WO2003070174A3 - Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof - Google Patents

Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof Download PDF

Info

Publication number
WO2003070174A3
WO2003070174A3 PCT/US2003/004609 US0304609W WO03070174A3 WO 2003070174 A3 WO2003070174 A3 WO 2003070174A3 US 0304609 W US0304609 W US 0304609W WO 03070174 A3 WO03070174 A3 WO 03070174A3
Authority
WO
WIPO (PCT)
Prior art keywords
conjugates
formulation
preparation
methods
transportophore
Prior art date
Application number
PCT/US2003/004609
Other languages
French (fr)
Other versions
WO2003070174A2 (en
Inventor
Michael Burnet
Jan-Hinrich Guse
Hans-Jurgen Gutke
Albert Beck
Georgia Tsotsou
Irina Droste-Borel
Jeannette Reichert
Kattie Luyten
Maximilian Busch
Michael Wolff
Moussa Khobzaoui
Simona Margutti
Thomas Meindl
Gene Kim
Laurence Barker
Original Assignee
Sympore Gmbh
Michael Burnet
Jan-Hinrich Guse
Hans-Jurgen Gutke
Albert Beck
Georgia Tsotsou
Irina Droste-Borel
Jeannette Reichert
Kattie Luyten
Maximilian Busch
Michael Wolff
Moussa Khobzaoui
Simona Margutti
Thomas Meindl
Gene Kim
Laurence Barker
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sympore Gmbh, Michael Burnet, Jan-Hinrich Guse, Hans-Jurgen Gutke, Albert Beck, Georgia Tsotsou, Irina Droste-Borel, Jeannette Reichert, Kattie Luyten, Maximilian Busch, Michael Wolff, Moussa Khobzaoui, Simona Margutti, Thomas Meindl, Gene Kim, Laurence Barker filed Critical Sympore Gmbh
Priority to US10/504,787 priority Critical patent/US20050171342A1/en
Priority to EP03716044A priority patent/EP1483277A4/en
Priority to NZ535354A priority patent/NZ535354A/en
Priority to IL16355203A priority patent/IL163552A0/en
Priority to AU2003219770A priority patent/AU2003219770B2/en
Priority to CA002476423A priority patent/CA2476423A1/en
Publication of WO2003070174A2 publication Critical patent/WO2003070174A2/en
Publication of WO2003070174A3 publication Critical patent/WO2003070174A3/en
Priority to IL163552A priority patent/IL163552A/en
Priority to HR20040850A priority patent/HRP20040850A2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids

Abstract

This invention features a compound of the following formula T-(-L-C)m, wherein T is a transportophore (a transport mediating molecule), L is a a non-antibiotic therapeutic agent, and m is l- 8, in which the transportophore has an immune selectivity ratio of at least 2, the transportophore is covalently bonded to the non-antibiotic therapeutic agent via the bond or the linker, and the compound has an immune selectivity ratio of at least 2. Figure 1 depicts comparison of selective uptake of diverse structure types into white blood cells from a complex blood mix.
PCT/US2003/004609 2002-02-15 2003-02-14 Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof WO2003070174A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
US10/504,787 US20050171342A1 (en) 2002-02-15 2003-02-14 Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
EP03716044A EP1483277A4 (en) 2002-02-15 2003-02-14 Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
NZ535354A NZ535354A (en) 2002-02-15 2003-02-14 Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
IL16355203A IL163552A0 (en) 2002-02-15 2003-02-14 Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
AU2003219770A AU2003219770B2 (en) 2002-02-15 2003-02-14 Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
CA002476423A CA2476423A1 (en) 2002-02-15 2003-02-14 Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
IL163552A IL163552A (en) 2002-02-15 2004-08-15 Conjugates of biologically active compounds, uses thereof and pharmaceutical compositions comprising the same
HR20040850A HRP20040850A2 (en) 2002-02-15 2004-09-15 Conjugates of biologically active compounds, methods for their preparation and use formulation and pharmaceutical applications thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35743402P 2002-02-15 2002-02-15
US60/357,434 2002-02-15

Publications (2)

Publication Number Publication Date
WO2003070174A2 WO2003070174A2 (en) 2003-08-28
WO2003070174A3 true WO2003070174A3 (en) 2003-11-13

Family

ID=27757618

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/004609 WO2003070174A2 (en) 2002-02-15 2003-02-14 Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof

Country Status (8)

Country Link
US (2) US7579324B2 (en)
EP (1) EP1483277A4 (en)
AU (1) AU2003219770B2 (en)
CA (1) CA2476423A1 (en)
HR (1) HRP20040850A2 (en)
IL (1) IL163552A (en)
NZ (1) NZ535354A (en)
WO (1) WO2003070174A2 (en)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3945985B2 (en) * 2000-12-28 2007-07-18 株式会社リコー Digital camera device
HRP20010018A2 (en) 2001-01-09 2002-12-31 Pliva D D Novel anti-inflammatory compounds
KR20040066788A (en) 2001-08-31 2004-07-27 더 락커펠러 유니버시티 Phosphodiesterase activity and regulation of phosphodiesterase 1b-mediated signaling in brain
EP1483579A4 (en) * 2002-02-15 2006-07-12 Merckle Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
WO2003070254A1 (en) * 2002-02-15 2003-08-28 Sympore Gmbh Antibiotic conjugates
ATE429441T1 (en) 2002-07-08 2009-05-15 Glaxosmithkline Zagreb HYBRID MOLECULES OF MACROLIDS WITH STEROIDAL/NON-STEROIDAL ANTI-INFLAMMATORY ACTIVE MOLECULES
US7091187B2 (en) 2002-07-08 2006-08-15 Pliva-Istrazivacki Institut D.O.O. Compounds, compositions and methods for treatment of inflammatory diseases and conditions
BR0312584A (en) 2002-07-08 2005-04-12 Pliva Istrazivacki Inst D O O New non-steroidal anti-inflammatory substances, compounds and methods for their use
TW200420573A (en) 2002-09-26 2004-10-16 Rib X Pharmaceuticals Inc Bifunctional heterocyclic compounds and methods of making and using same
HRP20030324A2 (en) 2003-04-24 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. Compounds of antiinflammatory effect
EP1682563A1 (en) * 2003-10-30 2006-07-26 Rib-X Pharmaceuticals, Inc. Bifunctional macrolide heterocyclic compounds and mehtods of making and using the same
WO2005049632A1 (en) * 2003-11-18 2005-06-02 Rib-X Pharmaceuticals, Inc. Bifunctional macrolide heterocyclic compounds and methods of making and using the same
US8202843B2 (en) 2004-02-27 2012-06-19 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
KR20070046917A (en) * 2004-08-12 2007-05-03 글락소스미쓰클라인 이스트라지바치키 센타 자그레브 디.오.오. Use of cell-specific conjugates for treatment of inflammatory diseases of the gastrointestinal tract
US20060183696A1 (en) * 2004-08-12 2006-08-17 Pliva-Istrazivacki Institut D.O.O. Use of immune cell specific conjugates for treatment of inflammatory diseases of gastrointestinal tract
US7767797B1 (en) 2004-09-30 2010-08-03 Synovo Gmbh Macrocyclic compounds and methods of use thereof
GB0421908D0 (en) 2004-10-01 2004-11-03 Angeletti P Ist Richerche Bio New uses
AU2005298312A1 (en) 2004-10-27 2006-05-04 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Conjugates with anti-inflammatory activity
EP1846428A1 (en) * 2005-01-14 2007-10-24 GlaxoSmithKline istrazivacki centar Zagreb d.o.o. Anti-inflammatory conjugates of macrolides and coumarins
JP5084725B2 (en) 2005-06-06 2012-11-28 武田薬品工業株式会社 Organic compounds
WO2007012464A1 (en) * 2005-07-26 2007-02-01 Merckle Gmbh Macrolide conjugates of pyrrolizine and indolizine compounds as inhibitors of 5-lipooxygenase and cyclooxygenase
AU2006272496B2 (en) * 2005-07-27 2013-03-07 University Of Southern California Coumarin-based amino acids for use in enzyme activity and substrate specificity assays
EP1919287A4 (en) * 2005-08-23 2010-04-28 Intra Cellular Therapies Inc Organic compounds for treating reduced dopamine receptor signalling activity
JP5126685B2 (en) 2006-05-01 2013-01-23 大正製薬株式会社 Macrolide derivatives
EP2081431B1 (en) * 2006-11-13 2013-01-16 Intra-Cellular Therapies, Inc. Organic compounds
EP2089034A4 (en) 2006-12-05 2010-07-28 Intra Cellular Therapies Inc Novel uses
US20110281812A1 (en) * 2009-01-30 2011-11-17 Sulejman Alihodzic Compounds
WO2010098839A1 (en) 2009-02-25 2010-09-02 Intra-Cellular Therapies, Inc. Pde 1 inhibitors for ophthalmic disorders
WO2010132127A1 (en) 2009-05-13 2010-11-18 Intra-Cellular Therapies, Inc. Organic compounds
EP2461673A4 (en) 2009-08-05 2013-08-07 Intra Cellular Therapies Inc Novel regulatory proteins and inhibitors
AU2011313862A1 (en) * 2010-10-10 2013-05-30 Synovo Gmbh Anti-inflammatory macrolides
WO2013148874A1 (en) 2012-03-27 2013-10-03 Burnet Michael W Anti-inflammatory macrolides
DK2849567T3 (en) 2012-05-17 2022-06-20 Extend Biosciences Inc CARRIERS FOR IMPROVED MEDICINE ADMINISTRATION
JP6549040B2 (en) 2013-02-17 2019-07-24 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． New use
EP3479825B1 (en) 2013-03-15 2021-02-17 Intra-Cellular Therapies, Inc. Pde1 inhibitors for use in the treatment and/or prevention of cns or pns diseases or disorders
US9073936B2 (en) 2013-03-15 2015-07-07 Intra-Cellular Therapies, Inc. Organic compounds
US9884872B2 (en) 2014-06-20 2018-02-06 Intra-Cellular Therapies, Inc. Organic compounds
WO2016022893A1 (en) 2014-08-07 2016-02-11 Intra-Cellular Therapies, Inc. Organic compounds
US10285992B2 (en) 2014-08-07 2019-05-14 Intra-Cellular Therapies, Inc. Combinations of PDE1 inhibitors and NEP inhibitors and associated methods
RU2711442C2 (en) 2014-09-17 2020-01-17 Интра-Селлулар Терапиз, Инк. Compounds and methods
WO2016065052A1 (en) 2014-10-22 2016-04-28 Extend Biosciences, Inc. Insulin vitamin d conjugates
US9789197B2 (en) 2014-10-22 2017-10-17 Extend Biosciences, Inc. RNAi vitamin D conjugates
EP3220961B1 (en) 2014-10-22 2023-07-05 Extend Biosciences, Inc. Therapeutic vitamin d conjugates
GB201520419D0 (en) 2015-11-19 2016-01-06 Epi Endo Pharmaceuticals Ehf Compounds
EP3436083A4 (en) 2016-03-28 2019-11-27 Intra-Cellular Therapies, Inc. Novel compositions and methods
WO2018049417A1 (en) 2016-09-12 2018-03-15 Intra-Cellular Therapies, Inc. Novel uses
JP7401442B2 (en) 2018-01-31 2023-12-19 イントラ－セルラー・セラピーズ・インコーポレイテッド new use
JP2022529315A (en) 2019-04-18 2022-06-21 アズーラ オフサルミックス エルティーディー． Compounds and methods for treating eye disorders
WO2023248010A2 (en) 2022-06-23 2023-12-28 Synovo Gmbh Targeted modulators of jak3 for treatment of inflammatory and autoimmune diseases

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750493A (en) * 1995-08-30 1998-05-12 Raymond F. Schinazi Method to improve the biological and antiviral activity of protease inhibitors
US6562796B2 (en) * 2000-01-14 2003-05-13 Micrologix Biotech Inc. Derivatives of polyene macrolides and preparation and use thereof

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3417077A (en) * 1966-05-16 1968-12-17 Lilly Co Eli Erythromycin derivative and process for the preparation thereof
US4375414A (en) * 1971-05-20 1983-03-01 Meir Strahilevitz Immunological methods for removing species from the blood circulatory system and devices therefor
US3884903A (en) * 1973-06-21 1975-05-20 Abbott Lab 4{41 -Deoxy-4{41 -oxoerythromycin B derivatives
EP0009944B1 (en) 1978-10-02 1983-05-18 Merck & Co. Inc. Lysosomotropic fluorinated amine therapeutic agents and compositions containing them
YU43116B (en) * 1979-04-02 1989-04-30 Pliva Pharm & Chem Works Process for preparing 11-aza-4-o-cladinosyl-6-o-desosaminyl-15-ethyl-7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl-oxacyclopentadecane-2-one(11-aza-10-deox
SI8110592A8 (en) * 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4382086A (en) * 1982-03-01 1983-05-03 Pfizer Inc. 9-Dihydro-11,12-ketal derivatives of erythromycin A and epi-erythromycin A
US4474768A (en) 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
US4518590A (en) 1984-04-13 1985-05-21 Pfizer Inc. 9α-Aza-9α-homoerythromycin compounds, pharmaceutical compositions and therapeutic method
US4585759A (en) 1985-01-22 1986-04-29 Pfizer Inc. Antibacterial derivatives of a neutral macrolide
JPH0720857B2 (en) 1988-08-11 1995-03-08 テルモ株式会社 Liposome and its manufacturing method
US5466681A (en) * 1990-02-23 1995-11-14 Microcarb, Inc. Receptor conjugates for targeting penicillin antibiotics to bacteria
US5405975A (en) * 1993-03-29 1995-04-11 Molecular Probes, Inc. Fluorescent ion-selective diaryldiaza crown ether conjugates
SI9011409A (en) 1990-07-18 1995-10-31 Pliva Pharm & Chem Works O-methyl azitromycin derivates, methods and intermediates for their preparation and methods for preparation of pharmaceuticals products which comprise them
JPH07103148B2 (en) 1991-12-16 1995-11-08 株式会社ディ・ディ・エス研究所 Anthracycline-macrolide complex
US20030068362A1 (en) 1993-02-22 2003-04-10 American Bioscience, Inc. Methods and formulations for the delivery of pharmacologically active agents
US5486536A (en) * 1994-08-15 1996-01-23 The Regents Of The University Of Michigan Sulfatides as anti-inflammatory compounds
FR2738571B1 (en) * 1995-09-11 1997-10-17 Roussel Uclaf NOVEL DERIVATIVES OF 5-0-DESOSAMINYL 6-0-METHYL- ERYTHRONOLIDE A, THEIR PREPARATION PROCESS AND THEIR APPLICATION TO THE PREPARATION OF BIOLOGICALLY ACTIVE PRODUCTS
JP2000508923A (en) * 1996-04-26 2000-07-18 マサチューセッツ・インスティテュート・オブ・テクノロジー 3-Hybrid screening assay
WO1998029437A2 (en) 1996-12-30 1998-07-09 Governors Of The University Of Alberta Mammalian equilibrative nucleoside transporters
US5827533A (en) 1997-02-06 1998-10-27 Duke University Liposomes containing active agents aggregated with lipid surfactants
EP0895999A1 (en) 1997-08-06 1999-02-10 Pfizer Products Inc. C-4" substituted macrolide antibiotics
KR100554549B1 (en) 1997-10-16 2006-03-03 플리바 파마세우츠카 인두스트리야, 디오닉코, 드러스트보 NOVEL 3,6-HEMIKETALS FROM THE CLASS OF 9a-AZALIDES
HRP980189B1 (en) 1998-04-06 2004-04-30 Pliva Pharm & Chem Works Novel 15-membered lactams ketolides
CA2318547A1 (en) 1998-06-08 1999-12-16 Advanced Medicine, Inc. Combinatorial synthesis of multibinding libraries
CA2319495A1 (en) 1998-06-08 1999-12-16 Advanced Medicine, Inc. Multibinding inhibitors of microsomal triglyceride transferase protein
AU4549999A (en) 1998-06-08 1999-12-30 Advanced Medicine, Inc. Novel polyene macrolide compounds and uses
US6043227A (en) 1998-08-19 2000-03-28 Pfizer Inc. C11 carbamates of macrolide antibacterials
US6100240A (en) 1998-10-09 2000-08-08 Pfizer Inc Macrolide derivatives
EP1210121A2 (en) 1999-08-24 2002-06-05 Cellgate Inc. Enhancing drug delivery across and into epithelial tissues using oligo arginine moieties
EP1212619B1 (en) 1999-09-14 2007-05-23 Xenoport, Inc. Substrates and screening methods for transport proteins
ID27331A (en) 1999-09-29 2001-03-29 Pfizer Prod Inc MAKING ANTIBIOTIC-ANTIBIOTIC KETOLIDA CARBAMATE
EP1122261A3 (en) 2000-01-31 2001-09-26 Pfizer Products Inc. 13 and 14-membered antibacterial macrolides
ES2222966T3 (en) 2000-06-30 2005-02-16 Pfizer Products Inc. ANTIBIOTIC MACROLIDS.
HRP20010018A2 (en) * 2001-01-09 2002-12-31 Pliva D D Novel anti-inflammatory compounds
EP1453837A4 (en) 2001-11-21 2007-11-07 Activbiotics Inc Targeted therapeutics and uses thereof
WO2003070254A1 (en) 2002-02-15 2003-08-28 Sympore Gmbh Antibiotic conjugates
EP1483579A4 (en) 2002-02-15 2006-07-12 Merckle Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
US7091187B2 (en) * 2002-07-08 2006-08-15 Pliva-Istrazivacki Institut D.O.O. Compounds, compositions and methods for treatment of inflammatory diseases and conditions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750493A (en) * 1995-08-30 1998-05-12 Raymond F. Schinazi Method to improve the biological and antiviral activity of protease inhibitors
US6562796B2 (en) * 2000-01-14 2003-05-13 Micrologix Biotech Inc. Derivatives of polyene macrolides and preparation and use thereof

Also Published As

Publication number Publication date
EP1483277A2 (en) 2004-12-08
US20040087517A1 (en) 2004-05-06
WO2003070174A2 (en) 2003-08-28
US7579324B2 (en) 2009-08-25
AU2003219770B2 (en) 2008-10-09
AU2003219770A1 (en) 2003-09-09
US20050171342A1 (en) 2005-08-04
NZ535354A (en) 2008-01-31
EP1483277A4 (en) 2007-10-03
IL163552A (en) 2010-11-30
HRP20040850A2 (en) 2005-08-31
CA2476423A1 (en) 2003-08-28

Similar Documents

Publication Publication Date Title
WO2003070174A3 (en) Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
KR100581443B1 (en) Drug Composites
CN102516417B (en) Cyclodextrin-based polymers for therapeutics delivery
WO2003061577A3 (en) Polyalkylene glycol with moiety for conjugating biologically active compound
EP3100719A3 (en) Delivery of nucleic acid-like compounds
WO2005028516A3 (en) Albumin-binding derivatives of therapeutic peptides
WO2003028527A3 (en) Diagnostic or therapeutic somatostatin or bombesin analog conjugates and uses thereof
BR0008590A (en) Polymeric delivery agent, composition, unit dosage form, method for administering a biologically active agent to an animal requiring the agent, method for preparing a composition; it's composed
WO2002024715A3 (en) Gamma-hydroxybutyrate compositions containing carbohydrate, lipid or amino acid carriers
CA2439500A1 (en) Drug delivery system for hydrophobic drugs
EP2253333A3 (en) Contrast Agents for Myocardial Perfusion Imaging
TWI315203B (en) Process for producing sterile suspensions of slightly soluble basic peptide complexes, sterile suspensions of slightly soluble basic peptide complexes, pharmaceutical formulations containing them, and the use thereof as medicaments
WO2005027828A3 (en) Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
WO2002088172A3 (en) Pentapeptide compounds and uses related thereto
AU6011701A (en) Therapeutic and diagnostic ligand systems comprising transport molecule binding properties and medicaments containing the same
WO2007060104A3 (en) Aerosol formulation for inhalation containing an anticholinergic agent
WO2009150284A3 (en) Apo-a conjugates for the administration of biologically active compounds
AU2003215245A8 (en) Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
WO2001092283A3 (en) Cobalamin compounds useful as cardiovascular agents and as imaging agents
WO2007060408A3 (en) L-phenylalanine derivatives and their use as integrin antagonists
WO1999024076A3 (en) Salicylate derivatized therapeutic and diagnostic agents
EP1666459A3 (en) Aminocyclohexyl ether compounds and uses thereof
WO2014180533A2 (en) Conjugates for protection from nephrotoxic active substances
TW200634002A (en) Chemical compounds
WO2004112838A3 (en) Codrugs of diclofenac

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SC SD SE SG SK SL TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 1815/CHENP/2004

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 163552

Country of ref document: IL

WWE Wipo information: entry into national phase

Ref document number: 2476423

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2003219770

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: P20040850A

Country of ref document: HR

Ref document number: 535354

Country of ref document: NZ

Ref document number: 2003716044

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2003716044

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 10504787

Country of ref document: US

NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Ref document number: JP