EP1223866A1 - Dispositif de prelevement d'echantillons - Google Patents

Dispositif de prelevement d'echantillons

Info

Publication number
EP1223866A1
EP1223866A1 EP00968131A EP00968131A EP1223866A1 EP 1223866 A1 EP1223866 A1 EP 1223866A1 EP 00968131 A EP00968131 A EP 00968131A EP 00968131 A EP00968131 A EP 00968131A EP 1223866 A1 EP1223866 A1 EP 1223866A1
Authority
EP
European Patent Office
Prior art keywords
container
probe
sampler device
sample
reservoir
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00968131A
Other languages
German (de)
English (en)
Inventor
Denis Marshall-Fraser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MARSHALL FRASER DENIS
Original Assignee
MARSHALL FRASER DENIS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9924449.3A external-priority patent/GB9924449D0/en
Application filed by MARSHALL FRASER DENIS filed Critical MARSHALL FRASER DENIS
Publication of EP1223866A1 publication Critical patent/EP1223866A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045Devices for taking samples of body liquids
    • A61B10/0051Devices for taking samples of body liquids for taking saliva or sputum samples
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/90Identification means for patients or instruments, e.g. tags
    • A61B90/94Identification means for patients or instruments, e.g. tags coded with symbols, e.g. text
    • A61B90/96Identification means for patients or instruments, e.g. tags coded with symbols, e.g. text using barcodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0096Casings for storing test samples
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B2010/0009Testing for drug or alcohol abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B50/00Containers, covers, furniture or holders specially adapted for surgical or diagnostic appliances or instruments, e.g. sterile covers
    • A61B2050/005Containers, covers, furniture or holders specially adapted for surgical or diagnostic appliances or instruments, e.g. sterile covers with a lid or cover
    • A61B2050/0067Types of closures or fasteners
    • A61B2050/0083Snap connection

Definitions

  • Drug abuse extends to all walks of life and persons in positions of trust such as heavy plant operators, airline pilots, train drivers, bus drivers etc. are sometimes randomly or routinely tested for drug abuse.
  • Current devices for testing for drugs are time consuming, cumbersome and require specialist knowledge to operate and frequently rely upon taking a blood sample from a subject
  • Samples taken from a subject alternatively or additionally may be held in storage for other tests in particular DNA tests. In this case it is desirable that test samples should be held in safe storage for prolonged periods of time until further tests, or research can be carried out.
  • the present invention provides a simple device for taking an sample from the mouth of a subject and storage means for storing said device and sample in a tamper evident container.
  • a sampler device comprising a probe for taking a sample, and a container into which the probe is an irreversible snap-fit after the taking of the sample.
  • the probe is preferably shaped for taking material from the gingival cavity of mammals.
  • the probe further comprises a stem with a handle and a shield located between the handle and the stem.
  • the shield forms a snap-fit lid to the container after the stem is inserted into the container and may include a sealing lip on the side of the shield adjacent the stem for sealing the container once the sample probe is retained therein.
  • the distal end portion of the stem has an absorbent sample collecting area which absorbs bodily exudates, preferably from inside the mouth and jaw.
  • the absorbent area comprises a pad of high salt concentrate which is covered in a semi-permeable membrane.
  • the container comprises and inner liquid retaining reservoir and an outer plastic sleeve cover into which the reservoir is sealed, the cover having an aperture with a tear-away lid, which aperture may closed after removal of the lid, by the probe when inserted.
  • the shield forms the snap-in lid for said aperture and the seal on the shield sits against the reservoir.
  • Each handle and/or cover may be given a unique bar code so that taken samples once sealed into the container cannot be mixed up or wrongly identified with other samples.
  • the handle and/or shield may be formed with a thinned down area to guide and permit a hyperdermic needle to be inserted through the lid for removing test samples from the container, and preferably the handle has a guide channel to the thinned area.
  • the reservoir may be formed from an optically transparent material e.g. glass or transparent plastics material, and the sleeve has openings therein on opposite sides of the reservoir to allow a directed light beam to pass through the container to excite or illuminate any suitable chemical solution stored within the reservoir.
  • the openings are located in the lower portion of the container so that any light beam passing through the container will not be distorted by the meniscus of any solution at the correct level within the reservoir.
  • a combination of enzymes and antibodies may be targeted at the direct metabolites of drugs and these may be detected in fluoroscene based solutions using optical transmissions through the solution to excite any the metabolites or derivatives thereof, as is described in US patent 5164504.
  • Other materials may be tested in situ in the tube using other chemistries and various light transmission and absorption techniques.
  • the container may be formed as a one piece container having optical windows formed in the lower half of the container.
  • a sample container having an aperture with a tear-away portion lid allowing a sample to be placed in the container through the aperture, and an irreversible snap fit lid which is insertable into the aperture to lock the sample therein.
  • Fig. 1 is a side view of a sample taking probe
  • Fig. 2 is an end elevation of the probe of Fig.l
  • Fig. 3 is a side view of a container reservoir
  • Fig. 4 is an end elevation of the reservoir of Fig.2
  • Fig. 5 is a side view of a container cover which fits over the reservoir
  • Fig. 6 is an end elevation of the cover shown in Fig.5
  • Fig. 7 is a side view of the cover and reservoir when assembled
  • Fig. 8 is an end view of the assembly of Fig.7
  • Fig. 9 is a side view of the container and probe in an assembled state
  • Fig. 10 is an end view of the container and probe shown in Fig 9
  • Fig. 11 shows an alternative container in the open and closed conditions.
  • a probe 11 for taking samples from the mouth or jaw of a person or animal suspected of drug abuse.
  • the probe 11 has a stem 12 with a handle 13 at one end with transverse rectangular shield 14 located between the stem and handle.
  • the distal end portion 15 of the stem is broadened out and has pad 16 on each side of the end portion which is formed from an absorptive material .
  • an absorptive material is a hypertonic salt as is described in US 5830 410.
  • the shield 14 on its side adjacent the stem 12 has a pair of resilient undercut catches 17 at opposite ends thereof, and a rectangular collar 18 around the stem 12.
  • the collar 18 has a peripheral seal 19 formed thereon.
  • the handle 13 may have a vertical channel 20 located therein extending into the shield to form a thinned or weakened area 20A which permits easier penetration of a hyperdermic needle allowing the extraction of fluids for tests. The rupture of the area 20A will also indicate if a sample has been tampered with.
  • a container 70 which will be used together with the probe 11.
  • the container comprises an inner reservoir 20 and an outer sleeve-like cover 40.
  • the probe and assembled container are supplied as a matched pair in sealed bags.
  • the distal end portion 15 of the probe 11 is placed in a suspects mouth between the gums and the cheek for a predetermined time period, probably about three minutes.
  • the pads 16 collect the bioexudate.
  • the shield 14 prevents any cross contamination between the handle and the stem and between the testers hands and suspects mouth.
  • the cover 42 is removed from the sealed container 70 by tearing off said cover, and the stem 12 of the probe 11 is pushed into the solution within the reservoir 20.
  • the catches 17 on the shield 14 engage within opening 47 on the cover to lock the probe within the container 70.
  • the seal 19 on the shield seats against the lip 22 around the mouth 21 of the reservoir to seal the taken sample and detection fluid within the container.
  • the locked in probe provides a tamper evident closure device once the sample has been placed within the detection fluid and the shield 14 snapped into place.
  • the arch shaped inclined edges 46 to the cut outs provide a location device within the reader and light proof seals.

Abstract

L'invention porte sur un dispositif de prélèvement d'échantillons dans la bouche d'un patient ou d'un animal comprenant une sonde (11) buccale et un récipient (70), où l'on place la sonde (11) après la prise, muni d'un cran (17, 47) permettant un encliquetage irréversible après insertion de la sonde (11).
EP00968131A 1999-10-18 2000-10-17 Dispositif de prelevement d'echantillons Withdrawn EP1223866A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB9924449 1999-10-18
GBGB9924449.3A GB9924449D0 (en) 1999-10-18 1999-10-18 Rapid drug detection system
GB0021698 2000-09-05
GB0021698A GB2355525A (en) 1999-10-18 2000-09-05 Sampling device for oral cavity
PCT/GB2000/003983 WO2001028428A1 (fr) 1999-10-18 2000-10-17 Dispositif de prelevement d'echantillons

Publications (1)

Publication Number Publication Date
EP1223866A1 true EP1223866A1 (fr) 2002-07-24

Family

ID=26244964

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00968131A Withdrawn EP1223866A1 (fr) 1999-10-18 2000-10-17 Dispositif de prelevement d'echantillons

Country Status (6)

Country Link
EP (1) EP1223866A1 (fr)
JP (1) JP2003511186A (fr)
CN (1) CN1379641A (fr)
AU (1) AU7808500A (fr)
CA (1) CA2386987A1 (fr)
WO (1) WO2001028428A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10399269B2 (en) 2013-12-20 2019-09-03 Xerox Corporation Three dimensional (3D) printing of epoxy, hardener, and parts of an object to be assembled later

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2391813B (en) * 2002-08-14 2006-03-29 Cozart Bioscience Ltd An oral fluid collection, transfer and transportation device and method
CA2552686A1 (fr) * 2003-11-12 2005-05-26 Trustees Of Boston University Extraction d'acide nucleique de cellules epitheliales de la bouche
AU2006236621B2 (en) 2005-04-14 2011-10-06 The Trustees Of Boston University Diagnostic for lung disorders using class prediction
CN101990577A (zh) 2007-09-19 2011-03-23 波士顿大学理事会 鉴定肺病药物开发的新途径
US9495515B1 (en) 2009-12-09 2016-11-15 Veracyte, Inc. Algorithms for disease diagnostics
JP6114566B2 (ja) * 2013-02-06 2017-04-12 公益財団法人鉄道総合技術研究所 トイレの尿汚れの判定方法
EP3626308A1 (fr) 2013-03-14 2020-03-25 Veracyte, Inc. Procédés d'évaluation de l'état d'une maladie pulmonaire obstructive chronique (copd)
CN104434227B (zh) * 2013-09-21 2017-05-10 邹建文 一种一次往返自锁口腔细胞采集与保存装置
CN104306029A (zh) * 2014-11-04 2015-01-28 温鑫 一种显色的组织渗液采样和检测装置
EP3770274A1 (fr) 2014-11-05 2021-01-27 Veracyte, Inc. Systèmes et procédés de diagnostic de la fibrose pulmonaire idiopathique sur des biopsies transbronchiques à l'aide de l'apprentissage automatique et de données de transcription dimensionnelle élevée
WO2018009915A1 (fr) 2016-07-08 2018-01-11 Trustees Of Boston University Biomarqueur basé sur l'expression génique pour la détection et la surveillance de lésions précancéreuses bronchiques
CN106190801A (zh) * 2016-07-17 2016-12-07 佛山市大臻医学检验所有限公司 分离式口腔采样拭子

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522302A (en) * 1984-03-05 1985-06-11 Sterling Drug Inc. Pre-sterilized medical procedure kit packages
US5479937A (en) 1989-09-21 1996-01-02 Epitope, Inc. Oral collection device
CA2007620A1 (fr) * 1990-02-11 1991-07-11 Charles Terrence Macartney Tube pour la collecte d'echantillons biologiques
US5164504A (en) 1991-01-16 1992-11-17 Abbott Laboratories Haptens, tracers, immunogens and antibodies for immunoassays for cotinine derivatives
US5609160A (en) * 1995-03-30 1997-03-11 Ortho Pharmaceutical Corporation In home oral fluid sample collection device and package for mailing of such device
AU3879595A (en) * 1995-12-01 1997-06-27 Lamprecht Ag Saliva sampling device

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO0128428A1 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10399269B2 (en) 2013-12-20 2019-09-03 Xerox Corporation Three dimensional (3D) printing of epoxy, hardener, and parts of an object to be assembled later

Also Published As

Publication number Publication date
CA2386987A1 (fr) 2001-04-26
WO2001028428A1 (fr) 2001-04-26
JP2003511186A (ja) 2003-03-25
CN1379641A (zh) 2002-11-13
AU7808500A (en) 2001-04-30

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