DE69032742T2 - Direkte radioetikettierung von antikörpern und sonstigen proteinen mittels technetium oder rhenium - Google Patents
Direkte radioetikettierung von antikörpern und sonstigen proteinen mittels technetium oder rheniumInfo
- Publication number
- DE69032742T2 DE69032742T2 DE69032742T DE69032742T DE69032742T2 DE 69032742 T2 DE69032742 T2 DE 69032742T2 DE 69032742 T DE69032742 T DE 69032742T DE 69032742 T DE69032742 T DE 69032742T DE 69032742 T2 DE69032742 T2 DE 69032742T2
- Authority
- DE
- Germany
- Prior art keywords
- addition
- technetium
- rhenium
- accomplished
- proteins
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/391,474 US5078985A (en) | 1989-08-09 | 1989-08-09 | Radiolabeling antibodies and other proteins with technetium or rhenium by regulated reduction |
US07/565,275 US5102990A (en) | 1989-08-09 | 1990-08-08 | Direct radiolabeling of antibodies and other proteins with technetium or rhenium |
PCT/US1990/004461 WO1991001754A1 (en) | 1989-08-09 | 1990-08-08 | Direct radiolabeling of antibodies and other proteins with technetium or rhenium |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69032742D1 DE69032742D1 (de) | 1998-12-10 |
DE69032742T2 true DE69032742T2 (de) | 1999-06-17 |
Family
ID=27013516
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69032742T Expired - Fee Related DE69032742T2 (de) | 1989-08-09 | 1990-08-08 | Direkte radioetikettierung von antikörpern und sonstigen proteinen mittels technetium oder rhenium |
Country Status (10)
Country | Link |
---|---|
US (3) | US5102990A (de) |
EP (1) | EP0486622B1 (de) |
JP (2) | JP3070763B2 (de) |
AT (1) | ATE172879T1 (de) |
AU (1) | AU650629B2 (de) |
CA (1) | CA2065299C (de) |
DE (1) | DE69032742T2 (de) |
DK (1) | DK0486622T3 (de) |
ES (1) | ES2125854T3 (de) |
WO (1) | WO1991001754A1 (de) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19911329A1 (de) * | 1998-03-27 | 2000-09-21 | Benes Ivan Friedrich | Humantherapeutisch anwendbares Radioimmunkonjugat und Verfahren zu seiner Herstellung |
Families Citing this family (127)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5164175A (en) * | 1986-12-10 | 1992-11-17 | Hoechst Aktiengesellschaft | Diagnostic aid containing an organ-specific substance labeled with technetium-99m |
US5612016A (en) * | 1988-04-01 | 1997-03-18 | Immunomedics, Inc. | Conjugates of antibodies and bifunctional ligands |
US5061641A (en) * | 1988-04-01 | 1991-10-29 | Immunomedics, Inc. | Method for radiolabeling proteins |
US5443816A (en) * | 1990-08-08 | 1995-08-22 | Rhomed Incorporated | Peptide-metal ion pharmaceutical preparation and method |
US5346687A (en) * | 1989-08-09 | 1994-09-13 | Rhomed Incorporated | Direct radiolabeling of antibody against stage specific embryonic antigen for diagnostic imaging |
US5759515A (en) * | 1989-08-09 | 1998-06-02 | Rhomed Incorporated | Polyvalent peptide pharmaceutical applications |
US5078985A (en) * | 1989-08-09 | 1992-01-07 | Rhomed, Incorporated | Radiolabeling antibodies and other proteins with technetium or rhenium by regulated reduction |
US5700444A (en) * | 1992-02-20 | 1997-12-23 | Rhomed Incorporated | Chemotactic peptide pharmaceutical applications |
US5985240A (en) * | 1989-08-09 | 1999-11-16 | Rhomed Incorporated | Peptide radiopharmaceutical applications |
US5460785A (en) * | 1989-08-09 | 1995-10-24 | Rhomed Incorporated | Direct labeling of antibodies and other protein with metal ions |
DK0486622T3 (da) * | 1989-08-09 | 1999-07-19 | Rhomed Inc | Direkte radiomærkning af antistoffer og andre proteiner med technetium eller rhenium |
US5630011A (en) * | 1990-12-05 | 1997-05-13 | Digital Voice Systems, Inc. | Quantization of harmonic amplitudes representing speech |
US5431899A (en) * | 1991-02-04 | 1995-07-11 | University Of Saskatchewan | Rotavirus VP6 as a diagnostic and targeting agent |
DE59207867D1 (de) * | 1991-02-05 | 1997-02-27 | Cis Bio International Saclay | Verfahren zur Herstellung einer mit Technetium-99m markierten organspezifischen Substanz |
JP2774378B2 (ja) * | 1991-02-08 | 1998-07-09 | ダイアテク,インコーポレイテッド | 映像用テクネチウム−99m標識化ポリペプチド |
US5645815A (en) | 1991-02-08 | 1997-07-08 | Diatide, Inc. | Radiolabled compounds for thrombus imaging |
US5317091A (en) * | 1991-02-27 | 1994-05-31 | Akzo N.V. | Technetium-99m labeling of proteins |
JPH06505990A (ja) * | 1991-02-27 | 1994-07-07 | アクゾ・エヌ・ヴエー | タンパク質のテクネチウム−99m標識 |
US5401489A (en) * | 1991-05-01 | 1995-03-28 | University Of New Mexico | Biomodulators as universal imaging agents |
WO1992021383A1 (en) * | 1991-06-03 | 1992-12-10 | Mallinckrodt Medical, Inc. | Radiolabelled somatostatin derivatives, their preparation and use |
US5738838A (en) * | 1992-02-20 | 1998-04-14 | Rhomed Incorporated | IKVAV peptide radiopharmaceutical applications |
US5556609A (en) * | 1992-02-20 | 1996-09-17 | Rhomed Incorporated | YIGSR peptide radiopharmaceutical applications |
ES2155447T3 (es) * | 1992-01-03 | 2001-05-16 | Rhomed Inc | Aplicaciones farmaceuticas de peptidos-iones metalicos. |
US5643549A (en) * | 1992-02-20 | 1997-07-01 | Rhomed Incorporated | Leukostimulatory agent for in vivo leukocyte tagging |
US5403573A (en) * | 1992-04-23 | 1995-04-04 | The Curators Of The University Of Missouri | Radiolabeled protein composition and method for radiation synovectomy |
US5746996A (en) * | 1994-06-03 | 1998-05-05 | Immunomedics, Inc. | Thiolation of peptides for radionuclide-based radiodetection and radiotherapy |
IL113610A0 (en) * | 1994-06-03 | 1995-08-31 | Immunomedics Inc | A method of radiolabeling a protein, radiolabeled proteins prepared thereby and diagnostic kits containing the same |
US5670132A (en) * | 1994-09-20 | 1997-09-23 | Immunomedics, Inc. | Modified radioantibody fragments for reduced renal uptake |
US6027711A (en) * | 1995-06-07 | 2000-02-22 | Rhomed Incorporated | Structurally determined metallo-constructs and applications |
US6066309A (en) | 1996-02-02 | 2000-05-23 | Rhomed Incorporated | Post-labeling stabilization of radiolabeled proteins and peptides |
US20010055563A1 (en) * | 1999-09-09 | 2001-12-27 | Rhomed Incorporated | Post-labeling stabilization of radiolabeled proteins and peptides |
US6080384A (en) * | 1997-03-25 | 2000-06-27 | American Biogenetic Sciences, Inc. | Methods for radionuclide-labeling of biomolecules and kits utilizing the same |
KR100501534B1 (ko) * | 1997-12-23 | 2005-10-26 | 정재민 | 방사성 동위원소 치료를 위한 방사성 레늄주석콜로이드 및 그 제법 |
US6759243B2 (en) | 1998-01-20 | 2004-07-06 | Board Of Trustees Of The University Of Illinois | High affinity TCR proteins and methods |
US20030176663A1 (en) * | 1998-05-11 | 2003-09-18 | Eidgenossische Technische Hochscule | Specific binding molecules for scintigraphy |
WO2000006243A2 (en) | 1998-07-28 | 2000-02-10 | Innerdyne, Inc. | Absorbable brachytherapy and chemotherapy delivery devices and methods |
CN1077440C (zh) * | 1998-11-27 | 2002-01-09 | 中国科学院上海原子核研究所 | 放射性铼标记锡硫胶体制剂、制备方法及其应用 |
US6682736B1 (en) * | 1998-12-23 | 2004-01-27 | Abgenix, Inc. | Human monoclonal antibodies to CTLA-4 |
PT2112166T (pt) | 1998-12-23 | 2019-01-30 | Pfizer | Anticorpos monoclonais humanos contra ctla-4 |
US7109003B2 (en) | 1998-12-23 | 2006-09-19 | Abgenix, Inc. | Methods for expressing and recovering human monoclonal antibodies to CTLA-4 |
US7049398B1 (en) * | 1999-08-12 | 2006-05-23 | Palatin Technologies, Inc. | Melanocortin metallopeptide constructs, combinatorial libraries and applications |
JP2004519410A (ja) * | 1999-08-12 | 2004-07-02 | パラチン テクノロジーズ インク. | メラノコルチンメタロペプチド構成体、無作為配列ライブラリー及び適用法 |
US7605238B2 (en) | 1999-08-24 | 2009-10-20 | Medarex, Inc. | Human CTLA-4 antibodies and their uses |
ATE354655T1 (de) | 1999-08-24 | 2007-03-15 | Medarex Inc | Humane antikörper gegen ctla-4 und deren verwendungen |
IL148797A0 (en) | 1999-10-01 | 2002-09-12 | Dmi Biosciences Inc | Metal-binding compounds and uses therefor |
EP1247095B1 (de) | 1999-12-06 | 2008-10-15 | Board Of Trustees Of The University Of Illinois | Hochaffine t-zellrezeptorproteine und verfahren |
EP1259548A1 (de) * | 2000-02-24 | 2002-11-27 | Eidgenössische Technische Hochschule Zürich | Antikörper gegen die ed-b domäne von fibronektin, konjugate die diesen antikörper enthalten, und deren verwendung zum nachweis und zur behandlung von angiogenese |
US6801270B2 (en) * | 2000-06-26 | 2004-10-05 | Reveo, Inc. | Backlight for a liquid crystal display having high light-recycling efficiency |
PL364358A1 (en) * | 2000-09-07 | 2004-12-13 | Schering Ag | Receptor in the edb fibronectin domain (ii) |
AU2002252444A1 (en) * | 2001-03-23 | 2002-10-08 | Board Of Regents, The University Of Texas System | Methods for inhibition of angiogenesis, tumor growth and metastasis by fully human anti-il8 and anti-muc18 in diverse types of tumors |
JP2005516965A (ja) * | 2001-12-28 | 2005-06-09 | アブジェニックス・インコーポレーテッド | 抗muc18抗体を使用する方法 |
JP2005514409A (ja) * | 2001-12-28 | 2005-05-19 | アブジェニックス・インコーポレーテッド | Muc18抗原に対する抗体の使用 |
WO2003057838A2 (en) * | 2001-12-28 | 2003-07-17 | Abgenix, Inc. | Antibodies against the muc18 antigen |
EP1461360B1 (de) * | 2002-01-03 | 2010-08-18 | Bayer Schering Pharma Aktiengesellschaft | Konjugate mit einem für die ed-b-domäne von fibronectin spezifischen antikörper, und deren verwendung zum nachweis und zur behandlung von tumoren |
IL164287A0 (en) * | 2002-04-12 | 2005-12-18 | Medarex Inc | Methods of treatment using ctla-4 antibodies |
WO2004035608A2 (en) * | 2002-10-18 | 2004-04-29 | Abgenix, Inc. | System and method for cleaving antibodies |
US7651689B2 (en) * | 2002-11-15 | 2010-01-26 | Albert Einstein College Of Medicine Of Yeshiva University | Methods of applying ionization radiation for therapy of infections |
WO2004050683A2 (en) | 2002-12-02 | 2004-06-17 | Abgenix, Inc. | Antibodies directed to tumor necrosis factor and uses thereof |
US7402385B2 (en) * | 2003-02-11 | 2008-07-22 | Albert Einstein College Of Medicine Of Yeshiva University | Radiolabeled antibodies for treatment of tumors |
US8067544B2 (en) | 2003-03-19 | 2011-11-29 | Curagen Corporation | Antibodies against T cell immunoglobulin domain and mucin domain 1 (TIM-1) antigen and uses thereof |
CA2530172A1 (en) * | 2003-06-27 | 2005-02-10 | Abgenix, Inc. | Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof |
EP2335727A3 (de) | 2004-07-16 | 2011-09-28 | Pfizer Products Inc. | Kombinationsbehandlung für nicht-hämatologische bösartige Erkrankungen mit einem anti-IGF-1R-Antikörper |
DK1827492T3 (da) | 2004-11-30 | 2010-11-22 | Curagen Corp | Antistoffer rettet mod GPNMB og anvendelser deraf |
AU2005319404B2 (en) | 2004-12-20 | 2011-10-20 | Amgen Fremont Inc. | Binding proteins specific for human Matriptase |
CA2602375C (en) | 2005-03-23 | 2018-07-24 | Genmab A/S | Antibodies against cd38 for treatment of multiple myeloma |
US8323645B2 (en) | 2005-03-24 | 2012-12-04 | Millennium Pharmaceuticals, Inc. | Antibodies that bind OV064 and methods of use therefor |
CA2615460A1 (en) * | 2005-08-08 | 2007-02-15 | Onconon, Llc | Antibody compositions, methods for treating neoplastic disease and methods for regulating fertility |
CA2629453C (en) | 2005-11-10 | 2018-03-06 | Curagen Corporation | Method of treating ovarian and renal cancer using antibodies against t cell immunoglobulin domain and mucin domain 1 (tim-1) antigen |
AU2006321593B2 (en) | 2005-12-07 | 2012-10-04 | E. R. Squibb & Sons, L.L.C. | CTLA-4 antibody dosage escalation regimens |
ATE552853T1 (de) | 2005-12-13 | 2012-04-15 | Medimmune Ltd | Proteine die spezifisch insulin-ähnliche wachstumsfaktoren binden, und deren anwendungen |
US8071323B2 (en) * | 2006-04-07 | 2011-12-06 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Human monoclonal antibodies that bind human insulin like growth factors and their use |
TW200813091A (en) | 2006-04-10 | 2008-03-16 | Amgen Fremont Inc | Targeted binding agents directed to uPAR and uses thereof |
CL2007002225A1 (es) | 2006-08-03 | 2008-04-18 | Astrazeneca Ab | Agente de union especifico para un receptor del factor de crecimiento derivado de plaquetas (pdgfr-alfa); molecula de acido nucleico que lo codifica; vector y celula huesped que la comprenden; conjugado que comprende al agente; y uso del agente de un |
JP5213075B2 (ja) * | 2007-06-15 | 2013-06-19 | ジェネラックス・コーポレイション | 腫瘍の画像化および/または処置のための微生物 |
US8253725B2 (en) * | 2007-12-28 | 2012-08-28 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Method and system for generating surface models of geometric structures |
KR20140001257A (ko) | 2008-05-13 | 2014-01-06 | 유니버시티 오브 캔사스 | 금속 추출 펩타이드(map) 태그 및 관련된 방법 |
RU2581962C2 (ru) | 2008-09-19 | 2016-04-20 | Медиммун Ллк | Нацеленные средства связывания, направленные на dll4, и их применение |
UA109633C2 (uk) | 2008-12-09 | 2015-09-25 | Антитіло людини проти тканинного фактора | |
WO2010072740A2 (en) | 2008-12-23 | 2010-07-01 | Astrazeneca Ab | TARGETED BINDING AGENTS DIRECTED TO α5β1 AND USES THEREOF |
CN102458437B (zh) | 2009-05-05 | 2015-06-10 | 诺维莫尼公司 | 抗il-17f抗体及其使用方法 |
WO2011044186A1 (en) | 2009-10-06 | 2011-04-14 | The Board Of Trustees Of The University Of Illinois | Human single-chain t cell receptors |
EP3520816B1 (de) | 2009-10-23 | 2022-08-31 | Takeda Pharmaceutical Company Limited | Anti-gcc-antikörpermoleküle sowie entsprechende zusammensetzungen und verfahren |
EP3279215B1 (de) | 2009-11-24 | 2020-02-12 | MedImmune Limited | Gezielte bindemittel gegen b7-h1 |
SI2580243T1 (sl) | 2010-06-09 | 2020-02-28 | Genmab A/S | Protitelesa proti humanemu CD38 |
KR101935058B1 (ko) | 2010-06-15 | 2019-01-03 | 젠맵 에이/에스 | 조직 인자에 대한 인간 항체 약물 접합체 |
EP3214442A1 (de) | 2010-10-25 | 2017-09-06 | F. Hoffmann-La Roche AG | Behandlung von gastrointestinalen entzündungen und psoriasis und asthmaentzündung und psoriasis a |
WO2012099871A1 (en) | 2011-01-17 | 2012-07-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Modulation of lrch4 activity and therapeutic application thereof |
WO2012136552A1 (en) | 2011-04-08 | 2012-10-11 | H. Lundbeck A/S | ANTIBODIES SPECIFIC TO PYROGLUTAMATED Αβ |
WO2012142164A1 (en) | 2011-04-12 | 2012-10-18 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Human monoclonal antibodies that bind insulin-like growth factor (igf) i and ii |
WO2012143523A1 (en) | 2011-04-20 | 2012-10-26 | Genmab A/S | Bispecifc antibodies against her2 |
UA117901C2 (uk) | 2011-07-06 | 2018-10-25 | Ґенмаб Б.В. | Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування |
KR20140091064A (ko) | 2011-11-16 | 2014-07-18 | 암젠 인크 | 표피 성장 인자 결실 돌연변이체 vⅲ 관련 장애를 치료하는 방법 |
AU2013217114B2 (en) | 2012-02-06 | 2017-03-30 | Inhibrx, Inc. | CD47 antibodies and methods of use thereof |
US9156915B2 (en) | 2012-04-26 | 2015-10-13 | Thomas Jefferson University | Anti-GCC antibody molecules |
US9187735B2 (en) | 2012-06-01 | 2015-11-17 | University Of Kansas | Metal abstraction peptide with superoxide dismutase activity |
EP3632462A1 (de) | 2012-07-06 | 2020-04-08 | Genmab B.V. | Dimerprotein mit dreifacher mutation |
WO2014006217A1 (en) | 2012-07-06 | 2014-01-09 | Genmab B.V. | Dimeric protein with triple mutations |
WO2014018863A1 (en) | 2012-07-27 | 2014-01-30 | The Board Of Trustees Of The University Of Illinois | Engineering t-cell receptors |
AU2013372331A1 (en) | 2013-01-10 | 2015-07-23 | Genmab B.V. | Human IgG1 Fc region variants and uses thereof |
TWI635098B (zh) | 2013-02-01 | 2018-09-11 | 再生元醫藥公司 | 含嵌合恆定區之抗體 |
CA2900468A1 (en) | 2013-02-06 | 2014-08-14 | Inhibrx Llc | Non-platelet depleting and non-red blood cell depleting cd47 antibodies and methods of use thereof |
EA201591700A1 (ru) | 2013-03-14 | 2015-12-30 | Ридженерон Фармасьютикалз, Инк. | Гибридные белки апелина и их применение |
WO2015023851A1 (en) | 2013-08-14 | 2015-02-19 | The Governing Council Of The University Of Toronto | Antibodies against frizzled proteins and methods of use thereof |
WO2015077607A1 (en) | 2013-11-22 | 2015-05-28 | The Board Of Trustees Of The University Of Illinois | Engineered high-affinity human t cell receptors |
EP3134439B1 (de) | 2014-04-21 | 2018-12-26 | Millennium Pharmaceuticals, Inc. | Anti-psyk-antikörpermoleküle und verwendung davon für eine auf syk abzielende therapie |
CN107073297B (zh) | 2014-07-08 | 2021-09-14 | 纽约大学 | Tau显像配体和其在Tau蛋白病的诊断和治疗中的用途 |
KR102586656B1 (ko) | 2014-07-11 | 2023-10-11 | 젠맵 에이/에스 | Axl에 결합하는 항체 |
JP6740906B2 (ja) * | 2015-02-12 | 2020-08-19 | コニカミノルタ株式会社 | 抗体結合蛍光体集積ナノ粒子、抗体結合蛍光体集積ナノ粒子の製造方法および免疫染色キット |
US10556952B2 (en) | 2015-03-30 | 2020-02-11 | Regeneron Pharmaceuticals, Inc. | Heavy chain constant regions with reduced binding to Fc gamma receptors |
PT3319993T (pt) | 2015-07-10 | 2020-04-22 | Genmab As | Conjugados de anticorpo-fármaco específicos de axl para tratamento de cancro |
GB201512215D0 (en) | 2015-07-13 | 2015-08-19 | Lundbeck & Co As H | Agents,uses and methods |
JO3711B1 (ar) | 2015-07-13 | 2021-01-31 | H Lundbeck As | أجسام مضادة محددة لبروتين تاو وطرق استعمالها |
FI3334761T3 (fi) | 2015-08-13 | 2023-08-14 | Univ New York | Vasta-ainepohjaisia molekyylejä, jotka ovat selektiivisiä Taun {p}Ser404-epitoopille, ja niiden käyttöjä tauopatian diagnosoinnissa ja hoidossa |
EP3334453A4 (de) | 2015-08-13 | 2019-02-06 | New York University | Antikörperbasierte, für das verkürzte asp421-epitop von tau spezifische moleküle und deren verwendungen in der diagnose und behandlung von tauopathie |
US11105807B2 (en) | 2015-09-28 | 2021-08-31 | Konica Minolta, Inc. | Method for estimating pathological tissue diagnosis result (Gleason score) of prostate cancer |
EP3426305A4 (de) | 2016-03-07 | 2020-01-08 | Actinium Pharmaceuticals, Inc. | Stabilisierte radioaktiv markierte anti-cd45-immunglobulinzusammensetzungen |
TN2018000419A1 (en) | 2016-07-12 | 2020-06-15 | H Lundbeck As | Antibodies specific for hyperphosphorylated tau and methods of use thereof. |
JP7277363B2 (ja) | 2016-11-01 | 2023-05-18 | ジェンマブ ビー.ブイ. | ポリペプチド変異体およびその使用 |
MA47019A (fr) | 2016-12-16 | 2021-04-21 | H Lundbeck As | Agents, utilisations et procédés |
EP3565836A1 (de) | 2017-01-04 | 2019-11-13 | H. Lundbeck A/S | Für hypophosphoryliertes tau spezifische antikörper zur behandlung von augenerkrankungen |
US10894833B2 (en) | 2017-07-20 | 2021-01-19 | H. Lundbeck A/S | Agents, uses and methods for treatment |
US20210107988A1 (en) | 2018-01-24 | 2021-04-15 | Genmab B.V. | Polypeptide variants and uses thereof |
JP7171702B2 (ja) * | 2018-03-23 | 2022-11-15 | 大塚製薬株式会社 | 標識化抗体分散液、spfs用キット |
BR112020026432A2 (pt) | 2018-07-13 | 2021-03-23 | Genmab A/S | variante de anticorpo, ácido nucleico isolado, vetor de expressão, ácido nucleico, combinação de ácidos nucleicos, veículo de dispensação, célula hospedeira recombinante, métodos para produção de uma variante de um anticorpo, para aumentar pelo menos uma função efetora de um anticorpo parental e para tratar uma doença, anticorpo, composição, composição farmacêutica, e, variante de anticorpo para uso |
KR20220003572A (ko) | 2019-04-24 | 2022-01-10 | 하이델베르크 파마 리서치 게엠베하 | 아마톡신 항체-약물 결합체 및 이의 용도 |
CN115066439A (zh) | 2020-01-10 | 2022-09-16 | 科凌生物医疗有限公司 | 上皮钙黏素特异性抗体 |
EP3909601A1 (de) | 2020-05-11 | 2021-11-17 | LeukoCom GmbH | Neuer antikörper, der spezifisch an menschliches ceacam1/3/5 bindet, und dessen verwendung |
Family Cites Families (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2043459A1 (de) * | 1969-05-05 | 1971-02-19 | Philips France | |
US3725295A (en) * | 1971-07-20 | 1973-04-03 | Atomic Energy Commission | Technetium labeling |
US4323546A (en) * | 1978-05-22 | 1982-04-06 | Nuc Med Inc. | Method and composition for cancer detection in humans |
US4305922A (en) * | 1978-10-04 | 1981-12-15 | University Patents, Inc. | Labeling proteins with 99m-Tc by ligand exchange |
US4424200A (en) * | 1979-05-14 | 1984-01-03 | Nuc Med Inc. | Method for radiolabeling proteins with technetium-99m |
US4472371A (en) * | 1979-10-29 | 1984-09-18 | Summa Medical Corporation | Radiolabeled antibody to anti-tumor associated antigen and process |
US4311688A (en) * | 1979-10-29 | 1982-01-19 | Serono Laboratories Inc. | Composition and method for cancer detection in humans |
US4348376A (en) * | 1980-03-03 | 1982-09-07 | Goldenberg Milton David | Tumor localization and therapy with labeled anti-CEA antibody |
US4331647A (en) * | 1980-03-03 | 1982-05-25 | Goldenberg Milton David | Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers |
US4421735A (en) * | 1980-04-17 | 1983-12-20 | The Massachusetts General Hospital | Radiolabeled diagnostic compositions and method for making the same |
US4427646A (en) * | 1981-04-02 | 1984-01-24 | Research Corporation | Use of radiolabeled peptide derived from crosslinked fibrin to locate thrombi in vivo |
US4470925A (en) * | 1982-05-05 | 1984-09-11 | E. I. Du Pont De Nemours And Company | Immunoglobulin half-molecules and process for producing hybrid antibodies |
US4479930A (en) * | 1982-07-26 | 1984-10-30 | Trustees Of The University Of Massachusetts | Amines coupled wth dicyclic dianhydrides capable of being radiolabeled product |
US4668503A (en) * | 1982-07-26 | 1987-05-26 | Trustees Of University Of Massachusetts | Process for labeling amines with 99m Tc |
DE3237573A1 (de) * | 1982-10-09 | 1984-04-12 | Hoechst Ag, 6230 Frankfurt | Technetium-99m-tri- und tetraphosphonate zur szintigraphischen dastellung res-haltiger organe und der lymphgefaesse und verfahren zu deren herstellung |
DE3331159A1 (de) * | 1983-08-30 | 1985-03-14 | Hoechst Ag, 6230 Frankfurt | N-(4-aminobenzoyl)-aminodicarbonsaeuren zur stabilisierung von technetium-99m-praeparaten, stabilisierte injektionspraeparate und verfahren zu ihrer herstellung |
US4732864A (en) * | 1983-10-06 | 1988-03-22 | E. I. Du Pont De Nemours And Company | Trace-labeled conjugates of metallothionein and target-seeking biologically active molecules |
DE3577274D1 (de) * | 1984-01-23 | 1990-05-31 | Inst Energiteknik | Zusammensetzung zur technetium-99m-markierung von proteinhaltigem material. |
US4647445A (en) * | 1984-03-28 | 1987-03-03 | Massachusetts Institute Of Technology | Radiolabelled lipoproteins and method for making same |
US4652440A (en) * | 1984-05-03 | 1987-03-24 | Paik Chang H | Method of stably radiolabeling antibodies with technetium and rhenium |
US4670545A (en) * | 1984-05-11 | 1987-06-02 | University Patents, Inc. | Chelating agents for technetium-99M |
US4810693A (en) * | 1985-02-08 | 1989-03-07 | Procyte Corporation | Method for inducing biological coverings in wounds |
US4622240A (en) * | 1985-11-12 | 1986-11-11 | Air Products And Chemicals, Inc. | Process for manufacturing thick-film electrical components |
EP0252951A4 (de) * | 1986-01-06 | 1988-09-07 | Univ Melbourne | Technetium-antikörper konjugate. |
US4877868A (en) * | 1986-03-12 | 1989-10-31 | Neorx Corporation | Radionuclide antibody coupling |
DE3728599A1 (de) * | 1986-12-10 | 1988-06-23 | Hoechst Ag | Verfahren zur herstellung einer mit technetium-99m-markierten organspezifischen substanz |
US5177192A (en) * | 1987-04-02 | 1993-01-05 | Centocor, Incorporated | Method for labeling antibodies with a metal ion |
DE3850497T2 (de) * | 1987-04-02 | 1995-02-23 | Centocor Inc | Methode zur markierung von antikörpern mit einem metallion. |
US5053493A (en) * | 1987-04-02 | 1991-10-01 | Centocor Cardiovascular Imaging Partners, L.P. | Method for labeling antibodies with a metal ion |
US5328679A (en) * | 1988-04-01 | 1994-07-12 | Immunomedics, Inc. | Methods for technetium/rhenium labeling of proteins |
US5061641A (en) * | 1988-04-01 | 1991-10-29 | Immunomedics, Inc. | Method for radiolabeling proteins |
US5128119A (en) * | 1989-06-12 | 1992-07-07 | Immunomedics, Inc. | Methods for technetium/rhenium labeling of f(ab1)2 fragments |
US4917878A (en) * | 1988-05-02 | 1990-04-17 | Thomas Jefferson University | Novel use of a radiolabelled antibody against stage specific embryonic antigen for the detection of occult abscesses in mammals |
US4986979A (en) * | 1989-03-14 | 1991-01-22 | Neorx Corporation | Imaging tissue sites of inflammation |
NZ314680A (en) * | 1989-05-09 | 2000-08-25 | Ortho Pharma Corp | Treating localised infection or inflammation with a therapeutically conjugated chemotactic peptide |
US5346687A (en) * | 1989-08-09 | 1994-09-13 | Rhomed Incorporated | Direct radiolabeling of antibody against stage specific embryonic antigen for diagnostic imaging |
DK0486622T3 (da) * | 1989-08-09 | 1999-07-19 | Rhomed Inc | Direkte radiomærkning af antistoffer og andre proteiner med technetium eller rhenium |
US5078985A (en) * | 1989-08-09 | 1992-01-07 | Rhomed, Incorporated | Radiolabeling antibodies and other proteins with technetium or rhenium by regulated reduction |
US5023237A (en) * | 1989-08-30 | 1991-06-11 | Procyte Corporation | Methods and compositions for healing ulcers |
US5059588A (en) * | 1989-10-13 | 1991-10-22 | Procyte Corporation, Incorporated | Methods and compositions for healing bone using gly his lys: copper |
US5011676A (en) * | 1990-03-27 | 1991-04-30 | Thomas Jefferson University | Method to directly radiolabel antibodies for diagnostic imaging and therapy |
US5344708A (en) * | 1992-05-12 | 1994-09-06 | E. I. Du Pont De Nemours And Company | Bulked random copolyamide yarns of nylon 6 and nylon 6,6 having enhanced dyeability |
-
1990
- 1990-08-08 DK DK90915377T patent/DK0486622T3/da active
- 1990-08-08 WO PCT/US1990/004461 patent/WO1991001754A1/en active IP Right Grant
- 1990-08-08 EP EP90915377A patent/EP0486622B1/de not_active Expired - Lifetime
- 1990-08-08 AT AT90915377T patent/ATE172879T1/de not_active IP Right Cessation
- 1990-08-08 US US07/565,275 patent/US5102990A/en not_active Ceased
- 1990-08-08 AU AU65434/90A patent/AU650629B2/en not_active Ceased
- 1990-08-08 CA CA002065299A patent/CA2065299C/en not_active Expired - Fee Related
- 1990-08-08 JP JP2514313A patent/JP3070763B2/ja not_active Expired - Fee Related
- 1990-08-08 ES ES90915377T patent/ES2125854T3/es not_active Expired - Lifetime
- 1990-08-08 DE DE69032742T patent/DE69032742T2/de not_active Expired - Fee Related
-
1992
- 1992-04-06 US US07/864,470 patent/US5277893A/en not_active Expired - Lifetime
-
1995
- 1995-02-16 US US08/389,269 patent/USRE35500E/en not_active Expired - Lifetime
-
1999
- 1999-08-11 JP JP11227755A patent/JP2000053590A/ja active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19911329A1 (de) * | 1998-03-27 | 2000-09-21 | Benes Ivan Friedrich | Humantherapeutisch anwendbares Radioimmunkonjugat und Verfahren zu seiner Herstellung |
Also Published As
Publication number | Publication date |
---|---|
CA2065299A1 (en) | 1991-02-10 |
EP0486622A4 (en) | 1992-08-12 |
EP0486622A1 (de) | 1992-05-27 |
USRE35500E (en) | 1997-05-06 |
US5102990A (en) | 1992-04-07 |
EP0486622B1 (de) | 1998-11-04 |
WO1991001754A1 (en) | 1991-02-21 |
JP3070763B2 (ja) | 2000-07-31 |
AU6543490A (en) | 1991-03-11 |
CA2065299C (en) | 2001-07-24 |
JPH05508699A (ja) | 1993-12-02 |
ES2125854T3 (es) | 1999-03-16 |
DK0486622T3 (da) | 1999-07-19 |
DE69032742D1 (de) | 1998-12-10 |
AU650629B2 (en) | 1994-06-30 |
US5277893A (en) | 1994-01-11 |
JP2000053590A (ja) | 2000-02-22 |
ATE172879T1 (de) | 1998-11-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69032742T2 (de) | Direkte radioetikettierung von antikörpern und sonstigen proteinen mittels technetium oder rhenium | |
EP0188256A3 (en) | Metal radionuclide labeled proteins for diagnosis and therapy | |
LV10178A (lv) | Fiziologiski saderigu glabajot stabilu cilveka olbaltumvielu preparatu iegusanas panemiens | |
UA32577C2 (uk) | Радіомічена сполука для утворення зображення тромбів при радіонуклідній діагностиці, радіофармацевтичний препарат та радіофармацевтична композиція на їх основі та комплект для приготування радіофармацевтичних препаратів | |
IE842979L (en) | Desulfatohirudins | |
ATE11372T1 (de) | Von vernetztem fibrin abgeleitete radiomarkierte peptide zur bestimmung von thrombi und die dieselben enthaltenden injektierbaren zusammensetzungen. | |
EP0629133A4 (de) | Pharmazeutische anwendungen auf der basis von protein- und peptid-metall-ionen. | |
EP0151239A3 (en) | Monoclonal antibodies specific to in vivo fragments derived from fibrinogen | |
DE69021000D1 (de) | Radiomarkierte Peptide mit Antikoagulanswirkung. | |
ATE273997T1 (de) | Zyklische hexapeptid somatostatin analoga | |
DK302288D0 (da) | Proteiner | |
FR2297034A1 (fr) | Composition pour la localisation d'isotopes radioactifs en medecine | |
EP0827412A4 (de) | Verwendung von peptid-radiopharmazeutika | |
ZA887113B (en) | Boronic acid adducts of rhenium and radioactive isotopes of rhenium dioxime complexes | |
SE8301549D0 (sv) | Peroxydiphosphate toothpaste composition | |
EP0433927A3 (en) | Substance to improve the recovery of annexins | |
CH613177A5 (en) | Process for labelling proteins using technetium | |
JPS5761725B2 (de) | ||
EP0446797A3 (en) | Synthetic peptides containing factor viia sequences and their use | |
ES1015609U (es) | Cepillo dental perfeccionado. | |
IL76121A0 (en) | Protein absorption enhancing agents | |
DE3875290D1 (de) | Verwendung eines vehikels mit hoher affinitaet zu tumoren. | |
IE902090L (en) | Technetium/rhenium labeling of proteins. | |
ES292940U (es) | Pulsera curativa | |
ZA848046B (en) | Monoclonal antibodies specific to in vivo fragments derived from fibrinogen |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |