EP0596034A4 - Purification of recombinant ciliary neurotrophic factor and c-terminal truncated ciliary neurotrophic factor and methods for treating peripheral nerve damage. - Google Patents

Purification of recombinant ciliary neurotrophic factor and c-terminal truncated ciliary neurotrophic factor and methods for treating peripheral nerve damage.

Info

Publication number: EP0596034A4
Authority: EP; European Patent Office
Prior art keywords: neurotrophic factor; ciliary neurotrophic; purification; methods; peripheral nerve
Prior art date: 1991-07-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP92917747A

Other languages

German (de)

French (fr)

Other versions

EP0596034A1 (en

Inventor

Franklin D Collins

Deborah Russell

John R Mcdonald

Erwin Freund

Larry J Wilhelm

Duane Mach Bonam

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Syntex USA LLC

Original Assignee

Syntex USA LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-07-23

Filing date

1992-07-21

Publication date

1995-05-24

1992-07-21 Application filed by Syntex USA LLC filed Critical Syntex USA LLC

1994-05-11 Publication of EP0596034A1 publication Critical patent/EP0596034A1/en

1995-05-24 Publication of EP0596034A4 publication Critical patent/EP0596034A4/en

Status Withdrawn legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

EP92917747A 1991-07-23 1992-07-21 Purification of recombinant ciliary neurotrophic factor and c-terminal truncated ciliary neurotrophic factor and methods for treating peripheral nerve damage. Withdrawn EP0596034A4 (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US753176		1985-07-09
US73553891A	1991-07-23	1991-07-23
US75317691A	1991-08-30	1991-08-30
PCT/US1992/006136 WO1993002206A1 (en)	1991-07-23	1992-07-21	Purification of recombinant ciliary neurotrophic factor and c-terminal truncated ciliary neurotrophic factor and methods for treating peripheral nerve damage
US735538		1996-10-23

Publications (2)

Publication Number	Publication Date
EP0596034A1 EP0596034A1 (en)	1994-05-11
EP0596034A4 true EP0596034A4 (en)	1995-05-24

Family

ID=27112907

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP92917747A Withdrawn EP0596034A4 (en)	1991-07-23	1992-07-21	Purification of recombinant ciliary neurotrophic factor and c-terminal truncated ciliary neurotrophic factor and methods for treating peripheral nerve damage.

Country Status (12)

Country	Link
EP (1)	EP0596034A4 (en)
JP (1)	JPH07500725A (en)
AU (1)	AU666327B2 (en)
CA (1)	CA2113815A1 (en)
FI (1)	FI940302A (en)
HU (1)	HUT67352A (en)
IE (1)	IE922402A1 (en)
IL (1)	IL102607A0 (en)
MX (1)	MXPA92004329A (en)
NO (2)	NO940194L (en)
NZ (1)	NZ243691A (en)
WO (1)	WO1993002206A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5349056A (en) *	1992-10-09	1994-09-20	Regeneron Pharmaceuticals	Modified ciliary neurotrophic factors
IT1288388B1 (en)	1996-11-19	1998-09-22	Angeletti P Ist Richerche Bio	USE OF SUBSTANCES THAT ACTIVATE THE CNTF RECEPTOR (NEUROTROPHIC CHILI FACTOR) FOR THE PREPARATION OF DRUGS FOR THERAPY
WO1999064058A1 (en) *	1998-06-10	1999-12-16	Bml, Inc.	Skin preparations for external use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0446931A1 (en) *	1990-03-14	1991-09-18	FIDIA S.p.A.	Human ciliary neuronotrophic factor, DNA sequence encoding the factor, and production of the factor by recombinant technology
WO1993010233A1 (en) *	1991-11-11	1993-05-27	Fidia S.P.A.	Synthesis and purification of truncated and mutein forms of human ciliary neuronotrophic factor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US501914A (en) *		1893-07-25		Method of building engine-foundations
US5011914A (en) *	1989-01-05	1991-04-30	Collins Franklin D	Purified ciliary neurotrophic factor
JPH04503811A (en) *	1989-03-15	1992-07-09	ザリージェンツオブザユニバーシティオブカリフォルニア	Purified ciliary neurotropin factor
IE903130A1 (en) *	1989-09-15	1991-03-27	Regeneron Pharma	Ciliary neurotrophic factor

1992
- 1992-07-21 AU AU24432/92A patent/AU666327B2/en not_active Ceased
- 1992-07-21 WO PCT/US1992/006136 patent/WO1993002206A1/en not_active Application Discontinuation
- 1992-07-21 JP JP5503057A patent/JPH07500725A/en active Pending
- 1992-07-21 CA CA002113815A patent/CA2113815A1/en not_active Abandoned
- 1992-07-21 HU HU9400133A patent/HUT67352A/en unknown
- 1992-07-21 EP EP92917747A patent/EP0596034A4/en not_active Withdrawn
- 1992-07-22 IL IL102607A patent/IL102607A0/en unknown
- 1992-07-23 NZ NZ243691A patent/NZ243691A/en unknown
- 1992-07-23 IE IE240292A patent/IE922402A1/en not_active Application Discontinuation
- 1992-07-23 MX MXPA92004329A patent/MXPA92004329A/en unknown
1994
- 1994-01-19 NO NO949194A patent/NO940194L/en unknown
- 1994-01-19 NO NO940194A patent/NO940194D0/en unknown
- 1994-01-21 FI FI940302A patent/FI940302A/en not_active Application Discontinuation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0446931A1 (en) *	1990-03-14	1991-09-18	FIDIA S.p.A.	Human ciliary neuronotrophic factor, DNA sequence encoding the factor, and production of the factor by recombinant technology
WO1993010233A1 (en) *	1991-11-11	1993-05-27	Fidia S.P.A.	Synthesis and purification of truncated and mutein forms of human ciliary neuronotrophic factor

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
A. NEGRO ET AL: "Synthesis, purification, and characterization of human ciliary neurotrophic factor from E.coli", JOURNAL OF NEUROSCIENCE RESEARCH, vol. 29, 1991, pages 251 - 260 *
G. BARBIN ET AL: "Purification of the chick eye ciliary neurothropic factor", JOURNAL OF NEUROCHEMISTRY, vol. 43, no. 5, 1984, pages 1468 - 1478 *
J. MCDONALD ET AL: "Expression and characterization of recombinant human ciliary neurotrphic factor from Escherichia coli", BIOCHIMICA BIOPHYSICA ACTA, vol. 1090, no. 1, 30 August 1991 (1991-08-30), pages 70 - 80 *
L-F LIN ET AL: "Isolation and characterization of ciliary neurotrpohic factor from rabbit sciatic nerves", JOURNAL OF BIOLOGICAL CHEMISTRY., vol. 265, no. 15, 25 May 1990 (1990-05-25), BALTIMORE US, pages 8942 - 8947 *
S. SAADAT ET AL: "Ciliary neurotrpohic factor induces cholinergic differentiation of rat sympathetic neurons in culture", JOURNAL OF CELL BIOLOGY, vol. 108, May 1989 (1989-05-01), pages 1807 - 1816 *
See also references of WO9302206A1 *

Also Published As

Publication number	Publication date
NO940194D0 (en)	1994-01-19
IL102607A0 (en)	1993-01-14
AU2443292A (en)	1993-02-23
NZ243691A (en)	1995-12-21
NO940194L (en)	1994-02-08
AU666327B2 (en)	1996-02-08
CA2113815A1 (en)	1993-02-04
EP0596034A1 (en)	1994-05-11
HU9400133D0 (en)	1994-05-30
FI940302A0 (en)	1994-01-21
HUT67352A (en)	1995-03-28
JPH07500725A (en)	1995-01-26
FI940302A (en)	1994-01-21
IE922402A1 (en)	1993-01-27
WO1993002206A1 (en)	1993-02-04
MXPA92004329A (en)	2005-04-01

Legal Events

Date	Code	Title	Description
1994-03-25	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1994-05-11	17P	Request for examination filed	Effective date: 19940120
1994-05-11	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE
1995-05-24	A4	Supplementary search report drawn up and despatched	Effective date: 19950406
1995-05-24	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE
1995-05-24	RHK1	Main classification (correction)	Ipc: C12N 15/12
1997-12-05	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN
1998-01-21	18W	Application withdrawn	Withdrawal date: 19971121

Publication	Publication Date	Title
GB2246132B (en)	1993-09-15	Purified and recombinant ciliary neurotrophic factor
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PT84850A (en)	1987-06-01	Process for isolating and purifying p.falciparum cs protein vaccine expressed in recombinant e.coli
IL109280A0 (en)	1994-07-31	Neurotrophins for treatment of depression
EP0596034A4 (en)	1995-05-24	Purification of recombinant ciliary neurotrophic factor and c-terminal truncated ciliary neurotrophic factor and methods for treating peripheral nerve damage.
GB9201920D0 (en)	1992-03-18	Novel treatment i
ZA925465B (en)	1994-01-21	Purification of recombinant ciliary neurotrophic factor and C-terminal truncated ciliary neurothropic factor and methods for treating peripheral nerve damage
GB9218027D0 (en)	1992-10-14	Novel method of treatment
EP0408146A3 (en)	1991-06-12	Method for the purification of therapeutically active recombinant acidic fibroblast growth factor
GB9202196D0 (en)	1992-03-18	Method of treatment
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GB9317943D0 (en)	1993-10-13	Treatment of laminitis
HU913022D0 (en)	1992-01-28	Fibroplast increasing factor for treating and preventing virus caused diseases
GB9201391D0 (en)	1992-03-11	Method of treatment
GB2266241B (en)	1996-02-28	Treatment of pastures
IL108464A0 (en)	1994-04-12	Methods of treatment using ciliary neurotrophic factor
SU1572547A1 (en)	1990-06-23	Method of treating direct inguinal hernia
GB9317989D0 (en)	1993-10-13	Treatment of laminitis
ZA923505B (en)	1993-02-24	Treatment of fatigue syndrome
GB9218597D0 (en)	1992-10-14	Novel method of treatment
GB9211272D0 (en)	1992-07-15	Treatment of catalysts
GB9218289D0 (en)	1992-10-14	Treated oxide catalysts