DE69631330D1 - C-4' modifizierte adenosinkinaseinhibitoren - Google Patents

C-4' modifizierte adenosinkinaseinhibitoren

Info

Publication number: DE69631330D1
Authority: DE; Germany
Prior art keywords: kinase inhibitors; adenosine kinase; modified adenosine; modified; inhibitors
Prior art date: 1995-06-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE69631330T

Other languages

English (en)

Other versions

DE69631330T2 (de

Inventor

Serge H Boyer

Mark D Erion

Bheemarao G Ugarkar

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Metabasis Therapeutics Inc

Original Assignee

Sicor Inc

Gensia Sicor Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-07

Filing date

1996-06-07

Publication date

2004-02-19

1996-06-07 Application filed by Sicor Inc, Gensia Sicor Inc filed Critical Sicor Inc

2004-02-19 Application granted granted Critical

2004-02-19 Publication of DE69631330D1 publication Critical patent/DE69631330D1/de

2004-10-28 Publication of DE69631330T2 publication Critical patent/DE69631330T2/de

2016-06-08 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

OOXNYFKPOPJIOT-UHFFFAOYSA-N 5-(3-bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d]pyrimidin-4-amine;dihydrochloride Chemical class Cl.Cl.C=12C(N)=NC=NC2=NC(C=2C=NC(=CC=2)N2CCOCC2)=CC=1C1=CC=CC(Br)=C1 OOXNYFKPOPJIOT-UHFFFAOYSA-N 0.000 title 1
239000003121 adenosine kinase inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/14—Pyrrolo-pyrimidine radicals

DE69631330T 1995-06-07 1996-06-07 C-4' modifizierte adenosinkinaseinhibitoren Expired - Fee Related DE69631330T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US486161		1995-06-07
US08/486,161 US5674998A (en)	1989-09-15	1995-06-07	C-4' modified adenosine kinase inhibitors
PCT/US1996/010404 WO1996040705A1 (en)	1995-06-07	1996-06-07	C-4' modified adenosine kinase inhibitors

Publications (2)

Publication Number	Publication Date
DE69631330D1 true DE69631330D1 (de)	2004-02-19
DE69631330T2 DE69631330T2 (de)	2004-10-28

Family

ID=23930844

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69631330T Expired - Fee Related DE69631330T2 (de)	1995-06-07	1996-06-07	C-4' modifizierte adenosinkinaseinhibitoren

Country Status (24)

Country	Link
US (1)	US5674998A (de)
EP (1)	EP0832091B1 (de)
JP (1)	JPH11507387A (de)
KR (1)	KR19990022740A (de)
CN (1)	CN1190401A (de)
AP (1)	AP9701165A0 (de)
AT (1)	ATE257841T1 (de)
AU (1)	AU6178396A (de)
BG (1)	BG102163A (de)
BR (1)	BR9609013A (de)
CA (1)	CA2220642A1 (de)
CZ (1)	CZ392797A3 (de)
DE (1)	DE69631330T2 (de)
EA (1)	EA199800009A1 (de)
HU (1)	HUP9802193A3 (de)
IL (1)	IL122335A0 (de)
IS (1)	IS4621A (de)
MX (1)	MX9709859A (de)
NO (1)	NO975585L (de)
OA (1)	OA10639A (de)
PL (1)	PL323904A1 (de)
SK (1)	SK166097A3 (de)
TR (1)	TR199701539T1 (de)
WO (1)	WO1996040705A1 (de)

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YU25500A (sh)	1999-05-11	2003-08-29	Pfizer Products Inc.	Postupak za sintezu analoga nukleozida
US6831069B2 (en)	1999-08-27	2004-12-14	Ribapharm Inc.	Pyrrolo[2,3-d]pyrimidine nucleoside analogs
WO2001027114A1 (en) *	1999-08-27	2001-04-19	Icn Pharmaceuticals, Inc.	PYRROLO[2,3-d]PYRIMIDINE NUCLEOSIDE ANALOGS
US7071199B1 (en)	1999-09-17	2006-07-04	Abbott Gmbh & Cco. Kg	Kinase inhibitors as therapeutic agents
PT1212327E (pt)	1999-09-17	2004-01-30	Abbott Gmbh & Co Kg	Pirazolopirimidinas como agentes terapeuticos
WO2001043731A2 (en) *	1999-12-16	2001-06-21	Alcon, Inc.	Inhibitors of adenosine kinase for the treatment of optic nerve and retinal damage
WO2001058920A2 (fr) *	2000-02-10	2001-08-16	Mitsui Chemicals, Inc.	Procede de production selective d'un anomere derive d'un sucre 1-phosphoryle
US7638496B2 (en)	2000-02-15	2009-12-29	Valeant Pharmaceuticals North America	Nucleoside analogs with carboxamidine modified monocyclic base
US7414036B2 (en) *	2002-01-25	2008-08-19	Muscagen Limited	Compounds useful as A3 adenosine receptor agonists
AU2002951247A0 (en)	2002-09-06	2002-09-19	Alchemia Limited	Compounds that interact with kinases
BRPI0400869B8 (pt) *	2004-03-02	2021-05-25	Univ Estadual Campinas Unicamp	novos compostos derivados de 4-anilinoquinazolinas com propriedade inibidora de adenosinacinases
US9512125B2 (en)	2004-11-19	2016-12-06	The Regents Of The University Of California	Substituted pyrazolo[3.4-D] pyrimidines as anti-inflammatory agents
RS52458B (en)	2005-02-04	2013-02-28	Millennium Pharmaceuticals Inc.	E1 ENZYMING ENZYME INHIBITORS
EP1915053A2 (de) *	2005-08-12	2008-04-30	Merck & Co., Inc.	Neue 2'-c-methyl- und 4'-c-methyl-nukleosid-derivate
EP1989206B1 (de)	2006-02-02	2012-07-04	Millennium Pharmaceuticals, Inc.	Hemmer von e1-aktivierenden enzymen
MX2008012928A (es)	2006-04-04	2009-03-06	Univ California	Antagonistas de pi3-cinasa.
WO2009046448A1 (en)	2007-10-04	2009-04-09	Intellikine, Inc.	Chemical entities and therapeutic uses thereof
KR101897881B1 (ko)	2008-01-04	2018-09-12	인텔리카인, 엘엘씨	특정 화학 물질, 조성물 및 방법
US8193182B2 (en) *	2008-01-04	2012-06-05	Intellikine, Inc.	Substituted isoquinolin-1(2H)-ones, and methods of use thereof
EP2252293B1 (de)	2008-03-14	2018-06-27	Intellikine, LLC	Kinasehemmer und verwendungsverfahren
US8993580B2 (en)	2008-03-14	2015-03-31	Intellikine Llc	Benzothiazole kinase inhibitors and methods of use
EP3009436B1 (de)	2008-07-08	2019-06-05	Intellikine, LLC	Kinasehemmer und verwendungsverfahren
WO2010006072A2 (en)	2008-07-08	2010-01-14	The Regents Of The University Of California	Mtor modulators and uses thereof
JP5731978B2 (ja)	2008-09-26	2015-06-10	インテリカイン，エルエルシー	複素環キナーゼ阻害剤
EP2358720B1 (de)	2008-10-16	2016-03-02	The Regents of The University of California	Heteroarylkinasehemmer mit kondensierten ringen
US8476282B2 (en)	2008-11-03	2013-07-02	Intellikine Llc	Benzoxazole kinase inhibitors and methods of use
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CN106619647A (zh)	2011-02-23	2017-05-10	因特利凯有限责任公司	激酶抑制剂的组合及其用途
US8969363B2 (en)	2011-07-19	2015-03-03	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
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EP2751112B1 (de)	2011-09-02	2019-10-09	The Regents of The University of California	Substituierte pyrazolo[3,4-d]pyrimidine und ihre verwendung
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US8828998B2 (en)	2012-06-25	2014-09-09	Infinity Pharmaceuticals, Inc.	Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
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BR112015006828A8 (pt)	2012-09-26	2019-09-17	Univ California	composto, ou um sal farmaceuticamente aceitável do mesmo; composição farmacêutica; uso do composto; e método para modular a atividade de uma proteína ire1
US9481667B2 (en)	2013-03-15	2016-11-01	Infinity Pharmaceuticals, Inc.	Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
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US9751888B2 (en)	2013-10-04	2017-09-05	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
TWI657085B (zh)	2013-10-04	2019-04-21	英菲尼提製藥股份有限公司	雜環化合物及其用途
SG11201602595TA (en)	2013-10-11	2016-04-28	Alios Biopharma Inc	Substituted nucleosides, nucleotides and analogs thereof
EP3083618B1 (de)	2013-12-17	2018-02-21	Pfizer Inc	Neuartige 3,4-disubstituierte-1h-pyrrolo[2,3-b]pyridine und 4,5-disubstituierte 7h-pyrrolo[2,3-c]pyridazine als lrrk2-hemmer
JP6701088B2 (ja)	2014-03-19	2020-05-27	インフィニティーファーマシューティカルズ，インコーポレイテッド	Ｐｉ３ｋ−ガンマ媒介障害の治療で使用するための複素環式化合物
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EP3212201B1 (de)	2014-10-28	2022-10-19	BCI Pharma	Nukleosidkinaseinhibitoren
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1995
- 1995-06-07 US US08/486,161 patent/US5674998A/en not_active Expired - Fee Related
1996
- 1996-06-07 AU AU61783/96A patent/AU6178396A/en not_active Abandoned
- 1996-06-07 DE DE69631330T patent/DE69631330T2/de not_active Expired - Fee Related
- 1996-06-07 HU HU9802193A patent/HUP9802193A3/hu unknown
- 1996-06-07 PL PL96323904A patent/PL323904A1/xx unknown
- 1996-06-07 IL IL12233596A patent/IL122335A0/xx unknown
- 1996-06-07 TR TR97/01539T patent/TR199701539T1/xx unknown
- 1996-06-07 CA CA002220642A patent/CA2220642A1/en not_active Abandoned
- 1996-06-07 AP APAP/P/1997/001165A patent/AP9701165A0/en unknown
- 1996-06-07 CN CN96195383A patent/CN1190401A/zh active Pending
- 1996-06-07 CZ CZ973927A patent/CZ392797A3/cs unknown
- 1996-06-07 SK SK1660-97A patent/SK166097A3/sk unknown
- 1996-06-07 JP JP9502290A patent/JPH11507387A/ja not_active Ceased
- 1996-06-07 BR BR9609013-8A patent/BR9609013A/pt unknown
- 1996-06-07 EA EA199800009A patent/EA199800009A1/ru unknown
- 1996-06-07 WO PCT/US1996/010404 patent/WO1996040705A1/en active IP Right Grant
- 1996-06-07 KR KR1019970709182A patent/KR19990022740A/ko not_active Application Discontinuation
- 1996-06-07 AT AT96919442T patent/ATE257841T1/de not_active IP Right Cessation
- 1996-06-07 EP EP96919442A patent/EP0832091B1/de not_active Expired - Lifetime
1997
- 1997-11-26 IS IS4621A patent/IS4621A/is unknown
- 1997-12-03 OA OA70150A patent/OA10639A/en unknown
- 1997-12-03 NO NO975585A patent/NO975585L/no unknown
- 1997-12-08 MX MX9709859A patent/MX9709859A/es unknown
1998
- 1998-01-07 BG BG102163A patent/BG102163A/xx unknown

Also Published As

Publication number	Publication date
BR9609013A (pt)	1999-12-14
CZ392797A3 (cs)	1999-04-14
CA2220642A1 (en)	1996-12-19
EP0832091A1 (de)	1998-04-01
EP0832091B1 (de)	2004-01-14
KR19990022740A (ko)	1999-03-25
WO1996040705A1 (en)	1996-12-19
HUP9802193A2 (hu)	1999-05-28
US5674998A (en)	1997-10-07
EA199800009A1 (ru)	1998-06-25
OA10639A (en)	2002-09-17
PL323904A1 (en)	1998-04-27
AU6178396A (en)	1996-12-30
ATE257841T1 (de)	2004-01-15
DE69631330T2 (de)	2004-10-28
JPH11507387A (ja)	1999-06-29
NO975585D0 (no)	1997-12-03
AP9701165A0 (en)	1998-01-31
IS4621A (is)	1997-11-26
BG102163A (en)	1998-10-30
TR199701539T1 (xx)	1998-04-21
MX9709859A (es)	1998-08-30
CN1190401A (zh)	1998-08-12
HUP9802193A3 (en)	1999-10-28
IL122335A0 (en)	1998-04-05
NO975585L (no)	1998-02-05
SK166097A3 (en)	1999-06-11

Legal Events

Date	Code	Title	Description
2005-02-10	8364	No opposition during term of opposition
2005-03-24	8327	Change in the person/name/address of the patent owner	Owner name: METABASIS THERAPEUTICS,INC.(N.D.GES.D.STAATES DELA
2010-04-22	8339	Ceased/non-payment of the annual fee

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