WO2001032702A3 - Molecular structure of rhd negative locus - Google Patents
Molecular structure of rhd negative locus Download PDFInfo
- Publication number
- WO2001032702A3 WO2001032702A3 PCT/EP2000/010745 EP0010745W WO0132702A3 WO 2001032702 A3 WO2001032702 A3 WO 2001032702A3 EP 0010745 W EP0010745 W EP 0010745W WO 0132702 A3 WO0132702 A3 WO 0132702A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- rhesus
- relates
- rhd
- box
- molecular structure
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
Abstract
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00972884A EP1226169B1 (en) | 1999-11-02 | 2000-10-31 | Molecular structure of rhd negative locus |
US10/129,580 US9034573B1 (en) | 1999-11-02 | 2000-10-31 | Molecular structure of RHD negative |
CNB008177775A CN100475842C (en) | 1999-11-02 | 2000-10-31 | Molecular structure of RHD negative genes locus |
DE60033954T DE60033954T2 (en) | 1999-11-02 | 2000-10-31 | MOLECULAR STRUCTURE OF THE RHD-NEGATIVE GENESIS |
JP2001535401A JP4620920B2 (en) | 1999-11-02 | 2000-10-31 | Molecular structure of RHD negative locus |
AU11455/01A AU784319B2 (en) | 1999-11-02 | 2000-10-31 | Molecular structure of RHD negative locus |
AU2006202359A AU2006202359B2 (en) | 1999-11-02 | 2006-06-02 | Molecular structure of RHD negative locus |
US12/390,982 US9217181B2 (en) | 1999-11-02 | 2009-02-23 | Molecular structure of RHD negative |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99121686 | 1999-11-02 | ||
EP99121686.2 | 1999-11-02 | ||
EP00111696.1 | 2000-05-31 | ||
EP00111696 | 2000-05-31 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/129,580 A-371-Of-International US9034573B1 (en) | 1999-11-02 | 2000-10-31 | Molecular structure of RHD negative |
US12/390,982 Division US9217181B2 (en) | 1999-11-02 | 2009-02-23 | Molecular structure of RHD negative |
Publications (4)
Publication Number | Publication Date |
---|---|
WO2001032702A2 WO2001032702A2 (en) | 2001-05-10 |
WO2001032702A9 WO2001032702A9 (en) | 2001-10-11 |
WO2001032702A3 true WO2001032702A3 (en) | 2002-02-28 |
WO2001032702B1 WO2001032702B1 (en) | 2002-03-28 |
Family
ID=26071006
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2000/010745 WO2001032702A2 (en) | 1999-11-02 | 2000-10-31 | Molecular structure of rhd negative locus |
Country Status (9)
Country | Link |
---|---|
US (2) | US9034573B1 (en) |
EP (2) | EP1780217B1 (en) |
JP (1) | JP4620920B2 (en) |
CN (1) | CN100475842C (en) |
AT (2) | ATE462722T1 (en) |
AU (2) | AU784319B2 (en) |
DE (2) | DE60044105D1 (en) |
ES (2) | ES2283324T3 (en) |
WO (1) | WO2001032702A2 (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001081621A2 (en) * | 2000-04-20 | 2001-11-01 | Adnagen Ag | Method, diagnostic kit and microarray for determining the rhesus factor |
US20080261205A1 (en) * | 2004-02-06 | 2008-10-23 | Canadian Blood Services | Method for the Simultaneous Determination of Blood Group and Platelet Antigen Genotypes |
CN1570148B (en) * | 2004-03-25 | 2010-08-18 | 深圳市血液中心 | Individual RHD gene zygote type detection PCR primer and detergent kit and detection method |
AU2008213634B2 (en) | 2007-02-08 | 2013-09-05 | Sequenom, Inc. | Nucleic acid-based tests for RhD typing, gender determination and nucleic acid quantification |
CA2731086A1 (en) * | 2008-07-18 | 2010-01-21 | Wen-Hua Fan | Non-invasive fetal rhd genotyping from maternal whole blood |
US20110070590A1 (en) | 2009-09-22 | 2011-03-24 | Jan Rohozinski | Primers and Methods for Determining RhD Zygosity |
EP2721171A1 (en) | 2011-06-17 | 2014-04-23 | Progenika Biopharma, S.A. | Discrimination of blood type variants |
US9359643B2 (en) | 2013-03-08 | 2016-06-07 | Progenika Biopharma S.A. | Discrimination of blood type variants |
CN103966228B (en) * | 2014-04-25 | 2015-12-09 | 无锡市第五人民医院 | A kind of Rh blood group DEL type RHD93T > A allelotrope and detection method thereof |
EP3545102B1 (en) | 2016-11-23 | 2021-07-28 | Gassner, Christoph | Determination of the genotype underlying the s-s-u- phenotype of the mnss blood group system |
TWI709188B (en) | 2018-09-27 | 2020-11-01 | 財團法人工業技術研究院 | Fusion-based classifier, classification method, and classification system |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998045712A2 (en) * | 1997-04-08 | 1998-10-15 | Human Genome Sciences, Inc. | 20 human secreted proteins |
WO1999037763A2 (en) * | 1998-01-23 | 1999-07-29 | Drk Blutspendedienst Baden-Wuerttemberg Ggmbh | Novel nucleic acid molecules correlated with the rhesus weak d phenotype |
WO1999047555A1 (en) * | 1998-03-20 | 1999-09-23 | Genetics Institute, Inc. | Secreted proteins and polynucleotides encoding them |
US5972602A (en) * | 1993-08-27 | 1999-10-26 | Australian Red Cross Society | Quantitative PCR-based method of gene detection |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5474796A (en) * | 1991-09-04 | 1995-12-12 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface |
US5654419A (en) * | 1994-02-01 | 1997-08-05 | The Regents Of The University Of California | Fluorescent labels and their use in separations |
US6821724B1 (en) * | 1998-09-17 | 2004-11-23 | Affymetrix, Inc. | Methods of genetic analysis using nucleic acid arrays |
-
2000
- 2000-10-31 DE DE60044105T patent/DE60044105D1/en not_active Expired - Lifetime
- 2000-10-31 AT AT06026286T patent/ATE462722T1/en active
- 2000-10-31 ES ES00972884T patent/ES2283324T3/en not_active Expired - Lifetime
- 2000-10-31 ES ES06026286T patent/ES2342837T3/en not_active Expired - Lifetime
- 2000-10-31 JP JP2001535401A patent/JP4620920B2/en not_active Expired - Lifetime
- 2000-10-31 EP EP06026286A patent/EP1780217B1/en not_active Expired - Lifetime
- 2000-10-31 DE DE60033954T patent/DE60033954T2/en not_active Expired - Lifetime
- 2000-10-31 EP EP00972884A patent/EP1226169B1/en not_active Expired - Lifetime
- 2000-10-31 AT AT00972884T patent/ATE356828T1/en active
- 2000-10-31 AU AU11455/01A patent/AU784319B2/en not_active Ceased
- 2000-10-31 WO PCT/EP2000/010745 patent/WO2001032702A2/en active IP Right Grant
- 2000-10-31 US US10/129,580 patent/US9034573B1/en not_active Expired - Fee Related
- 2000-10-31 CN CNB008177775A patent/CN100475842C/en not_active Expired - Lifetime
-
2006
- 2006-06-02 AU AU2006202359A patent/AU2006202359B2/en not_active Ceased
-
2009
- 2009-02-23 US US12/390,982 patent/US9217181B2/en not_active Expired - Fee Related
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5972602A (en) * | 1993-08-27 | 1999-10-26 | Australian Red Cross Society | Quantitative PCR-based method of gene detection |
WO1998045712A2 (en) * | 1997-04-08 | 1998-10-15 | Human Genome Sciences, Inc. | 20 human secreted proteins |
WO1999037763A2 (en) * | 1998-01-23 | 1999-07-29 | Drk Blutspendedienst Baden-Wuerttemberg Ggmbh | Novel nucleic acid molecules correlated with the rhesus weak d phenotype |
WO1999047555A1 (en) * | 1998-03-20 | 1999-09-23 | Genetics Institute, Inc. | Secreted proteins and polynucleotides encoding them |
Non-Patent Citations (11)
Title |
---|
AVENT ND ET AL: "Evidence of genetic diversity underlying Rh D-, weak D (Du), and partial D phenotypes as determined by multiplex polymerase chain reaction analysis of the RHD gene", BLOOD, W.B. SAUNDERS, PHILADELPHIA, VA, US, vol. 89, no. 7, 1 April 1997 (1997-04-01), pages 2568 - 2577, XP002108680, ISSN: 0006-4971 * |
BLUNT, T. ET AL.: "Serotype switching in a partially deleted RHD gene", VOX SANGUINIS, vol. 67, no. 4, 1994, pages 397 - 401, XP000926512 * |
CARRITT, B. ET AL.: "Evolution of the Rh (rhesus) blood group genes: a 50 year old predication (partially) fulfilled", HUMAN MOLECULAR GENETICS., vol. 6, no. 6, 1997, OXFORD UNIVERSITY PRESS, SURREY., GB, pages 843 - 850, XP000998694, ISSN: 0964-6906 * |
CARRITT, B. ET AL.: "Rh null phenotypes are not due to a gross deletion and can occur on different Rh genetic backgrounds", ANNALS OF HUMAN GENETICS, vol. 57, no. 4, 1993, pages 273 - 279, XP000926510 * |
CHERIF-ZAHAR B ET AL: "Organization of the gene ( RHCE) encoding the human blood group RhCcEe antigens and characterization of the promoter region.", GENOMICS, vol. 19, no. 1, 1994, pages 68 - 74, XP000926511, ISSN: 0888-7543 * |
DATABASE EM_HUM [online] EMBL; 13 August 1998 (1998-08-13), COBLEY. V. ET AL.: "Human DNA sequence clone RP3-469D22 on chromosome 1p35.1-36.13, contains the 5'part of the gene for RHCE.", XP002178290, retrieved from EBI accession no. HS469D22 Database accession no. AL031284 * |
HU, G.: "Human small membrane protein 1 (SMP1) mRNA", EMBL SEQUENCE DATABASE, HEIDELBERG DE, XP002170737 * |
LE VAN KIM CAROLINE ET AL: "Molecular cloning and primary structure of the human blood group RhD polypeptide.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 89, no. 22, 1992, 1992, pages 10925 - 10929, XP002134526, ISSN: 0027-8424 * |
OKUDA H ET AL: "SEQUENCE ANALYSIS OF THE SPACER REGION BETWEEN THE RHD AND RHCE GENES", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS., vol. 263, 24 September 1999 (1999-09-24), ACADEMIC PRESS INC. ORLANDO, FL., US, pages 378 - 383, XP000998148, ISSN: 0006-291X * |
SINGLETON BELINDA K ET AL: "The presence of an RHD pseudogene containing a 37 base pair duplication and a nonsense mutation in Africans with the Rh D-negative blood group phenotype.", BLOOD, vol. 95, no. 1, 1 January 2000 (2000-01-01), pages 12 - 18, XP001011309, ISSN: 0006-4971 * |
WAGNER, F.F. ET AL.: "RHD gene deletion occured in the Rhesus box", BLOOD, vol. 29, no. 12, 15 June 2000 (2000-06-15), WASHINGTON US, pages 3662 - 3668, XP000926502 * |
Also Published As
Publication number | Publication date |
---|---|
DE60033954D1 (en) | 2007-04-26 |
ATE462722T1 (en) | 2010-04-15 |
ES2342837T3 (en) | 2010-07-15 |
AU2006202359B2 (en) | 2008-11-06 |
WO2001032702A2 (en) | 2001-05-10 |
ATE356828T1 (en) | 2007-04-15 |
US20110172406A1 (en) | 2011-07-14 |
AU784319B2 (en) | 2006-03-09 |
AU2006202359A1 (en) | 2006-06-29 |
JP2003513620A (en) | 2003-04-15 |
DE60044105D1 (en) | 2010-05-12 |
JP4620920B2 (en) | 2011-01-26 |
CN1413219A (en) | 2003-04-23 |
EP1226169A2 (en) | 2002-07-31 |
US9217181B2 (en) | 2015-12-22 |
EP1226169B1 (en) | 2007-03-14 |
CN100475842C (en) | 2009-04-08 |
US9034573B1 (en) | 2015-05-19 |
EP1780217B1 (en) | 2010-03-31 |
DE60033954T2 (en) | 2008-04-17 |
AU1145501A (en) | 2001-05-14 |
WO2001032702A9 (en) | 2001-10-11 |
ES2283324T3 (en) | 2007-11-01 |
EP1780217A1 (en) | 2007-05-02 |
WO2001032702B1 (en) | 2002-03-28 |
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