WO2006091506A3 - Neuropeptide y4 receptor agonists - Google Patents

Neuropeptide y4 receptor agonists Download PDF

Info

Publication number
WO2006091506A3
WO2006091506A3 PCT/US2006/005819 US2006005819W WO2006091506A3 WO 2006091506 A3 WO2006091506 A3 WO 2006091506A3 US 2006005819 W US2006005819 W US 2006005819W WO 2006091506 A3 WO2006091506 A3 WO 2006091506A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptor agonists
peptides
neuropeptide
mammal
food intake
Prior art date
Application number
PCT/US2006/005819
Other languages
French (fr)
Other versions
WO2006091506A2 (en
Inventor
Kevin Lumb
Lynn Decarr
Original Assignee
Bayer Pharmaceuticals Corp
Kevin Lumb
Lynn Decarr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharmaceuticals Corp, Kevin Lumb, Lynn Decarr filed Critical Bayer Pharmaceuticals Corp
Publication of WO2006091506A2 publication Critical patent/WO2006091506A2/en
Publication of WO2006091506A3 publication Critical patent/WO2006091506A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57545—Neuropeptide Y

Abstract

This invention provides peptides that act as selective NPY4 receptor agonists in vitro and are efficacious in vivo to reduce food intake. The invention is a peptide selected from a specific group of derivatized PP-related peptides, or functional equivalents thereof. The invention is also directed to a method of treating a metabolic disease in a mammal comprising administering a therapeutically effective amount of the peptides to said mammal to reduce food intake and body weight.
PCT/US2006/005819 2005-02-24 2006-02-17 Neuropeptide y4 receptor agonists WO2006091506A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65572705P 2005-02-24 2005-02-24
US60/655,727 2005-02-24

Publications (2)

Publication Number Publication Date
WO2006091506A2 WO2006091506A2 (en) 2006-08-31
WO2006091506A3 true WO2006091506A3 (en) 2006-11-02

Family

ID=36927919

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/005819 WO2006091506A2 (en) 2005-02-24 2006-02-17 Neuropeptide y4 receptor agonists

Country Status (1)

Country Link
WO (1) WO2006091506A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007075534A2 (en) 2005-12-16 2007-07-05 Nektar Therapeutics Al, Corporation Polymer conjugates of glp-1
US20070197445A1 (en) 2006-01-18 2007-08-23 University Of Cincinnati Compounds for control of appetite
RU2506273C2 (en) * 2007-07-09 2014-02-10 Импиэриэл Инноувейшнс Лимитид Analogue of human pancreatic polypeptide (versions), pharmaceutical composition based thereon, method of treating obesity or diabetes, method of reducing appetite, reducing food intake or reducing calorie intake and method for cosmetic weight reduction using said analogue
KR20110050708A (en) * 2008-09-04 2011-05-16 아디아 바이오사이언스즈 인크. Compounds, compositions and methods of using same for modulating uric acid levels
TW201124391A (en) 2009-10-20 2011-07-16 Lundbeck & Co As H 2-substituted-ethynylthiazole derivatives and uses of same
CN103298469A (en) 2010-08-31 2013-09-11 首尔大学校产学协力财团 Use of the fetal reprogramming of a PPAR delta agonist
US9346852B2 (en) 2011-03-14 2016-05-24 Bristol-Myers Scuibb Company Substituted adipic acid amides and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5516653A (en) * 1993-12-28 1996-05-14 Synaptic Pharmaceutical Corporation DNA encoding a human neuropeptide Y/peptide YY/pancreatic polypeptide receptor (Y4) and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5516653A (en) * 1993-12-28 1996-05-14 Synaptic Pharmaceutical Corporation DNA encoding a human neuropeptide Y/peptide YY/pancreatic polypeptide receptor (Y4) and uses thereof

Also Published As

Publication number Publication date
WO2006091506A2 (en) 2006-08-31

Similar Documents

Publication Publication Date Title
WO2006049681A3 (en) Selective neuropeptide y2 receptor agonists
WO2006091506A3 (en) Neuropeptide y4 receptor agonists
WO2006034373A3 (en) Variants and chemically-modified variants of phenylalanine ammonia-lyase
WO2005120557A3 (en) Inhibition of macrophage-stimulating protein receptor (ron)
WO2007073486A3 (en) Methods and compositions for delivering active agents with enhanced pharmacological properties
WO2006089114A3 (en) Methods and compositions for treating an anthrax toxin mediated condition
EA200971130A1 (en) GUANILACYCLAZE AGONISTS SUITABLE FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS, INFLAMMATION, CANCER AND OTHER DISEASES
IL222880A (en) Peptides and uses thereof in the treatment and diagnosis of diseases and pharmaceutical compositions comprising the same
EP2447280A3 (en) VEGF analogs and methods of use
EP2239328A3 (en) Methods and compositions for treating neurological disease
EP1764370A3 (en) Methods of treatment of inflammatory diseases using specific binding agents of human angiopoietin - 2
EP2330111A3 (en) Oligoribonucleotides and methods of use thereof for treatment of fibrotic conditions and other diseases
EP2628486A3 (en) Method for treating bone fracture with anti-sclerostin antibodies
NZ623123A (en) A process for concentration of a polypeptide
EP2628749A3 (en) Antimicrobial kinocidin compostions and methods of use
WO2011156453A3 (en) Therapeutic peptides
WO2006023359A3 (en) Selective vpac2 receptor peptide agonists
EP2319531A3 (en) Stimulation of proliferation of pluripotential stem cells through administration of pregnancy associated compounds
WO2008142303A3 (en) Use of an anti-cxcr4 antibody for treating cancer
WO2009010968A3 (en) Disease treatment via antimicrobial peptides or their inhibitors
WO2008033987A3 (en) Compositions and methods to prevent cancer with cupredoxins
WO2008070011A3 (en) Combination of an hdac inhibitor and an antimetabolite
WO2005072277A3 (en) Amidated parathyroid hormone fragments and uses thereof
WO2007019860A3 (en) Gdnf derived peptides
WO2007095729A8 (en) Cytotoxicity mediation of cells evidencing surface expression of cd63

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 06735470

Country of ref document: EP

Kind code of ref document: A2