US20020198598A1 - Dynamic fusion mechanostat devices - Google Patents
Dynamic fusion mechanostat devices Download PDFInfo
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- US20020198598A1 US20020198598A1 US10/157,649 US15764902A US2002198598A1 US 20020198598 A1 US20020198598 A1 US 20020198598A1 US 15764902 A US15764902 A US 15764902A US 2002198598 A1 US2002198598 A1 US 2002198598A1
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- bone structures
- fusion device
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/4455—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/442—Intervertebral or spinal discs, e.g. resilient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/286—Bone stimulation by mechanical vibrations for enhancing ossification
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/3006—Properties of materials and coating materials
- A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30565—Special structural features of bone or joint prostheses not otherwise provided for having spring elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30621—Features concerning the anatomical functioning or articulation of the prosthetic joint
- A61F2002/30622—Implant for fusing a joint or bone material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S606/00—Surgery
- Y10S606/907—Composed of particular material or coated
- Y10S606/908—Bioabsorbable material
Definitions
- the present invention relates to dynamic bone fusion devices and associated techniques and, more particularly, to such fusion devices and associated techniques for effecting optimal spinal fusion.
- the present invention is directed to dynamic fusion devices, such as spinal implant devices for vertebral fusion, that are selected within the parameters of available data and modeling to determine optimum ranges of strain and loading for initiating and sustaining highly successful rates of fusion.
- dynamic fusion devices such as spinal implant devices for vertebral fusion
- various available data for a variety of fusion cases has been analyzed and is used as a basis for modeling the fusion conditions of vertebrae.
- data available from intra medullary nail systems is used with beam deflection principles to arrive at stiffness constants and applicable strain conditions for ideal states in which high fusion success rates are likely.
- FIG. 1 is a table illustrating bone fusion strain ranges and corresponding ossification characteristics.
- FIG. 2 is a schematic, side view of an intervertebral dynamic fusion device implanted between adjacent vertebrae according to the present invention.
- FIG. 3 is a table illustrating strain properties associated with typical bone fusion devices.
- FIG. 4 is a schematic, side view of an intervertebral dynamic fusion device implanted between adjacent vertebrae and having absorbable stiffening elements according to the present invention.
- An active zone for achieving successful rates of bone fusion is generally in the range of 0.0008-0.002 unit bone surface strain.
- Microstrains of 1700 have been used to perform studies on cell response to mechanical stimuli.
- Differences in mediators at rates of 200, 400 and 1000 microstrain have been observed.
- the strain-related variable which had the greatest influence on every remodeling parameter investigated was the ratio between the maximum strain rate of the artificial regime and the maximum strain rate during walking, or ambulation. The variation in this ratio accounts for approximately 70%-80% of the variation in the measurement of surface bone deposit. (O'Conner et al., J Biomech, 1982, 15(10): 767-81.)
- FIG. 3 Shown in FIG. 3, is a strain graph for various commercially available products including pedicle screws, vertebral implant cages, and long bone rods. Also included is the strain for a typical vertebral disc. As shown, the existing vertebral implants are outside of the target range of 0.5-15% strain, and certainly outside of the optimal range of 4-8%.
- the target or optimal ranges may be achieved by selecting dynamic fusion device materials and geometries that, together with physical parameters of the patient, create the ideal strain conditions identified above.
- a dynamic fusion device 10 for implanting between adjacent vertebrae 14 and 16 to be fused can be provided with compressive spring characteristics 12 along a vertical axis.
- performance may be enhanced with features that initially maintain the stiffness of the device and gradually reduce overall stiffness.
- polylactic acid inserts 18 designed to absorb after a predetermined time may be used to bolster the dynamic fusion device, adding stiffness and gradually reducing overall stiffness. Such a feature will, in appropriate instances, withhold excessive loading while ossification initiates and, after a desired period, increase the loading.
Abstract
A dynamic bone fusion device for facilitating fusion between bone sections, particularly vertebrae, is selected having certain stiffness to induce specific strain conditions associated with high success rates in bone fusion. Temporary stiffeners that are absorbable by the body may be implemented with the fusion device.
Description
- The present application claims priority from U.S. application Ser. No. 09/545,949 filed Apr. 10, 2000, now U.S. Pat. No. 6,395,033 B1, the disclosure of which is hereby incorporated by reference herein.
- The present invention relates to dynamic bone fusion devices and associated techniques and, more particularly, to such fusion devices and associated techniques for effecting optimal spinal fusion.
- It is known generally that, according to Wolff's law, every change in the form and function of a bone, or in its function alone, is followed by certain definite changes in its internal architecture and secondary alterations in its external conformation. (Stedman's Medical Dictionary, 26th Ed., 1995.) Based on this principle and others, dynamic bone fusion devices and procedures are designed to simulate strain conditions in which compressive forces are applied to the junction of bone segments to be fused, thereby initiating and sustaining fusion.
- The success rates of fusion depend on a variety of factors including the location and types of bones to be fused, and the techniques and devices used. There currently does not exist specific available data and correlating guidelines on the types of devices and techniques that, for a given set of parameters, provides ideal or optimum strain or loading conditions to initiate and sustain high success rate dynamic fusion. Nor does there currently exist specific available data for identifying ideal strain and loading conditions for vertebral dynamic fusion.
- It is an object of the present invention to provide devices and associated techniques for initiating and sustaining optimum dynamic bone fusion procedures and, particularly, such procedures for vertebral fusion. These objects and others are achieved by the present invention described herein.
- The present invention is directed to dynamic fusion devices, such as spinal implant devices for vertebral fusion, that are selected within the parameters of available data and modeling to determine optimum ranges of strain and loading for initiating and sustaining highly successful rates of fusion. In summary, various available data for a variety of fusion cases has been analyzed and is used as a basis for modeling the fusion conditions of vertebrae. Specifically, data available from intra medullary nail systems is used with beam deflection principles to arrive at stiffness constants and applicable strain conditions for ideal states in which high fusion success rates are likely.
- FIG. 1 is a table illustrating bone fusion strain ranges and corresponding ossification characteristics.
- FIG. 2 is a schematic, side view of an intervertebral dynamic fusion device implanted between adjacent vertebrae according to the present invention.
- FIG. 3 is a table illustrating strain properties associated with typical bone fusion devices.
- FIG. 4 is a schematic, side view of an intervertebral dynamic fusion device implanted between adjacent vertebrae and having absorbable stiffening elements according to the present invention.
- Applying Wolff's Law and analyzing data from various studies on bone mechanostat reaction to various strain rates, the present invention dynamic fusion device and its properties can be modeled. An active zone for achieving successful rates of bone fusion is generally in the range of 0.0008-0.002 unit bone surface strain. (Frost, H. M.,Clin Orthop May 1983, 286-92.) Microstrains of 1700 have been used to perform studies on cell response to mechanical stimuli. (Brighton et al., J Bone Joint Surg Am, September 1986, 78(9): 1337-47.) Differences in mediators at rates of 200, 400 and 1000 microstrain have been observed. (Brighton, JBJS 73A, March 1991, 320.) Data from tests applying a spatially uniform biaxial strain (1.3% applied strain) have been analyzed. (Toma, J Bone Miner Res, Oct. 12, 1997, 1626-36.)
- The highest strains were observed during distraction osteogenesis. Average maximum cyclic strains within the distraction zone during ambulation were estimated to be between 14% and 15%, and supported using fluoroscope imaging. These strains are higher than would be expected in spinal fusion, and thus serve as a high end limit for modeling. (Waanders et al.,Clin Orthop, April 1993, (349) 225-34.) Magnitudes of local strain are indicative of the type of fracture healing. (Claes, J Biomech, March 1999, 32(3): 255-66.) As shown in FIG. 1, up to 4% strain had more osteoblast proliferation than non-strained bone. Intramembranous bone formation was found for strains smaller than approximately 5% and small hydrostatic pressure. Strains less than 15% and hydrostatic pressure more than 0.15 MPa stimulated endochondral ossification. Larger strains led to connective tissue. (Claes, Clin Orthop, October 1998, (355 Suppl) S132-47.)
- The strain-related variable which had the greatest influence on every remodeling parameter investigated was the ratio between the maximum strain rate of the artificial regime and the maximum strain rate during walking, or ambulation. The variation in this ratio accounts for approximately 70%-80% of the variation in the measurement of surface bone deposit. (O'Conner et al.,J Biomech, 1982, 15(10): 767-81.)
- As a result of test data analysis and modeling using basic beam deflection equations for medullar nail systems, it is determined that the best range of strain for initiating and sustaining vertebral fusion between adjacent vertebrae for a
dynamic fusion device 10 implanted betweenadjacent vertebrae schematic spring element 12 represents the stiffness constant element. - Shown in FIG. 3, is a strain graph for various commercially available products including pedicle screws, vertebral implant cages, and long bone rods. Also included is the strain for a typical vertebral disc. As shown, the existing vertebral implants are outside of the target range of 0.5-15% strain, and certainly outside of the optimal range of 4-8%.
- The target or optimal ranges may be achieved by selecting dynamic fusion device materials and geometries that, together with physical parameters of the patient, create the ideal strain conditions identified above. As shown schematically in FIG. 4, a
dynamic fusion device 10 for implanting betweenadjacent vertebrae compressive spring characteristics 12 along a vertical axis. Optionally, performance may be enhanced with features that initially maintain the stiffness of the device and gradually reduce overall stiffness. For example,polylactic acid inserts 18 designed to absorb after a predetermined time may be used to bolster the dynamic fusion device, adding stiffness and gradually reducing overall stiffness. Such a feature will, in appropriate instances, withhold excessive loading while ossification initiates and, after a desired period, increase the loading. - While the preferred embodiment has been herein disclosed, it is understood and acknowledged that variation and modification to the preferred embodiment may be made without departing from the scope of the present invention.
Claims (13)
- 9. (New) A dynamic fusion device, which comprises:a spring mechanism positionable between adjacent bone structures, the spring mechanism having a spring constant to maintain a natural spacing between the bone structure and to simulate a strain condition in response to compressive forces on the bone structures sufficient to initiate and sustain fusion and healing thereof.
- 10. (New) The dynamic fusion device according to
claim 9 wherein the spring mechanism has a spring constant adapted to create a strain range between the bone structures ranging from about 0.5 to 15%. - 11. (New) The dynamic fusion device according to
claim 9 wherein the spring mechanism has a spring constant adapted to create a strain range between the bone structures ranging from about 2 to 10%. - 12. (New) The dynamic fusion device according to
claim 9 wherein the spring mechanism has a spring constant adapted to create a strain range between the bone structures ranging from about 4 to 8%. - 13. (New) The dynamic fusion device according to
claim 9 wherein the spring mechanism includes a stiffening element adapted to increase stiffness in the direction of the compressive force, the stiffening element comprising a bioabsorbable material. - 14. (New) The dynamic fusion device according to
claim 13 wherein the bioabsorbable material comprises a bioabsorbable polymeric material. - 15. (New) The dynamic fusion device according to
claim 9 wherein the spring mechanism is dimensioned to support adjacent vertebrae in spaced relation. - 16. (New) A method for facilitating healing of adjacent bone structures comprising the steps of:accessing an open space between adjacent bone structures; andpositioning a bone fusion device within the open space, the bone fusion device including a spring mechanism having a spring constant sufficient to support the adjacent bone structures in spaced relation and creating a strain condition in response to forces exerted on the bone structures sufficient to initiate and sustain ossification and fusion thereof.
- 17. (New) The method for facilitating healing of adjacent bone structures according to
claim 16 wherein the spring mechanism defines a spring constant which creates a strain condition having a strain range ranging from about 4% to 8%. - 18. (New) The method for facilitating healing of adjacent bone structures according to
claim 16 wherein the spring mechanism includes a bioabsorbable stiffening member, and further including the step of permitting the bioabsorbable member to absorb over time to gradually increase a load exerted on the spring mechanism. - 19. (New) The method for facilitating healing of adjacent bone structures according to
claim 16 wherein the spring mechanism includes a stiffening member comprising a bioabsorbable polymeric material, and further including the step of permitting the bioabsorbable member to absorb over time to gradually increase a load exerted on the spring mechanism. - 20. (New) A bone fusion device, which comprises:a spring element positionable relative to adjacent bone structures, the spring element having a spring constant sufficient to maintain the bone structures in spaced relation during healing; anda bioabsorbable stiffening element associated with the spring element, the stiffening element adapted to resist compressive forces exerted on the bone structures, the stiffening element being absorbable to increase a load on the spring element over a predetermined period of time.
- 21. (New) The bone fusion device according to claim 20 wherein the stiffening element comprises a bioabsorbable polymeric material.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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US10/157,649 US20020198598A1 (en) | 2000-04-10 | 2002-05-28 | Dynamic fusion mechanostat devices |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US09/545,949 US6395033B1 (en) | 2000-04-10 | 2000-04-10 | Dynamic fusion mechanostat devices |
US10/157,649 US20020198598A1 (en) | 2000-04-10 | 2002-05-28 | Dynamic fusion mechanostat devices |
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US09/545,949 Continuation US6395033B1 (en) | 2000-04-10 | 2000-04-10 | Dynamic fusion mechanostat devices |
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US20020198598A1 true US20020198598A1 (en) | 2002-12-26 |
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US09/545,949 Expired - Lifetime US6395033B1 (en) | 2000-04-10 | 2000-04-10 | Dynamic fusion mechanostat devices |
US10/157,649 Abandoned US20020198598A1 (en) | 2000-04-10 | 2002-05-28 | Dynamic fusion mechanostat devices |
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US09/545,949 Expired - Lifetime US6395033B1 (en) | 2000-04-10 | 2000-04-10 | Dynamic fusion mechanostat devices |
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AU (1) | AU2001247908A1 (en) |
WO (1) | WO2001076513A1 (en) |
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US8435301B2 (en) | 2002-08-15 | 2013-05-07 | DePuy Synthes Products, LLC | Artificial intervertebral disc implant |
US8454694B2 (en) | 2011-03-03 | 2013-06-04 | Warsaw Orthopedic, Inc. | Interbody device and plate for spinal stabilization and instruments for positioning same |
US9216096B2 (en) | 2010-03-16 | 2015-12-22 | Pinnacle Spine Group, Llc | Intervertebral implants and related tools |
US9380932B1 (en) | 2011-11-02 | 2016-07-05 | Pinnacle Spine Group, Llc | Retractor devices for minimally invasive access to the spine |
US10070970B2 (en) | 2013-03-14 | 2018-09-11 | Pinnacle Spine Group, Llc | Interbody implants and graft delivery systems |
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US8323341B2 (en) | 2007-09-07 | 2012-12-04 | Intrinsic Therapeutics, Inc. | Impaction grafting for vertebral fusion |
WO2009033100A1 (en) * | 2007-09-07 | 2009-03-12 | Intrinsic Therapeutics, Inc. | Bone anchoring systems |
WO2004100841A1 (en) | 1999-08-18 | 2004-11-25 | Intrinsic Therapeutics, Inc. | Devices and method for augmenting a vertebral disc nucleus |
US7220281B2 (en) * | 1999-08-18 | 2007-05-22 | Intrinsic Therapeutics, Inc. | Implant for reinforcing and annulus fibrosis |
US7998213B2 (en) | 1999-08-18 | 2011-08-16 | Intrinsic Therapeutics, Inc. | Intervertebral disc herniation repair |
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US7588577B2 (en) * | 2004-07-15 | 2009-09-15 | Wright Medical Technology, Inc. | Guide assembly for intramedullary fixation and method of using the same |
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US20060116766A1 (en) * | 2004-12-01 | 2006-06-01 | Jean-Philippe Lemaire | Anterior lumbar interbody implant |
AU2006269900A1 (en) | 2005-07-19 | 2007-01-25 | Stephen Ritland | Rod extension for extending fusion construct |
US7691130B2 (en) * | 2006-01-27 | 2010-04-06 | Warsaw Orthopedic, Inc. | Spinal implants including a sensor and methods of use |
US7959564B2 (en) | 2006-07-08 | 2011-06-14 | Stephen Ritland | Pedicle seeker and retractor, and methods of use |
US8771283B2 (en) | 2007-12-17 | 2014-07-08 | Wright Medical Technology, Inc. | Guide assembly for intramedullary fixation and method of using the same |
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US20020138145A1 (en) * | 1998-03-30 | 2002-09-26 | Marchosky J. Alexander | Prosthetic system |
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US20060235539A1 (en) * | 2003-02-03 | 2006-10-19 | Gordon Blunn | Surgical kit for hemiarthroplasty hip replacement |
US8034081B2 (en) | 2007-02-06 | 2011-10-11 | CollabComl, LLC | Interspinous dynamic stabilization implant and method of implanting |
US9216096B2 (en) | 2010-03-16 | 2015-12-22 | Pinnacle Spine Group, Llc | Intervertebral implants and related tools |
US9788973B2 (en) | 2010-03-16 | 2017-10-17 | Pinnacle Spine Group, Llc | Spinal implant |
US9649203B2 (en) | 2010-03-16 | 2017-05-16 | Pinnacle Spine Group, Llc | Methods of post-filling an intervertebral implant |
US8454694B2 (en) | 2011-03-03 | 2013-06-04 | Warsaw Orthopedic, Inc. | Interbody device and plate for spinal stabilization and instruments for positioning same |
US9526532B2 (en) | 2011-03-03 | 2016-12-27 | Warsaw Orthopedic, Inc. | Interbody device and plate for spinal stabilization and instruments for positioning same |
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US9925063B2 (en) | 2011-03-03 | 2018-03-27 | Warsaw Orthopedic, Inc. | Interbody device and plate for spinal stabilization and instruments for positioning same |
US9380932B1 (en) | 2011-11-02 | 2016-07-05 | Pinnacle Spine Group, Llc | Retractor devices for minimally invasive access to the spine |
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Also Published As
Publication number | Publication date |
---|---|
AU2001247908A1 (en) | 2001-10-23 |
US6395033B1 (en) | 2002-05-28 |
WO2001076513A1 (en) | 2001-10-18 |
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