WO2001052837A3 - Utilisation d'au moins un ester gras pour la preparation d'une composition destinee a inhiber l'activite de la 5 alpha reductase, en pharmacie notamment en dermatologie, en cosmetique et en tant qu'additif alimentaire - Google Patents

Utilisation d'au moins un ester gras pour la preparation d'une composition destinee a inhiber l'activite de la 5 alpha reductase, en pharmacie notamment en dermatologie, en cosmetique et en tant qu'additif alimentaire Download PDF

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Publication number
WO2001052837A3
WO2001052837A3 PCT/FR2001/000168 FR0100168W WO0152837A3 WO 2001052837 A3 WO2001052837 A3 WO 2001052837A3 FR 0100168 W FR0100168 W FR 0100168W WO 0152837 A3 WO0152837 A3 WO 0152837A3
Authority
WO
WIPO (PCT)
Prior art keywords
methyl
reductase activity
fatty ester
inhibit
preparing
Prior art date
Application number
PCT/FR2001/000168
Other languages
English (en)
Other versions
WO2001052837A2 (fr
Inventor
Philippe Msika
Antoine Piccirilli
Jacques Legrand
Original Assignee
Pharmascience Lab
Philippe Msika
Antoine Piccirilli
Jacques Legrand
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmascience Lab, Philippe Msika, Antoine Piccirilli, Jacques Legrand filed Critical Pharmascience Lab
Priority to CA2397987A priority Critical patent/CA2397987C/fr
Priority to JP2001552885A priority patent/JP4948732B2/ja
Priority to AU35549/01A priority patent/AU782758B2/en
Priority to EP01907633A priority patent/EP1248610B1/fr
Priority to MXPA02006986A priority patent/MXPA02006986A/es
Priority to DE60111489T priority patent/DE60111489T2/de
Priority to AT01907633T priority patent/ATE297725T1/de
Publication of WO2001052837A2 publication Critical patent/WO2001052837A2/fr
Publication of WO2001052837A3 publication Critical patent/WO2001052837A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/008—Preparations for oily skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/158—Fatty acids; Fats; Products containing oils or fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/231—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having one or two double bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A61Q7/02—Preparations for inhibiting or slowing hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782—Enzyme inhibitors; Enzyme antagonists

Abstract

La présente invention se rapporte à l'utilisation d'au moins un ester gras pour la préparation d'une composition destinée à inhiber l'activité de la 5a-réductase, procurant ainsi une réponse pour le traitement des pathologies et/ou désordres dermatologiques liés à une exagération congénitale ou acquise de l'activité de la 5a-réductase, notamment pour le traitement de l'hypertrophie prostatique, de l'adénome prostatique, de l'acné, de l'hyperséborrhée, de l'alopécie et de l'hirsutisme. L'invention se rapporte également à des méthodes de traitement cosmétique, notamment de la peau grasse, ainsi qu'à l'utilisation des esters gras décrits en tant qu'additifs dans un aliment pour l'être humain et/ou l'animal. Plus particulierement l'ester gras est constitué des esters méthyliques ou butyligues de l'huile d'advocat, des esters butyliques de l'huile de soja, ou d'un mélange de ces derniers ou choise dans le groupe constitué par l'oléate deméthyle, le linoléate de méthyle, le stéarate de méthyle, le laurate de méthyle, l'undécylénate de méthyle, l'oléste de butyle, l'oléate d'oléyle, le ricinoléate de méthyle, le palmitate de méthyle, le palmitoélate de méthyle et les mélanges de ces derniers.
PCT/FR2001/000168 2000-01-18 2001-01-18 Utilisation d'au moins un ester gras pour la preparation d'une composition destinee a inhiber l'activite de la 5 alpha reductase, en pharmacie notamment en dermatologie, en cosmetique et en tant qu'additif alimentaire WO2001052837A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CA2397987A CA2397987C (fr) 2000-01-18 2001-01-18 Utilisation d'au moins un ester gras pour la preparation d'une composition destinee a inhiber l'activite de la 5.alpha.reductase, en pharmacie notamment en dermatologie, en cosmetique et en tant qu'additif alimentaire
JP2001552885A JP4948732B2 (ja) 2000-01-18 2001-01-18 ５α−レダクターゼ活性を阻害するように設計された組成物を調製するための少なくとも１つの脂肪酸エステルの薬理学、特定の皮膚科学、化粧品における使用および食品添加物としての使用。
AU35549/01A AU782758B2 (en) 2000-01-18 2001-01-18 Use of at least a fatty ester for preparing a composition designed to inhibit 5-alpha-reductase activity, in pharmacology, in particular dermatology, in cosmetics and as food additive
EP01907633A EP1248610B1 (fr) 2000-01-18 2001-01-18 Utilisation d'au moins un ester gras pour la preparation d'une composition destinee au traitement therapeutique et/ou cosmetique de l'hypertrophie prostatique, l'adenome prostatique, l'acne, l'hyperseborrhee, l'alopecie et l'hirsutisme
MXPA02006986A MXPA02006986A (es) 2000-01-18 2001-01-18 El uso por lo menos de un ester graso para la preparacion de una composicion destinada a inhibir la actividad de 5 alfa-reductasa, en farmacologia, principalmente en dermatologia, en cosmeticos y como aditivo de alimentos.
DE60111489T DE60111489T2 (de) 2000-01-18 2001-01-18 Verwendung mindestens eines fettsäureesters zur zubereitung einer pharmazeutischen oder kosmetischen zusammensetzung zur behandlung von prostatahypertrophie, prostata-adenom, akne, seborrhoe, haarausfall und hirsutismus
AT01907633T ATE297725T1 (de) 2000-01-18 2001-01-18 Verwendung mindestens eines fettsäureesters zur zubereitung einer pharmazeutischen oder kosmetischen zusammensetzung zur behandlung von prostatahypertrophie, prostata-adenom, akne, seborrhoe, haarausfall und hirsutismus

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR00/00577 2000-01-18
FR0000577A FR2803749B1 (fr) 2000-01-18 2000-01-18 Utilisation d'au moins un ester gras pour la preparation d'une composition destinee a inhiber l'activite de la 5 alpha-reductase, en pharmacie notamment en dermatologie, en cosmetique et en tant qu'additif alimentaire

Publications (2)

Publication Number Publication Date
WO2001052837A2 WO2001052837A2 (fr) 2001-07-26
WO2001052837A3 true WO2001052837A3 (fr) 2002-06-20

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2001/000168 WO2001052837A2 (fr) 2000-01-18 2001-01-18 Utilisation d'au moins un ester gras pour la preparation d'une composition destinee a inhiber l'activite de la 5 alpha reductase, en pharmacie notamment en dermatologie, en cosmetique et en tant qu'additif alimentaire

Country Status (12)

Country Link
US (1) US8318186B2 (fr)
EP (1) EP1248610B1 (fr)
JP (1) JP4948732B2 (fr)
KR (1) KR100763728B1 (fr)
AT (1) ATE297725T1 (fr)
AU (1) AU782758B2 (fr)
CA (1) CA2397987C (fr)
DE (1) DE60111489T2 (fr)
ES (1) ES2240414T3 (fr)
FR (1) FR2803749B1 (fr)
MX (1) MXPA02006986A (fr)
WO (1) WO2001052837A2 (fr)

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EP2158906A1 (fr) 2008-08-28 2010-03-03 ProxiPHARM GmbH Composition pour le traitement de l'alopécie
IT1391663B1 (it) 2008-11-10 2012-01-17 Giuliani Spa Uso di composti atti ad inibire l' attivita' dell'enzima 5alfa-reduttasi e composizioni farmaceutiche e cosmetiche che li contengono
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FR2948566B1 (fr) 2009-07-30 2012-08-10 Expanscience Lab Extrait du fruit de schizandra sphenanthera et compositions cosmetiques, dermatologiques et nutraceutiques le comprenant
FR2953135B1 (fr) 2009-11-30 2012-05-11 Expanscience Lab Extrait de graines d'acacia macrostachya et compositions cosmetiques, pharmaceutiques, dermatologiques, nutraceutiques ou alimentaires le comprenant
FR2953136B1 (fr) 2009-11-30 2012-05-11 Expanscience Lab Extrait de graines de vigna unguiculata et compositions cosmetiques, pharmaceutiques, dermatologiques, nutraceutiques ou alimentaires le comprenant
FR2953722B1 (fr) 2009-12-16 2012-03-09 Expanscience Lab Composition comprenant au moins un sucre en c7 pour le traitement de l'alopecie, pour le traitement cosmetique des phaneres, et pour le soin des cheveux, cils ou ongles
FR2969496B1 (fr) 2010-12-22 2013-11-08 Expanscience Lab Extrait de pulpe et/ou de peau d'avocat riche en polyphenols et compositions cosmetiques, dermatologiques et nutraceutiques le comprenant
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FR2975004B1 (fr) 2011-05-13 2013-06-28 Expanscience Lab Nouvel actif anti-rougeurs et compositions cosmetiques le comprenant
FR2999429B1 (fr) 2012-12-18 2015-01-02 Expanscience Lab Extrait de graines de passiflore et compositions cosmetiques, pharmaceutiques, dermatologiques ou nutraceutiques le comprenant
FR3001889B1 (fr) 2013-02-11 2021-02-12 Expanscience Lab Utilisation d'une composition comprenant un perseose d'avocat dans la protection des cellules souches epidermiques .
EP2962732A4 (fr) * 2013-02-28 2016-07-27 Martínez Leonardo Jimeno Produit à usage topique pour le cuir chevelu et son procédé d'élaboration
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EP1248610B1 (fr) 2005-06-15
DE60111489D1 (de) 2005-07-21
WO2001052837A2 (fr) 2001-07-26
AU782758B2 (en) 2005-08-25
ES2240414T3 (es) 2005-10-16
JP4948732B2 (ja) 2012-06-06
JP2003520229A (ja) 2003-07-02
KR20020087394A (ko) 2002-11-22
MXPA02006986A (es) 2002-12-13
FR2803749A1 (fr) 2001-07-20
US20030129268A1 (en) 2003-07-10
ATE297725T1 (de) 2005-07-15
FR2803749B1 (fr) 2006-09-22
CA2397987A1 (fr) 2001-07-26
EP1248610A2 (fr) 2002-10-16
DE60111489T2 (de) 2006-05-11
CA2397987C (fr) 2013-05-21
AU3554901A (en) 2001-07-31
US8318186B2 (en) 2012-11-27

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