WO2008091569A3 - Devices, systems, and methods for promoting endothelialization - Google Patents

Devices, systems, and methods for promoting endothelialization Download PDF

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Publication number
WO2008091569A3
WO2008091569A3 PCT/US2008/000763 US2008000763W WO2008091569A3 WO 2008091569 A3 WO2008091569 A3 WO 2008091569A3 US 2008000763 W US2008000763 W US 2008000763W WO 2008091569 A3 WO2008091569 A3 WO 2008091569A3
Authority
WO
WIPO (PCT)
Prior art keywords
systems
methods
devices
endothelialization
promoting endothelialization
Prior art date
Application number
PCT/US2008/000763
Other languages
French (fr)
Other versions
WO2008091569A2 (en
Inventor
Ghassan S Kassab
Original Assignee
Dtherapeutics Llc
Ghassan S Kassab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dtherapeutics Llc, Ghassan S Kassab filed Critical Dtherapeutics Llc
Priority to US12/521,196 priority Critical patent/US20090319020A1/en
Publication of WO2008091569A2 publication Critical patent/WO2008091569A2/en
Publication of WO2008091569A3 publication Critical patent/WO2008091569A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/005—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/02—Inorganic materials
    • A61L31/022—Metals or alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/043—Proteins; Polypeptides; Degradation products thereof
    • A61L31/044—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/043—Proteins; Polypeptides; Degradation products thereof
    • A61L31/046—Fibrin; Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/18—Materials at least partially X-ray or laser opaque
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2/958—Inflatable balloons for placing stents or stent-grafts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/009—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof magnetic

Abstract

Devices, systems, and methods for promoting endothelialization and preventing restenosis are disclosed. At least some of the embodiments disclosed herein promote endothelialization and prevent restenosis by reducing local blood flow turbulence. At least some of the embodiments disclosed herein promote endothelialization and prevent restenosis by directing endothelial progenitor cells to a targeted site using magnetic and other means.
PCT/US2008/000763 2007-01-23 2008-01-22 Devices, systems, and methods for promoting endothelialization WO2008091569A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US12/521,196 US20090319020A1 (en) 2007-01-23 2008-01-22 Devices, systems, and methods for promoting endothelialization

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88183407P 2007-01-23 2007-01-23
US60/881,834 2007-01-23

Publications (2)

Publication Number Publication Date
WO2008091569A2 WO2008091569A2 (en) 2008-07-31
WO2008091569A3 true WO2008091569A3 (en) 2008-09-25

Family

ID=39645053

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/000763 WO2008091569A2 (en) 2007-01-23 2008-01-22 Devices, systems, and methods for promoting endothelialization

Country Status (2)

Country Link
US (1) US20090319020A1 (en)
WO (1) WO2008091569A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7807624B2 (en) * 2006-01-11 2010-10-05 Affinergy, Inc. Methods and compositions for promoting attachment of cells of endothelial cell lineage to medical devices
WO2012006373A1 (en) * 2010-07-06 2012-01-12 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Systems and methods for magnetized stent having growth-promoting properties
EP3064127B1 (en) 2011-10-14 2019-06-12 Acist Medical Systems, Inc. Device and methods for measuring and treating an anatomical structure
US9549679B2 (en) 2012-05-14 2017-01-24 Acist Medical Systems, Inc. Multiple transducer delivery device and method
WO2015171897A1 (en) * 2014-05-09 2015-11-12 Mayo Foundation For Medical Education And Research Devices and methods for endothelialization of magnetic vascular grafts
CN108354698A (en) * 2018-03-29 2018-08-03 秦高平 A kind of magnesium alloy biliary tract rack and preparation method thereof
EP4181793A1 (en) * 2020-07-17 2023-05-24 Squadra Lifesciences, Inc Systems and methods for entrapping and/or removing clots to provide blood flow restoration in a vessel
CN113017914B (en) * 2021-03-17 2023-07-04 复旦大学附属中山医院 Peripheral vascular composite stent for preventing intimal hyperplasia at access of covered stent

Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030191526A1 (en) * 1999-10-27 2003-10-09 Atritech, Inc. Barrier device for ostium of left atrial appendage
US20040034408A1 (en) * 2002-05-10 2004-02-19 Majercak David Christopher Method of placing a tubular membrane on a structural frame
US20040073295A1 (en) * 2000-04-13 2004-04-15 Chaikof Elliot L. Antithrombogenic membrane mimetic compositions and methods
US6800753B2 (en) * 2001-09-04 2004-10-05 University Of Iowa Research Foundation Regenerated cellulose and oxidized cellulose membranes as potential biodegradable platforms for drug delivery and tissue engineering
US20050032246A1 (en) * 2002-11-14 2005-02-10 Mcmaster University Method of immobilizing membrane-associated molecules
US20050142178A1 (en) * 2002-12-31 2005-06-30 Bharats Serums & Vaccines Ltd. Non-pegylated long-circulating liposomes
US20050202076A1 (en) * 2002-06-26 2005-09-15 Medigene Oncology Gmbh Method of producing a cationic liposomal preparation comprising a lipophilic compound
US20060008472A1 (en) * 2004-04-30 2006-01-12 Leaf Huang Antigen delivery compositions and methods of use
US20060041182A1 (en) * 2003-04-16 2006-02-23 Forbes Zachary G Magnetically-controllable delivery system for therapeutic agents
US20060106448A1 (en) * 2004-03-04 2006-05-18 Yoav Shaked Vessel treatment devices
US20060136047A1 (en) * 2002-09-06 2006-06-22 Obermiller F J Tissue graft prosthesis devices containing juvenile or small diameter submucosa
US20060263303A1 (en) * 2000-06-02 2006-11-23 Bracco International Bv Compounds for Targeting Endothelial Cells, Compositions Containing the Same and Methods for Their Use
US20060269540A1 (en) * 2002-09-27 2006-11-30 Vaccinex, Inc. Targeted cd1d molecules
US20070010871A1 (en) * 2002-05-02 2007-01-11 Scimed Life Systems, Inc. Energetically-controlled delivery of biologically active material from an implanted medical device

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3886467B2 (en) * 2003-04-10 2007-02-28 株式会社日本製鋼所 Screw kneading extruder
US8465453B2 (en) * 2003-12-03 2013-06-18 Mayo Foundation For Medical Education And Research Kits, apparatus and methods for magnetically coating medical devices with living cells
KR100735445B1 (en) * 2004-10-06 2007-07-04 삼성전자주식회사 Method for managing an individual identify information card of subcriber identify module inserted mobile phone

Patent Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030191526A1 (en) * 1999-10-27 2003-10-09 Atritech, Inc. Barrier device for ostium of left atrial appendage
US20040073295A1 (en) * 2000-04-13 2004-04-15 Chaikof Elliot L. Antithrombogenic membrane mimetic compositions and methods
US20060263303A1 (en) * 2000-06-02 2006-11-23 Bracco International Bv Compounds for Targeting Endothelial Cells, Compositions Containing the Same and Methods for Their Use
US6800753B2 (en) * 2001-09-04 2004-10-05 University Of Iowa Research Foundation Regenerated cellulose and oxidized cellulose membranes as potential biodegradable platforms for drug delivery and tissue engineering
US20070010871A1 (en) * 2002-05-02 2007-01-11 Scimed Life Systems, Inc. Energetically-controlled delivery of biologically active material from an implanted medical device
US20040034408A1 (en) * 2002-05-10 2004-02-19 Majercak David Christopher Method of placing a tubular membrane on a structural frame
US20050202076A1 (en) * 2002-06-26 2005-09-15 Medigene Oncology Gmbh Method of producing a cationic liposomal preparation comprising a lipophilic compound
US20060136047A1 (en) * 2002-09-06 2006-06-22 Obermiller F J Tissue graft prosthesis devices containing juvenile or small diameter submucosa
US20060269540A1 (en) * 2002-09-27 2006-11-30 Vaccinex, Inc. Targeted cd1d molecules
US20050032246A1 (en) * 2002-11-14 2005-02-10 Mcmaster University Method of immobilizing membrane-associated molecules
US20050142178A1 (en) * 2002-12-31 2005-06-30 Bharats Serums & Vaccines Ltd. Non-pegylated long-circulating liposomes
US20060041182A1 (en) * 2003-04-16 2006-02-23 Forbes Zachary G Magnetically-controllable delivery system for therapeutic agents
US20060106448A1 (en) * 2004-03-04 2006-05-18 Yoav Shaked Vessel treatment devices
US20060008472A1 (en) * 2004-04-30 2006-01-12 Leaf Huang Antigen delivery compositions and methods of use

Also Published As

Publication number Publication date
US20090319020A1 (en) 2009-12-24
WO2008091569A2 (en) 2008-07-31

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