DE68919772D1 - Liposomen, an deren Oberfläche die Adsorption on Proteinen verhindert wird. - Google Patents

Liposomen, an deren Oberfläche die Adsorption on Proteinen verhindert wird.

Info

Publication number
DE68919772D1
DE68919772D1 DE68919772T DE68919772T DE68919772D1 DE 68919772 D1 DE68919772 D1 DE 68919772D1 DE 68919772 T DE68919772 T DE 68919772T DE 68919772 T DE68919772 T DE 68919772T DE 68919772 D1 DE68919772 D1 DE 68919772D1
Authority
DE
Germany
Prior art keywords
liposomes
adsorption
proteins
prevented
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE68919772T
Other languages
English (en)
Other versions
DE68919772T2 (de
Inventor
Hiroshi Yoshida
Hiroshi Goto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Terumo Corp
Original Assignee
Terumo Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Terumo Corp filed Critical Terumo Corp
Application granted granted Critical
Publication of DE68919772D1 publication Critical patent/DE68919772D1/de
Publication of DE68919772T2 publication Critical patent/DE68919772T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • A61K9/1271Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • A61K9/1271Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984Microcapsule with fluid core [includes liposome]
DE68919772T 1988-08-11 1989-08-11 Liposomen, an deren Oberfläche die Adsorption on Proteinen verhindert wird. Expired - Lifetime DE68919772T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP19891588 1988-08-11
JP1063507A JPH0720857B2 (ja) 1988-08-11 1989-03-17 リポソームおよびその製法

Publications (2)

Publication Number Publication Date
DE68919772D1 true DE68919772D1 (de) 1995-01-19
DE68919772T2 DE68919772T2 (de) 1995-07-13

Family

ID=26404636

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68919772T Expired - Lifetime DE68919772T2 (de) 1988-08-11 1989-08-11 Liposomen, an deren Oberfläche die Adsorption on Proteinen verhindert wird.

Country Status (5)

Country Link
US (3) US5676971A (de)
EP (1) EP0354855B1 (de)
JP (1) JPH0720857B2 (de)
DE (1) DE68919772T2 (de)
ES (1) ES2064470T3 (de)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0720857B2 (ja) * 1988-08-11 1995-03-08 テルモ株式会社 リポソームおよびその製法
GB8824593D0 (en) * 1988-10-20 1988-11-23 Royal Free Hosp School Med Liposomes
US6132763A (en) * 1988-10-20 2000-10-17 Polymasc Pharmaceuticals Plc Liposomes
US20010051183A1 (en) * 1989-10-20 2001-12-13 Alza Corporation Liposomes with enhanced circulation time and method of treatment
US5013556A (en) * 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
US20020150539A1 (en) * 1989-12-22 2002-10-17 Unger Evan C. Ultrasound imaging and treatment
US5626863A (en) * 1992-02-28 1997-05-06 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5462990A (en) * 1990-10-15 1995-10-31 Board Of Regents, The University Of Texas System Multifunctional organic polymers
US5380536A (en) 1990-10-15 1995-01-10 The Board Of Regents, The University Of Texas System Biocompatible microcapsules
JP3220180B2 (ja) * 1991-05-23 2001-10-22 三菱化学株式会社 薬剤含有タンパク質結合リポソーム
CA2117588C (en) 1992-02-28 1998-08-25 Jeffrey A. Hubbell Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5464696A (en) * 1992-08-13 1995-11-07 Bracco International B.V. Particles for NMR imaging
JP3351476B2 (ja) * 1993-01-22 2002-11-25 三菱化学株式会社 リン脂質誘導体及びそれを含有するリポソーム
US5359030A (en) * 1993-05-10 1994-10-25 Protein Delivery, Inc. Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same
US5885613A (en) * 1994-09-30 1999-03-23 The University Of British Columbia Bilayer stabilizing components and their use in forming programmable fusogenic liposomes
US5820873A (en) * 1994-09-30 1998-10-13 The University Of British Columbia Polyethylene glycol modified ceramide lipids and liposome uses thereof
GB9509016D0 (en) * 1995-05-03 1995-06-21 Royal Free Hosp School Med Tissue entrapment
US6673364B1 (en) 1995-06-07 2004-01-06 The University Of British Columbia Liposome having an exchangeable component
JP4018141B2 (ja) * 1995-11-01 2007-12-05 ブラッコ・リサーチ・ソシエテ・アノニム Nmr画像形成用の標的磁気標識分子マーカーシステム
JP3956402B2 (ja) * 1996-03-04 2007-08-08 日本油脂株式会社 アンホテリシンb運搬体
US5919480A (en) * 1996-06-24 1999-07-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Liposomal influenza vaccine composition and method
US6056973A (en) 1996-10-11 2000-05-02 Sequus Pharmaceuticals, Inc. Therapeutic liposome composition and method of preparation
TW520297B (en) * 1996-10-11 2003-02-11 Sequus Pharm Inc Fusogenic liposome composition and method
US6224903B1 (en) 1996-10-11 2001-05-01 Sequus Pharmaceuticals, Inc. Polymer-lipid conjugate for fusion of target membranes
US6103599A (en) * 1997-07-25 2000-08-15 Silicon Genesis Corporation Planarizing technique for multilayered substrates
US6734171B1 (en) 1997-10-10 2004-05-11 Inex Pharmaceuticals Corp. Methods for encapsulating nucleic acids in lipid bilayers
WO1999033493A1 (en) * 1997-12-23 1999-07-08 Inex Pharmaceuticals Corporation Polyamide oligomers
US6320017B1 (en) 1997-12-23 2001-11-20 Inex Pharmaceuticals Corp. Polyamide oligomers
CA2309373A1 (en) * 1999-05-27 2000-11-27 Johnson & Johnson Consumer Companies, Inc. Novel topical formulations
AU2136501A (en) * 1999-12-10 2001-06-18 Celator Technologies Inc. Lipid carrier compositions with protected surface reactive functions
EP1340494A4 (de) * 2000-11-10 2006-08-02 Univ Waseda Verfahren zur herstellung einer mikrosom-dispersion
US7713932B2 (en) 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
JPWO2003015753A1 (ja) * 2001-08-20 2004-12-02 テルモ株式会社 リポソーム製剤
NZ535355A (en) * 2002-02-15 2007-09-28 Merckle Gmbh Antibiotic conjugates
EP1483579A4 (de) * 2002-02-15 2006-07-12 Merckle Gmbh Konjugate biologisch aktiver verbindungen, verfahren zu ihrer herstellung und verwendung, formulierung und pharmazeutische anwendungen davon
US20040186063A1 (en) * 2002-02-15 2004-09-23 Hans-Jurgen Gutke Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
EP1483277A4 (de) 2002-02-15 2007-10-03 Merckle Gmbh Konjugate biologisch aktiver verbindungen, verfahren zu deren herstellung und anwendung, formulierung und pharmazeutische anwendungen davon
ES2411656T3 (es) * 2002-03-13 2013-07-08 Thomas SKÖLD Sistemas de administración a base de agua
ES2354607T3 (es) 2002-06-28 2011-03-16 Protiva Biotherapeutics Inc. Procedimiento y aparato para producir liposomas.
WO2004004635A2 (en) 2002-07-02 2004-01-15 Board Of Regents, The University Of Texas System Radiolabeled compounds and liposomes and their methods of making and using the same
CA2505918C (en) * 2002-11-15 2011-02-01 Nipro Corporation A liposome having bound albumin and peg
CA2504287A1 (en) 2002-11-26 2004-06-10 Nobex Corporation Natriuretic compounds, conjugates, and uses thereof
MXPA05007102A (es) 2002-12-31 2005-08-26 Bharat Serums & Vaccines Ltd Liposomas de larga circulacion sin peg.
US8980310B2 (en) * 2002-12-31 2015-03-17 Bharat Serums and Vaccines, Ltd. Non-pegylated long-circulating liposomes
JP2004307404A (ja) 2003-04-08 2004-11-04 Nipro Corp 人工酸素運搬体を含む医薬組成物
JP4804923B2 (ja) * 2003-09-03 2011-11-02 協和発酵キリン株式会社 グリセロール誘導体で修飾された化合物
CN1938048B (zh) * 2004-03-26 2010-05-12 泰尔茂株式会社 脂质体制剂
KR101223366B1 (ko) 2004-05-03 2013-01-16 헤르메스 바이오사이언스, 인코포레이티드 약물 전달에 유용한 리포좀
US7749485B2 (en) 2004-06-03 2010-07-06 Bracco Research S.A. Liposomal assembly for therapeutic and/or diagnostic use
JP4692983B2 (ja) 2004-07-12 2011-06-01 独立行政法人科学技術振興機構 リポソーム封入物質がエンドソームから脱出可能なリポソーム
US20090285878A1 (en) 2004-11-05 2009-11-19 Tekmira Pharmaceuticals Corporation Compositions and methods for stabilizing liposomal drug formulations
US20070298094A1 (en) * 2004-11-18 2007-12-27 Terumo Kabushiki Kaisha Medicinal Composition, Preparation and Combined Preparation
WO2006080452A1 (ja) * 2005-01-28 2006-08-03 Kyowa Hakko Kogyo Co., Ltd. 水溶性物質で表面修飾された微粒子の製造方法
JP2006248978A (ja) 2005-03-10 2006-09-21 Mebiopharm Co Ltd 新規なリポソーム製剤
US20090305409A1 (en) 2005-03-24 2009-12-10 National University Corporation Hokkaido University Liposome Capable of Effective Delivery of Given Substance Into Nucleus
WO2007005754A2 (en) * 2005-07-01 2007-01-11 Alza Corporation Liposomal delivery vehicle for hydrophobic drugs
CN101228171A (zh) * 2005-07-26 2008-07-23 默克勒有限公司 作为5-脂氧化酶和环加氧酶抑制剂的吡咯里嗪和中氮茚化合物的大环内酯偶联物
US20070055199A1 (en) 2005-08-10 2007-03-08 Gilbert Scott J Drug delivery device for buccal and aural applications and other areas of the body difficult to access
US20070154403A1 (en) * 2006-01-05 2007-07-05 Thomas Skold Oral, Pulmonary and Transmucosal Delivery Composition
JP5072275B2 (ja) * 2006-07-03 2012-11-14 テルモ株式会社 閉鎖小胞の分離方法、製剤の製造方法および評価方法
EP2127640A1 (de) * 2008-05-27 2009-12-02 Koninklijke Philips Electronics N.V. Modifizierte azid-enthaltende Proteine
JP5094696B2 (ja) * 2008-12-18 2012-12-12 テルモ株式会社 ヘモグロビン含有リポソーム懸濁液中のヘモグロビン及びヘモグロビン類縁物質の分離定量方法。
WO2010110471A1 (ja) * 2009-03-23 2010-09-30 国立大学法人北海道大学 脂質膜構造体
JPWO2011083845A1 (ja) * 2010-01-08 2013-05-16 富士フイルム株式会社 腫瘍部位に対する標的化剤
CN103037840A (zh) 2010-04-21 2013-04-10 国立大学法人北海道大学 具有核内转运性的脂质膜结构体
CN107252417A (zh) 2010-12-06 2017-10-17 梅里麦克制药股份有限公司 在使用包含蒽环类化疗剂的erbb2靶向免疫脂质体的治疗中防止心肌毒性的剂量和给药
US8993614B2 (en) 2012-03-15 2015-03-31 F. Hoffmann-La Roche Ag Substituted pyrrolidine-2-carboxamides
JP6057317B2 (ja) * 2012-04-05 2017-01-11 セイコーエプソン株式会社 分離装置
US9717724B2 (en) 2012-06-13 2017-08-01 Ipsen Biopharm Ltd. Methods for treating pancreatic cancer using combination therapies
AU2013202947B2 (en) 2012-06-13 2016-06-02 Ipsen Biopharm Ltd. Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan
CA2879139C (en) 2012-07-18 2021-05-11 Onyx Therapeutics, Inc. Liposomal compositions of epoxyketone-based proteasome inhibitors
JP2016501234A (ja) 2012-12-03 2016-01-18 メリマック ファーマスーティカルズ, インコーポレイテッドMerrimack Pharmaceuticals, Inc. Her2陽性癌を処置するための併用療法
CA2974196C (en) 2015-01-20 2023-12-12 TetraDerm Group LLC Versatile topical drug delivery vehicle and multifactorial tissue moisturizer that provides mucosal and skin barrier restoration
US11318131B2 (en) 2015-05-18 2022-05-03 Ipsen Biopharm Ltd. Nanoliposomal irinotecan for use in treating small cell lung cancer
KR20180037210A (ko) 2015-08-20 2018-04-11 입센 바이오팜 리미티드 암 치료를 위한 리포좀 이리노테칸 및 parp 저해제를 이용하는 조합요법
EP3337478B1 (de) 2015-08-21 2020-08-12 Ipsen Biopharm Ltd. Arzneimittelkombination enthaltend liposomales irinotecan, oxaliplatin, 5-fluorouracil und leucovorin zur behandlung von metastasierendem pankreaskrebs
KR20180063255A (ko) 2015-10-16 2018-06-11 입센 바이오팜 리미티드 캄프토테신 제약 조성물의 안정화
TWI754659B (zh) 2016-08-08 2022-02-11 台灣微脂體股份有限公司 用於製備含有弱酸性劑之微脂體組合物的傳輸載體、方法及套組
EP3535026A1 (de) 2016-11-02 2019-09-11 Ipsen Biopharm Limited Behandlung von magenkrebs durch kombinationstherapien mit liposomalem irinotecan, oxaliplatin, 5-fluoruracil (und leucovorin)
CN109996809A (zh) 2016-11-14 2019-07-09 诺华股份有限公司 与促融合蛋白minion相关的组合物、方法和治疗用途
EP3640237B1 (de) 2017-06-15 2024-02-28 National University Corporation Hokkaido University Lipidmembranstruktur zur verabreichung in sirna-zellen

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1578776A (en) * 1976-06-10 1980-11-12 Univ Illinois Hemoglobin liposome and method of making the same
US4217344A (en) * 1976-06-23 1980-08-12 L'oreal Compositions containing aqueous dispersions of lipid spheres
US4598051A (en) * 1980-03-12 1986-07-01 The Regents Of The University Of California Liposome conjugates and diagnostic methods therewith
US4331654A (en) * 1980-06-13 1982-05-25 Eli Lilly And Company Magnetically-localizable, biodegradable lipid microspheres
DE3161962D1 (en) * 1980-07-01 1984-02-23 Oreal Process for obtaining stable dispersions in an aqueous phase of at least a water immiscible liquid phase, and corresponding dispersions
US4534899A (en) * 1981-07-20 1985-08-13 Lipid Specialties, Inc. Synthetic phospholipid compounds
US4426330A (en) * 1981-07-20 1984-01-17 Lipid Specialties, Inc. Synthetic phospholipid compounds
US4429008B1 (en) * 1981-12-10 1995-05-16 Univ California Thiol reactive liposomes
US4480041A (en) * 1982-07-09 1984-10-30 Collaborative Research, Inc. Use of phosphotriester intermediates for preparation of functionalized liposomes
JPS59137409A (ja) * 1983-01-27 1984-08-07 Green Cross Corp:The ベンゾジアゼピン系化合物脂肪小体製剤
JPS6058915A (ja) * 1983-09-12 1985-04-05 Fujisawa Pharmaceut Co Ltd 薬物含有脂質小胞体製剤
JPS6072830A (ja) * 1983-09-29 1985-04-24 Kao Corp ベシクル用組成物
US4971803A (en) * 1985-04-08 1990-11-20 California Institute Of Technology Lamellar vesicles formed of cholesterol derivatives
AT393169B (de) * 1985-06-05 1991-08-26 Staudinger Gernot Verfahren und vorrichtung zur korngroessenanalyse
US4885172A (en) * 1985-06-26 1989-12-05 The Liposome Company, Inc. Composition for targeting, storing and loading of liposomes
JPS6295134A (ja) * 1985-10-21 1987-05-01 Nippon Saafuakutanto Kogyo Kk リポソ−ムの製造法
AU6593386A (en) * 1985-10-24 1987-05-19 Research Corp. Ltd. Biochemical reagent
GB8601100D0 (en) * 1986-01-17 1986-02-19 Cosmas Damian Ltd Drug delivery system
US4776991A (en) * 1986-08-29 1988-10-11 The United States Of America As Represented By The Secretary Of The Navy Scaled-up production of liposome-encapsulated hemoglobin
US4920016A (en) * 1986-12-24 1990-04-24 Linear Technology, Inc. Liposomes with enhanced circulation time
US4837028A (en) * 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US4855090A (en) * 1987-03-13 1989-08-08 Micro-Pak, Inc. Method of producing high aqueous volume multilamellar vesicles
US4948590A (en) * 1987-06-09 1990-08-14 Yale University Avidin or streptavidin conjugated liposomes
US4921838A (en) * 1987-06-16 1990-05-01 Trustees Of Boston University Angiogenic and blood perfusion inducing properties of amphiphilic compounds
US4853228A (en) * 1987-07-28 1989-08-01 Micro-Pak, Inc. Method of manufacturing unilamellar lipid vesicles
US4915951A (en) * 1987-12-03 1990-04-10 California Institute Of Technology Cryoprotective reagent
JPH0720857B2 (ja) * 1988-08-11 1995-03-08 テルモ株式会社 リポソームおよびその製法
GB8824593D0 (en) * 1988-10-20 1988-11-23 Royal Free Hosp School Med Liposomes
US4931361A (en) * 1988-11-18 1990-06-05 California Institute Of Technology Cryoprotective reagents in freeze-drying membranes
US5013556A (en) * 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5225212A (en) * 1989-10-20 1993-07-06 Liposome Technology, Inc. Microreservoir liposome composition and method
EP0525188B1 (de) * 1990-04-18 1995-03-01 Takeda Chemical Industries, Ltd. Liposomenzusammensetzung
JP3220180B2 (ja) * 1991-05-23 2001-10-22 三菱化学株式会社 薬剤含有タンパク質結合リポソーム

Also Published As

Publication number Publication date
EP0354855A2 (de) 1990-02-14
JPH02149512A (ja) 1990-06-08
EP0354855B1 (de) 1994-12-07
US5676971A (en) 1997-10-14
US5593622A (en) 1997-01-14
ES2064470T3 (es) 1995-02-01
DE68919772T2 (de) 1995-07-13
US5846458A (en) 1998-12-08
JPH0720857B2 (ja) 1995-03-08
EP0354855A3 (de) 1991-06-05

Similar Documents

Publication Publication Date Title
DE68919772T2 (de) Liposomen, an deren Oberfläche die Adsorption on Proteinen verhindert wird.
NO891726D0 (no) Anti-isingsbeleggblandinger.
DE68905687T2 (de) Kopfbaenderung.
DE69006441D1 (de) Flächenhaftverschluss.
DE3774959D1 (de) Ultraschall-zerstaeuber.
DE68919104D1 (de) Vollreifen.
NO891754L (no) Ikke-traaddannende fuktighets-herdende blandinger.
DE68902806T2 (de) Beschichtungsverfahren.
DE68915309T2 (de) Zerstäuber.
FI893616A0 (fi) Ny anvaendning foer 5-hetero-aryl- eller 5-arylsubstituerade imidazo/2,1-a/ isokinoliner.
DE3850329D1 (de) Thermoplastische Polymethacrylimidzusammensetzung.
DE68909457D1 (de) Beschichtungsverfahren.
DE68901000D1 (de) Beschichtungsverfahren.
DE68900848D1 (de) Radzierblende.
FI890699A0 (fi) Renin inhiberande aminosyraderivat.
DE68902527T2 (de) Rasierapparat.
IT8521944A0 (it) 1,4-diidropiridine-2-sostituite.
DE58905143D1 (de) Mitnehmeranordnung.
DE3777467D1 (de) Ultraschallzerstaeuber.
DE68922798D1 (de) Montierverfahren.
FI894455A0 (fi) 1,4-dihydropyridinderivat.
FI861950A (fi) 1,3-dioxan-etrar.
FI863300A (fi) 7-oxo-4-tia-1-azabicyclo/3,2,0/ hept-2-enderivat.
IT1229579B (it) 10 norantracicline.
FI865158A0 (fi) 1-h-pyrido/3,2//1,4/-tiaziner.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition