WO2007059946A3 - Verfahren zur herstellung aryl-aryl gekoppelter verbindungen - Google Patents

Verfahren zur herstellung aryl-aryl gekoppelter verbindungen Download PDF

Info

Publication number
WO2007059946A3
WO2007059946A3 PCT/EP2006/011202 EP2006011202W WO2007059946A3 WO 2007059946 A3 WO2007059946 A3 WO 2007059946A3 EP 2006011202 W EP2006011202 W EP 2006011202W WO 2007059946 A3 WO2007059946 A3 WO 2007059946A3
Authority
WO
WIPO (PCT)
Prior art keywords
aryl
producing
coupled compounds
compounds
bol
Prior art date
Application number
PCT/EP2006/011202
Other languages
English (en)
French (fr)
Other versions
WO2007059946B1 (de
WO2007059946A2 (de
Inventor
Torsten Zech
Gunilla Kaiser
Oliver Koechel
Oliver Laus
Denis Huertgen
Original Assignee
Hte Ag The High Throughput Exp
Torsten Zech
Gunilla Kaiser
Oliver Koechel
Oliver Laus
Denis Huertgen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hte Ag The High Throughput Exp, Torsten Zech, Gunilla Kaiser, Oliver Koechel, Oliver Laus, Denis Huertgen filed Critical Hte Ag The High Throughput Exp
Priority to JP2008541635A priority Critical patent/JP2009516716A/ja
Priority to EP06829097A priority patent/EP1965901A2/de
Priority to US12/085,497 priority patent/US20100216964A1/en
Publication of WO2007059946A2 publication Critical patent/WO2007059946A2/de
Publication of WO2007059946A3 publication Critical patent/WO2007059946A3/de
Publication of WO2007059946B1 publication Critical patent/WO2007059946B1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00788—Three-dimensional assemblies, i.e. the reactor comprising a form other than a stack of plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00835—Comprising catalytically active material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00858—Aspects relating to the size of the reactor
    • B01J2219/0086—Dimensions of the flow channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00873—Heat exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00889—Mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00891—Feeding or evacuation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00905—Separation
    • B01J2219/00916—Separation by chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00952—Sensing operations
    • B01J2219/00954—Measured properties
    • B01J2219/00957—Compositions or concentrations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00952—Sensing operations
    • B01J2219/00968—Type of sensors
    • B01J2219/0097—Optical sensors
    • B01J2219/00972—Visible light
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00952—Sensing operations
    • B01J2219/00968—Type of sensors
    • B01J2219/0097—Optical sensors
    • B01J2219/00975—Ultraviolet light
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00952—Sensing operations
    • B01J2219/00968—Type of sensors
    • B01J2219/0097—Optical sensors
    • B01J2219/00977—Infrared light
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00984—Residence time
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00986—Microprocessor

Abstract

Die vorliegende Erfindung betrifft ein Verfahren zur Herstellung Aryl-Aryl gekoppelter Verbindungen. Das Verfahren wird kontinuierlich durchgeführt, wobei zumindest zwei nicht miteinander mischbare flüssige Phasen (MOl) und (BOl) optional zunächst in einem Mischer (020) vermischt werden, anschließend die Reaktion kontinuierlich in einem Festbettreaktor (030) durchgeführt wird, und danach optional eine Online- Analyse (060) der Produkte (POl) vorgenommen wird.
PCT/EP2006/011202 2005-11-23 2006-11-22 Verfahren zur herstellung aryl-aryl gekoppelter verbindungen WO2007059946A2 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2008541635A JP2009516716A (ja) 2005-11-23 2006-11-22 アリール−アリールカップリング化合物を製造する方法
EP06829097A EP1965901A2 (de) 2005-11-23 2006-11-22 Verfahren zur herstellung aryl-aryl gekoppelter verbindungen
US12/085,497 US20100216964A1 (en) 2005-11-23 2006-11-22 Method for producing aryl-aryl coupled compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005055866A DE102005055866A1 (de) 2005-11-23 2005-11-23 Verfahren zur Herstellung von Aryl-Aryl gekoppelter Verbindungen
DE102005055866.6 2005-11-23

Publications (3)

Publication Number Publication Date
WO2007059946A2 WO2007059946A2 (de) 2007-05-31
WO2007059946A3 true WO2007059946A3 (de) 2007-08-02
WO2007059946B1 WO2007059946B1 (de) 2007-09-20

Family

ID=37882550

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/011202 WO2007059946A2 (de) 2005-11-23 2006-11-22 Verfahren zur herstellung aryl-aryl gekoppelter verbindungen

Country Status (5)

Country Link
US (1) US20100216964A1 (de)
EP (1) EP1965901A2 (de)
JP (1) JP2009516716A (de)
DE (1) DE102005055866A1 (de)
WO (1) WO2007059946A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2523004B1 (de) 2004-01-26 2020-05-20 President and Fellows of Harvard College Verfahren zur Bestimmung eines Analyten und Immunoassay
EP1676632A1 (de) 2004-12-28 2006-07-05 Covion Organic Semiconductors GmbH Verfahren zur Herstellung von Polymeren
JP5222632B2 (ja) * 2008-06-13 2013-06-26 白鳥製薬株式会社 ビアリール化合物の製造方法
WO2014158367A1 (en) 2013-03-13 2014-10-02 Opko Diagnostics, Llc Mixing of fluids in fluidic systems
MX2017007576A (es) 2014-12-12 2018-03-09 Opko Diagnostics Llc Sistemas fluídicos que comprenden un canal de incubación, que incluye sistemas fluídicos formados por moldeo.
US9481764B1 (en) * 2015-10-13 2016-11-01 The Boeing Company Flow reactor synthesis of polymers
GB2571696B (en) 2017-10-09 2020-05-27 Compass Pathways Ltd Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
JP7075247B2 (ja) * 2018-03-19 2022-05-25 東レエンジニアリング株式会社 リアクタ
CN110961060A (zh) * 2018-09-30 2020-04-07 中国石油化工股份有限公司 微通道反应器
CN113993523A (zh) 2019-04-17 2022-01-28 指南针探路者有限公司 用赛洛西宾治疗抑郁症和其他各种病症
CN110732298B (zh) * 2019-11-21 2024-02-23 温州国仕邦高分子材料有限公司 微波辐射连续式水性树脂合成管道反应器
JP2022163533A (ja) * 2021-04-14 2022-10-26 オルガノ株式会社 白金族金属担持触媒カラムおよび炭素－炭素結合形成方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5108654A (en) * 1987-11-20 1992-04-28 Vittorio Ragaini Method for conducting chemical reactions in polyphase systems
WO1996004547A1 (en) * 1994-08-01 1996-02-15 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis
WO2001064332A1 (en) * 2000-03-02 2001-09-07 Newcastle Universtiy Ventures Limited Capillary reactor distribution device and method
US20020143437A1 (en) * 2001-03-28 2002-10-03 Kalyan Handique Methods and systems for control of microfluidic devices

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4426671A1 (de) * 1994-07-28 1996-02-01 Hoechst Ag Verfahren zur Kreuzkupplung von aromatischen Borverbindungen mit aromatischen Halogenverbindungen oder Perfluoralkylsulfonaten
DE19816886C2 (de) * 1998-04-17 2001-06-07 Axiva Gmbh Verfahren und Vorrichtung zur kontinuierlichen Herstellung von Polymerisaten
DE19925384A1 (de) * 1999-06-02 2000-12-07 Oxeno Olefinchemie Gmbh Verfahren zur katalytischen Durchführung von Mehrphasenreaktionen, insbesondere Hydroformylierungen
DE19927554C2 (de) * 1999-06-16 2002-12-19 Inst Mikrotechnik Mainz Gmbh Mikromischer
DE10020630A1 (de) * 2000-04-27 2001-11-08 Merck Patent Gmbh Verfahren zur Oxidation von tertiären Aminen und Stickstoff-haltigen aromatischen Heterocyclen
JP2002273206A (ja) * 2001-03-16 2002-09-24 Mitsubishi Chemicals Corp 合成反応装置及びそれを用いる合成反応方法
WO2002078842A1 (en) * 2001-03-30 2002-10-10 Council Of Scientific And Industrial Research A novel catalytic formulation and its preparation
US6880576B2 (en) * 2001-06-07 2005-04-19 Nanostream, Inc. Microfluidic devices for methods development
DE10138828A1 (de) * 2001-08-14 2003-03-06 Bruno Berger Schrägrohrreaktor
GB0125622D0 (en) * 2001-10-25 2001-12-19 Cambridge Display Tech Ltd Method of polymerisation
DE10159946A1 (de) * 2001-12-06 2003-06-18 Covion Organic Semiconductors Prozess zur Herstellung von Aryl-Aryl gekoppelten Verbindungen
AU2003256422A1 (en) * 2002-08-15 2004-03-03 Velocys, Inc. Tethered catalyst processes in microchannel reactors and systems containing a tethered catalyst or tethered chiral auxiliary
DE10241814A1 (de) * 2002-09-06 2004-03-25 Covion Organic Semiconductors Gmbh Prozeß zur Herstellung von Aryl-Aryl gekoppelten Verbindungen
SK285692B6 (sk) * 2002-11-26 2007-06-07 Novácke Chemické Závody, Akciová Spoločnosť Zariadenie tvaru dvoch súosových stojatých valcovpre podmienky chemických technológií a spôsob jeho využitia
US6979751B2 (en) * 2002-12-23 2005-12-27 Eastman Chemical Company Processes for the preparation of higher molecular weight ketones
US7178386B1 (en) * 2003-04-10 2007-02-20 Nanostream, Inc. Parallel fluid processing systems and methods
CN101132854B (zh) * 2004-11-16 2011-07-06 万罗赛斯公司 使用微通道技术的多相反应方法
EP1833859A2 (de) * 2004-12-16 2007-09-19 ExxonMobil Chemical Patents Inc. Halogensubstituierte metallocenverbindungen für die olefinpolymerisation
EP1676632A1 (de) * 2004-12-28 2006-07-05 Covion Organic Semiconductors GmbH Verfahren zur Herstellung von Polymeren
US7547757B2 (en) * 2006-08-01 2009-06-16 Headwaters Technology Innovation, Llc Methods for manufacturing aryl-aryl coupled polymers
US20080076049A1 (en) * 2006-09-26 2008-03-27 Xerox Corporation Arylamine processes

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5108654A (en) * 1987-11-20 1992-04-28 Vittorio Ragaini Method for conducting chemical reactions in polyphase systems
WO1996004547A1 (en) * 1994-08-01 1996-02-15 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis
WO2001064332A1 (en) * 2000-03-02 2001-09-07 Newcastle Universtiy Ventures Limited Capillary reactor distribution device and method
US20020143437A1 (en) * 2001-03-28 2002-10-03 Kalyan Handique Methods and systems for control of microfluidic devices

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BASHEER C ET AL: "Design of a capillary-microreactor for efficient Suzuki coupling reactions", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 45, no. 39, 20 September 2004 (2004-09-20), pages 7297 - 7300, XP004558986, ISSN: 0040-4039 *
C. K. Y. LEE ET AL.: "Efficient batch and continuous flow Suzuki cross-coupling reactions under mild conditions, catalysed by polyurea-encapsulated palladium (II) acetate and tetra-n-butylammonium salts", CHEMICAL COMMUNICATIONS, 9 March 2005 (2005-03-09), pages 2175 - 2177, XP002433870 *
COMER EAMON ET AL: "A microreactor for microwave-assisted capillary (continuous flow) organic synthesis", J. AM. CHEM. SOC.; JOURNAL OF THE AMERICAN CHEMICAL SOCIETY JUN 8 2005, vol. 127, no. 22, 8 June 2005 (2005-06-08), pages 8160 - 8167, XP002433884 *
FLETCHER P D I ET AL: "Micro reactors: principles and applications in organic synthesis", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 58, no. 24, 10 June 2002 (2002-06-10), pages 4735 - 4757, XP004366393, ISSN: 0040-4020 *
HE P ET AL: "Microwave-assisted Suzuki reactions in a continuous flow capillary reactor", APPLIED CATALYSIS A: GENERAL, ELSEVIER SCIENCE, AMSTERDAM, NL, vol. 274, no. 1-2, 28 October 2004 (2004-10-28), pages 111 - 114, XP004558605, ISSN: 0926-860X *
J. HASWELL ET AL.: "microwave heating of heterogeneously catalysed suzuki reactions in a micro reactor", LAB CHIP, vol. 4, 2 December 2003 (2003-12-02), pages 38 - 41, XP002433996 *

Also Published As

Publication number Publication date
JP2009516716A (ja) 2009-04-23
US20100216964A1 (en) 2010-08-26
DE102005055866A1 (de) 2007-05-24
EP1965901A2 (de) 2008-09-10
WO2007059946B1 (de) 2007-09-20
WO2007059946A2 (de) 2007-05-31

Similar Documents

Publication Publication Date Title
WO2007059946A3 (de) Verfahren zur herstellung aryl-aryl gekoppelter verbindungen
WO2006010148A3 (en) Combination of amorphous materials for hydrocracking catalysts
WO2006005479A3 (de) Kontinuierliches metatheseverfahren mit ruthenium-katalysatoren
EP1952280A4 (de) System, verfahren und computerprogrammprodukt für suche und analyse auf konzeptbasis
EG24829A (en) Process for the conversion of heavy charges such as heavy crude oils and distillation residues.
EP1733789A4 (de) Hydrocracking-katalysator und verfahren zur herstellung von flüssigem kohlenwasserstoff
WO2010027790A3 (en) Apparatus for forming a kinematic coupling and related methods
IL182449A0 (en) Process for conversion of organic, waste, or low value materials into useful products
EG23196A (en) Process for the conversion of heavy charages such as heavy crude oils and distillation residues.
ZA200507817B (en) Process and apparatus for conversion of organic, waste, or low-value materials into useful products
TW200631659A (en) Process for continuous ringclosing metathesis in compressed carbondioxide
WO2007008847A8 (en) A dual catalyst system for alkane metathesis
WO2006110659A3 (en) Systems, methods, and catalysts for producing a crude product
EP1615862A4 (de) Verfahren und gerät für die umwandlung von organischem abfall oder minderwertigem material in nützliche produkte
HK1103151A1 (en) System, method and computer program product for providing content based upon a representation of the same
WO2009051741A3 (en) Methods for processing generic chemical structure representations
EP2202204A4 (de) Feste säure, verfahren zur herstellung der festen säure, verfahren zur entschwefelung von kohlenwasserstofföl unter verwendung von fester säure als entschwefelungsmittel
MY147861A (en) Method for grignard type reactions in microreactors
WO2007103677A3 (en) Catalytic distillation process for hydroprocessing fischer-tropsch liquids
WO2009037281A3 (de) Verfahren zur hydrierenden spaltung von lignin an übergangsmetallcarbiden
WO2006014461A3 (en) Reducing metal corrosion of hydrocarbons using acidic fischer-tropsch products
EP1809417A4 (de) Kohlenwasserstoffcrackkatalysator unter verwendung von chemischer flüssigphasenabscheidung und herstellungsverfahren dafür
EP1600207A4 (de) Emulgator, verfahren zur herstellung desselben und den emulgator verwendende emulgierte zusammensetzung
EP1975156A4 (de) Verfahren zur depolymerisierung eines polyamids und verfahren zur herstellung eines monomers eines polyamids
EP1914025A4 (de) Zweiteilige dose, herstellungsverfahren dafür und stahlplatte für zweiteilige dose

Legal Events

Date Code Title Description
DPE1 Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2008541635

Country of ref document: JP

REEP Request for entry into the european phase

Ref document number: 2006829097

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2006829097

Country of ref document: EP

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 06829097

Country of ref document: EP

Kind code of ref document: A2

WWP Wipo information: published in national office

Ref document number: 2006829097

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 12085497

Country of ref document: US