DE60044004D1 - Verwendung von Omega-Carboxyaryl-substituierten Diphenylharnstoffen als raf-Kinase-Inhibitoren - Google Patents
Verwendung von Omega-Carboxyaryl-substituierten Diphenylharnstoffen als raf-Kinase-InhibitorenInfo
- Publication number
- DE60044004D1 DE60044004D1 DE60044004T DE60044004T DE60044004D1 DE 60044004 D1 DE60044004 D1 DE 60044004D1 DE 60044004 T DE60044004 T DE 60044004T DE 60044004 T DE60044004 T DE 60044004T DE 60044004 D1 DE60044004 D1 DE 60044004D1
- Authority
- DE
- Germany
- Prior art keywords
- diphenylureas
- carboxyaryl
- omega
- substituted
- kinase inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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DE05028442T Pending DE05028442T1 (de) | 1999-01-13 | 2000-01-12 | W-carboxyaryl substituierte diphenyl Harnstoffe als raf kinase inhibitoren |
DE2000626822 Pending DE122006000059I1 (de) | 1999-01-13 | 2000-01-12 | -G(V)-Carboxyaryl substituierte Diphenyl Harnstoffe als Raf Kinase Inhibitoren |
DE60044004T Expired - Lifetime DE60044004D1 (de) | 1999-01-13 | 2000-01-12 | Verwendung von Omega-Carboxyaryl-substituierten Diphenylharnstoffen als raf-Kinase-Inhibitoren |
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DE05028442T Pending DE05028442T1 (de) | 1999-01-13 | 2000-01-12 | W-carboxyaryl substituierte diphenyl Harnstoffe als raf kinase inhibitoren |
DE2000626822 Pending DE122006000059I1 (de) | 1999-01-13 | 2000-01-12 | -G(V)-Carboxyaryl substituierte Diphenyl Harnstoffe als Raf Kinase Inhibitoren |
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EP1730111A2 (de) * | 2004-01-30 | 2006-12-13 | MERCK PATENT GmbH | Bisarylharnstoffderivate zur verwendung als kinase inhibitoren |
TW200530236A (en) * | 2004-02-23 | 2005-09-16 | Chugai Pharmaceutical Co Ltd | Heteroaryl phenylurea |
MY191349A (en) * | 2004-08-27 | 2022-06-17 | Bayer Pharmaceuticals Corp | New pharmaceutical compositions for the treatment of hyper-proliferative disorders |
JP2008514657A (ja) * | 2004-09-29 | 2008-05-08 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | 4−{4−[({[4−クロロ−3−(トリフルオロメチル)フェニル]アミノ}カルボニル)アミノ]フェノキシ}−n−メチルピリジン−2−カルボキサミドの製造方法 |
DE102005015253A1 (de) * | 2005-04-04 | 2006-10-05 | Merck Patent Gmbh | Pyrazolderivate |
WO2007075650A2 (en) | 2005-12-21 | 2007-07-05 | Bayer Healthcare Ag | Substituted pyrimidine derivatives useful in the treatment of cancer and other disorders |
WO2008044688A1 (fr) * | 2006-10-11 | 2008-04-17 | Daiichi Sankyo Company, Limited | Dérivé de l'urée |
WO2008115263A2 (en) * | 2007-03-20 | 2008-09-25 | Curis, Inc. | Raf kinase inhibitors containing a zinc binding moiety |
JP5438680B2 (ja) * | 2007-09-10 | 2014-03-12 | シプラ・リミテッド | Rafキナーゼ阻害剤の製造方法及び該方法に使用する中間体 |
CN101372475B (zh) * | 2008-03-19 | 2012-01-04 | 南京工业大学 | 芳杂环取代的二苯脲类衍生物及其用途 |
CN101298427B (zh) * | 2008-06-26 | 2012-03-21 | 中国科学院广州生物医药与健康研究院 | 二芳基脲类化合物及其应用 |
TW201012467A (en) | 2008-09-16 | 2010-04-01 | Taiho Pharmaceutical Co Ltd | Antitumor agent containing 4-[[3,5-bis(trimethylsilyl)benzoyl]amino]benzoic acid |
CN103254126A (zh) * | 2008-09-19 | 2013-08-21 | 苏州泽璟生物制药有限公司 | 氘代的ω-二苯基脲及衍生物以及包含该化合物的药物组合物 |
CN101362717B (zh) * | 2008-09-28 | 2013-02-06 | 四川大学 | 4-(4-氨基苯胺基)-2-(甲基氨甲酰基)吡啶及其衍生物和它们的制备方法、用途 |
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CN102216280B (zh) * | 2009-01-22 | 2014-06-18 | 沈阳药科大学 | 双芳基脲类衍生物及用途 |
US9181238B2 (en) * | 2010-02-05 | 2015-11-10 | Novartis Ag | N-(pyridin-2-yl)sulfonamides and compositions thereof as protein kinase inhibitors |
CN102219733A (zh) * | 2010-04-14 | 2011-10-19 | 上海医药工业研究院 | 索拉非尼的制备方法 |
CN102617458A (zh) * | 2010-05-18 | 2012-08-01 | 张南 | 抗癌用化合物的制备方法 |
CN101830847B (zh) * | 2010-05-18 | 2012-10-10 | 张南 | 抗癌用化合物及制备方法 |
KR20130099117A (ko) | 2010-10-01 | 2013-09-05 | 바이엘 인텔렉쳐 프로퍼티 게엠베하 | 치환된 n-(2-아릴아미노)아릴 설폰아미드 함유 배합물 |
US8937088B2 (en) * | 2011-01-06 | 2015-01-20 | Astar Biotech Llc | Ureas for the treatment and prevention of cancer |
CN102875460A (zh) * | 2012-05-17 | 2013-01-16 | 上海奥博生物医药技术有限公司 | 一种制备索拉非尼的方法 |
CN103508961B (zh) * | 2012-06-26 | 2015-07-22 | 中美冠科生物技术(太仓)有限公司 | 抗肿瘤药物 |
CN103408488A (zh) * | 2013-08-13 | 2013-11-27 | 张家港威胜生物医药有限公司 | 一种索拉非尼的优化合成方法 |
CN103435553A (zh) * | 2013-09-16 | 2013-12-11 | 中国药科大学 | 基于哌嗪结构的芳甲酰胺类Raf激酶抑制剂及其制备方法和用途 |
CN104672129B (zh) * | 2013-11-26 | 2019-06-25 | 广东东阳光药业有限公司 | 一种脲类化合物的制备方法 |
CN106866623A (zh) | 2014-04-08 | 2017-06-20 | 北大方正集团有限公司 | 多取代的吡啶化合物、制备方法、用途及药物组合物 |
CN104177292A (zh) * | 2014-08-08 | 2014-12-03 | 亿腾药业(泰州)有限公司 | 一种工业化生产甲苯磺酸索拉非尼多晶型ⅰ的方法 |
EP3201174A4 (de) * | 2014-10-03 | 2018-06-06 | The Royal Institution for the Advancement of Learning / McGill University | Auf harnstoff- und bis-harnstoff basierende verbindungen und analoga davon zur behandlung von androgenrezeptorvermittelten erkrankungen oder störungen |
CN105348186B (zh) * | 2015-10-15 | 2018-05-22 | 青岛海洋生物医药研究院股份有限公司 | 氘代双芳基脲类化合物及其制备方法和在制备抗肿瘤的药物中的应用 |
CN105753841B (zh) * | 2016-01-18 | 2018-01-05 | 西安交通大学 | 一种n‑吲唑取代硫脲类衍生物及其制备方法和应用 |
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