WO2010059838A3 - Pde4 inhibitors selective for the long form of pde4 for treating inflammation and avoiding side effects - Google Patents
Pde4 inhibitors selective for the long form of pde4 for treating inflammation and avoiding side effects Download PDFInfo
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- WO2010059838A3 WO2010059838A3 PCT/US2009/065164 US2009065164W WO2010059838A3 WO 2010059838 A3 WO2010059838 A3 WO 2010059838A3 US 2009065164 W US2009065164 W US 2009065164W WO 2010059838 A3 WO2010059838 A3 WO 2010059838A3
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- pde4
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- treating inflammation
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- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
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- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
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Abstract
The present invention relates to compounds which are inhibitors of phosphodiesterase-4 (PDE4) useful for the treatment and prevention of stroke, myocardial infarct, cardiovascular inflammatory diseases and disorders and central nervous system disorders, to compounds with a selectivity for a non-catalytic portion of PDE4, to methods of determining this selectivity.
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JP2011504505A (en) | 2007-11-21 | 2011-02-10 | デコード ジェネティクス イーエイチエフ | Biaryl PDE4 inhibitors for treating pulmonary and cardiovascular disorders |
KR101774035B1 (en) | 2009-10-30 | 2017-09-01 | 얀센 파마슈티카 엔.브이. | IMIDAZO[l,2-b]PYRIDAZINE DERIVATIVES AND THEIR USE AS PDE1O INHIBITORS |
AR080754A1 (en) | 2010-03-09 | 2012-05-09 | Janssen Pharmaceutica Nv | IMIDAZO DERIVATIVES (1,2-A) PIRAZINA AND ITS USE AS PDE10 INHIBITORS |
EA027418B1 (en) | 2011-06-27 | 2017-07-31 | Янссен Фармацевтика Нв | 1-ARYL-4-METHYL-[1,2,4]TRIAZOLO[4,3-a]QUINOXALINE DERIVATIVES, PHARMACEUTICAL COMPOSITION BASED THEREON, PROCESSES FOR PREPARING AND USING THE SAME, INTERMEDIATES |
CA2872216C (en) | 2012-06-26 | 2021-07-20 | Janssen Pharmaceutica Nv | Combinations comprising pde 2 inhibitors such as 1-aryl-4-methyl-[1,2,4] triazolo [4,3-a] quinoxaline compounds and pde 10 inhibitors for use in the treatment of neurological or metabolic disorders |
CA2875057C (en) | 2012-07-09 | 2021-07-13 | Janssen Pharmaceutica Nv | Imidazo[1,2-b]pyridazine and imidazo[1,2-a]pyrazine compounds and their use as inhibitors of the phosphodiesterase 10 enzyme |
WO2014066659A1 (en) | 2012-10-25 | 2014-05-01 | Tetra Discovery Partners, Llc. | Heteroaryl inhibitors of pde4 |
CN105705489B (en) * | 2013-09-04 | 2019-04-26 | 百时美施贵宝公司 | Compound as immunomodulator |
US20150086480A1 (en) * | 2013-09-26 | 2015-03-26 | Tetra Discovery Partners, LLC | Heteroaryl inhibitors of pde4 |
WO2016049595A1 (en) * | 2014-09-26 | 2016-03-31 | Tetra Discovery Partners, LLC | Heteroaryl inhibitors of pde4 |
GB201504763D0 (en) | 2015-03-20 | 2015-05-06 | Mironid Ltd | Compounds and uses |
JP6745820B2 (en) * | 2015-05-29 | 2020-08-26 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | Prostate Cancer Prognosis Judgment Method |
EP3374350B1 (en) | 2015-11-09 | 2022-01-05 | Forge Therapeutics, Inc. | Hydroxypyridinone and hydroxypyrimidinone based compounds for treating bacterial infections |
WO2017083434A1 (en) | 2015-11-09 | 2017-05-18 | Forge Therapeutics, Inc. | Pyrone based compounds for treating bacterial infections |
WO2017089347A1 (en) | 2015-11-25 | 2017-06-01 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas |
GB201616439D0 (en) | 2016-09-28 | 2016-11-09 | Mironid Limited | Compounds and uses |
WO2018099884A1 (en) | 2016-12-01 | 2018-06-07 | Koninklijke Philips N.V. | Risk scores based on human phosphodiesterase 4d variant 7 expression |
WO2018208985A2 (en) | 2017-05-10 | 2018-11-15 | Forge Therapeutics, Inc. | Antibacterial compounds |
GB201805527D0 (en) | 2018-04-04 | 2018-05-16 | Mironid Ltd | Compounds and their use as pde4 activators |
WO2020061375A1 (en) | 2018-09-20 | 2020-03-26 | Forge Therapeutics, Inc. | Antibacterial compounds |
WO2021195260A1 (en) | 2020-03-25 | 2021-09-30 | Forge Therapeutics, Inc. | Lpxc inhibitor and methods of making |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5594141A (en) * | 1994-11-23 | 1997-01-14 | Neurogen Corporation | Certain aminomethyl biphenyl, aminomethyl phenyl pyridine and aminomethyl phenyl pyrimidine derivatives; novel dopamine receptor subtype selective ligands |
WO1999031062A1 (en) * | 1997-12-17 | 1999-06-24 | Shionogi & Co., Ltd. | Novel pyridine compounds |
EP1227086A1 (en) * | 1999-10-22 | 2002-07-31 | Takeda Chemical Industries, Ltd. | 1-substituted phenyl-1-(1h-imidazol-4-yl) alcohols, process for producing the same and use thereof |
WO2004093799A2 (en) * | 2003-04-18 | 2004-11-04 | Bristol-Myers Squibb Company | Thyroid receptor ligands |
WO2006056854A1 (en) * | 2004-11-23 | 2006-06-01 | Pfizer Products Inc. | Dibenzyl amine compounds and derivatives |
US20070254913A1 (en) * | 2006-04-19 | 2007-11-01 | Dunn Robert F | Phosphodiesterase 4 inhibitors |
WO2009067600A2 (en) * | 2007-11-21 | 2009-05-28 | Decode Genetics Ehf | Biaryl pde4 inhibitors for treating inflammation |
WO2009067621A1 (en) * | 2007-11-21 | 2009-05-28 | Decode Genetics Ehf | Biaryl pde4 inhibitors for treating pulmonary and cardiovascular disorders |
-
2009
- 2009-11-19 WO PCT/US2009/065164 patent/WO2010059838A2/en active Application Filing
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5594141A (en) * | 1994-11-23 | 1997-01-14 | Neurogen Corporation | Certain aminomethyl biphenyl, aminomethyl phenyl pyridine and aminomethyl phenyl pyrimidine derivatives; novel dopamine receptor subtype selective ligands |
WO1999031062A1 (en) * | 1997-12-17 | 1999-06-24 | Shionogi & Co., Ltd. | Novel pyridine compounds |
EP1227086A1 (en) * | 1999-10-22 | 2002-07-31 | Takeda Chemical Industries, Ltd. | 1-substituted phenyl-1-(1h-imidazol-4-yl) alcohols, process for producing the same and use thereof |
WO2004093799A2 (en) * | 2003-04-18 | 2004-11-04 | Bristol-Myers Squibb Company | Thyroid receptor ligands |
WO2006056854A1 (en) * | 2004-11-23 | 2006-06-01 | Pfizer Products Inc. | Dibenzyl amine compounds and derivatives |
US20070254913A1 (en) * | 2006-04-19 | 2007-11-01 | Dunn Robert F | Phosphodiesterase 4 inhibitors |
WO2009067600A2 (en) * | 2007-11-21 | 2009-05-28 | Decode Genetics Ehf | Biaryl pde4 inhibitors for treating inflammation |
WO2009067621A1 (en) * | 2007-11-21 | 2009-05-28 | Decode Genetics Ehf | Biaryl pde4 inhibitors for treating pulmonary and cardiovascular disorders |
Non-Patent Citations (5)
Title |
---|
J. N. HAMBLIN ET. AL.: "Pyrazolopyridines as a novel structural class of potent and selective PDE4 inhibitors.", BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 18, 17 May 2008 (2008-05-17), pages 4237 - 4241, XP002574821, ISSN: 0960-894X * |
NG. PH BUU-HOI ET. AL.: "The Pfitzinger Reaction with Ketones Derived from o-Hydroxydiphenyl.", JOURNAL OF ORGANIC CHEMISTRY, vol. 21, no. 1, 1 January 1956 (1956-01-01), pages 136 - 138, XP002517829 * |
R. FUSCO ET. AL.: "Rearrangement of Arylhydrazones of aromatic and Arylaliphatic Carbonyl Compounds to Biphenyl Derivatives.", JOURNAL OF ORGANIC CHEMISTRY, vol. 46, no. 1, 1 January 1981 (1981-01-01), pages 83 - 89, XP002517830, ISSN: 0022-3263 * |
S. YOGI ET. AL.: "Synthesis of Imido-Substituted 3,8-Diphenyl-1,2-diazacycloocta-2,4,6,8-tetraenes and Their Thermolysis.", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, vol. 60, 1 February 1987 (1987-02-01), pages 731 - 735, XP002517828 * |
S.A. BABU ET. AL.: "In(III) Mediated Chemoselective Dehydrogenase Interaction of ClMe2SiH with Carboxylic Acids: Direct Chemo- and Regioselective Friedel-Crafts Acylation of Aromatic Ethers.", ORGANIC LETTERS, vol. 9, no. 3, 12 January 2007 (2007-01-12), pages 405 - 408, XP002517831 * |
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