DE60238485D1 - Humanisierte antikörper gegen icam-1, deren herstellung und verwendungen - Google Patents
Humanisierte antikörper gegen icam-1, deren herstellung und verwendungenInfo
- Publication number
- DE60238485D1 DE60238485D1 DE60238485T DE60238485T DE60238485D1 DE 60238485 D1 DE60238485 D1 DE 60238485D1 DE 60238485 T DE60238485 T DE 60238485T DE 60238485 T DE60238485 T DE 60238485T DE 60238485 D1 DE60238485 D1 DE 60238485D1
- Authority
- DE
- Germany
- Prior art keywords
- icam
- humanized antibodies
- preparation
- antibodies
- methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000015271 Intercellular Adhesion Molecule-1 Human genes 0.000 title abstract 2
- 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 title abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2821—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/910,483 US20030035798A1 (en) | 2000-08-16 | 2001-07-19 | Humanized antibodies |
PCT/US2002/023002 WO2003035696A2 (en) | 2001-07-19 | 2002-07-19 | Humanized antibodies against icam-1, their production and uses |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60238485D1 true DE60238485D1 (de) | 2011-01-13 |
Family
ID=25428849
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60238485T Expired - Lifetime DE60238485D1 (de) | 2001-07-19 | 2002-07-19 | Humanisierte antikörper gegen icam-1, deren herstellung und verwendungen |
Country Status (10)
Country | Link |
---|---|
US (4) | US20030035798A1 (de) |
EP (2) | EP1414861B1 (de) |
JP (3) | JP4516312B2 (de) |
AT (1) | ATE490276T1 (de) |
AU (3) | AU2002363027C1 (de) |
CA (2) | CA2793019A1 (de) |
DE (1) | DE60238485D1 (de) |
DK (1) | DK1414861T3 (de) |
ES (1) | ES2356896T3 (de) |
WO (1) | WO2003035696A2 (de) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69829995T2 (de) * | 1997-12-01 | 2006-02-23 | Fang, Fang, San Diego | Multivalente rekombinante antikörper zur behandlung von hrv infektionen |
US20030035798A1 (en) * | 2000-08-16 | 2003-02-20 | Fang Fang | Humanized antibodies |
US20030138440A1 (en) | 2001-07-19 | 2003-07-24 | Fang Fang | Multimeric proteins and methods of making and using same |
WO2005086568A2 (en) * | 2004-01-26 | 2005-09-22 | Morphosys Ag | Anti-icam-1 human antibodies and uses thereof |
SV2007002227A (es) * | 2004-09-10 | 2007-03-20 | Wyeth Corp | Anticuerpos anti-5t4 humanizados y conjugados anticuerpo anti-5t4/calicheamicina ref. 040000-0317637 |
GB2430030B (en) * | 2005-09-07 | 2009-04-01 | Ethicon Inc | Diagnostic markers of wound infection III |
GB0525214D0 (en) | 2005-12-12 | 2006-01-18 | Bioinvent Int Ab | Biological materials and uses thereof |
US9266967B2 (en) | 2007-12-21 | 2016-02-23 | Hoffmann-La Roche, Inc. | Bivalent, bispecific antibodies |
US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
BRPI1014089A2 (pt) * | 2009-04-02 | 2016-04-19 | Roche Glycart Ag | anticorpos multiespecíficos que compreendem anticorpos de comprimento completo e fragmentos fab de cadeia simples |
JP5616428B2 (ja) | 2009-04-07 | 2014-10-29 | ロシュ グリクアート アクチェンゲゼルシャフト | 三価の二重特異性抗体 |
US9676845B2 (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
KR101570898B1 (ko) | 2009-06-18 | 2015-11-23 | 화이자 인코포레이티드 | 항-노치-1 항체 |
SG10201408401RA (en) | 2009-09-16 | 2015-01-29 | Genentech Inc | Coiled coil and/or tether containing protein complexes and uses thereof |
TW201138821A (en) | 2010-03-26 | 2011-11-16 | Roche Glycart Ag | Bispecific antibodies |
GB2482535A (en) * | 2010-08-05 | 2012-02-08 | Hera Pharmaceuticals Inc | Expression of antibody or a fragment thereof in lactobacillus |
GB2482536B (en) | 2010-08-05 | 2013-07-24 | Hera Pharmaceuticals Inc | Expression of antibody or a fragment thereof in lactobacillus |
WO2012022734A2 (en) | 2010-08-16 | 2012-02-23 | Medimmune Limited | Anti-icam-1 antibodies and methods of use |
WO2012025530A1 (en) | 2010-08-24 | 2012-03-01 | F. Hoffmann-La Roche Ag | Bispecific antibodies comprising a disulfide stabilized - fv fragment |
EP2651977A2 (de) | 2010-12-15 | 2013-10-23 | Wyeth LLC | Anti-notch1-antikörper |
WO2012085111A1 (en) | 2010-12-23 | 2012-06-28 | F. Hoffmann-La Roche Ag | Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery |
AR085403A1 (es) | 2011-02-28 | 2013-09-25 | Hoffmann La Roche | Proteinas monovalentes que se unen a antigenos |
RU2607038C2 (ru) | 2011-02-28 | 2017-01-10 | Ф. Хоффманн-Ля Рош Аг | Антигенсвязывающие белки |
CA2861124A1 (en) | 2012-02-10 | 2013-08-15 | Genentech, Inc. | Single-chain antibodies and other heteromultimers |
RU2015100656A (ru) | 2012-06-27 | 2016-08-20 | Ф. Хоффманн-Ля Рош Аг | Способ получения конъюгатов fc-фрагмента антитела, включающих по меньшей мере одну связывающую группировку, которая специфически связывается с мишенью, и их применения |
CN104395339A (zh) | 2012-06-27 | 2015-03-04 | 弗·哈夫曼-拉罗切有限公司 | 用于选择并产生含有至少两种不同结合实体的定制高度选择性和多特异性靶向实体的方法及其用途 |
JP6422956B2 (ja) | 2013-10-11 | 2018-11-14 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 多重特異性ドメイン交換共通可変軽鎖抗体 |
WO2015174439A1 (ja) * | 2014-05-13 | 2015-11-19 | 中外製薬株式会社 | 免疫抑制機能を有する細胞に対するt細胞リダイレクト抗原結合分子 |
CN107001482B (zh) | 2014-12-03 | 2021-06-15 | 豪夫迈·罗氏有限公司 | 多特异性抗体 |
WO2017086367A1 (ja) | 2015-11-18 | 2017-05-26 | 中外製薬株式会社 | 免疫抑制機能を有する細胞に対するt細胞リダイレクト抗原結合分子を用いた併用療法 |
Family Cites Families (99)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
CH668554A5 (de) | 1984-04-09 | 1989-01-13 | Sandoz Ag | Liposomen welche polypeptide mit interleukin-2-aktivitaet enthalten sowie verfahren zu ihrer herstellung. |
EP0169146A3 (de) | 1984-07-20 | 1988-07-20 | Merck & Co. Inc. | Monoklonale Antikörper gegen den Rezeptor des menschlichen Rhinovirus |
US4698420A (en) * | 1985-02-25 | 1987-10-06 | Xoma Corporation | Antibody hybrid molecules and process for their preparation |
US5077195A (en) * | 1985-03-01 | 1991-12-31 | Board Of Reagents, The University Of Texas System | Polypeptides complementary to peptides or proteins having an amino acid sequence or nucleotide coding sequence at least partially known and methods of design therefor |
US4975282A (en) | 1985-06-26 | 1990-12-04 | The Liposome Company, Inc. | Multilamellar liposomes having improved trapping efficiencies |
ES2039203T3 (es) | 1985-11-22 | 1993-09-16 | Takeda Chemical Industries, Ltd. | Composicion de liposomas. |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
US5869620A (en) * | 1986-09-02 | 1999-02-09 | Enzon, Inc. | Multivalent antigen-binding proteins |
US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
ATE87659T1 (de) | 1986-09-02 | 1993-04-15 | Enzon Lab Inc | Bindungsmolekuele mit einzelpolypeptidkette. |
US5260203A (en) * | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
JP2666345B2 (ja) | 1987-04-16 | 1997-10-22 | 武田薬品工業株式会社 | リポソーム製剤およびその製造法 |
US5284931A (en) | 1987-05-04 | 1994-02-08 | Dana Farber Cancer Institute | Intercellular adhesion molecules, and their binding ligands |
US5565550A (en) | 1987-05-04 | 1996-10-15 | Dana Farber Cancer Institute | Antibodies to ICAM-2, and fragments thereof |
ES2080044T3 (es) | 1987-05-04 | 1996-02-01 | Dana Farber Cancer Inst Inc | Moleculas de adhesion intercelular y sus ligandos de fijacion. |
US5273876A (en) | 1987-06-26 | 1993-12-28 | Syntro Corporation | Recombinant human cytomegalovirus containing foreign gene |
US5223409A (en) * | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
AU643189B2 (en) | 1988-09-06 | 1993-11-11 | Xoma Corporation | Production of chimeric mouse-human antibodies with specificity to human tumor antigens |
ES2077572T3 (es) | 1988-09-28 | 1995-12-01 | Dana Farber Cancer Inst Inc | Moleculas de adhesion intercelular, y sus ligandos de fijacion. |
IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
CA2045129A1 (en) | 1989-02-01 | 1990-08-02 | Alfred I. Geller | Herpes simplex virus type i expression vector |
US5665577A (en) | 1989-02-06 | 1997-09-09 | Dana-Farber Cancer Institute | Vectors containing HIV packaging sequences, packaging defective HIV vectors, and uses thereof |
EP0387701B1 (de) | 1989-03-09 | 1992-08-12 | Boehringer Ingelheim Pharmaceuticals Inc. | Verwendung von interzellularen Adhäsions-Molekülen und deren Bindungsliganden bei der Behandlung von Asthma |
US5081584A (en) * | 1989-03-13 | 1992-01-14 | United States Of America | Computer-assisted design of anti-peptides based on the amino acid sequence of a target peptide |
AU627591B2 (en) | 1989-06-19 | 1992-08-27 | Xoma Corporation | Chimeric mouse-human km10 antibody with specificity to a human tumor cell antigen |
US5324510A (en) | 1989-09-01 | 1994-06-28 | Boehringer Ingelheim Pharmaceuticals, Inc. | Use of antibodies to intercellular adhesion molecule-1 (ICAM-1) in the treatment of asthma |
KR910009285A (ko) | 1989-11-13 | 1991-06-28 | 원본미기재 | Hiv 항원에 특이적인 키메라형 생쥐-인간항체 |
AU634314B2 (en) | 1989-11-13 | 1993-02-18 | Green Cross Corporation, The | Chimeric mouse-human a10 antibody with specificity to a human tumor cell antigen |
WO1991007493A1 (en) | 1989-11-13 | 1991-05-30 | Xoma Corporation | Chimeric mouse human antibodies with specificity to hiv antigens |
US5264618A (en) | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
GB9009548D0 (en) | 1990-04-27 | 1990-06-20 | Celltech Ltd | Chimeric antibody and method |
GB9009549D0 (en) * | 1990-04-27 | 1990-06-20 | Celltech Ltd | Recombinant antibody and method |
EP0459577A3 (en) | 1990-06-01 | 1992-08-05 | Merck & Co. Inc. | Microbially expressed portions of a monoclonal antibody block rhinovirus attachment to cell receptors |
US5723286A (en) | 1990-06-20 | 1998-03-03 | Affymax Technologies N.V. | Peptide library and screening systems |
AU665176B2 (en) | 1990-09-21 | 1995-12-21 | Novartis Vaccines And Diagnostics, Inc. | Packaging cells |
US5582996A (en) * | 1990-12-04 | 1996-12-10 | The Wistar Institute Of Anatomy & Biology | Bifunctional antibodies and method of preparing same |
EP0572401B2 (de) | 1991-02-19 | 2007-11-07 | The Regents of the University of California | Viruspartikel mit veraendertem wirtspektrum |
GB9105383D0 (en) | 1991-03-14 | 1991-05-01 | Immunology Ltd | An immunotherapeutic for cervical cancer |
US5223396A (en) | 1991-05-03 | 1993-06-29 | Boehringer Ingelheim Pharmaceuticals, Inc. | Method for detecting organ transplant rejection |
DE69233254T2 (de) | 1991-06-14 | 2004-09-16 | Genentech, Inc., South San Francisco | Humanisierter Heregulin Antikörper |
EP0605522B1 (de) | 1991-09-23 | 1999-06-23 | Medical Research Council | Methoden zur Herstellung humanisierter Antikörper |
US5565332A (en) * | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
US5716805A (en) * | 1991-10-25 | 1998-02-10 | Immunex Corporation | Methods of preparing soluble, oligomeric proteins |
US6027725A (en) * | 1991-11-25 | 2000-02-22 | Enzon, Inc. | Multivalent antigen-binding proteins |
CA2122732C (en) | 1991-11-25 | 2008-04-08 | Marc D. Whitlow | Multivalent antigen-binding proteins |
US5932448A (en) | 1991-11-29 | 1999-08-03 | Protein Design Labs., Inc. | Bispecific antibody heterodimers |
JP4157160B2 (ja) | 1991-12-13 | 2008-09-24 | ゾーマ テクノロジー リミテッド | 改変抗体可変領域の調製のための方法 |
CA2128511C (en) | 1992-01-23 | 2006-11-07 | Andreas Pluckthun | Monomeric and dimeric antibody-fragment fusion proteins |
US6129914A (en) | 1992-03-27 | 2000-10-10 | Protein Design Labs, Inc. | Bispecific antibody effective to treat B-cell lymphoma and cell line |
AU3972893A (en) | 1992-04-03 | 1993-11-08 | Baylor College Of Medicine | Gene therapy using the intestine |
US6329507B1 (en) | 1992-08-21 | 2001-12-11 | The Dow Chemical Company | Dimer and multimer forms of single chain polypeptides |
US5639641A (en) * | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
US5832448A (en) * | 1996-10-16 | 1998-11-03 | Health Hero Network | Multiple patient monitoring system for proactive health management |
AU5670194A (en) * | 1992-11-20 | 1994-06-22 | Enzon, Inc. | Linker for linked fusion polypeptides |
AU6014094A (en) | 1992-12-02 | 1994-06-22 | Baylor College Of Medicine | Episomal vectors for gene therapy |
US5837242A (en) * | 1992-12-04 | 1998-11-17 | Medical Research Council | Multivalent and multispecific binding proteins, their manufacture and use |
US6307026B1 (en) * | 1992-12-10 | 2001-10-23 | Celltech Limited | Humanized antibodies directed against A33 antigen |
FR2702160B1 (fr) | 1993-03-02 | 1995-06-02 | Biovecteurs As | Vecteurs particulaires synthétiques et procédé de préparation. |
US5491074A (en) * | 1993-04-01 | 1996-02-13 | Affymax Technologies Nv | Association peptides |
CA2163218C (en) * | 1993-05-18 | 2002-09-10 | Mohamed Chokri | New macrophages, process for preparing the same and their use as active substances of pharmaceutical compositions |
JPH09510601A (ja) | 1993-11-12 | 1997-10-28 | ケース・ウエスタン・リザーブ・ユニバーシティ | ヒト遺伝子治療用のエピソーム発現ベクター |
US5928944A (en) | 1994-02-04 | 1999-07-27 | The United States Of America As Represented By The Department Of Health And Human Services | Method of adenoviral-medicated cell transfection |
US5731172A (en) | 1994-03-09 | 1998-03-24 | Sumitomo Pharmaceuticals Company, Ltd. | Recombinant adenovirus and process for producing the same |
GB9409768D0 (en) * | 1994-05-16 | 1994-07-06 | Medical Res Council | Trimerising polypeptides |
US5604090A (en) | 1994-06-06 | 1997-02-18 | Fred Hutchinson Cancer Research Center | Method for increasing transduction of cells by adeno-associated virus vectors |
US5763733A (en) * | 1994-10-13 | 1998-06-09 | Enzon, Inc. | Antigen-binding fusion proteins |
US5693508A (en) | 1994-11-08 | 1997-12-02 | Chang; Lung-Ji | Retroviral expression vectors containing MoMLV/CMV-IE/HIV-TAR chimeric long terminal repeats |
US5721340A (en) * | 1994-11-28 | 1998-02-24 | The Wistar Institute Of Anatomy & Biology | p53 proteins with altered tetramerization domains |
US5573925A (en) * | 1994-11-28 | 1996-11-12 | The Wistar Institute Of Anatomy And Biology | P53 proteins with altered tetramerization domains |
US5632448A (en) * | 1995-01-25 | 1997-05-27 | Ransburg Corporation | Rotary powder applicator |
US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
JP3770333B2 (ja) | 1995-03-15 | 2006-04-26 | 大日本住友製薬株式会社 | 組換えdnaウイルスおよびその製造方法 |
ATE274064T1 (de) * | 1995-05-23 | 2004-09-15 | Morphosys Ag | Multimere proteine |
US6110456A (en) | 1995-06-07 | 2000-08-29 | Yale University | Oral delivery or adeno-associated viral vectors |
JP2783276B2 (ja) * | 1995-07-04 | 1998-08-06 | 日本電気株式会社 | 半導体装置の製造方法 |
US5942433A (en) | 1995-07-31 | 1999-08-24 | The United States Of America As Represented By The Department Of Health And Human Services | Extension of a protein-protein interaction surface to inactivate the function of a cellular protein |
US6013516A (en) | 1995-10-06 | 2000-01-11 | The Salk Institute For Biological Studies | Vector and method of use for nucleic acid delivery to non-dividing cells |
JP2000504934A (ja) | 1995-12-22 | 2000-04-25 | バクスター バイオテク テクノロジー エス.アー.アール.エル. | 結合ドメインを含むグロビン |
ATE318147T1 (de) * | 1996-03-25 | 2006-03-15 | Medarex Inc | Spezifische monoklonale antikörperfür die extrazelluläre domäne von protasta-spezifischem membranantigen |
US5861397A (en) | 1996-10-03 | 1999-01-19 | Vical Incorporated | Piperazine based cytofectins |
US6096291A (en) | 1996-12-27 | 2000-08-01 | Biovector Therapeutics, S.A. | Mucosal administration of substances to mammals |
DK0971959T3 (da) * | 1997-04-07 | 2006-05-15 | Genentech Inc | Humaniserede antistoffer og fremgangsmåder til dannelse af humaniserede antistoffer |
DE69829995T2 (de) | 1997-12-01 | 2006-02-23 | Fang, Fang, San Diego | Multivalente rekombinante antikörper zur behandlung von hrv infektionen |
JPH11228446A (ja) * | 1998-02-16 | 1999-08-24 | Mitsubishi Chemical Corp | 抗マラリア剤 |
US20020165153A1 (en) | 1998-04-06 | 2002-11-07 | Peter Angel | Transcription factors and their use |
US5965712A (en) * | 1998-06-19 | 1999-10-12 | Virginia Commonwealth University | LZ-CD23 chimera for inhibition of IgE-mediated allergic disease |
SK287491B6 (sk) * | 1998-10-16 | 2010-11-08 | Biogen Idec Ma Inc. | Fúzne proteíny interferónu- beta-1a a ich použitie |
US20030035798A1 (en) * | 2000-08-16 | 2003-02-20 | Fang Fang | Humanized antibodies |
EP1135415B1 (de) | 1998-12-01 | 2010-08-11 | Facet Biotech Corporation | Humanisierte antikoerper gegen gamma-interferon |
CA2377513A1 (en) | 1999-06-25 | 2001-01-04 | Universitat Zurich | Hetero-associating coiled-coil peptides |
CA2384766A1 (en) | 1999-09-17 | 2001-03-22 | Genzyme Transgenics Corporation | Subunit optimized fusion proteins |
AUPQ425699A0 (en) * | 1999-11-25 | 1999-12-23 | University Of Newcastle Research Associates Limited, The | A method of treating a malignancy in a subject and a pharmaceutical composition for use in same |
JP2003516150A (ja) * | 1999-12-08 | 2003-05-13 | ジェンセット | 潜在性分泌タンパク質をコードする全長ヒトcDNA |
CN1440423A (zh) | 2000-04-28 | 2003-09-03 | 行星生物技术有限公司 | 预防鼻病毒感染的新型免疫粘附素 |
US20030138440A1 (en) | 2001-07-19 | 2003-07-24 | Fang Fang | Multimeric proteins and methods of making and using same |
JP4236000B2 (ja) | 2003-09-25 | 2009-03-11 | 元気株式会社 | 3次元画像処理装置、3次元画像処理方法及びプログラム |
-
2001
- 2001-07-19 US US09/910,483 patent/US20030035798A1/en not_active Abandoned
-
2002
- 2002-07-19 ES ES02798403T patent/ES2356896T3/es not_active Expired - Lifetime
- 2002-07-19 EP EP02798403A patent/EP1414861B1/de not_active Expired - Lifetime
- 2002-07-19 CA CA2793019A patent/CA2793019A1/en not_active Abandoned
- 2002-07-19 AT AT02798403T patent/ATE490276T1/de not_active IP Right Cessation
- 2002-07-19 AU AU2002363027A patent/AU2002363027C1/en not_active Ceased
- 2002-07-19 WO PCT/US2002/023002 patent/WO2003035696A2/en active Application Filing
- 2002-07-19 EP EP10010857A patent/EP2336186A1/de not_active Withdrawn
- 2002-07-19 DE DE60238485T patent/DE60238485D1/de not_active Expired - Lifetime
- 2002-07-19 CA CA2454361A patent/CA2454361C/en not_active Expired - Fee Related
- 2002-07-19 JP JP2003538209A patent/JP4516312B2/ja not_active Expired - Fee Related
- 2002-07-19 DK DK02798403.8T patent/DK1414861T3/da active
-
2006
- 2006-09-11 US US11/519,322 patent/US7696324B2/en not_active Expired - Fee Related
-
2008
- 2008-12-18 AU AU2008258214A patent/AU2008258214B2/en not_active Ceased
-
2009
- 2009-05-15 JP JP2009119326A patent/JP2009183303A/ja active Pending
-
2010
- 2010-03-26 US US12/748,304 patent/US8586712B2/en not_active Expired - Fee Related
-
2012
- 2012-06-07 AU AU2012203365A patent/AU2012203365A1/en not_active Abandoned
-
2013
- 2013-02-14 JP JP2013026399A patent/JP2013116119A/ja active Pending
- 2013-11-18 US US14/083,146 patent/US20140308269A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2009183303A (ja) | 2009-08-20 |
AU2002363027B2 (en) | 2008-09-18 |
JP2013116119A (ja) | 2013-06-13 |
AU2002363027C1 (en) | 2009-04-30 |
US20070071742A1 (en) | 2007-03-29 |
CA2454361C (en) | 2013-01-08 |
EP1414861A2 (de) | 2004-05-06 |
US20140308269A1 (en) | 2014-10-16 |
AU2012203365A1 (en) | 2012-06-28 |
US20030035798A1 (en) | 2003-02-20 |
CA2454361A1 (en) | 2003-05-01 |
CA2793019A1 (en) | 2003-05-01 |
WO2003035696A3 (en) | 2003-11-27 |
EP2336186A1 (de) | 2011-06-22 |
ATE490276T1 (de) | 2010-12-15 |
US8586712B2 (en) | 2013-11-19 |
EP1414861B1 (de) | 2010-12-01 |
AU2008258214A1 (en) | 2009-01-15 |
JP2005524385A (ja) | 2005-08-18 |
US20110044976A1 (en) | 2011-02-24 |
AU2008258214B2 (en) | 2012-03-08 |
DK1414861T3 (da) | 2011-03-21 |
WO2003035696A2 (en) | 2003-05-01 |
ES2356896T3 (es) | 2011-04-14 |
US7696324B2 (en) | 2010-04-13 |
JP4516312B2 (ja) | 2010-08-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE60238485D1 (de) | Humanisierte antikörper gegen icam-1, deren herstellung und verwendungen | |
ATE470714T1 (de) | Antikörper gegen doppelintegrinen, zusammensetzungen, verfahren und verwendungen | |
DE60140973D1 (de) | Kristallines und reines Modafinil und Verfahren zu seiner Herstellung | |
DE50303413D1 (de) | Befestigungsmittel und Verfahren zu seiner Herstellung | |
MXPA02011656A (es) | Moleculas de acido nucleico nrg-2, polipeptidos, y metodos de diagnostico y terapeuticos. | |
DE122012000001I1 (de) | Humane antikorper gegen CTLA-4 und deren verwendungen. | |
CY1109151T1 (el) | Αντισωματα dr4 και χρησεις αυτων | |
ATE309196T1 (de) | Verfahren zur herstellung von 3-aryloxy-3- arylpropylamine und deren zwischenprodukte | |
DE60013228D1 (de) | Sorptionsfähige verbundwerkstoffe die unabhängig sind von aktivierungsbehandlungen und verfahren zur herstellung | |
DE60141855D1 (de) | Antikörper gegen den rezeptor für den insulinähnlichen wachstumsfaktor i | |
DE59914538D1 (de) | Tetravalente Antikörperkonstrukte | |
ATE366746T1 (de) | Gegen das semp1-protein gerichtete antikörper, verfahren zu deren herstellung, und deren anwendungen | |
DE60328502D1 (de) | Verfahren zur herstellung von 2-amino-4,5,6,7-tetrahydro-6-aminobenzothiazolen aus cyclohexanen und cycylohexanonen als zwischenprodukte | |
DE60214035D1 (de) | Olefinisches thermoplastisches elastomer, verfahren zu seiner herstellung, olefinisches thermoplastisches elastomer enthaltende zusammensetzungen, verfahren zu ihrer herstellung und formkörper daraus | |
DE60017341D1 (de) | Emulsion, und Verfahren zur Herstellung von Emulsionen und öligen Zusammensetzungen | |
DE60227517D1 (de) | Verfahren zur herstellung von 10,11 dihydro 10 hydroxy 5h-dibenz/b,f/azepin-5-carbonsäureamid und 10,11 dihydro 10 oxo-5h-dibenz/b,f/azepin-5 carbonsäureamid | |
ATE362490T1 (de) | Monoklonale antikörper gegen den menschlichen ldl-rezeptor, deren herstellung und verwendung | |
DE69426767D1 (de) | Anti idiotypische Antikörper gegen Gonococcen und diese verwendende Verfahren und Zusammensetzungen. | |
DE69205752T2 (de) | Katalytische Zusammensetzung zum Deodorieren von Gasen und Verfahren zur Herstellung derselben. | |
DE69809284D1 (de) | Immunomodulator mit anti-mikrobakteriellen und anti-mykobakteriellen eigenschaften, verfahren zu seiner herstellung und pharmazeutische zusammensetzungen zur behandlung von mykobakteriosen sowie von chronischen und nicht-spezifischen lungenzuständen, sexuell übertragbaren krankheiten und den daraus resultierenden immunschwächen | |
DE60222806D1 (de) | Verfahren zur herstellung von (1,4,5)-oxadiazepinderivaten | |
ATE393160T1 (de) | Derivative von 9,10-dihydro-9-oxa-10- phosphaphenanthren-10-oxid | |
DE60218203D1 (de) | Verbindungen und verfahren zur behandlung einer hyperaktiven blase | |
DE60104789D1 (de) | Verfahren zur Herstellung von 2,4,5-Trialkylbenzaldehyden | |
ATE339423T1 (de) | Verfahren zur herstellung von 4'-o-substituierten 4'-demethyl-1 desoxypodophyllotoxinderivaten und geometrischen isomeren davon ,und antikrebspräparat, das diese enthält |