DE60041243D1 - Gebrauchsverfaheren eines neuen lysyloxidase-verwandten proteins - Google Patents

Gebrauchsverfaheren eines neuen lysyloxidase-verwandten proteins

Info

Publication number
DE60041243D1
DE60041243D1 DE60041243T DE60041243T DE60041243D1 DE 60041243 D1 DE60041243 D1 DE 60041243D1 DE 60041243 T DE60041243 T DE 60041243T DE 60041243 T DE60041243 T DE 60041243T DE 60041243 D1 DE60041243 D1 DE 60041243D1
Authority
DE
Germany
Prior art keywords
lor
nucleic acid
proteins
new
related protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60041243T
Other languages
English (en)
Inventor
Mehran M Khodadoust
Kyle J Macbeth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Millennium Pharmaceuticals Inc
Original Assignee
Millennium Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/276,400 external-priority patent/US6140056A/en
Application filed by Millennium Pharmaceuticals Inc filed Critical Millennium Pharmaceuticals Inc
Application granted granted Critical
Publication of DE60041243D1 publication Critical patent/DE60041243D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0022—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE60041243T 1999-01-27 2000-01-27 Gebrauchsverfaheren eines neuen lysyloxidase-verwandten proteins Expired - Lifetime DE60041243D1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11758099P 1999-01-27 1999-01-27
US09/276,400 US6140056A (en) 1999-01-27 1999-03-25 MSP-18 protein and nucleic acid molecules and uses therefor
US09/448,076 US6300092B1 (en) 1999-01-27 1999-11-23 Methods of use of a novel lysyl oxidase-related protein
PCT/US2000/002125 WO2000044910A1 (en) 1999-01-27 2000-01-27 Methods of use of a novel lysyl oxidase-related protein

Publications (1)

Publication Number Publication Date
DE60041243D1 true DE60041243D1 (de) 2009-02-12

Family

ID=27382012

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60041243T Expired - Lifetime DE60041243D1 (de) 1999-01-27 2000-01-27 Gebrauchsverfaheren eines neuen lysyloxidase-verwandten proteins

Country Status (7)

Country Link
US (2) US6300092B1 (de)
EP (1) EP1149169B1 (de)
AT (1) ATE419358T1 (de)
AU (1) AU3217100A (de)
DE (1) DE60041243D1 (de)
ES (1) ES2320622T3 (de)
WO (1) WO2000044910A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020068322A1 (en) * 2000-05-26 2002-06-06 Rachel Meyers 47765, a novel human lysyl oxidase and uses thereof
US20030114410A1 (en) * 2000-08-08 2003-06-19 Technion Research And Development Foundation Ltd. Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis
DK2078531T3 (da) * 2000-08-08 2012-09-10 Technion Res & Dev Foundation Farmaceutiske sammensætninger og fremgangsmåder, der kan anvendes til modulering af angiogenese
US6489456B1 (en) * 2000-10-27 2002-12-03 Pe Corporation (Ny) Isolated human secreted proteins, nucleic acid molecules encoding human secreted proteins, and uses thereof
US20030040604A1 (en) * 2001-05-29 2003-02-27 Anderson Dirk M. Siglec-12 polypeptides, polynucleotides, and methods of use thereof
WO2003046224A1 (en) 2001-11-28 2003-06-05 The General Hospital Corporation A blood-based assay for dysferlinopathies
FR2855968B1 (fr) * 2003-06-13 2012-11-30 Coletica Stimulation de la synthese et de l'activite d'une isoforme de la lysyl oxydase-like loxl pour stimuler la formation de fibres elastiques
US7255856B2 (en) 2004-01-23 2007-08-14 Massachusetts Eye & Ear Infirmary Lysyl oxidase-like 1 (LOXL1) and elastogenesis
US20070225242A1 (en) * 2005-06-21 2007-09-27 The Board Of Trustees Of The Leland Stanford Junior University Method and composition for treating and preventing tumor metastasis in vivo
US20070021365A1 (en) * 2005-06-21 2007-01-25 The Board Of Trustees Of The Leland Stanford Junior University Inhibition of Lysyl oxidase for treating tumor growth and diagnostics relating thereto
IL184627A0 (en) 2007-07-15 2008-12-29 Technion Res & Dev Foundation Agents for diagnosing and modulating metastasis and fibrosis as well as inflammation in a mammalian tissue
US8461303B2 (en) * 2007-08-02 2013-06-11 Gilead Biologics, Inc. LOX and LOXL2 inhibitors and uses thereof
WO2010080769A2 (en) 2009-01-06 2010-07-15 Arresto Biosciences, Inc. Chemotherapeutic methods and compositions
CA2751438A1 (en) * 2009-02-06 2010-08-12 Arresto Biosciences, Inc. Methods and compositions for treatment of neovascularization
WO2011022709A1 (en) * 2009-08-21 2011-02-24 Arresto Biosciences, Inc In vitro screening assays
SG2014004816A (en) 2009-08-21 2014-03-28 Gilead Biologics Inc Catalytic domains from lysyl oxidase and loxl2
CN102711839A (zh) * 2009-08-21 2012-10-03 吉联亚生物科技有限公司 体内筛选试验
CN102711753A (zh) * 2009-09-29 2012-10-03 吉联亚生物科技有限公司 治疗眼纤维化的方法和组合物
RU2015108348A (ru) * 2010-02-04 2015-07-20 Джилид Байолоджикс, Инк. Антитела, связывающиеся с лизилоксидазоподобным ферментом-2 (loxl2), и способы их применения
EP2694554A1 (de) 2011-04-08 2014-02-12 Gilead Biologics, Inc. Verfahren und zusammensetzungen zur normalisierung einer tumorvaskulatur mittels loxl2-hemmung
WO2012155071A1 (en) * 2011-05-12 2012-11-15 Gilead Biologics, Inc. Methods of identifying lysyl oxidase - like - 2 (loxl2) binding partners

Also Published As

Publication number Publication date
US6300092B1 (en) 2001-10-09
AU3217100A (en) 2000-08-18
ATE419358T1 (de) 2009-01-15
US20020151007A1 (en) 2002-10-17
EP1149169B1 (de) 2008-12-31
WO2000044910A1 (en) 2000-08-03
EP1149169A1 (de) 2001-10-31
ES2320622T3 (es) 2009-05-27

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