EP1324758B1 - Plga/pla-type polymer microspheres encapsulating a water-soluble substance and process thereof - Google Patents

Plga/pla-type polymer microspheres encapsulating a water-soluble substance and process thereof

Info

Publication number: EP1324758B1
Authority: EP; European Patent Office
Prior art keywords: plga; pla; water; type polymer; soluble substance
Prior art date: 2000-10-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

EP01971588A

Other languages

German (de)

French (fr)

Other versions

EP1324758A1 (en

Inventor

Frédéric LAGARCE

Odile Cruaud

Jean-Pierre Benoit

Christine Deuschel

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Debiopharm SA

Original Assignee

Debiopharm SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-03

Filing date

2001-10-03

Publication date

2005-01-12

2001-10-03 Application filed by Debiopharm SA filed Critical Debiopharm SA

2003-07-09 Publication of EP1324758A1 publication Critical patent/EP1324758A1/en

2005-01-12 Application granted granted Critical

2005-01-12 Publication of EP1324758B1 publication Critical patent/EP1324758B1/en

2021-10-03 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/282—Platinum compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

EP01971588A 2000-10-03 2001-10-03 Plga/pla-type polymer microspheres encapsulating a water-soluble substance and process thereof Expired - Lifetime EP1324758B1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
CH19412000		2000-10-03
CH194100		2000-10-03
PCT/CH2001/000596 WO2002028386A1 (en)	2000-10-03	2001-10-03	Method for preparing microspheres containing a water-soluble substance

Publications (2)

Publication Number	Publication Date
EP1324758A1 EP1324758A1 (en)	2003-07-09
EP1324758B1 true EP1324758B1 (en)	2005-01-12

Family

ID=4566851

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP01971588A Expired - Lifetime EP1324758B1 (en)	2000-10-03	2001-10-03	Plga/pla-type polymer microspheres encapsulating a water-soluble substance and process thereof

Country Status (5)

Country	Link
US (1)	US20040126431A1 (en)
EP (1)	EP1324758B1 (en)
AU (1)	AU2001291583A1 (en)
DE (1)	DE60108405D1 (en)
WO (1)	WO2002028386A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7829113B2 (en)	2005-03-10	2010-11-09	Mebiopharm Co., Ltd.	Liposome compositions

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2435415A1 (en) *	2001-01-26	2002-08-01	Debio Recherche Pharmaceutique S.A.	Microparticles of biodegradable polymer encapsulating a biologically active substance
FR2869801B1 (en) *	2004-05-05	2008-09-12	Ethypharm Sa	PROCESS FOR THE PREPARATION OF PROLONGED RELEASE COMPOSITIONS AND USE THEREOF FOR THE TREATMENT OF CHRONIC AFFECTIONS OF THE CENTRAL NERVOUS SYSTEM (CNS)
US20070253994A1 (en) *	2006-04-28	2007-11-01	Medtronic, Inc.	Intraspinal Drug Delivery Methods and Devices To Alleviate Chronic Pelvic Pain
US8940315B2 (en) *	2008-04-18	2015-01-27	Medtronic, Inc.	Benzodiazepine formulation in a polyorthoester carrier
US8956642B2 (en) *	2008-04-18	2015-02-17	Medtronic, Inc.	Bupivacaine formulation in a polyorthoester carrier
WO2010056065A2 (en) *	2008-11-14	2010-05-20	Ewha University-Industry Collaboration Foundation	Method for preparing microspheres and microspheres produced thereby
GB201016436D0 (en)	2010-09-30	2010-11-17	Q Chip Ltd	Method of making solid beads
GB201016433D0 (en)	2010-09-30	2010-11-17	Q Chip Ltd	Apparatus and method for making solid beads
CN105943506B (en) *	2016-06-22	2019-01-11	山东省药学科学院	One kind is absorbable from pore microsphere for injection and preparation method thereof
CN107596376A (en) *	2017-09-27	2018-01-19	同济大学	Compound medicine and preparation method and application
CN114634634A (en) *	2022-03-22	2022-06-17	陈凌卉	Biological function composite porous polyester microsphere and preparation method thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4389330A (en) *	1980-10-06	1983-06-21	Stolle Research And Development Corporation	Microencapsulation process
US5238714A (en) *	1990-10-02	1993-08-24	Board Of Regents, The University Of Texas System	Efficient microcapsule preparation and method of use
AU5416394A (en) *	1992-11-24	1994-06-22	Debiopharm S.A.	Cisplatinum/oxaliplatinum combination
PT929293E (en) *	1996-08-23	2004-03-31	Sequus Pharm Inc	LIPOSOMES CONTAINING A COMPOSITE OF CISPLATIN

2001
- 2001-10-03 DE DE60108405T patent/DE60108405D1/en not_active Expired - Lifetime
- 2001-10-03 WO PCT/CH2001/000596 patent/WO2002028386A1/en not_active Application Discontinuation
- 2001-10-03 AU AU2001291583A patent/AU2001291583A1/en not_active Abandoned
- 2001-10-03 EP EP01971588A patent/EP1324758B1/en not_active Expired - Lifetime
- 2001-10-03 US US10/398,024 patent/US20040126431A1/en not_active Abandoned

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7829113B2 (en)	2005-03-10	2010-11-09	Mebiopharm Co., Ltd.	Liposome compositions
US8758810B2 (en)	2005-03-10	2014-06-24	Mebiopharm Co., Ltd.	Liposome compositions

Also Published As

Publication number	Publication date
US20040126431A1 (en)	2004-07-01
WO2002028386A1 (en)	2002-04-11
EP1324758A1 (en)	2003-07-09
AU2001291583A1 (en)	2002-04-15
DE60108405D1 (en)	2005-02-17

Legal Events

Date	Code	Title	Description
2003-05-23	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2003-07-09	17P	Request for examination filed	Effective date: 20030429
2003-07-09	AK	Designated contracting states	Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
2003-07-09	AX	Request for extension of the european patent	Extension state: AL LT LV MK RO SI
2003-12-03	17Q	First examination report despatched	Effective date: 20031021
2004-06-16	RTI1	Title (correction)	Free format text: PLGA/PLA-TYPE POLYMER MICROSPHERES ENCAPSULATING A WATER-SOLUBLE SUBSTANCE AND PROCESS THEREOF
2004-06-25	GRAP	Despatch of communication of intention to grant a patent	Free format text: ORIGINAL CODE: EPIDOSNIGR1
2004-07-06	GRAP	Despatch of communication of intention to grant a patent	Free format text: ORIGINAL CODE: EPIDOSNIGR1
2004-11-17	GRAS	Grant fee paid	Free format text: ORIGINAL CODE: EPIDOSNIGR3
2004-11-26	GRAA	(expected) grant	Free format text: ORIGINAL CODE: 0009210
2004-12-08	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: DEBIOPHARM S.A.
2004-12-10	PUAC	Information related to the publication of a b1 document modified or deleted	Free format text: ORIGINAL CODE: 0009299EPPU
2004-12-17	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN
2005-01-12	AK	Designated contracting states	Kind code of ref document: B1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
2005-01-12	REG	Reference to a national code	Ref country code: GB Ref legal event code: FG4D Free format text: NOT ENGLISH
2005-01-14	REG	Reference to a national code	Ref country code: CH Ref legal event code: EP
2005-01-26	DB1	Publication of patent cancelled
2005-02-02	18W	Application withdrawn	Effective date: 20041130
2005-02-17	REF	Corresponds to:	Ref document number: 60108405 Country of ref document: DE Date of ref document: 20050217 Kind code of ref document: P
2005-02-23	REG	Reference to a national code	Ref country code: IE Ref legal event code: FG4D Free format text: FRENCH
2006-10-20	REG	Reference to a national code	Ref country code: FR Ref legal event code: ST Effective date: 20060630
2007-12-31	BERE	Be: lapsed	Owner name: DEBIOPHARM S.A. Effective date: 20051031

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