORT6 differentiated endometrial adenocarcino L0664 NCI_CGAP_Ut3 poorly-differentiateduterus pCMV-SPORT6 endometrial adenocarcinoma, L0665 NCI_CGAP_Ut4 serous papillaryuterus pCMV-SPORT6 carcinoma, high rade, 2 ooled t L0666 NCI_CGAP_Utl well-differentiateduterus pCMV-SPORT6 endometrial adenocarcinoma, L0667NCI_CGAP_CMLl myeloid cells,whole pCMV-SPORT6 18 blood pooled CML
cases, BCR/ABL rearra L0683Stanley Frontalfrontal lobebrain pCR2.1-TOPO
NS pool 2 (see descri lion) (Invitro en) L0686Stanley Frontalfrontal lobebrain pCR2.1-TOPO
SN pool 2 (see descri lion) (Invitro en) L0697Testis 1 PGEM Szf(+) L0698Testis 2 PGEM Szf(+) L0717Gessler Wilms SPORT1 tumor L0719human embryo Whole embryo pSPORTl cDNA

libr L073ISoares_pregnant uterus pT7T3-Pac uterus_ NbHPU

L0738Human colorectal T7T3D
cancer L0740Soares melanocytemelanocyte pT7T3D

2NbHM (Pharmacia) with a modified of linker L0741Soares adult brain pT7T3D
brain N2b4HB55Y (Pharmacia) with a modified of linker L0742Soares adult brain pT7T3D
brain N2b5HB55Y (Pharmacia) with a modified polylinker L0743Soares breast breast pT7T3D
2NbHBst (Pharmacia) with a modified of linker L0744Soares breast breast pT7T3D
3NbHBst (Pharmacia) with a modified of linker L07455oares retina retina eye pTTT3D
N2b4HR

(Pharmacia) with a modified of linker L0746Soares retina retina eye pTTT3D
N2b5HR

(Pharmacia) with a modified oI linker L0747Soares fetal heart pT7T3D
heart NbHH

19W (Pharmacia) with a modified polylinker L0748Soares fetal Liver pT7T3D
liver spleen and 1NFLS Spleen (Pharmacia) with a modified of tinker L0749Soares fetal Liver T7T3D
liver s leen and 1NFLS_S1 Spleen (Pharmacia) with a modified polylinker L0750Soares_fetal lung pTTT3D
lung_NbHLl 9W (Pharmacia) with a modified of linker L0751Soares ovary ovarian tumorovary pT7T3D
tumor NbHOT
(Pharmacia) with a modified of linker L0752Soares_parathyroid_tumorparathyroid parathyroid pTTT3D
tumor NbHPA gland (Pharmacia) with a modified of linker L0753Soares_pineal_gland pineal pTTT3D
N3H gland PG (Pharmacia) with a modified of linker L0754Soares placenta placenta pTTT3D
Nb2HP

(Pharmacia) with a modified olylinker L0755Soares_placenta placenta pTTT3D
8to9wee ks 2NbHP8to9W (Pharmacia) with a modified of linker L0756Soares_multiplemultiple pTTT3D
sclerosis sclerosis 2NbHMSP lesions (Pharmacia) with a modified polylinker V TYPE

L0757Soares_senescentsenescent pT7T3D
fibrobla fibroblast sts_NbHSF (Pharmacia) with a modified polylinker V TYPE

L0758Soares testis_NHT pTTT3D-Pac (Pharmacia) with a modified olylinker L0759Soares_total pTTT3D-Pac fetus_Nb2H

F8_9w (Pharmacia) with a modified olylinker L0760Barstead aorta aorta pTTT3D-Pac (Pharmacia) with a modified polylinker L0761NCI_CGAP_CLLl B-cell, chronic pTTT3D-Pac lymphotic (Pharmacia) leukemia with a modified olylinker ~L0762NCI_CGAP_Brl.l breast pTTT3D-Pac ~

(Pharmacia) with a modified polylinker L0763NCI_CGAP_Br2 breast pTTT3D-Pac (Pharmacia) with a modified of linker L0764NCI_CGAP_Co3 colon pT7T3D-Pac (Pharmacia) with a modified of linker L0765NCI_CGAP_Co4 colon pTTT3D-Pac (Pharmacia) with a modified of linker L0766NCI_CGAP_GCB germinal pTTT3D-Pac 1 center B

cell (Pharmacia) ' with a modified of linker L0767NCI_CGAP_GC3 pooled germ pTTT3D-Pac cell tumors (Pharmacia) with a modified polylinker L0768NCI_CGAP GC4 pooled germ pTTT3D-Pac cell tumors (Pharmacia) with a modified of linker L0769NCI_CGAP_Brn25 anaplastic brain pTTT3D-Pac oligodendroglioma (Pharmacia) with a modified of linker L0770NCI_CGAP_Brn23 glioblastomabrain pTTT3D-Pac (pooled) (Pharmacia) with a modified of linker L0771NCI CGAP_Co8 adenocarcinomacolon pTTT3D-Pac (Pharmacia) with a modified of linker L0772NCI_CGAP_ColO colon tumor colon pT7T3D-Pac RER+

(Pharmacia) with a modified polylinker L0773NCI_CGAP_Co9 colon tumor colon pTTT3D-Pac RER+

(Pharmacia) with a modified of linker L0774NCI_CGAP_Kid3 kidney pTTT3D-Pac (Pharmacia) with a modified olylinker L0775NCI_CGAP_KidS 2 pooled kidney pTTT3D-Pac tumors (clear cell (Pharmacia) type) with a modified of linker L0776 NCI_CGAP_Lu5 carcinoid lung pTTT3D-Pac (Pharmacia) with a modified of linker L0777 Soares_NhHMPu Pooled humanmixed pTTT3D-Pac S1 (see melanocyte, below) (Pharmacia) fetal heart, and with a pregnant modified of linker L0779 Soares NFL_T_GBC_S1 pooled pTTT3D-Pac (Pharmacia) with a modified of tinker L0780 Soares_NSF_F8_9W_OT pooled pTTT3D-Pac PA_P_S 1 (Pharmacia) with a modified polylinker L0782 NCI_CGAP_Pr21 normal prostateprostate pTTT3D-Pac (Pharmacia) with a modified of linker L0783 NCI CGAP_Pr22 normal prostateprostate pTTT3D-Pac (Pharmacia) with a modified of linker L0784 NCI_CGAP_Lei2 leiomyosarcomasoft tissue pT7T3D-Pac (Pharnnacia) with a modified of linker L0785 Barstead spleen spleen pTTT3D-Pac (Pharmacia) with a modified of linker L0786 Soares_NbHFB whole pTTT3D-Pac brain (Pharmacia) with a modified polylinker L0787 NCI_CGAP Subl pTTT3D-Pac (Pharmacia) with a modified of linker L0788 NCI_CGAP_Sub2 pT7T3D-Pac (Pharmacia) with a modified of linker L0789 NCI CGAP_Sub3 pT7T3D-Pac (Pharmacia) with a modified of linker L0790 NCI_CGAP_Sub4 pTTT3D-Pac (Pharmacia) with a modified polylinker L0791 NCI_CGAP_SubS pT7T3D-Pac (Pharmacia) with a modified of linker L0792 NCI_CGAP_Sub6 pT7T3D-Pac (Pharmacia) with a modified of linker L0794 NCI_CGAP_GC6 pooled germ pT7T3D-Pac cell tumors (Pharmacia) with a modified of linker L0796 NCI_CGAP_Brn50 medulloblastomabrain pT7T3D-Pac (Pharmacia) with a modified polylinker L0800 NCI_CGAP_Col6 colon tumor,colon pT7T3D-Pac RER+

(Pharmacia) with a modified of linker L0803 NCI_CGAP_Kidll kidney pT7T3D-Pac (Pharmacia) with a modified of linker L0804 NCI_CGAP_Kidl2 2 pooled kidney pT7T3D-Pac tumors (clear cell (Pharmacia) type) with a modified of linker L0805 NCI_CGAP_Lu24 carcinoid lung pT7T3D-Pac (Pharmacia) with a modified of linker L0806 NCI_CGAP_Lul9 squamous lung pT7T3D-Pac cell carcinoma, (Pharmacia) poorly differentiated with a (4 modified polylinker L0807 NCI_CGAP_Ovl8 fibrotheoma ovary pT7T3D-Pac (Pharmacia) with a modified of linker L0808 Barstead prostate prostate pTTT3D-Pac BPH

HPLRB41 (Pharmacia) with a modified of linker L0809 NCI_CGAP_Pr28 prostate pTTT3D-Pac (Pharmacia) with a modified olylinker L2250 Human cerebral cerebral cortex cortex L2251 Human fetal Fetal lun lun OMIM Description Reference 103850 Aldolase A deficient 106165 H ertension, essential, 145500 107470 A ical m cobacterial infection, familial disseminated, 107470 BCG infection, eneralized familial 107470 Tuberculosis, susce tibili to 107777 Diabetes insi idus, ne hro enic, autosomal recessive, 107970 Arrh thmo enic ri ht ventricular d s lasia-1 108730 Brod m o ath , 601003 114835 Monoc a carbox esterase deficient 115650 Cataract, anterior olar-1 116800 Cataract, Marner a 117700 H ocerulo lasminemia, heredita 117700 Hemosiderosis, s stemic, due to acerulo lasminemia 120110 Meta h seal chondrod s lasia, Schmid a 121014 Heterotaxia, visceroatrial, autosomal recessive 123270 Creatine kinase, brain e, ecto is ex ression o 123940 White s on a nevus, 193900 126451 Schizo hrenia, susce tibility to 126650 Chloride diarrhea, con enital, Finnish e, 214700 126650 Colon cancer 139350 E idermol tic h erkeratosis, 113800 139350 Keratoderma, almo lantar, none idermol tic 140100 [Anna to lobinemia 140100 H oha to to inemia 147781 Ato , susce tibili to 148040 Epidermolysis bullosa simplex, Koebner, bowling-Meara, and Weber-Cocka ne es, 131900, 131760, 131800 148041 Pachyonychia con enita, Jadassohn-Lewandowsky e, 148043 Meesmann corneal d stro h , 122100 148070 Liver disease, susce tibili to, from he atotoxins or viruses 150210 Lactoferrin-deficient neutro hits, 245480 154276 Mali nant h erthermia susce tibili 3 164200 Oculodentodi ital d s lasia 164200 S ndac 1 , a III, 186100 169600 Haile -Haile disease 172471 Gl cogenosis, he atic, autosomal 173360 Thrombo hilia due to excessive lasmino en activator inhibitor 173360 Hemorrha is diathesis due to PAI1 deficient 180380 Ni ht blindness, con enital statione , rhodo sin-related 180380 Retinitis i mentosa, autosomal recessive 180380 Retinitis i entosa-4, autosomal dominant 182600 S astic ara 1e ia-3A

186580 Arthrocutaneouveal granulomatosis 190000 Atransferrinemia 192090 Ovarian carcinoma 192090 Breast cancer, lobular 192090 Endometrial carcinoma 192090 Gastric cancer, familial, 137215 203500 Alka tonuria 231550 Achalasia-addisonianism-alacrimia s ndrome 232050 Pro ionicacidemia, a II or ccB a 245200 Krabbe disease 245900 Norum disease 245900 Fish-a a disease 250100 Metachromatic leulcod stro h 250800 Methemo lobinemia, a I

250800 Methemo lobinemia, a II

251600 Micro hthalmia, autosomal recessive 261640 Phen lketonuria due to PTS deficienc 264800 Pseudoxanthoma elasticum 266600 Inflammato bowel disease-1 270100 Situs inversus viscerum 276600 T rosinemia, a II

276900 Usher s drome, a 1A

276902 Usher s drome, a 3 278760 Xeroderma i mentosum, ou F

300047 Mental retardation, X-linked 20 300062 Mental retardation, X-linked 14 300071 Ni ht blindness, con enital stations , a 2 300110 Ni ht blindness, con enital stations , X-linked incom lete, 300071 300600 Ocular albinism, Forsius-Eriksson a 301000 Thromboc to enia, X-linked, 313900 301000 Wiskott-Aldrich s ndrome 301830 Arthro osis, X-linked s final muscular afro h , infantile, X-linked 309470 Mental retardation, X-linked, s ndromic-3, with s astic di 1e is 309500 Ren ennin s ndrome-1 309610 Mental retardation, X-linked, syndromic-2, with dysmorphism and cerebral afro by 309850 Brunner s ndrome 310500 Ni ht blindness, con enital stations , a 1 310600 Norrie disease 310600 Exudative vitreoretino ath , X-linked, 305390 311050 O tic afro h , X-linked 312060 Pro erdin deficienc , X-linked 600194 Ichth osis bullosa of Siemens, 146800 600223 S inocerebellar ataxia-4 600231 Palmo lantar keratoderma, Bothnia a 600536 M o ath , con enital 600760 Pseudohypoaldosteronism, type I, 264350 600760 Liddle syndrome, 177200 600761 Pseudoh oaldosteronism, a I, 264350 600761 Liddle s ndrome, 177200 600808 Enuresis, nocturnal, 2 600882 Charcot-Marie-Tooth neuro ath -2B

600956 Persistent Mullerian duct s ndrome, a II, 261550 601199 Neonatal h a arath oidism, 239200 601199 H ocalcemia, autosomal dominant, 601198 601199 Hy ocalciuric h ercalcemia, ty a I, 145980 601284 Heredita hemorrha is telan iectasia-2, 600376 601316 Deafness, autosomal dominant 10 601471 Moebius s drome-2 601666 Insulin-de endent diabetes mellitus-15 601682 Glaucoma 1C, rima o en an 1e 601757 Rhizomelic chondrod s lasia unctata, a 1, 215100 601769 Osteo orosis, involutional 601769 Riclcets, vitamin D-resistant, 277440 601928 Monilethrix, 158000 602066 Convulsions, infantile and arox smal choreoathetosis 602091 Marfan s ndrome, a ical 602116 Glioma 602136 Refsum disease, infantile, 266510 602136 Zellwe er s ndrome-l, 214100 602136 Adrenoleukod stro h , neonatal, 202370 602153 Monilethrix, 158000 602447 Corona arte disease, susce tibili to 602574 Deafness, autosomal dominant 12, 601842 602574 Deafness, autosomal dominant 8, 601 602772 _ Retinitis pitmentosa-24 Polynucleotide afzd Polypeptide ha~iahts [82] The present invention is directed to variants of the polynucleotide sequence disclosed in SEQ ID NO:X or the complementary strand thereto, nucleotide sequences encoding the polypeptide of SEQ ID NO:Y, the nucleotide sequence of SEQ ID
NO:X
encoding the polypeptide sequence as defined in column 7 of Table 1A, nucleotide sequences encoding the polypeptide as defined in column 7 of Table 1A, the nucleotide sequence as defined in columns 8 and 9 of Table 2, nucleotide sequences encoding the polypeptide encoded by the nucleotide sequence as defined in columns 8 and 9 of Table 2, the nucleotide sequence as defined in column 6 of Table 1B, nucleotide sequences encoding the polypeptide encoded by the nucleotide sequence as defined in column 6 of Table 1B, the cDNA sequence contained in Clone ID NO:Z, and/or nucleotide sequences encoding the polypeptide encoded by the cDNA sequence contained in Clone ID NO:Z.
[83] The present invention also encompasses variants of the polypeptide sequence disclosed in SEQ ID NO:Y, the polypeptide sequence as defined in column 7 of Table 1A, a polypeptide sequence encoded by the polynucleotide sequence in SEQ ID NO:X, a polypeptide sequence encoded by the nucleotide sequence as defined in columns 8 and 9 of Table 2, a polypeptide sequence encoded by the nucleotide sequence as defined in column 6 of Table 1B, a polypeptide sequence encoded by the complement of the polynucleotide sequence in SEQ ID NO:X, and/or a polypeptide sequence encoded by the cDNA
sequence contained in Clone ID NO:Z.
[84] "Variant" refers to a polynucleotide or polypeptide differing from the polynucleotide or polypeptide of the present invention, but retaining essential properties thereof. Generally, variants are overall closely similar, and, in many regions, identical to the polynucleotide or polypeptide of the present invention.
(85] Thus, one aspect of the invention provides an isolated nucleic acid molecule comprising, or alternatively consisting of, a polynucleotide having a nucleotide sequence selected from the group consisting of: (a) a nucleotide sequence described in SEQ ID NO:X
or contained in the cDNA sequence of Clone ID NO:Z; (b) a nucleotide sequence in SEQ
ID NO:X or the cDNA in Clone ID NO:Z which encodes the complete amino acid sequence of SEQ ID NO:Y or the complete amino acid sequence encoded by the cDNA in Clone ID
NO:Z; (c) a nucleotide sequence in SEQ ID NO:X or the cDNA in Clone ID NO:Z
which encodes a mature polypeptide; (d) a nucleotide sequence in SEQ ID NO:X or the cDNA
sequence of Clone ID NO:Z, which encodes a biologically active fragment of a polypeptide;
(e) a nucleotide sequence in SEQ ID NO:X or the cDNA sequence of Clone ID
NO:Z, which encodes an antigenic fragment of a polypeptide; (f) a nucleotide sequence encoding a polypeptide comprising the complete amino acid sequence of SEQ ID NO:Y or the complete amino acid sequence encoded by the cDNA in Clone ID NO:Z; (g) a nucleotide sequence encoding a mature polypeptide of the amino acid sequence of SEQ ID
NO:Y or the amino acid sequence encoded by the cDNA in Clone ID NO:Z; (h) a nucleotide sequence encoding a biologically active fragment of a polypeptide having the complete amino acid sequence of SEQ ID NO:Y or the complete amino acid sequence encoded by the cDNA in Clone ID NO:Z; (i) a nucleotide sequence encoding an antigenic fragment of a polypeptide having the complete amino acid sequence of SEQ ID NO:Y or the complete amino acid sequence encoded by the cDNA in Clone ID NO:Z; and (j) a nucleotide sequence complementary to any of the nucleotide sequences in (a), (b), (c), (d), (e), (f), (g), (h), or (i) above.
[86] The present invention is also directed to nucleic acid molecules which comprise, or alternatively consist of, a nucleotide sequence which is at least 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99% or 100%, identical to, for example, any of the nucleotide sequences in (a), (b), (c), (d), (e), (f), (g), (h), (i), or (j) above, the nucleotide coding sequence in SEQ
ID NO:X or the complementary strand thereto, the nucleotide coding sequence of the cDNA
contained in Clone ID NO:Z or the complementary strand thereto, a nucleotide sequence encoding the polypeptide of SEQ ID NO:Y, a nucleotide sequence encoding a polypeptide sequence encoded by the nucleotide sequence in SEQ ID NO:X, a polypeptide sequence encoded by the complement of the polynucleotide sequence in SEQ ID NO:X, a nucleotide sequence encoding the polypeptide encoded by the cDNA contained in Clone ID
NO:Z, the nucleotide coding sequence in SEQ ID NO:X as defined in columns 8 and 9 of Table 2 or the complementary strand thereto, a nucleotide sequence encoding the polypeptide encoded by the nucleotide sequence in SEQ ID NO:X as defined in columns 8 and 9 of Table 2 or the complementary strand thereto, the nucleotide coding sequence in SEQ ID
NO:B as defined in column 6 of Table 1B or the complementary strand thereto, a nucleotide sequence encoding the polypeptide encoded by the nucleotide sequence in SEQ ID
NO:B as defined in column 6 of Table 1B or the complementary strand thereto, the nucleotide sequence in SEQ ID NO:X encoding the polypeptide sequence as defined in column 7 of Table 1A or the complementary strand thereto, nucleotide sequences encoding the polypeptide as defined in column 7 of Table 1A or the complementary strand thereto, and/or polynucleotide fragments of any of these nucleic acid molecules (e.g., those fragments described herein). Polynucleotides which hybridize to the complement of these nucleic acid molecules under stringent hybridization conditions or alternatively, under lower stringency conditions, are also encompassed by the invention, as are polypeptides encoded by these polynucleotides and nucleic acids.
[87] In a preferred embodiment, the invention encompasses nucleic acid molecules which comprise, or alternatively, consist of a polynucleotide which hybridizes under stringent hybridization conditions, or alternatively, under lower stringency conditions, to a polynucleotide in (a), (b), (c), (d), (e), (f), (g), (h), or (i), above, as are polypeptides encoded by these polynucleotides. In another preferred embodiment, polynucleotides which hybridize to the complement of these nucleic acid molecules under stringent hybridization conditions, or alternatively, under lower stringency conditions, are also encompassed by the invention, as are polypeptides encoded by these polynucleotides.
[88] In another embodiment, the invention provides a purified protein comprising, or alternatively consisting of, a polypeptide having an amino acid sequence selected from the group consisting of: (a) the complete amino acid sequence of SEQ ID NO:Y or the complete amino acid sequence encoded by the cDNA in Clone ID NO:Z; (b) the amino acid sequence of a mature form of a polypeptide having the amino acid sequence of SEQ ID
NO:Y or the amino acid sequence encoded by the cDNA in Clone ID NO:Z; (c) the amino acid sequence of a biologically active fragment of a polypeptide having the complete amino acid sequence of SEQ ID NO:Y or the complete amino acid sequence encoded by the cDNA in Clone ID NO:Z; and (d) the amino acid sequence of an antigenic fragment of a polypeptide having the complete amino acid sequence of SEQ ID NO:Y or the complete amino acid sequence encoded by the cDNA in Clone ID NO:Z.
[89] The present invention is also directed to proteins which comprise, or alternatively consist of, an amino acid sequence which is at least 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99% or 100%, identical to, for example, any of the amino acid sequences in (a), (b), (c), or (d), above, the amino acid sequence shown in SEQ ID NO:Y, the amino acid sequence encoded by the cDNA contained in Clone ID NO:Z, the amino acid sequence of the polypeptide encoded by the nucleotide sequence in SEQ ID NO:X as defined in columns 8 and 9 of Table 2, the amino acid sequence of the polypeptide encoded by the nucleotide sequence in SEQ ID NO:B as defined in column 6 of Table 1B, the amino acid sequence as defined in column 7 of Table 1A, an amino acid sequence encoded by the nucleotide sequence in SEQ ID NO:X, and an amino acid sequence encoded by the complement of the polynucleotide sequence in SEQ ID NO:X. Fragments of these polypeptides are also provided (e.g., those fragments described herein). Further proteins encoded by polynucleotides which hybridize to the complement of the nucleic acid molecules encoding these amino acid sequences under stringent hybridization conditions or alternatively, under lower stringency conditions, are also encompassed by the invention, as are the polynucleotides encoding these proteins.
[90] By a nucleic acid having a nucleotide sequence at least, for example, 95%
"identical" to a reference nucleotide sequence of the present invention, it is intended that the nucleotide sequence of the nucleic acid is identical to the reference sequence except that the nucleotide sequence may include up to five point mutations per each 100 nucleotides of the reference nucleotide sequence encoding the polypeptide. In other words, to obtain a nucleic acid having a nucleotide sequence at least 95% identical to a reference nucleotide sequence, up to 5% of the nucleotides in the reference sequence may be deleted or substituted with another nucleotide, or a number of nucleotides up to 5% of the total nucleotides in the reference sequence may be inserted into the reference sequence. The query sequence may be an entire sequence referred to in Table 1A or 2 as the ORF (open reading frame), or any fragment specified as described herein.
[91] As a practical matter, whether any particular nucleic acid molecule or polypeptide is at least 80%, 85%, 90%, 95%, 96%, 97%, 98% or 99% identical to a nucleotide sequence of the present invention can be determined conventionally using known computer programs. A preferred method for determining the best overall match between a query sequence (a sequence of the present invention) and a subject sequence, also referred to as a global sequence alignment, can be determined using the FASTDB
computer program based on the algorithm of Brutlag et al. (Comp. App. Biosci. 6:237-245 (1990)).
In a sequence alignment the query and subject sequences are both DNA
sequences. An RNA sequence can be compared by converting U's to T's. The result of said global sequence alignment is expressed as percent identity. Preferred parameters used in a FASTDB alignment of DNA sequences to calculate percent identity are:
Matrix=Unitary, k-tuple=4, Mismatch Penalty=1, Joining Penalty=30, Randomization Group Length=0, Cutoff Score=1, Gap Penalty=5, Gap Size Penalty 0.05, Window Size=500 or the length of the subject nucleotide sequence, whichever is shorter.
[92] If the subject sequence is shorter than the query sequence because of 5' or 3' deletions, not because of internal deletions, a manual correction must be made to the results.
This is because the FASTDB program does not account for 5' and 3' truncations of the subject sequence when calculating percent identity. For subject sequences truncated at the 5' or 3' ends, relative to the query sequence, the percent identity is corrected by calculating the number of bases of the query sequence that are 5' and 3' of the subject sequence, which are not matched/aligned, as a percent of the total bases of the query sequence. Whether a nucleotide is matchedlaligned is determined by results of the FASTDB sequence alignment.
This percentage is then subtracted from the percent identity, calculated by the above FASTDB program using the specified parameters, to arrive at a final percent identity score.
This corrected score is what is used for the purposes of the present invention. Only bases outside the 5' and 3' bases of the subject sequence, as displayed by the FASTDB alignment, which are not matched/aligned with the query sequence, are calculated for the purposes of manually adjusting the percent identity score.
[93] For example, a 90 base subject sequence is aligned to a 100 base query sequence to determine percent identity. The deletions occur at the 5' end of the subject sequence and therefore, the FASTDB alignment does not show a matched/alignment of the first 10 bases at 5' end. The 10 unpaired bases represent 10% of the sequence (number of bases at the 5' and 3' ends not matched/total number of bases in the query sequence) so 10% is subtracted from the percent identity score calculated by the FASTDB program. If the remaining 90 bases were perfectly matched the final percent identity would be 90%. In another example, a 90 base subject sequence is compared with a 100 base query sequence. This time the deletions are internal deletions so that there are no bases on the 5' or 3' of the subject sequence which are not matched/aligned with the query. In this case the percent identity calculated by FASTDB is not manually corrected. Once again, only bases 5' and 3' of the subject sequence which are not matched/aligned with the query sequence are manually corrected for. No other manual corrections are to be made for the purposes of the present invention.
[94] By a polypeptide having an amino acid sequence at least, for example, 95%
"identical" to a query amino acid sequence of the present invention, it is intended that the amino acid sequence of the subject polypeptide is identical to the query sequence except that the subject polypeptide sequence may include up to five amino acid alterations per each 100 amino acids of the query amino acid sequence. In other words, to obtain a polypeptide having an amino acid sequence at least 95% identical to a query amino acid sequence, up to 5% of the amino acid residues in the subject sequence may be inserted, deleted, (indels) or substituted with another amino acid. These alterations of the reference sequence may occur at the amino or carboxy terminal positions of the reference amino acid sequence or anywhere between those terminal positions, interspersed either individually among residues in the reference sequence or in one or more contiguous groups within the reference sequence.
(95] As a practical matter, whether any particular polypeptide is at least 80%, 85%, 90%, 95%, 96%, 97%, 98% or 99% identical to, for instance, the amino acid sequence of a polypeptide referred to in Table 1A (e.g., the amino acid sequence identified in column 6) or Table 2 (e.g., the amino acid sequence of the polypeptide encoded by the polynucleotide DEMANDE OU BREVET VOLUMINEUX
LA PRESENTE PARTIE DE CETTE DEMANDE OU CE BREVET COMPREND
PLUS D'UN TOME.

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Claims

What Is Claimed Is:

1. An isolated nucleic acid molecule comprising a polynucleotide having a nucleotide sequence at least 95% identical to a sequence selected from the group consisting of:
(a) a polynucleotide fragment of SEQ ID NO:X or a polynucleotide fragment of the cDNA sequence contained in Clone ID NO:Z, which is hybridizable to SEQ ID
NO:X;
(b) a polynucleotide encoding a polypeptide fragment of SEQ ID NO:Y or a polypeptide fragment encoded by the cDNA sequence contained in cDNA Clone ID
NO:Z, which is hybridizable to SEQ ID NO:X;
(c) a polynucleotide encoding a polypeptide fragment of a polypeptide encoded by SEQ ID NO:X or a polypeptide fragment encoded by the cDNA sequence contained in cDNA Clone ID NO:Z, which is hybridizable to SEQ ID NO:X;
(d) a polynucleotide encoding a polypeptide domain of SEQ ID NO:Y or a polypeptide domain encoded by the cDNA sequence contained in cDNA Clone ID
NO:Z, which is hybridizable to SEQ ID NO:X;
(e) a polynucleotide encoding a polypeptide epitope of SEQ ID NO:Y or a polypeptide epitope encoded by the cDNA sequence contained in cDNA Clone ID
NO:Z, which is hybridizable to SEQ ID NO:X;
(f) a polynucleotide encoding a polypeptide of SEQ ID NO:Y or the cDNA
sequence contained in cDNA Clone ID NO:Z, which is hybridizable to SEQ ID NO:X, having biological activity;
(g) a polynucleotide which is a variant of SEQ ID NO:X;
(h) a polynucleotide which is an allelic variant of SEQ ID NO:X;
(i) a polynucleotide which encodes a species homologue of the SEQ ID NO:Y;
(j) a polynucleotide capable of hybridizing under stringent conditions to any one of the polynucleotides specified in (a)-(i), wherein said polynucleotide does not hybridize under stringent conditions to a nucleic acid molecule having a nucleotide sequence of only A
residues or of only T residues.

2. The isolated nucleic acid molecule of claim 1, wherein the polynucleotide fragment comprises a nucleotide sequence encoding a protein.

3. The isolated nucleic acid molecule of claim 1, wherein the polynucleotide fragment comprises a nucleotide sequence encoding the sequence identified as SEQ ID NO:Y
or the polypeptide encoded by the cDNA sequence contained in cDNA Clone ID
NO:Z, which is hybridizable to SEQ ID NO:X.

4. The isolated nucleic acid molecule of claim 1, wherein the polynucleotide fragment comprises the entire nucleotide sequence of SEQ ID NO:X or the cDNA
sequence contained in cDNA Clone ID NO:Z, which is hybridizable to SEQ ID NO:X.

5. The isolated nucleic acid molecule of claim 2, wherein the nucleotide sequence comprises sequential nucleotide deletions from either the C-terminus or the N-terminus.

6. The isolated nucleic acid molecule of claim 3, wherein the nucleotide sequence comprises sequential nucleotide deletions from either the C-terminus or the N-terminus.

7. A recombinant vector comprising the isolated nucleic acid molecule of claim 1.

8. A method of making a recombinant host cell comprising the isolated nucleic acid molecule of claim 1.

9. A recombinant host cell produced by the method of claim 8.

10. The recombinant host cell of claim 9 comprising vector sequences.

11. An isolated polypeptide comprising an amino acid sequence at least 90%
identical to a sequence selected from the group consisting of:
(a) a polypeptide fragment of SEQ ID NO:Y or the encoded sequence contained in cDNA Clone ID NO:Z;
(b) a polypeptide fragment of SEQ ID NO:Y or the encoded sequence contained in cDNA Clone ID NO:Z, having biological activity;

(c) a polypeptide domain of SEQ ID NO:Y or the encoded sequence contained in cDNA Clone ID NO:Z;
(d) a polypeptide epitope of SEQ ID NO:Y or the encoded sequence contained in cDNA Clone ID NO:Z;
(e) a full length protein of SEQ ID NO:Y or the encoded sequence contained in cDNA
Clone ID NO:Z;
(f) a variant of SEQ ID NO:Y;
(g) an allelic variant of SEQ ID NO:Y; or (h) a species homologue of the SEQ ID NO:Y.

12. The isolated polypeptide of claim 11, wherein the full length protein comprises sequential amino acid deletions from either the C-terminus or the N-terminus.

13. An isolated antibody that binds specifically to the isolated polypeptide of claim 11.

14. A recombinant host cell that expresses the isolated polypeptide of claim 11.

15. A method of making an isolated polypeptide comprising:
(a) culturing the recombinant host cell of claim 14 under conditions such that said polypeptide is expressed; and (b) recovering said polypeptide.

16. The polypeptide produced by claim 15.

17. A method for preventing, treating, or ameliorating a medical condition, comprising administering to a mammalian subject a therapeutically effective amount of the polynucleotide of claim 1.

18. A method of diagnosing a pathological condition or a susceptibility to a pathological condition in a subject comprising:
(a) determining the presence or absence of a mutation in the polynucleotide of claim 1; and (b) diagnosing a pathological condition or a susceptibility to a pathological condition based on the presence or absence of said mutation.

19. A method of diagnosing a pathological condition or a susceptibility to a pathological condition in a subject comprising:
(a) determining the presence or amount of expression of the polypeptide of claim 11 in a biological sample; and (b) diagnosing a pathological condition or a susceptibility to a pathological condition based on the presence or amount of expression of the polypeptide.

20. A method for identifying a binding partner to the polypeptide of claim 11 comprising:
(a) contacting the polypeptide of claim 11 with a binding partner; and (b) determining whether the binding partner effects an activity of the polypeptide.

21. The gene corresponding to the cDNA sequence of SEQ ID NO:Y.

22. A method of identifying an activity in a biological assay, wherein the method comprises:
(a) expressing SEQ ID NO:X in a cell;
(b) isolating the supernatant;
(c) detecting an activity in a biological assay; and identifying the protein in the supernatant having the activity.

23. The product produced by the method of claim 20.

24. A method for preventing, treating, or ameliorating a medical condition, comprising administering to a mammalian subject a therapeutically effective amount of the polypeptide of claim 11.