WO2014137249A3 - Method for producing a vaccine against foot-and-mouth disease - Google Patents

Method for producing a vaccine against foot-and-mouth disease Download PDF

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Publication number
WO2014137249A3
WO2014137249A3 PCT/RU2014/000151 RU2014000151W WO2014137249A3 WO 2014137249 A3 WO2014137249 A3 WO 2014137249A3 RU 2014000151 W RU2014000151 W RU 2014000151W WO 2014137249 A3 WO2014137249 A3 WO 2014137249A3
Authority
WO
WIPO (PCT)
Prior art keywords
virus
dihydrochloride
vaccine against
mouth disease
against foot
Prior art date
Application number
PCT/RU2014/000151
Other languages
French (fr)
Russian (ru)
Other versions
WO2014137249A2 (en
Inventor
Анатолий Яковлевич САМУЙЛЕНКО
Владимир Иванович ЕРЕМЕЦ
Николай Иванович ЗЕНОВ
Ирина Юрьевна ЛИТЕНКОВА
Николай Васильевич МЕЛЬНИК
Сергей Николаевич КРАСУТКИН
Ольга Филипповна СОРОКИНА
Евгений Витальевич МАСЛОВ
Павел Игоревич КАЛИНИН
Original Assignee
Федеральное Казенное Предприятие "Щелковский Биокомбинат"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Федеральное Казенное Предприятие "Щелковский Биокомбинат" filed Critical Федеральное Казенное Предприятие "Щелковский Биокомбинат"
Publication of WO2014137249A2 publication Critical patent/WO2014137249A2/en
Publication of WO2014137249A3 publication Critical patent/WO2014137249A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32111—Aphthovirus, e.g. footandmouth disease virus
    • C12N2770/32134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Abstract

The invention relates to the field of veterinary virology and biotechnology and can be used for preparing a vaccine against foot-and-mouth disease. In order to increase the purification level of a virus-containing suspension from inactive impurities and to increase the immunogenicity of the desired product in the method for producing the vaccine against foot-and-mouth disease comprising cultivating a viral antigen in a suspension of BHK-21 cell culture at a temperature of 36-37°C, purifying the virus-containing suspension from inactive impurities, inactivating the antigen to the foot-and-mouth virus obtained by concentration, and combining the antigen concentrate with an adjuvant, according to the invention, the purification of the virus-containing suspension from inactive impurities is performed by the addition of polyguanidine derivatives in a final concentration of 0.005-0.01% or of a mixture of chloroform and polyguanidine derivatives in a weight ratios of (40-160):1, respectively, in a final concentration of 0.4-0.8, wherein 1-12-di(guanidine)hexane dihydrochloride, or bis(3-guanidino-propyl)piperazine dihydrochloride, or 3,6-dioxaoctane-1,8-diguanidine dihydrochloride, or 4,9-dioxadodecane-1,2-dibiguanide dihydrochloride is used as the polyguanidine derivatives.
PCT/RU2014/000151 2013-03-06 2014-03-06 Method for producing a vaccine against foot-and-mouth disease WO2014137249A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2013109994 2013-03-06
RU2013109994/15A RU2522868C1 (en) 2013-03-06 2013-03-06 Method of production of vaccine against foot-and-mouth disease

Publications (2)

Publication Number Publication Date
WO2014137249A2 WO2014137249A2 (en) 2014-09-12
WO2014137249A3 true WO2014137249A3 (en) 2015-03-05

Family

ID=51217519

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/RU2014/000151 WO2014137249A2 (en) 2013-03-06 2014-03-06 Method for producing a vaccine against foot-and-mouth disease

Country Status (2)

Country Link
RU (1) RU2522868C1 (en)
WO (1) WO2014137249A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2619878C1 (en) * 2016-10-14 2017-05-18 Федеральное государственное бюджетное учреждение "Федеральный центр охраны здоровья животных" (ФГБУ "ВНИИЗЖ") Method for foot and mouth disease virus 146s-component concentration determination in virus-containing raw material for vaccine using reverse transcription-polymerase chain reaction method in real time mode

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2498814A (en) * 1943-11-02 1950-02-28 Gen Motors Corp Battery charging system
RU2054039C1 (en) * 1992-02-07 1996-02-10 Всероссийский научно-исследовательский институт защиты животных Method of purification and sterilization of cultured foot-and-mouth virus
RU2230734C1 (en) * 2003-06-09 2004-06-20 Общество с ограниченной ответственностью "Международный институт эколого-технологических проблем" Derivatives of polyguanidines
US7531182B2 (en) * 2000-06-29 2009-05-12 Merial Limited Vaccine against foot-and-mouth disease

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106987595B (en) * 2009-11-02 2021-07-06 宾夕法尼亚大学托管会 Foot and Mouth Disease Virus (FMDV) consensus proteins, their coding sequences and vaccines prepared therefrom

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2498814A (en) * 1943-11-02 1950-02-28 Gen Motors Corp Battery charging system
RU2054039C1 (en) * 1992-02-07 1996-02-10 Всероссийский научно-исследовательский институт защиты животных Method of purification and sterilization of cultured foot-and-mouth virus
US7531182B2 (en) * 2000-06-29 2009-05-12 Merial Limited Vaccine against foot-and-mouth disease
RU2230734C1 (en) * 2003-06-09 2004-06-20 Общество с ограниченной ответственностью "Международный институт эколого-технологических проблем" Derivatives of polyguanidines

Also Published As

Publication number Publication date
WO2014137249A2 (en) 2014-09-12
RU2522868C1 (en) 2014-07-20

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