WO2003016291A1 - Activateur du recepteur $g(d) sensible au proliferateur de peroxysome - Google Patents

Activateur du recepteur $g(d) sensible au proliferateur de peroxysome Download PDF

Info

Publication number: WO2003016291A1
Authority: WO; WIPO (PCT)
Prior art keywords: activator; peroxisome proliferator; hydrogen; responsive receptor; compound
Prior art date: 2001-08-10

Application number

PCT/JP2002/007897

Other languages

English (en)

French (fr)

Inventor

Shogo Sakuma

Tomio Yamakawa

Takashi Kanda

Seiichiro Masui

Original Assignee

Nippon Chemiphar Co., Ltd.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-08-10

Filing date

2002-08-02

Publication date

2003-02-27

2002-08-02 Priority to KR1020047002008A priority Critical patent/KR100901683B1/ko

2002-08-02 Priority to AT02755779T priority patent/ATE526319T1/de

2002-08-02 Priority to CA2457054A priority patent/CA2457054C/en

2002-08-02 Priority to US10/486,783 priority patent/US7265137B2/en

2002-08-02 Application filed by Nippon Chemiphar Co., Ltd. filed Critical Nippon Chemiphar Co., Ltd.

2002-08-02 Priority to IL16030402A priority patent/IL160304A0/xx

2002-08-02 Priority to AU2002323776A priority patent/AU2002323776B2/en

2002-08-02 Priority to JP2003521216A priority patent/JP4421895B2/ja

2002-08-02 Priority to EP02755779A priority patent/EP1424330B1/en

2002-08-02 Priority to BR0211844A priority patent/BRPI0211844B8/pt

2002-08-02 Priority to MXPA04001258A priority patent/MXPA04001258A/es

2002-08-02 Priority to DK02755779.2T priority patent/DK1424330T3/da

2003-02-27 Publication of WO2003016291A1 publication Critical patent/WO2003016291A1/ja

2004-02-10 Priority to IL160304A priority patent/IL160304A/en

2007-07-31 Priority to US11/888,493 priority patent/US7652045B2/en

2007-07-31 Priority to US11/888,492 priority patent/US7648999B2/en

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/62—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems having two or more ring systems containing condensed 1,3-oxazole rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms

PCT/JP2002/007897 2001-08-10 2002-08-02 Activateur du recepteur $g(d) sensible au proliferateur de peroxysome WO2003016291A1 (fr)

Priority Applications (14)

Application Number	Priority Date	Filing Date	Title
AU2002323776A AU2002323776B2 (en)	2001-08-10	2002-08-02	Activator for peroxisome proliferator-responsive receptor Delta
CA2457054A CA2457054C (en)	2001-08-10	2002-08-02	Activator of peroxisome proliferator-activated receptor .delta.
US10/486,783 US7265137B2 (en)	2001-08-10	2002-08-02	Activator of peroxisome proliferator-activated re-ceptor δ
EP02755779A EP1424330B1 (en)	2001-08-10	2002-08-02	Activator for peroxisome proliferator-responsive receptor delta
IL16030402A IL160304A0 (en)	2001-08-10	2002-08-02	ACTIVATOR FOR PEROXISOME PROLIFERATOR-RESPONSIVE RECEPTOR delta
AT02755779T ATE526319T1 (de)	2001-08-10	2002-08-02	Aktivator für den peroxisome proliferator- responsiven rezeptor delta
JP2003521216A JP4421895B2 (ja)	2001-08-10	2002-08-02	ペルオキシソーム増殖剤応答性受容体δの活性化剤
KR1020047002008A KR100901683B1 (ko)	2001-08-10	2002-08-02	퍼옥시좀 증식제 응답성 수용체 δ의 활성화제
BR0211844A BRPI0211844B8 (pt)	2001-08-10	2002-08-02	composto de ácido fenóxi-acético ou um de seus sais farmaceuticamente aceitáveis, e, composição farmacêutica
MXPA04001258A MXPA04001258A (es)	2001-08-10	2002-08-02	Activador para el receptor d que responde al proliferador de peroxisoma.
DK02755779.2T DK1424330T3 (da)	2001-08-10	2002-08-02	Aktivator for peroxisom proliferator-responsiv receptor delta
IL160304A IL160304A (en)	2001-08-10	2004-02-10	Compounds and composition for activating peroxisome proliferators-responsive receptor ??
US11/888,493 US7652045B2 (en)	2001-08-10	2007-07-31	Activator of peroxisome proliferator-activated receptor δ
US11/888,492 US7648999B2 (en)	2001-08-10	2007-07-31	Activator for peroxisome proliferator-activated receptor δ

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2001-243734		2001-08-10
JP2001243734		2001-08-10

Related Child Applications (2)

Application Number	Title	Priority Date	Filing Date
US11/888,493 Continuation US7652045B2 (en)	2001-08-10	2007-07-31	Activator of peroxisome proliferator-activated receptor δ
US11/888,492 Division US7648999B2 (en)	2001-08-10	2007-07-31	Activator for peroxisome proliferator-activated receptor δ

Publications (1)

Publication Number	Publication Date
WO2003016291A1 true WO2003016291A1 (fr)	2003-02-27

Family

ID=19073779

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PCT/JP2002/007897 WO2003016291A1 (fr)	2001-08-10	2002-08-02	Activateur du recepteur $g(d) sensible au proliferateur de peroxysome

Country Status (16)

Country	Link
US (3)	US7265137B2 (ja)
EP (1)	EP1424330B1 (ja)
JP (3)	JP4421895B2 (ja)
KR (1)	KR100901683B1 (ja)
CN (1)	CN1330641C (ja)
AT (1)	ATE526319T1 (ja)
AU (1)	AU2002323776B2 (ja)
BR (1)	BRPI0211844B8 (ja)
CA (1)	CA2457054C (ja)
CY (1)	CY1112130T1 (ja)
DK (1)	DK1424330T3 (ja)
ES (1)	ES2372813T3 (ja)
IL (2)	IL160304A0 (ja)
MX (1)	MXPA04001258A (ja)
PT (1)	PT1424330E (ja)
WO (1)	WO2003016291A1 (ja)

Cited By (34)

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WO2004093910A1 (ja) *	2003-04-22	2004-11-04	Astellas Pharma Inc.	ＰＰＡＲδアゴニストによる脳神経変性疾患治療剤
WO2005060958A1 (en) *	2003-12-19	2005-07-07	Kalypsys, Inc.	(5- (2-phenyl)-thiazol-5-ylmethoxy)-indol-1-yl) -acetic acid derivatives and related compounds as modulators of the human ppar-delta receptor for the treatment of metabolic disorders such as type 2 diabetes
WO2006041197A1 (ja) *	2004-10-14	2006-04-20	Nippon Chemiphar Co., Ltd.	ペルオキシソーム増殖剤活性化受容体δの活性化剤
WO2006090920A1 (ja) *	2005-02-28	2006-08-31	Nippon Chemiphar Co., Ltd.	ペルオキシソーム増殖剤活性化受容体δの活性化剤
WO2006126714A1 (ja) *	2005-05-25	2006-11-30	Nippon Chemiphar Co., Ltd.	ペルオキシソーム増殖剤活性化受容体の活性化剤
WO2007003581A1 (en)	2005-06-30	2007-01-11	Novo Nordisk A/S	Phenoxy acetic acids as ppar delta activators
WO2007119887A1 (ja)	2006-04-18	2007-10-25	Nippon Chemiphar Co., Ltd.	ペルオキシソーム増殖剤活性化受容体δの活性化剤
WO2007122970A1 (ja) *	2006-04-20	2007-11-01	Osaka University	核内受容体に結合するリガンド
WO2008143254A1 (ja)	2007-05-21	2008-11-27	Senju Pharmaceutical Co., Ltd.	ＰＰＡＲδアゴニスト含有医薬
JP2009509989A (ja) *	2005-09-29	2009-03-12	サノフィ−アベンティス	フェニル基を有するフェニル−［１，２，４］−オキサジアゾール−５−オン誘導体、その製造方法、及び医薬品としてのその使用
WO2009128558A1 (ja)	2008-04-15	2009-10-22	日本ケミファ株式会社	ペルオキシソーム増殖剤活性化受容体の活性化剤
WO2010047982A1 (en)	2008-10-22	2010-04-29	Merck Sharp & Dohme Corp.	Novel cyclic benzimidazole derivatives useful anti-diabetic agents
WO2010051206A1 (en)	2008-10-31	2010-05-06	Merck Sharp & Dohme Corp.	Novel cyclic benzimidazole derivatives useful anti-diabetic agents
EP2305352A1 (en)	2004-04-02	2011-04-06	Merck Sharp & Dohme Corp.	5-alpha-reductase inhibitors for use in the treatment of men with metabolic and anthropometric disorders
US7943612B2 (en)	2006-03-09	2011-05-17	High Point Pharmaceuticals, Llc	Compounds that modulate PPAR activity, their preparation and use
US7943613B2 (en)	2005-12-22	2011-05-17	High Point Pharmaceuticals, Llc	Compounds, their preparation and use
US7968723B2 (en)	2004-05-05	2011-06-28	High Point Pharmaceuticals, Llc	Compounds, their preparation and use
WO2011106273A1 (en)	2010-02-25	2011-09-01	Merck Sharp & Dohme Corp.	Novel cyclic benzimidazole derivatives useful anti-diabetic agents
US8053598B2 (en)	2004-05-05	2011-11-08	High Point Pharmaceuticals, Llc	Compounds, their preparation and use
US8106070B2 (en)	2006-10-20	2012-01-31	Merck Sharp & Dohme Corp.	Substituted imidazoles as bombesin receptor subtype-3 modulators
WO2012027331A1 (en)	2010-08-27	2012-03-01	Ironwood Pharmaceuticals, Inc.	Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
US8183275B2 (en)	2006-10-20	2012-05-22	Merck Sharp & Dohme Corp.	Substituted imidazoles as bombesin receptor subtype-3 modulators
US8193228B2 (en)	2006-10-20	2012-06-05	Merck Sharp & Dohme Corp.	Substituted imidazole as bombesin receptor subtype-3 modulators
WO2012116145A1 (en)	2011-02-25	2012-08-30	Merck Sharp & Dohme Corp.	Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents
US8497382B2 (en)	2008-12-01	2013-07-30	Mitsubishi Tanabe Pharma Corporation	Carboxylic acid derivative containing thiazole ring and pharmaceutical use thereof
WO2014022528A1 (en)	2012-08-02	2014-02-06	Merck Sharp & Dohme Corp.	Antidiabetic tricyclic compounds
WO2014130608A1 (en)	2013-02-22	2014-08-28	Merck Sharp & Dohme Corp.	Antidiabetic bicyclic compounds
WO2014139388A1 (en)	2013-03-14	2014-09-18	Merck Sharp & Dohme Corp.	Novel indole derivatives useful as anti-diabetic agents
WO2015051725A1 (en)	2013-10-08	2015-04-16	Merck Sharp & Dohme Corp.	Antidiabetic tricyclic compounds
WO2017195875A1 (ja) *	2016-05-12	2017-11-16	日本ケミファ株式会社	創傷治療剤
WO2018106518A1 (en)	2016-12-06	2018-06-14	Merck Sharp & Dohme Corp.	Antidiabetic heterocyclic compounds
WO2018118670A1 (en)	2016-12-20	2018-06-28	Merck Sharp & Dohme Corp.	Antidiabetic spirochroman compounds
US10456406B2 (en)	2013-09-09	2019-10-29	Vtv Therapeutics Llc	Use of a PPAR-δ agonist for reducing loss of muscle strength, muscle mass, or type I muscle fibers in an immobilized limb
US11931365B2 (en)	2022-01-25	2024-03-19	Reneo Pharmaceuticals, Inc.	Use of PPAR-delta agonists in the treatment of disease

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DK1424330T3 (da)	2001-08-10	2012-01-16	Nippon Chemiphar Co	Aktivator for peroxisom proliferator-responsiv receptor delta
EP1445258B1 (en) *	2001-10-12	2009-06-24	Nippon Chemiphar Co., Ltd.	Activator for peroxisome proliferator-activated receptor delta
US7301050B2 (en)	2003-09-19	2007-11-27	Janssen Pharmaceutical N.V.	4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs
US7554974B2 (en) *	2004-03-09	2009-06-30	Tekelec	Systems and methods of performing stateful signaling transactions in a distributed processing environment
RU2008108221A (ru) *	2005-09-07	2009-10-20	Плекссикон, Инк. (Us)	Соединения, активные в отношении ppar (рецепторов активаторов пролиферации пероксисом)
JO3006B1 (ar)	2005-09-14	2016-09-05	Janssen Pharmaceutica Nv	املاح ليسين مبتكرة من مشتقات حامض 4-((فينوكسي الكيل)ثيو) فينوكسي الخليك
BRPI0617207A2 (pt)	2005-09-29	2011-07-19	Sanofi Aventis	derivados de fenil-1,2,4-oxadiazolona, processos para sua preparação e seu uso como produtos farmacêuticos
US7649098B2 (en) *	2006-02-24	2010-01-19	Lexicon Pharmaceuticals, Inc.	Imidazole-based compounds, compositions comprising them and methods of their use
PE20080188A1 (es)	2006-04-18	2008-03-10	Janssen Pharmaceutica Nv	Derivados del acido benzoazepin-oxi-acetico como agonistas de ppar-delta usados para aumentar hdl-c, reducir ldl-c y reducir colesterol
AU2013202514B2 (en) *	2006-04-18	2015-09-17	Nippon Chemiphar Co., Ltd.	Activating agent for peroxisome proliferator activated receptor delta
FR2910893A1 (fr) *	2006-12-29	2008-07-04	Genfit Sa	Derives de (phenylthiazolyl)-phenyl-propan-1-one et de (phenyloxazolyl)-phenyl-propan-1-one substitues, preparations et utilisations.
TW200920355A (en) *	2007-09-06	2009-05-16	Lexicon Pharmaceuticals Inc	Compositions and methods for treating immunological and inflammatory diseases and disorders
WO2009078981A2 (en) *	2007-12-13	2009-06-25	Sri International	Ppar-delta ligands and methods of their use
JP2012116753A (ja) *	2009-03-26	2012-06-21	Nippon Chemiphar Co Ltd	ペルオキシソーム増殖剤活性化受容体の活性化剤
EP2464349A2 (en)	2009-08-14	2012-06-20	Cerenis Therapeutics S.A.	Use of ppar delta ligands for the treatment or prevention of inflammation or energy metabolism/production related diseases
CN105237487B (zh) *	2015-10-19	2017-10-10	安徽中医药大学	含川芎嗪基查尔酮芳氧烷酸类化合物、制备方法及其应用
US11634387B2 (en)	2019-09-26	2023-04-25	Abionyx Pharma Sa	Compounds useful for treating liver diseases
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US7652045B2 (en)	2010-01-26
JP4421895B2 (ja)	2010-02-24
US20080009525A1 (en)	2008-01-10
CN1330641C (zh)	2007-08-08
IL160304A0 (en)	2004-07-25
JP2009280622A (ja)	2009-12-03
US7265137B2 (en)	2007-09-04
US7648999B2 (en)	2010-01-19
KR20040023741A (ko)	2004-03-18
ATE526319T1 (de)	2011-10-15
JP5097180B2 (ja)	2012-12-12
EP1424330A1 (en)	2004-06-02
US20050054674A1 (en)	2005-03-10
CN1568316A (zh)	2005-01-19
BR0211844A (pt)	2004-08-31
CA2457054A1 (en)	2003-02-27
PT1424330E (pt)	2011-12-22
JPWO2003016291A1 (ja)	2004-12-02
BRPI0211844B8 (pt)	2021-05-25
ES2372813T3 (es)	2012-01-26
US20080009631A1 (en)	2008-01-10
KR100901683B1 (ko)	2009-06-08
IL160304A (en)	2010-12-30
CY1112130T1 (el)	2015-11-04
CA2457054C (en)	2011-10-11
MXPA04001258A (es)	2005-06-06
BRPI0211844B1 (pt)	2019-08-27
DK1424330T3 (da)	2012-01-16
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Publication	Publication Date	Title
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