EP1141419A4 - Methods and compositions for identifying protease modulators - Google Patents

Methods and compositions for identifying protease modulators

Info

Publication number
EP1141419A4
EP1141419A4 EP99966678A EP99966678A EP1141419A4 EP 1141419 A4 EP1141419 A4 EP 1141419A4 EP 99966678 A EP99966678 A EP 99966678A EP 99966678 A EP99966678 A EP 99966678A EP 1141419 A4 EP1141419 A4 EP 1141419A4
Authority
EP
European Patent Office
Prior art keywords
compositions
methods
identifying protease
protease modulators
modulators
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99966678A
Other languages
German (de)
French (fr)
Other versions
EP1141419A1 (en
Inventor
Rolf Menzel
Shaojie Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Small Molecule Therapeutics Inc
Original Assignee
Small Molecule Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Small Molecule Therapeutics Inc filed Critical Small Molecule Therapeutics Inc
Publication of EP1141419A1 publication Critical patent/EP1141419A1/en
Publication of EP1141419A4 publication Critical patent/EP1141419A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983Viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/16011Herpesviridae
    • C12N2710/16111Cytomegalovirus, e.g. human herpesvirus 5
    • C12N2710/16122New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/24011Flaviviridae
    • C12N2770/24211Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
EP99966678A 1998-12-24 1999-12-23 Methods and compositions for identifying protease modulators Withdrawn EP1141419A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11358998P 1998-12-24 1998-12-24
US113589P 1998-12-24
PCT/US1999/031026 WO2000039348A1 (en) 1998-12-24 1999-12-23 Methods and compositions for identifying protease modulators

Publications (2)

Publication Number Publication Date
EP1141419A1 EP1141419A1 (en) 2001-10-10
EP1141419A4 true EP1141419A4 (en) 2002-03-20

Family

ID=22350343

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99966678A Withdrawn EP1141419A4 (en) 1998-12-24 1999-12-23 Methods and compositions for identifying protease modulators

Country Status (3)

Country Link
EP (1) EP1141419A4 (en)
AU (1) AU2217800A (en)
WO (1) WO2000039348A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002038799A2 (en) * 2000-11-07 2002-05-16 University Of Victoria Innovation And Development Corporation Detection of proteases and screening for protease inhibitors
WO2003035832A2 (en) * 2001-10-22 2003-05-01 Exelixis, Inc. Ctsls as modifiers of the p53 and apaf-1 pathways and methods of use
CA2474130C (en) * 2002-01-29 2011-04-05 Pyare Khanna Enzyme activation protease assay
US7452690B2 (en) 2003-01-28 2008-11-18 Discoverx Corporation Protease EFC cell surface fusion protein assay
EP1994178A4 (en) 2006-03-13 2009-11-11 Univ Leland Stanford Junior Detection of molecular interactions using a reduced affinity enzyme complementation reporter system
US8101373B2 (en) 2007-10-12 2012-01-24 Discoverx Corporation β-galactosidase donor fragments
WO2012178079A1 (en) 2011-06-23 2012-12-27 Discoverx Corporation Monitoring protein trafficking using beta-galactosidase reporter fragment complementation
US20200308591A1 (en) * 2019-03-28 2020-10-01 Eurofins Discoverx Corporation Promoter region analysis methods and cells for practicing same

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991015575A1 (en) * 1990-04-04 1991-10-17 Chiron Corporation Hepatitis c virus protease
WO1992003559A2 (en) * 1990-08-28 1992-03-05 Boehringer Ingelheim International Gmbh Test system for checking the activity of viral proteinases
WO1993001291A1 (en) * 1991-07-05 1993-01-21 The Johns Hopkins University Herpes virus proteinase and method of assaying
WO1997027320A1 (en) * 1996-01-26 1997-07-31 Boehringer Mannheim Corporation ASSAYS USING CROSS-LINKED POLYPEPTIDE FRAGMENTS OF β-GALACTOSIDASE
WO1999006537A1 (en) * 1997-07-30 1999-02-11 Boehringer Mannheim Corporation Cross-linked polypeptide assay components

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991015575A1 (en) * 1990-04-04 1991-10-17 Chiron Corporation Hepatitis c virus protease
WO1992003559A2 (en) * 1990-08-28 1992-03-05 Boehringer Ingelheim International Gmbh Test system for checking the activity of viral proteinases
WO1993001291A1 (en) * 1991-07-05 1993-01-21 The Johns Hopkins University Herpes virus proteinase and method of assaying
WO1997027320A1 (en) * 1996-01-26 1997-07-31 Boehringer Mannheim Corporation ASSAYS USING CROSS-LINKED POLYPEPTIDE FRAGMENTS OF β-GALACTOSIDASE
WO1999006537A1 (en) * 1997-07-30 1999-02-11 Boehringer Mannheim Corporation Cross-linked polypeptide assay components

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO0039348A1 *

Also Published As

Publication number Publication date
EP1141419A1 (en) 2001-10-10
WO2000039348A1 (en) 2000-07-06
AU2217800A (en) 2000-07-31

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