WO2003035696A3 - Humanized antibodies against icam-1, their production and uses - Google Patents

Humanized antibodies against icam-1, their production and uses Download PDF

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Publication number
WO2003035696A3
WO2003035696A3 PCT/US2002/023002 US0223002W WO03035696A3 WO 2003035696 A3 WO2003035696 A3 WO 2003035696A3 US 0223002 W US0223002 W US 0223002W WO 03035696 A3 WO03035696 A3 WO 03035696A3
Authority
WO
WIPO (PCT)
Prior art keywords
humanized antibodies
production
antibodies against
against icam
antibodies
Prior art date
Application number
PCT/US2002/023002
Other languages
French (fr)
Other versions
WO2003035696A2 (en
Inventor
Fang Fang
Guang-Xiang Luo
Lori Allison Kohlstaedt
Catherine Helen Charles
Original Assignee
Perlan Therapeutics Inc
Fang Fang
Guang-Xiang Luo
Lori Allison Kohlstaedt
Catherine Helen Charles
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Perlan Therapeutics Inc, Fang Fang, Guang-Xiang Luo, Lori Allison Kohlstaedt, Catherine Helen Charles filed Critical Perlan Therapeutics Inc
Priority to AT02798403T priority Critical patent/ATE490276T1/en
Priority to JP2003538209A priority patent/JP4516312B2/en
Priority to EP02798403A priority patent/EP1414861B1/en
Priority to DE60238485T priority patent/DE60238485D1/en
Priority to DK02798403.8T priority patent/DK1414861T3/en
Priority to CA2454361A priority patent/CA2454361C/en
Priority to AU2002363027A priority patent/AU2002363027C1/en
Publication of WO2003035696A2 publication Critical patent/WO2003035696A2/en
Publication of WO2003035696A3 publication Critical patent/WO2003035696A3/en
Priority to AU2008258214A priority patent/AU2008258214B2/en
Priority to AU2012203365A priority patent/AU2012203365A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2821—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The invention provides humanized antibodies, for example, those that that bind ICAM-1, methods of use and methods of producing the antibodies. Antibodies include sequences having a VH and VL domain selected from HumA, HumB, HumC, HumD, HumE, HumF, HumG, HumH, HumI, Hum40 and Hum50.
PCT/US2002/023002 2001-07-19 2002-07-19 Humanized antibodies against icam-1, their production and uses WO2003035696A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
AT02798403T ATE490276T1 (en) 2001-07-19 2002-07-19 HUMANIZED ANTIBODIES AGAINST ICAM-1, THEIR PRODUCTION AND USES
JP2003538209A JP4516312B2 (en) 2001-07-19 2002-07-19 Humanized antibodies against ICAM-1, their production and use
EP02798403A EP1414861B1 (en) 2001-07-19 2002-07-19 Humanized antibodies against icam-1, their production and uses
DE60238485T DE60238485D1 (en) 2001-07-19 2002-07-19 HUMANIZED ANTIBODIES TO ICAM-1, THEIR PREPARATION AND USES
DK02798403.8T DK1414861T3 (en) 2001-07-19 2002-07-19 Humanized antibodies to ICAM-1, preparation and use thereof
CA2454361A CA2454361C (en) 2001-07-19 2002-07-19 Humanized antibodies
AU2002363027A AU2002363027C1 (en) 2001-07-19 2002-07-19 Humanized antibodies against ICAM-1, their production and uses
AU2008258214A AU2008258214B2 (en) 2001-07-19 2008-12-18 Humanized antibodies against ICAM-1, their production and uses
AU2012203365A AU2012203365A1 (en) 2001-07-19 2012-06-07 Humanized antibodies against ICAM-1, their production and uses

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/910,483 2001-07-19
US09/910,483 US20030035798A1 (en) 2000-08-16 2001-07-19 Humanized antibodies

Publications (2)

Publication Number Publication Date
WO2003035696A2 WO2003035696A2 (en) 2003-05-01
WO2003035696A3 true WO2003035696A3 (en) 2003-11-27

Family

ID=25428849

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/023002 WO2003035696A2 (en) 2001-07-19 2002-07-19 Humanized antibodies against icam-1, their production and uses

Country Status (10)

Country Link
US (4) US20030035798A1 (en)
EP (2) EP1414861B1 (en)
JP (3) JP4516312B2 (en)
AT (1) ATE490276T1 (en)
AU (3) AU2002363027C1 (en)
CA (2) CA2454361C (en)
DE (1) DE60238485D1 (en)
DK (1) DK1414861T3 (en)
ES (1) ES2356896T3 (en)
WO (1) WO2003035696A2 (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1039931T3 (en) * 1997-12-01 2005-08-08 Fang Fang Multivalent recombinant antibodies to treat HRV infections
US20030035798A1 (en) * 2000-08-16 2003-02-20 Fang Fang Humanized antibodies
JP2005522192A (en) 2001-07-19 2005-07-28 パーラン セラピューティクス， インコーポレイテッド Multimeric proteins and methods of making and using multimeric proteins
WO2005086568A2 (en) * 2004-01-26 2005-09-22 Morphosys Ag Anti-icam-1 human antibodies and uses thereof
AU2005285152A1 (en) * 2004-09-10 2006-03-23 Wyeth Humanized anti-5T4 antibodies and anti-5T4 antibody / calicheamicin conjugates
GB2430030B (en) * 2005-09-07 2009-04-01 Ethicon Inc Diagnostic markers of wound infection III
GB0525214D0 (en) 2005-12-12 2006-01-18 Bioinvent Int Ab Biological materials and uses thereof
US9266967B2 (en) 2007-12-21 2016-02-23 Hoffmann-La Roche, Inc. Bivalent, bispecific antibodies
US20090162359A1 (en) 2007-12-21 2009-06-25 Christian Klein Bivalent, bispecific antibodies
WO2010112193A1 (en) * 2009-04-02 2010-10-07 Roche Glycart Ag Multispecific antibodies comprising full length antibodies and single chain fab fragments
PL2417156T3 (en) * 2009-04-07 2015-07-31 Roche Glycart Ag Trivalent, bispecific antibodies
US9676845B2 (en) 2009-06-16 2017-06-13 Hoffmann-La Roche, Inc. Bispecific antigen binding proteins
US9090690B2 (en) 2009-06-18 2015-07-28 Pfizer Inc. Anti Notch-1 antibodies
CN102712696A (en) 2009-09-16 2012-10-03 弗·哈夫曼-拉罗切有限公司 Coiled coil and/or tether containing protein complexes and uses thereof
AR080793A1 (en) 2010-03-26 2012-05-09 Roche Glycart Ag BISPECIFIC ANTIBODIES
GB2482535A (en) * 2010-08-05 2012-02-08 Hera Pharmaceuticals Inc Expression of antibody or a fragment thereof in lactobacillus
GB2482536B (en) 2010-08-05 2013-07-24 Hera Pharmaceuticals Inc Expression of antibody or a fragment thereof in lactobacillus
WO2012022734A2 (en) 2010-08-16 2012-02-23 Medimmune Limited Anti-icam-1 antibodies and methods of use
RU2013110875A (en) 2010-08-24 2014-09-27 Ф.Хоффманн-Ля Рош Аг SPECIFIC ANTIBODIES CONTAINING DISSULPHIDE-STABILIZED Fv Fragment
CA2821130C (en) 2010-12-15 2017-11-07 Wyeth Llc Anti-notch1 antibodies
JP5766296B2 (en) 2010-12-23 2015-08-19 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Polypeptide-polynucleotide complexes and their use in targeted delivery of effector components
EP2681239B8 (en) 2011-02-28 2015-09-09 F. Hoffmann-La Roche AG Antigen binding proteins
BR112013020338A2 (en) 2011-02-28 2016-10-18 Hoffmann La Roche monovalent antigen binding protein, pharmaceutical composition, use of monovalent antigen binding protein, method for treating a patient in need of therapy, method for preparing a monovalent antigen binding protein, nucleic acid, vector and cell hostess
BR112014019579A2 (en) 2012-02-10 2019-10-15 Genentech, Inc SINGLE CHAIN ANTIBODY, POLYNUCLEOTIDE, VECTOR, HOST CELL, METHOD OF PRODUCTION OF A SINGLE CHAIN ANTIBODY, HETEROMULTYMER AND METHOD OF PRODUCTION
BR112014032193A2 (en) 2012-06-27 2017-06-27 Hoffmann La Roche bispecific antibody production and combination determination methods, bispecific antibody, formulation and use of bispecific antibody
WO2014001325A1 (en) 2012-06-27 2014-01-03 F. Hoffmann-La Roche Ag Method for making antibody fc-region conjugates comprising at least one binding entity that specifically binds to a target and uses thereof
CA2922912A1 (en) 2013-10-11 2015-04-16 F. Hoffmann-La Roche Ag Multispecific domain exchanged common variable light chain antibodies
EP3144388B1 (en) * 2014-05-13 2020-07-01 Chugai Seiyaku Kabushiki Kaisha T cell-redirecting antigen-binding molecule for cells having immunosuppression function
WO2016087416A1 (en) 2014-12-03 2016-06-09 F. Hoffmann-La Roche Ag Multispecific antibodies
WO2017086367A1 (en) 2015-11-18 2017-05-26 中外製薬株式会社 Combination therapy using t cell redirection antigen binding molecule against cell having immunosuppressing function

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991016927A1 (en) * 1990-04-27 1991-11-14 Celltech Limited Humanized cdr-grafted anti-icam-1 antibodies, methods of preparation and usage thereof

Family Cites Families (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
FR2562421B1 (en) 1984-04-09 1989-02-17 Sandoz Sa IMPROVEMENTS ON INTERLEUKIN THERAPY
EP0169146A3 (en) 1984-07-20 1988-07-20 Merck & Co. Inc. Monoclonal antibodies directed against the cellular receptor of human rhinovirus
US4698420A (en) * 1985-02-25 1987-10-06 Xoma Corporation Antibody hybrid molecules and process for their preparation
US5077195A (en) * 1985-03-01 1991-12-31 Board Of Reagents, The University Of Texas System Polypeptides complementary to peptides or proteins having an amino acid sequence or nucleotide coding sequence at least partially known and methods of design therefor
US4975282A (en) 1985-06-26 1990-12-04 The Liposome Company, Inc. Multilamellar liposomes having improved trapping efficiencies
EP0225130B1 (en) 1985-11-22 1991-10-30 Takeda Chemical Industries, Ltd. Liposome composition
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
WO1988001649A1 (en) 1986-09-02 1988-03-10 Genex Corporation Single polypeptide chain binding molecules
US4946778A (en) * 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5869620A (en) * 1986-09-02 1999-02-09 Enzon, Inc. Multivalent antigen-binding proteins
US5260203A (en) * 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules
JP2666345B2 (en) 1987-04-16 1997-10-22 武田薬品工業株式会社 Liposome preparation and method for producing the same
US5284931A (en) * 1987-05-04 1994-02-08 Dana Farber Cancer Institute Intercellular adhesion molecules, and their binding ligands
US5565550A (en) * 1987-05-04 1996-10-15 Dana Farber Cancer Institute Antibodies to ICAM-2, and fragments thereof
DE3854536T2 (en) 1987-05-04 1996-03-07 Dana Farber Cancer Inst Inc Intercellular adhesion molecules and their binding ligands.
US5273876A (en) 1987-06-26 1993-12-28 Syntro Corporation Recombinant human cytomegalovirus containing foreign gene
US5223409A (en) * 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
AU643189B2 (en) 1988-09-06 1993-11-11 Xoma Corporation Production of chimeric mouse-human antibodies with specificity to human tumor antigens
EP0365837B1 (en) 1988-09-28 1995-08-02 Dana Farber Cancer Institute Intercellular adhesion molecules, and their binding ligands
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
CA2045129A1 (en) 1989-02-01 1990-08-02 Alfred I. Geller Herpes simplex virus type i expression vector
US5665577A (en) 1989-02-06 1997-09-09 Dana-Farber Cancer Institute Vectors containing HIV packaging sequences, packaging defective HIV vectors, and uses thereof
ATE79270T1 (en) 1989-03-09 1992-08-15 Boehringer Ingelheim Pharma USE OF INTERCELLULAR ADHAESION MOLECULES AND THEIR BINDING LIGANDS IN THE TREATMENT OF ASTHMA.
US5081584A (en) * 1989-03-13 1992-01-14 United States Of America Computer-assisted design of anti-peptides based on the amino acid sequence of a target peptide
AU627591B2 (en) 1989-06-19 1992-08-27 Xoma Corporation Chimeric mouse-human km10 antibody with specificity to a human tumor cell antigen
US5324510A (en) * 1989-09-01 1994-06-28 Boehringer Ingelheim Pharmaceuticals, Inc. Use of antibodies to intercellular adhesion molecule-1 (ICAM-1) in the treatment of asthma
EP0453554A4 (en) 1989-11-13 1993-02-17 Xoma Corporation Chimeric mouse human antibodies with specificity to hiv antigens
WO1991007418A1 (en) 1989-11-13 1991-05-30 Xoma Corporation Chimeric mouse-human a10 antibody with specificity to a human tumor cell antigen
CA2044627A1 (en) 1989-11-13 1991-05-14 Randy R. Robinson Chimeric mouse human antibodies with specificity to hiv antigens
US5264618A (en) 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
GB9009548D0 (en) 1990-04-27 1990-06-20 Celltech Ltd Chimeric antibody and method
EP0459577A3 (en) * 1990-06-01 1992-08-05 Merck & Co. Inc. Microbially expressed portions of a monoclonal antibody block rhinovirus attachment to cell receptors
US5723286A (en) * 1990-06-20 1998-03-03 Affymax Technologies N.V. Peptide library and screening systems
WO1992005266A2 (en) 1990-09-21 1992-04-02 Viagene, Inc. Packaging cells
US5582996A (en) * 1990-12-04 1996-12-10 The Wistar Institute Of Anatomy & Biology Bifunctional antibodies and method of preparing same
EP0572401B2 (en) 1991-02-19 2007-11-07 The Regents of the University of California Viral particles having altered host range
GB9105383D0 (en) 1991-03-14 1991-05-01 Immunology Ltd An immunotherapeutic for cervical cancer
US5223396A (en) * 1991-05-03 1993-06-29 Boehringer Ingelheim Pharmaceuticals, Inc. Method for detecting organ transplant rejection
DE69233254T2 (en) 1991-06-14 2004-09-16 Genentech, Inc., South San Francisco Humanized Heregulin antibody
WO1993006213A1 (en) 1991-09-23 1993-04-01 Medical Research Council Production of chimeric antibodies - a combinatorial approach
US5565332A (en) * 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
US5716805A (en) * 1991-10-25 1998-02-10 Immunex Corporation Methods of preparing soluble, oligomeric proteins
US6025165A (en) * 1991-11-25 2000-02-15 Enzon, Inc. Methods for producing multivalent antigen-binding proteins
JPH07501451A (en) 1991-11-25 1995-02-16 エンゾン・インコーポレイテッド Multivalent antigen binding protein
US5932448A (en) 1991-11-29 1999-08-03 Protein Design Labs., Inc. Bispecific antibody heterodimers
DE69233204T2 (en) * 1991-12-13 2004-07-15 Xoma Corp., Berkeley METHOD AND MATERIALS FOR THE PRODUCTION OF MODIFIED VARIABLE ANTIBODY DOMAINS AND THEIR THERAPEUTIC USE
ES2102007T3 (en) 1992-01-23 1997-07-16 Merck Patent Gmbh MONOMER AND DIMER ANTIBODY FRAGMENT FUSION PROTEINS.
US6129914A (en) * 1992-03-27 2000-10-10 Protein Design Labs, Inc. Bispecific antibody effective to treat B-cell lymphoma and cell line
AU3972893A (en) 1992-04-03 1993-11-08 Baylor College Of Medicine Gene therapy using the intestine
US6329507B1 (en) * 1992-08-21 2001-12-11 The Dow Chemical Company Dimer and multimer forms of single chain polypeptides
US5639641A (en) * 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
US5832448A (en) * 1996-10-16 1998-11-03 Health Hero Network Multiple patient monitoring system for proactive health management
WO1994012520A1 (en) * 1992-11-20 1994-06-09 Enzon, Inc. Linker for linked fusion polypeptides
WO1994012629A1 (en) 1992-12-02 1994-06-09 Baylor College Of Medicine Episomal vectors for gene therapy
ATE199392T1 (en) 1992-12-04 2001-03-15 Medical Res Council MULTIVALENT AND MULTI-SPECIFIC BINDING PROTEINS, THEIR PRODUCTION AND USE
US6307026B1 (en) * 1992-12-10 2001-10-23 Celltech Limited Humanized antibodies directed against A33 antigen
FR2702160B1 (en) 1993-03-02 1995-06-02 Biovecteurs As Synthetic particulate vectors and method of preparation.
US5491074A (en) * 1993-04-01 1996-02-13 Affymax Technologies Nv Association peptides
CA2163218C (en) * 1993-05-18 2002-09-10 Mohamed Chokri New macrophages, process for preparing the same and their use as active substances of pharmaceutical compositions
AU7353494A (en) 1993-11-12 1995-05-29 Case Western Reserve University Episomal expression vector for human gene therapy
US5928944A (en) 1994-02-04 1999-07-27 The United States Of America As Represented By The Department Of Health And Human Services Method of adenoviral-medicated cell transfection
CA2117668C (en) 1994-03-09 2005-08-09 Izumu Saito Recombinant adenovirus and process for producing the same
GB9409768D0 (en) * 1994-05-16 1994-07-06 Medical Res Council Trimerising polypeptides
US5604090A (en) 1994-06-06 1997-02-18 Fred Hutchinson Cancer Research Center Method for increasing transduction of cells by adeno-associated virus vectors
US5763733A (en) * 1994-10-13 1998-06-09 Enzon, Inc. Antigen-binding fusion proteins
US5693508A (en) 1994-11-08 1997-12-02 Chang; Lung-Ji Retroviral expression vectors containing MoMLV/CMV-IE/HIV-TAR chimeric long terminal repeats
US5721340A (en) * 1994-11-28 1998-02-24 The Wistar Institute Of Anatomy & Biology p53 proteins with altered tetramerization domains
US5573925A (en) * 1994-11-28 1996-11-12 The Wistar Institute Of Anatomy And Biology P53 proteins with altered tetramerization domains
US5632448A (en) * 1995-01-25 1997-05-27 Ransburg Corporation Rotary powder applicator
US5731168A (en) * 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
JP3770333B2 (en) 1995-03-15 2006-04-26 大日本住友製薬株式会社 Recombinant DNA virus and method for producing the same
EP0827544B1 (en) * 1995-05-23 2004-08-18 MorphoSys AG Multimeric proteins
US6110456A (en) 1995-06-07 2000-08-29 Yale University Oral delivery or adeno-associated viral vectors
JP2783276B2 (en) * 1995-07-04 1998-08-06 日本電気株式会社 Method for manufacturing semiconductor device
JPH11510389A (en) 1995-07-31 1999-09-14 アメリカ合衆国 Extending protein-protein interaction surfaces to inactivate cellular protein functions
US6013516A (en) 1995-10-06 2000-01-11 The Salk Institute For Biological Studies Vector and method of use for nucleic acid delivery to non-dividing cells
EP0868521A2 (en) 1995-12-22 1998-10-07 Somatogen Inc. Globins containing binding domains
DK0914155T3 (en) * 1996-03-25 2006-06-26 Medarex Inc Monoclonal antibodies specific for the extracellular domain of prostate-specific membrane antigen
US5861397A (en) 1996-10-03 1999-01-19 Vical Incorporated Piperazine based cytofectins
US6096291A (en) 1996-12-27 2000-08-01 Biovector Therapeutics, S.A. Mucosal administration of substances to mammals
IL132239A0 (en) * 1997-04-07 2001-03-19 Genentech Inc Humanized antibodies and methods for forming humanized antibodies
DK1039931T3 (en) 1997-12-01 2005-08-08 Fang Fang Multivalent recombinant antibodies to treat HRV infections
JPH11228446A (en) * 1998-02-16 1999-08-24 Mitsubishi Chemical Corp Antimalarial agent
US20020165153A1 (en) 1998-04-06 2002-11-07 Peter Angel Transcription factors and their use
US5965712A (en) * 1998-06-19 1999-10-12 Virginia Commonwealth University LZ-CD23 chimera for inhibition of IgE-mediated allergic disease
PT1121382E (en) * 1998-10-16 2006-10-31 Biogen Idec Inc BETA INTERFERENCE FUSE PROTEINS AND THEIR RESPECTIVE USES
US20030035798A1 (en) * 2000-08-16 2003-02-20 Fang Fang Humanized antibodies
DE69942671D1 (en) * 1998-12-01 2010-09-23 Facet Biotech Corp HUMANIZED ANTIKOERPER AGAINST GAMMA INTERFERON
WO2001000814A2 (en) 1999-06-25 2001-01-04 Universität Zürich Hetero-associating coiled-coil peptides and screenign method therefor
WO2001019842A1 (en) 1999-09-17 2001-03-22 Genzyme Transgenics Corporation Subunit optimized fusion proteins
AUPQ425699A0 (en) * 1999-11-25 1999-12-23 University Of Newcastle Research Associates Limited, The A method of treating a malignancy in a subject and a pharmaceutical composition for use in same
CA2382165A1 (en) * 1999-12-08 2001-06-14 Genset S.A. Full-length human cdnas encoding potentially secreted proteins
EP1290027B1 (en) 2000-04-28 2009-09-09 Planet Biotechnology, Inc. Immunoadhesin for the prevention of rhinovirus infection
JP2005522192A (en) * 2001-07-19 2005-07-28 パーラン セラピューティクス， インコーポレイテッド Multimeric proteins and methods of making and using multimeric proteins
JP4236000B2 (en) 2003-09-25 2009-03-11 元気株式会社 3D image processing apparatus, 3D image processing method and program

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991016927A1 (en) * 1990-04-27 1991-11-14 Celltech Limited Humanized cdr-grafted anti-icam-1 antibodies, methods of preparation and usage thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHARLES CATHERINE H ET AL: "Prevention of human rhinovirus infection by multivalent Fab molecules directed against ICAM-1.", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 47, no. 5, 20 May 2003 (2003-05-20), pages 1503 - 1508, XP009015720, ISSN: 0066-4804 *
FOOTE J ET AL: "ANTIBODY FRAMEWORK RESIDUES AFFECTING THE CONFORMATION OF THE HYPERVARIABLE LOOPS", JOURNAL OF MOLECULAR BIOLOGY, vol. 224, no. 2, 1992, pages 487 - 499, XP000564649, ISSN: 0022-2836 *
LUO GUANG X ET AL: "Humanization of an anti-ICAM-1 antibody with over 50-fold affinity and functional improvement.", JOURNAL OF IMMUNOLOGICAL METHODS, vol. 275, no. 1-2, 2003, pages 31 - 40, XP004416747, ISSN: 0022-1759 *

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