WO2006099169A3 - Novel liposome compositions - Google Patents

Novel liposome compositions Download PDF

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Publication number
WO2006099169A3
WO2006099169A3 PCT/US2006/008650 US2006008650W WO2006099169A3 WO 2006099169 A3 WO2006099169 A3 WO 2006099169A3 US 2006008650 W US2006008650 W US 2006008650W WO 2006099169 A3 WO2006099169 A3 WO 2006099169A3
Authority
WO
WIPO (PCT)
Prior art keywords
liposome compositions
novel liposome
containing compositions
lipid
targeted liposomes
Prior art date
Application number
PCT/US2006/008650
Other languages
French (fr)
Other versions
WO2006099169A2 (en
Inventor
Kazushi Okada
Tadayuki Ibuki
Donghyun Kim
Tadashi Fujisawa
Original Assignee
Mebiopharm Co Ltd
Kazushi Okada
Tadayuki Ibuki
Donghyun Kim
Tadashi Fujisawa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to KR1020077023219A priority Critical patent/KR101352490B1/en
Priority to BRPI0608297-1A priority patent/BRPI0608297A2/en
Priority to SI200631892T priority patent/SI1863448T1/en
Priority to JP2008500977A priority patent/JP5438317B2/en
Priority to NZ561569A priority patent/NZ561569A/en
Priority to PL06737793T priority patent/PL1863448T3/en
Priority to CA002600446A priority patent/CA2600446A1/en
Priority to MX2007010996A priority patent/MX2007010996A/en
Application filed by Mebiopharm Co Ltd, Kazushi Okada, Tadayuki Ibuki, Donghyun Kim, Tadashi Fujisawa filed Critical Mebiopharm Co Ltd
Priority to AU2006223329A priority patent/AU2006223329B2/en
Priority to CN2006800159670A priority patent/CN101170995B/en
Priority to DK06737793.7T priority patent/DK1863448T3/en
Priority to ES06737793.7T priority patent/ES2529453T3/en
Priority to EP06737793.7A priority patent/EP1863448B1/en
Publication of WO2006099169A2 publication Critical patent/WO2006099169A2/en
Publication of WO2006099169A3 publication Critical patent/WO2006099169A3/en
Priority to NO20075136A priority patent/NO20075136L/en
Priority to HK08105936.8A priority patent/HK1111625A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The present disclosure provides lipid-containing compositions, including targeted liposomes encapsulating drug, and pharmaceutical formulations thereof, as well as methods for the making and using the lipid-containing compositions, including the use of the targeted liposomes in the treatment of cancer and other diseases.
PCT/US2006/008650 2005-03-10 2006-03-08 Novel liposome compositions WO2006099169A2 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
AU2006223329A AU2006223329B2 (en) 2005-03-10 2006-03-08 Novel liposome compositions
BRPI0608297-1A BRPI0608297A2 (en) 2005-03-10 2006-03-08 liposome compositions
CN2006800159670A CN101170995B (en) 2005-03-10 2006-03-08 Novel liposome compositions
NZ561569A NZ561569A (en) 2005-03-10 2006-03-08 Novel liposome compositions comprising SuccNomegaPE:NomegaPE:additional lipids and TF-NomegaPE:NomegaPE:additional lipids
PL06737793T PL1863448T3 (en) 2005-03-10 2006-03-08 Novel liposome compositions
CA002600446A CA2600446A1 (en) 2005-03-10 2006-03-08 Novel liposome compositions
MX2007010996A MX2007010996A (en) 2005-03-10 2006-03-08 Novel liposome compositions.
KR1020077023219A KR101352490B1 (en) 2005-03-10 2006-03-08 Novel liposome compositions
SI200631892T SI1863448T1 (en) 2005-03-10 2006-03-08 Novel liposome compositions
JP2008500977A JP5438317B2 (en) 2005-03-10 2006-03-08 Novel liposome composition
DK06737793.7T DK1863448T3 (en) 2005-03-10 2006-03-08 NEW LIPOSOM COMPOSITIONS
ES06737793.7T ES2529453T3 (en) 2005-03-10 2006-03-08 New liposome compositions
EP06737793.7A EP1863448B1 (en) 2005-03-10 2006-03-08 Novel liposome compositions
NO20075136A NO20075136L (en) 2005-03-10 2007-10-09 New liposome preparations
HK08105936.8A HK1111625A1 (en) 2005-03-10 2008-05-28 Novel liposome compositions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005067469A JP2006248978A (en) 2005-03-10 2005-03-10 New liposome preparation
JP2005-67469 2005-03-10

Publications (2)

Publication Number Publication Date
WO2006099169A2 WO2006099169A2 (en) 2006-09-21
WO2006099169A3 true WO2006099169A3 (en) 2007-02-22

Family

ID=36992280

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/008650 WO2006099169A2 (en) 2005-03-10 2006-03-08 Novel liposome compositions

Country Status (22)

Country Link
US (3) US7829113B2 (en)
EP (1) EP1863448B1 (en)
JP (2) JP2006248978A (en)
KR (1) KR101352490B1 (en)
CN (1) CN101170995B (en)
AU (1) AU2006223329B2 (en)
BR (1) BRPI0608297A2 (en)
CA (1) CA2600446A1 (en)
CY (1) CY1116075T1 (en)
DK (1) DK1863448T3 (en)
ES (1) ES2529453T3 (en)
HK (1) HK1111625A1 (en)
HU (1) HUE024290T2 (en)
MX (1) MX2007010996A (en)
NO (1) NO20075136L (en)
NZ (1) NZ561569A (en)
PL (1) PL1863448T3 (en)
PT (1) PT1863448E (en)
RU (1) RU2454229C2 (en)
SI (1) SI1863448T1 (en)
WO (1) WO2006099169A2 (en)
ZA (1) ZA200708600B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7829113B2 (en) 2005-03-10 2010-11-09 Mebiopharm Co., Ltd. Liposome compositions

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101462819B1 (en) 2004-05-03 2014-11-21 헤르메스 바이오사이언스, 인코포레이티드 Liposomes useful for drug delivery
CN101209243B (en) * 2006-12-29 2010-12-08 石药集团中奇制药技术（石家庄）有限公司 Liposome medicament and preparation thereof
WO2009097011A1 (en) * 2007-08-17 2009-08-06 Celator Pharmaceuticals, Inc. Improved platinum drug formulations
HUE027443T2 (en) * 2007-09-10 2016-10-28 Boston Biomedical Inc A novel group of stat3 pathway inhibitors and cancer stem cell pathway inhibitors
TWI468188B (en) 2008-01-30 2015-01-11 Univ Tokushima Anti-cancer effect enhancers consisting of oxaliplatin liposomal preparations and anticancer agents comprising the formulation
WO2011005769A1 (en) * 2009-07-06 2011-01-13 Variation Biotechnologies, Inc. Methods for preparing vesicles and formulations produced therefrom
US8956600B2 (en) 2009-08-10 2015-02-17 Taiwan Liposome Co. Ltd. Ophthalmic drug delivery system containing phospholipid and cholesterol
WO2011038068A1 (en) * 2009-09-23 2011-03-31 Formatech, Inc. Methods for the preparation of liposomes
US10143652B2 (en) * 2009-09-23 2018-12-04 Curirx Inc. Methods for the preparation of liposomes
WO2011102904A1 (en) * 2010-02-19 2011-08-25 Robert Shorr Imageable lipid-oil-water nanoemulsion therapeutic delivery system
RU2591823C2 (en) 2010-03-19 2016-07-20 Бостон Байомедикал, Инк. Novel methods for targeting cancer stem cells
EP2558108A1 (en) * 2010-04-12 2013-02-20 Ramot at Tel-Aviv University Ltd Iron oxide nanoparticles for use in treating non-infectious inflammatory disorders
EP2637697A4 (en) 2010-11-12 2016-07-13 Cour Pharmaceuticals Dev Company Modified immune-modulating particles
WO2012153616A1 (en) * 2011-05-10 2012-11-15 国立大学法人北海道大学 Lipid membrane structure capable of imigrating to target cell and method for producing same, and method for screening for substance exhibiting effect thereof in target cell
JP5983608B2 (en) * 2011-07-15 2016-09-06 コニカミノルタ株式会社 Liposome-containing preparation using dissolution aid and method for producing the same
EP2734621B1 (en) 2011-07-22 2019-09-04 President and Fellows of Harvard College Evaluation and improvement of nuclease cleavage specificity
US20150216998A1 (en) * 2012-01-01 2015-08-06 Ramot At Tel-Aviv University Ltd. Endo180-targeted particles for selective delivery of therapeutic and diagnostic agents
AU2013202947B2 (en) 2012-06-13 2016-06-02 Ipsen Biopharm Ltd. Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan
US9717724B2 (en) 2012-06-13 2017-08-01 Ipsen Biopharm Ltd. Methods for treating pancreatic cancer using combination therapies
PT2863942T (en) * 2012-06-21 2019-07-17 Univ Northwestern Peptide conjugated particles
SG11201501010QA (en) 2012-08-10 2015-04-29 Taiho Pharmaceutical Co Ltd Stable oxaliplatin-encapsulating liposome aqueous dispersion and method for stabilizing same
WO2014092858A1 (en) * 2012-12-12 2014-06-19 Temple University - Of The Commonwealth System Of Higher Education Compositions and methods for treatment of cancer
CN103083239B (en) * 2012-12-26 2015-11-25 中国人民解放军第四军医大学 A kind of bufalin liposome and its preparation method and application
TWI718086B (en) 2013-01-07 2021-02-11 英屬維爾京群島商遠東超級實驗室有限公司 Methods and compositions for treatment of bone, skin, subcutaneous, mucosal and/or submucosal cancer by percutaneous and/or transmucosal administration of interferon
US9468681B2 (en) 2013-03-01 2016-10-18 California Institute Of Technology Targeted nanoparticles
CN105263476A (en) 2013-03-13 2016-01-20 库尔制药开发公司 Immune-modifying particles for the treatment of inflammation
BR112015022415A2 (en) * 2013-03-13 2017-07-18 Mallinckrodt Llc Liposomal cisplatin compositions for cancer therapy
JP6341987B2 (en) * 2013-03-13 2018-06-13 マリンクロッド エルエルシー Liposomal oxaliplatin composition for cancer treatment
EP2983790A2 (en) 2013-04-09 2016-02-17 Boston Biomedical, Inc. Methods for treating cancer
US9163284B2 (en) 2013-08-09 2015-10-20 President And Fellows Of Harvard College Methods for identifying a target site of a Cas9 nuclease
KR20230008909A (en) 2013-08-13 2023-01-16 노쓰웨스턴유니버시티 Peptide conjugated particles
US9359599B2 (en) 2013-08-22 2016-06-07 President And Fellows Of Harvard College Engineered transcription activator-like effector (TALE) domains and uses thereof
US9737604B2 (en) 2013-09-06 2017-08-22 President And Fellows Of Harvard College Use of cationic lipids to deliver CAS9
US9340799B2 (en) 2013-09-06 2016-05-17 President And Fellows Of Harvard College MRNA-sensing switchable gRNAs
US9322037B2 (en) 2013-09-06 2016-04-26 President And Fellows Of Harvard College Cas9-FokI fusion proteins and uses thereof
ES2670983T3 (en) 2013-11-07 2018-06-04 Editas Medicine, Inc. Methods and compositions related to CRISPR with rRNA guiding
US11053481B2 (en) 2013-12-12 2021-07-06 President And Fellows Of Harvard College Fusions of Cas9 domains and nucleic acid-editing domains
WO2015183357A2 (en) * 2014-02-21 2015-12-03 The Curators Of The University Of Missouri Compositions and methods for boron neutron capture therapy
EP4079847A1 (en) 2014-07-30 2022-10-26 President And Fellows Of Harvard College Cas9 proteins including ligand-dependent inteins
US10098813B2 (en) * 2014-09-03 2018-10-16 Sun Pharmaceutical Industries Limited Perfusion dosage form
EP3212165B1 (en) 2014-10-30 2024-02-28 President and Fellows of Harvard College Delivery of negatively charged proteins using cationic lipids
US9816080B2 (en) 2014-10-31 2017-11-14 President And Fellows Of Harvard College Delivery of CAS9 via ARRDC1-mediated microvesicles (ARMMs)
US11318131B2 (en) 2015-05-18 2022-05-03 Ipsen Biopharm Ltd. Nanoliposomal irinotecan for use in treating small cell lung cancer
WO2016208481A1 (en) 2015-06-24 2016-12-29 日本化薬株式会社 Novel platinum (iv) complex
ES2848118T3 (en) 2015-08-20 2021-08-05 Ipsen Biopharm Ltd Combination therapy using liposomal irinotecan and a PARP inhibitor for the treatment of cancer
BR112018002941B1 (en) 2015-08-21 2023-12-05 Ipsen Biopharm Ltd USE OF LIPOSOMAL IRINOTECAN, OXALIPLATIN, LEUCOVORIN AND 5-FLUOROURACIL IN FIRST-LINE TREATMENT OF METASTATIC ADENOCARCINOMA OF THE PANCREAS
US10596191B2 (en) 2015-09-14 2020-03-24 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of hexa-coordinated platinum complex
MA42991A (en) 2015-10-16 2018-08-22 Ipsen Biopharm Ltd STABILIZATION OF PHARMACEUTICAL COMPOSITIONS OF CAMPTOTHECIN
CN108513575A (en) 2015-10-23 2018-09-07 哈佛大学的校长及成员们 Nucleobase editing machine and application thereof
WO2017087685A1 (en) * 2015-11-20 2017-05-26 The Regents Of The University Of California Deformable nano-scale vehicles (dnvs) for trans-blood brain barrier, trans-mucosal, and transdermal drug delivery
CA3009130A1 (en) 2015-12-22 2017-06-29 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of sulfoxide derivative-coordinated platinum(ii) complex
CN106995465B (en) 2016-01-25 2019-11-01 沈阳药科大学 A kind of compound and its application and a kind of platinum complexes and its liposome
CN109312341B (en) 2016-03-07 2024-02-27 美国政府(由卫生和人类服务部的部长所代表) Micrornas and methods of use thereof
JP6606600B2 (en) * 2016-04-15 2019-11-13 富士フイルム株式会社 Microneedle array
EP3493790A4 (en) * 2016-08-02 2020-03-25 Curirx Inc. Methods for the preparation of liposomes
KR20230095129A (en) 2016-08-03 2023-06-28 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 Adenosine nucleobase editors and uses thereof
EP3497214B1 (en) 2016-08-09 2023-06-28 President and Fellows of Harvard College Programmable cas9-recombinase fusion proteins and uses thereof
AU2017308158B2 (en) 2016-08-12 2023-08-10 L.E.A.F. Holdings Group Llc Alpha and gamma-D polyglutamated antifolates and uses thereof
WO2018039438A1 (en) 2016-08-24 2018-03-01 President And Fellows Of Harvard College Incorporation of unnatural amino acids into proteins using base editing
SG11201903089RA (en) 2016-10-14 2019-05-30 Harvard College Aav delivery of nucleobase editors
EA201990979A1 (en) 2016-11-02 2019-09-30 Ипсен Биофарм Лтд. METHODS FOR TREATING GASTROINTESTINAL CANCER USING COMBINATION TYPES OF THERAPY CONTAINING LIPOSOMAL IRINOTECAN AND OXALALPLATIN
WO2018087720A1 (en) 2016-11-14 2018-05-17 Novartis Ag Compositions, methods, and therapeutic uses related to fusogenic protein minion
WO2018102427A1 (en) 2016-11-29 2018-06-07 Boston Biomedical, Inc. Naphthofuran derivatives, preparation, and methods of use thereof
WO2018119359A1 (en) 2016-12-23 2018-06-28 President And Fellows Of Harvard College Editing of ccr5 receptor gene to protect against hiv infection
US11898179B2 (en) 2017-03-09 2024-02-13 President And Fellows Of Harvard College Suppression of pain by gene editing
JP2020510439A (en) 2017-03-10 2020-04-09 プレジデント アンド フェローズ オブ ハーバード カレッジ Base-editing factor from cytosine to guanine
US11268082B2 (en) 2017-03-23 2022-03-08 President And Fellows Of Harvard College Nucleobase editors comprising nucleic acid programmable DNA binding proteins
CN110869006A (en) * 2017-05-12 2020-03-06 库里纳尔克斯有限公司 Method for preparing liposome containing medicine
WO2018209320A1 (en) 2017-05-12 2018-11-15 President And Fellows Of Harvard College Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation
US10646464B2 (en) 2017-05-17 2020-05-12 Boston Biomedical, Inc. Methods for treating cancer
US11732274B2 (en) 2017-07-28 2023-08-22 President And Fellows Of Harvard College Methods and compositions for evolving base editors using phage-assisted continuous evolution (PACE)
WO2019139645A2 (en) 2017-08-30 2019-07-18 President And Fellows Of Harvard College High efficiency base editors comprising gam
US11795443B2 (en) 2017-10-16 2023-10-24 The Broad Institute, Inc. Uses of adenosine base editors
EP3749316A4 (en) 2018-02-07 2021-10-27 L.E.A.F Holdings Group LLC Alpha polyglutamated pralatrexate and uses thereof
CN111954531A (en) 2018-02-07 2020-11-17 L.E.A.F.控股集团公司 Alpha polyglutamated pemetrexed and its use
WO2019160734A1 (en) 2018-02-14 2019-08-22 L.E.A.F. Holdings Group Llc Gamma polyglutamated lometrexol and uses thereof
CN108524450A (en) * 2018-04-16 2018-09-14 温州医科大学 Oxaliplatin and MDC1-AS based on magnetic temperature-sensitive cationic-liposome transmit the preparation and application of pharmaceutical carrier altogether
KR20210068485A (en) 2018-09-28 2021-06-09 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 Cellular reprogramming to reverse aging and promote organ and tissue regeneration
CA3114699A1 (en) 2018-10-09 2020-04-16 The University Of British Columbia Compositions and systems comprising transfection-competent vesicles free of organic-solvents and detergents and methods related thereto
WO2020191249A1 (en) 2019-03-19 2020-09-24 The Broad Institute, Inc. Methods and compositions for editing nucleotide sequences
CN111721841B (en) * 2019-03-19 2022-07-12 海南长安国际制药有限公司 Detection of lobaplatin-related substances
CN110292563B (en) * 2019-06-12 2021-07-16 兰州大学 Method for inducing cancer cell apoptosis by using folic acid heat-sensitive liposome-based anion carrier
MX2022012265A (en) 2020-04-02 2023-01-11 Mirecule Inc Targeted inhibition using engineered oligonucleotides.
DE112021002672T5 (en) 2020-05-08 2023-04-13 President And Fellows Of Harvard College METHODS AND COMPOSITIONS FOR EDIT BOTH STRANDS SIMULTANEOUSLY OF A DOUBLE STRANDED NUCLEOTIDE TARGET SEQUENCE
CN112129871B (en) * 2020-09-04 2021-06-15 斯微(上海)生物科技有限公司 Method for detecting contents of DOPE and M5 phospholipids in composite phospholipid liposome
CN112870164B (en) * 2021-01-25 2021-12-17 山东大学 Double-targeting drug-loaded liposome and preparation method and application thereof
WO2023196851A1 (en) 2022-04-06 2023-10-12 President And Fellows Of Harvard College Reversing aging of the central nervous system

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986004232A1 (en) * 1985-01-18 1986-07-31 Cooper-Lipotech, Inc. Liposome composition and method
US5419914A (en) * 1990-10-09 1995-05-30 Vestar, Inc. Phospholipid analogue vesicle
WO1996021658A1 (en) * 1995-01-09 1996-07-18 The Liposome Company, Inc. Hydrophobic taxane derivatives
US5891468A (en) * 1996-10-11 1999-04-06 Sequus Pharmaceuticals, Inc. Fusogenic liposome compositions and method
EP1209469A1 (en) * 2000-11-22 2002-05-29 Vectron Therapeutics AG Production and use of a targeted diagnostic system
US20030129223A1 (en) * 2000-10-11 2003-07-10 Targesome, Inc. Targeted multivalent macromolecules

Family Cites Families (153)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6041077B2 (en) 1976-09-06 1985-09-13 喜徳 喜谷 Cis platinum(2) complex of 1,2-diaminocyclohexane isomer
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
GR75598B (en) 1980-04-29 1984-08-01 Sanofi Sa
US4534899A (en) 1981-07-20 1985-08-13 Lipid Specialties, Inc. Synthetic phospholipid compounds
US4565696A (en) 1983-08-03 1986-01-21 The Regents Of The University Of California Production of immunogens by antigen conjugation to liposomes
US4925661A (en) 1984-04-19 1990-05-15 Leaf Huang Target-specific cytotoxic liposomes
US4789633A (en) 1984-04-19 1988-12-06 University Of Tennessee Research Corporation Fused liposome and acid induced method for liposome fusion
US5736155A (en) 1984-08-08 1998-04-07 The Liposome Company, Inc. Encapsulation of antineoplastic agents in liposomes
US4762915A (en) * 1985-01-18 1988-08-09 Liposome Technology, Inc. Protein-liposome conjugates
US5026651A (en) 1985-04-25 1991-06-25 Board Of Regents, The University Of Texas System Methods and compositions for the production of human transferrin
PH26160A (en) * 1985-08-19 1992-03-18 Univ Texas Pharmaceutical compositions consisting of acylated phospholipids
US4983397A (en) 1985-08-19 1991-01-08 Board Of Regents, University Of Texas System Pharmaceutical compositions consisting of acylated phospholipids
US5384127A (en) 1985-10-18 1995-01-24 Board Of Regents, The University Of Texas System Stable liposomal formulations of lipophilic platinum compounds
JPH0714865B2 (en) 1986-10-28 1995-02-22 武田薬品工業株式会社 Liposome preparation and method for producing the same
US5049390A (en) 1987-09-02 1991-09-17 Allergy Immuno Technologies, Inc. Liposome containing immunotherapy agents for treating IgE mediated allergies
US4853224A (en) 1987-12-22 1989-08-01 Visionex Biodegradable ocular implants
FR2631826B1 (en) 1988-05-27 1992-06-19 Centre Nat Rech Scient PARTICULATE VECTOR USEFUL IN PARTICULAR FOR THE TRANSPORT OF BIOLOGICALLY ACTIVATED MOLECULES AND METHOD FOR THE PREPARATION THEREOF
JPH0720857B2 (en) 1988-08-11 1995-03-08 テルモ株式会社 Liposome and its manufacturing method
ES2188580T3 (en) 1989-08-02 2003-07-01 Mitra Medical Technology Ab SYSTEM FOR USE IN A THERAPEUTIC OR DIAGNOSTIC TREATMENT METHOD.
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5554728A (en) 1991-07-23 1996-09-10 Nexstar Pharmaceuticals, Inc. Lipid conjugates of therapeutic peptides and protease inhibitors
US6509032B1 (en) 1991-08-28 2003-01-21 Mcmaster University Cationic amphiphiles
US5292524A (en) 1991-09-06 1994-03-08 California Institute Of Technology Blood platelet loaded with diagnostic or therapeutic-containing liposome or reconstituted Sendai virus
JPH0776230B2 (en) 1992-01-13 1995-08-16 田中貴金属工業株式会社 Method for producing platinum compound
JP2673331B2 (en) 1993-01-12 1997-11-05 田中貴金属工業 株式会社 Optically pure cis-oxalate (trans-1-1,2-cyclohexanediamine) platinum (▲ II ▼)
JPH06287021A (en) 1992-04-22 1994-10-11 Tanaka Kikinzoku Kogyo Kk Optical resolution of optically active platinum complex compound
US20030190638A1 (en) 1992-05-13 2003-10-09 Board Of Regents, The University Of Texas System Methods of screening for compounds that derepress or increase telomerase activity
US20030100489A1 (en) 1992-10-16 2003-05-29 Beach David H. Cell-cycle regulatory proteins, and uses related thereto
US5962316A (en) 1992-10-16 1999-10-05 Cold Spring Harbor Laboratory Cell-cycle regulatory proteins, and uses related thereto
WO1994026254A1 (en) 1993-05-17 1994-11-24 The Liposome Company, Inc. Incorporation of taxol into liposomes and gels
JP3025602B2 (en) 1993-05-21 2000-03-27 デビオファーム エス．アー． Method for producing optically high purity cis-oxalate (trans-l-l, 2-cyclohexanediamine) platinum (II) complex
US5534241A (en) 1993-07-23 1996-07-09 Torchilin; Vladimir P. Amphipathic polychelating compounds and methods of use
ATE222752T1 (en) * 1993-10-06 2002-09-15 Amgen Inc STABLE PROTEIN PHOSPHOLIPID COMPOSITIONS AND METHODS
WO1995016774A1 (en) 1993-12-17 1995-06-22 Spinal Cord Society Method for inducing dna synthesis in neurons
US6057299A (en) 1994-01-13 2000-05-02 Calydon, Inc. Tissue-specific enhancer active in prostate
US5830686A (en) 1994-01-13 1998-11-03 Calydon Tissue-specific enhancer active in prostate
JP3590983B2 (en) * 1994-03-04 2004-11-17 日本油脂株式会社 Phospholipid derivatives
ATE219688T1 (en) 1994-03-28 2002-07-15 Nycomed Imaging As LIPOSOMES CONTAINING AN X-RAY OR ULTRASONIC CONTRAST AGENT
ATE187160T1 (en) 1994-07-29 1999-12-15 Abbott Lab METHOD FOR PRODUCING A SUBSTITUTED 2,5-DIAMINO-3-HYDROXY HEXANES
ATE197249T1 (en) 1994-08-08 2000-11-15 Debiopharm Sa STABLE MEDICINAL PRODUCT CONTAINING OXALIPLATIN
JPH10507450A (en) * 1994-10-14 1998-07-21 ザ リポソーム カンパニー、インコーポレーテッド Ether lipid liposomes and their therapeutic use
DE69531722T2 (en) 1994-11-11 2004-07-01 Debiopharm S.A. Carcinostatic compositions containing cis-oxaliplatin and one or more other compatible carcinostats
US5786214A (en) 1994-12-15 1998-07-28 Spinal Cord Society pH-sensitive immunoliposomes and method of gene delivery to the mammalian central nervous system
US6008202A (en) 1995-01-23 1999-12-28 University Of Pittsburgh Stable lipid-comprising drug delivery complexes and methods for their production
TW319763B (en) 1995-02-01 1997-11-11 Epix Medical Inc
US5780052A (en) 1995-04-24 1998-07-14 Northeastern University Compositions and methods useful for inhibiting cell death and for delivering an agent into a cell
US5834012A (en) 1995-05-03 1998-11-10 Roman Perez-Soler Lipid complexed topoisomerase I inhibitors
US20020022264A1 (en) 1995-05-26 2002-02-21 Sullivan Sean M. Delivery vehicles comprising stable lipid/nucleic acid complexes
US6825174B2 (en) 1995-06-07 2004-11-30 East Carolina University Composition, formulations & method for prevention & treatment of diseases and conditions associated with bronchoconstriction, allergy(ies) & inflammation
JPH09278785A (en) 1996-04-10 1997-10-28 Tanaka Kikinzoku Kogyo Kk Production of platinum compound
FR2740686B1 (en) 1995-11-03 1998-01-16 Sanofi Sa STABLE LYOPHILIZED PHARMACEUTICAL FORMULATION
US6428977B1 (en) 1995-12-20 2002-08-06 Curis, Inc. Signalin family of TGFβ signal transduction proteins, and uses related thereto
JP3735921B2 (en) 1996-02-07 2006-01-18 三菱ウェルファーマ株式会社 GPIb / lipid complex and uses thereof
AU2112697A (en) 1996-02-09 1997-08-28 Pi-Wan Cheng Receptor ligand-facilitated delivery of biologically active molecules
JP3862758B2 (en) 1996-03-11 2006-12-27 喜徳 喜谷 Binuclear platinum complex, preparation method thereof and pharmaceutical composition containing the complex
WO1997035560A1 (en) 1996-03-28 1997-10-02 The Board Of Trustees Of The University Of Illinois Materials and methods for making improved echogenic liposome compositions
JP3154399B2 (en) 1996-07-04 2001-04-09 デビオファーム エス．アー． Method for producing platinum compound
US6228391B1 (en) 1996-05-02 2001-05-08 Terumo Kabushiki Kaisha Amidine derivatives and drug carriers comprising the same
ES2208946T3 (en) 1996-08-23 2004-06-16 Sequus Pharmaceuticals, Inc. LIPOSOMES CONTAINING A CISPLATIN COMPOUND.
US6056973A (en) 1996-10-11 2000-05-02 Sequus Pharmaceuticals, Inc. Therapeutic liposome composition and method of preparation
IL130822A (en) 1996-10-15 2005-12-18 Elan Pharm Inc N-acyl phosphatidylethanolamine-mediated liposomaldrug delivery
US6087325A (en) * 1996-10-15 2000-07-11 The Liposome Company, Inc. Peptide-lipid conjugates
AU5729898A (en) 1996-12-18 1998-07-15 Emory University Polycationic oligomers
BR9808221A (en) 1997-03-07 2000-05-16 Sanofi Winthrop Inc Tumor treatment method.
DE19709704C2 (en) 1997-03-10 1999-11-04 Michael Georgieff Use of a liquid preparation of xenon for intravenous administration when inducing and / or maintaining anesthesia
JPH10253632A (en) 1997-03-10 1998-09-25 Nissui Pharm Co Ltd Method, kit and device for analysis
US6120751A (en) * 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
US6060082A (en) 1997-04-18 2000-05-09 Massachusetts Institute Of Technology Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery
US6524613B1 (en) 1997-04-30 2003-02-25 Regents Of The University Of Minnesota Hepatocellular chimeraplasty
US6272370B1 (en) 1998-08-07 2001-08-07 The Regents Of University Of Minnesota MR-visible medical device for neurological interventions using nonlinear magnetic stereotaxis and a method imaging
WO1998059035A2 (en) 1997-06-25 1998-12-30 The Goverment Of The United States Of America, Represented By The Secretary, Dept. Of Health And Human Services, National Institutes Of Health Serum-free cell growth medium
US6165719A (en) 1997-07-15 2000-12-26 The Regents Of The University Of California hKCa3/KCNN3 small conductance calcium activated potassium channel: a diagnostic marker and therapeutic target
DE69838584T2 (en) 1997-08-04 2008-06-26 Cell Genesys, Inc., Foster City ENHANCERS OF HUMAN GLANDULAR CALLIQUE, VECTORS CONTAINING HIM, AND METHODS FOR ITS USE
AU742438C (en) 1997-10-02 2003-05-22 Lantheus Medical Imaging, Inc. Contrast-enhanced diagnostic imaging method for monitoring interventional therapies
US6749863B1 (en) 1997-11-19 2004-06-15 Georgetown University Targeted liposome gene delivery
US6320017B1 (en) 1997-12-23 2001-11-20 Inex Pharmaceuticals Corp. Polyamide oligomers
WO1999041403A1 (en) 1998-02-12 1999-08-19 The Regents Of The University Of California Compositions for receptor/liposome mediated transfection and methods of using same
GB9804013D0 (en) 1998-02-25 1998-04-22 Sanofi Sa Formulations
US6245427B1 (en) 1998-07-06 2001-06-12 DüZGüNES NEJAT Non-ligand polypeptide and liposome complexes as intracellular delivery vehicles
CA2346564C (en) 1998-10-14 2011-05-03 Debiopharm S.A. Oxaliplatinum preparation packaging
US7311924B2 (en) 1999-04-01 2007-12-25 Hana Biosciences, Inc. Compositions and methods for treating cancer
US6723338B1 (en) 1999-04-01 2004-04-20 Inex Pharmaceuticals Corporation Compositions and methods for treating lymphoma
AU5136100A (en) 1999-05-17 2000-12-05 Avi Biopharma, Inc. Combined approach to treatment of cancer with hcg vaccines
JP2001002592A (en) 1999-06-18 2001-01-09 Dai Ichi Seiyaku Co Ltd Composition for gene-transducing
US6280054B1 (en) * 1999-07-02 2001-08-28 Zight Corporation Image generator having an improved illumination system
US6242188B1 (en) 1999-07-30 2001-06-05 Applied Gene Technologies, Inc. Sample processing to release nucleic acids for direct detection
EP1204241A1 (en) * 1999-08-09 2002-05-08 Fujitsu Limited Package control device and method
ES2206288T3 (en) 1999-08-30 2004-05-16 Debiopharm S.A. STABLE PHARMACEUTICAL PREPARATION OF OXYLIPLATINE FOR PARENTERAL ADMINISTRATION.
CN1433478A (en) 1999-12-30 2003-07-30 诺瓦提斯公司 Novel colloid synthetic vectors for gene therapy
CA2394717C (en) 1999-12-30 2011-05-17 Judith K. Gwathmey Iron chelator delivery system
US7034006B2 (en) * 2000-01-10 2006-04-25 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of disease
US6530944B2 (en) 2000-02-08 2003-03-11 Rice University Optically-active nanoparticles for use in therapeutic and diagnostic methods
US7001735B2 (en) 2000-03-01 2006-02-21 Albert Einstein College Of Medicine Of Yeshiva University Glucose transporter/sensor protein and uses thereof
AU2001236062A1 (en) 2000-03-02 2001-09-12 Yasuo Ikeda Gpib-lipid bond construct and use thereof
JP4449147B2 (en) 2000-03-22 2010-04-14 日油株式会社 Method for producing phosphatidylethanolamine derivative
FR2806727A1 (en) 2000-03-23 2001-09-28 Pf Medicament MOLECULE OF PHARMACEUTICAL INTEREST COMPRISING IN THE N-TERMINAL END A GLUTAMIC ACID OR GLUTAMINE IN THE FORM OF A PHYSIOLOGICALLY ACCEPTABLE ACID ADDITION SALT
EP1272160B1 (en) 2000-04-12 2007-01-17 Liplasome Pharma A/S Lipid-based drug delivery systems for topical application
WO2001082899A2 (en) 2000-05-03 2001-11-08 Mbt Munich Biotechnology Ag Cationic diagnostic, imaging and therapeutic agents associated with activated vascular sites
US20030059461A1 (en) 2000-06-06 2003-03-27 Sibtech, Inc. Molecular delivery vehicle for delivery of selected compounds to targets
US20030072794A1 (en) 2000-06-09 2003-04-17 Teni Boulikas Encapsulation of plasmid DNA (lipogenes™) and therapeutic agents with nuclear localization signal/fusogenic peptide conjugates into targeted liposome complexes
WO2002020570A2 (en) 2000-09-11 2002-03-14 Institut Pasteur Mitochondrial membrane permeabilization bv hiv-1 vpr and methods of screening
US20040234588A1 (en) 2000-09-21 2004-11-25 University Of Georgia Research Foundation, Inc. Artificial lipoprotein carrier system for bioactive materials
EP1324758B1 (en) 2000-10-03 2005-01-12 Debiopharm S.A. Plga/pla-type polymer microspheres encapsulating a water-soluble substance and process thereof
JP2004524516A (en) 2000-12-12 2004-08-12 オーストラリアン インスティチュート オブ マリーン サイエンス Paralytic shellfish poison assay
AU2002223013A1 (en) 2000-12-12 2002-06-24 Debiopharm S.A. Pharmaceutical oxaliplatinum preparation for parenteral administration and method for obtaining same
US6897196B1 (en) 2001-02-07 2005-05-24 The Regents Of The University Of California pH sensitive lipids based on ortho ester linkers, composition and method
US6703524B2 (en) 2001-02-20 2004-03-09 Lkt Laboratories, Inc. Organoselenium compounds for cancer chemoprevention
ATE365037T1 (en) 2001-03-02 2007-07-15 Debiopharm Sa USE OF A BOTTLE CONTAINING OXALIPLATIN SOLUTION
FI113840B (en) 2001-03-26 2004-06-30 Ctt Cancer Targeting Tech Oy Use of matrix metalloproteinase inhibitors in targeting liposomes
US20040049022A1 (en) 2001-04-24 2004-03-11 Nyce Jonathan W. Composition & methods for treatment and screening
US20030203865A1 (en) 2001-04-30 2003-10-30 Pierrot Harvie Lipid-comprising drug delivery complexes and methods for their production
WO2002089772A1 (en) 2001-05-09 2002-11-14 Inex Pharmaceuticals Corporation Anti-angiogenic therapy using liposome-encapsulated chemotherapeutic agents
US20030108986A1 (en) 2001-06-21 2003-06-12 Euroscreen, S.A. Compositions and methods comprising G-protein coupled receptors
WO2003004505A1 (en) 2001-07-02 2003-01-16 Debiopharm S.A. Oxaliplatin active substance with a very low content of oxalic acid
US20030096299A1 (en) 2001-07-09 2003-05-22 Valerie Wittamer Natural ligand of G protein coupled receptor ChemR23 and uses thereof
CA2457148A1 (en) 2001-08-20 2003-02-27 Transave, Inc. Treatment of cancers by inhalation of stable platinum-containing formulations
DE10144252A1 (en) 2001-08-31 2003-03-27 Fraunhofer Ges Forschung Nanoparticles with biologically active TNF immobilized on them
AU2002330139A1 (en) 2001-10-03 2003-04-14 Vanderbilt University In vivo panning for ligands to radiation-induced molecules
WO2003044214A2 (en) 2001-11-20 2003-05-30 Baylor College Of Medicine Methods and compositions in checkpoint signaling
JP4468617B2 (en) 2001-12-04 2010-05-26 デビオファーム エス．アー． Method for concomitant administration of anticancer agents and anticancer agents that can be used in combination
US6476068B1 (en) 2001-12-06 2002-11-05 Pharmacia Italia, S.P.A. Platinum derivative pharmaceutical formulations
AU2003202542A1 (en) 2002-01-07 2003-07-24 Euroscreen S.A. Ligand for g-protein coupled receptor gpr43 and uses thereof
US20030220284A1 (en) 2002-02-22 2003-11-27 Patricia Yotnda Delivery of adenoviral DNA in a liposomal formulation for treatment of disease
KR101017732B1 (en) 2002-03-01 2011-02-28 이뮤노메딕스, 인코오포레이티드 Internalizing anti-CD74 antibodies and methods of use
CA2513044A1 (en) 2002-03-01 2004-08-05 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
WO2003082907A1 (en) 2002-03-29 2003-10-09 Euroscreen Sa Ligands for g protein coupled receptor gpr7 and uses thereof
CA2391438A1 (en) 2002-05-01 2003-11-01 Procyon Biopharma Inc. Psp94 diagnostic reagents and assays
US20030228285A1 (en) 2002-05-03 2003-12-11 Mien-Chie Hung Bipartite T-cell factor (Tcf)-responsive promoter
US7460960B2 (en) 2002-05-10 2008-12-02 Epitome Biosystems, Inc. Proteome epitope tags and methods of use thereof in protein modification analysis
FR2840236B1 (en) 2002-06-03 2005-02-04 Inst Francais Du Petrole ZEOLITHIC MEMBRANE OF LOW THICKNESS, ITS PREPARATION AND USE IN SEPARATION
JP3415131B1 (en) * 2002-06-03 2003-06-09 メビオファーム株式会社 Liposome preparation
US20040022842A1 (en) 2002-06-03 2004-02-05 Mebiopharm Co., Ltd. Liposome preparations containing oxaliplatin
AU2003244766A1 (en) 2002-06-07 2003-12-22 Immunomedics, Inc. Neutrophil imaging methods in cyctic fibrosis
KR101143035B1 (en) 2002-06-14 2012-05-08 이뮤노메딕스, 인코오포레이티드 Monoclonal antibody hPAM4
CA2489469C (en) 2002-06-14 2016-03-22 Immunomedics, Inc. Monoclonal antibody pam4 and its use for diagnosis and therapy of pancreatic cancer
US6790632B2 (en) 2002-06-17 2004-09-14 Stephen Eliot Zweig Membrane receptor reagent and assay
AU2003245160B2 (en) 2002-06-28 2009-09-24 Arbutus Biopharma Corporation Method and apparatus for producing liposomes
EP1546203B1 (en) 2002-08-01 2012-06-20 Immunomedics, Inc. Alpha-fetoprotein immu31 antibodies and fusion proteins and methods of use thereof
US20040132652A1 (en) 2002-08-30 2004-07-08 Shire Biochem Inc. Pharmaceutical compositions
WO2004045519A2 (en) 2002-11-14 2004-06-03 Kirk Sperber Induction of apoptosis by hiv-1 infected monocytic cells
CN1711074B (en) 2002-11-15 2010-10-06 尼普洛株式会社 Liposomes
EP1595546A4 (en) 2003-02-17 2010-08-04 Mebiopharm Co Ltd Remedy for cancer
WO2004094613A2 (en) 2003-04-22 2004-11-04 Ibc Pharmaceuticals Polyvalent protein complex
CA2529027C (en) 2003-06-13 2013-09-10 Immunomedics, Inc. D-amino acid peptides
EP2216342B1 (en) 2003-07-31 2015-04-22 Immunomedics, Inc. Anti-CD19 antibodies
JP2005154282A (en) 2003-11-20 2005-06-16 Mebiopharm Co Ltd Method for producing gas-sealed liposome
US7582430B2 (en) * 2004-01-20 2009-09-01 United States Of America As Represented By The Secretary Of The Army Immunoliposome-nucleic acid amplification (ILNAA) assay
US7212869B2 (en) * 2004-02-04 2007-05-01 Medtronic, Inc. Lead retention means
EP1579850A3 (en) 2004-03-15 2009-12-16 Nipro Corporation A pharmaceutical composition containing liposomes for treating a cancer
JP2006248978A (en) 2005-03-10 2006-09-21 Mebiopharm Co Ltd New liposome preparation
WO2008030818A2 (en) 2006-09-05 2008-03-13 Mebiopharm Co., Ltd. Novel liposome compositions
JP5345792B2 (en) 2008-02-19 2013-11-20 テイ・エス テック株式会社 Vehicle storage seat
JP5331648B2 (en) 2009-10-22 2013-10-30 株式会社日立製作所 How to modify a pulverized coal boiler

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986004232A1 (en) * 1985-01-18 1986-07-31 Cooper-Lipotech, Inc. Liposome composition and method
US5419914A (en) * 1990-10-09 1995-05-30 Vestar, Inc. Phospholipid analogue vesicle
WO1996021658A1 (en) * 1995-01-09 1996-07-18 The Liposome Company, Inc. Hydrophobic taxane derivatives
US5891468A (en) * 1996-10-11 1999-04-06 Sequus Pharmaceuticals, Inc. Fusogenic liposome compositions and method
US20030129223A1 (en) * 2000-10-11 2003-07-10 Targesome, Inc. Targeted multivalent macromolecules
EP1209469A1 (en) * 2000-11-22 2002-05-29 Vectron Therapeutics AG Production and use of a targeted diagnostic system

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MARUYAMA K ET AL: "Intracellular targeting of sodium mercaptoundecahydrododecaborate (BSH) to solid tumors by transferrin-PEG liposomes, for boron neutron-capture therapy (BNCT)", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 98, no. 2, 11 August 2004 (2004-08-11), pages 195 - 207, XP004521710, ISSN: 0168-3659 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7829113B2 (en) 2005-03-10 2010-11-09 Mebiopharm Co., Ltd. Liposome compositions
US8758810B2 (en) 2005-03-10 2014-06-24 Mebiopharm Co., Ltd. Liposome compositions

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