Objective To investigate whether the presence of kidney stones increase the risk of end
stage renal disease (ESRD) or other adverse renal outcomes. Design A registry cohort study …

A dithymidine dinucleotide (V) has been synthesised by condensing 3’-O-acetylthymidine
with thymidine 3’-(benzyl phosphorochloridate) 5’-(dibenzyl phosphate) and subsequently …

Calcium (Ca 2+ ) and phosphate (P i ) are essential to many vital physiological processes.
Consequently the maintenance of Ca 2+ and P i homeostasis is essential to a healthy …

Recent identification of a mutation in the EGF gene that causes isolated recessive hypomagnesemia
led to the finding that EGF increases the activity of the epithelial magnesium (Mg 2+…

The past decade has witnessed multiple advances in our understanding of magnesium (Mg
2+) homeostasis. The discovery that mutations in claudin-16/paracellin-1 or claudin-19 are …

Acute kidney injury (AKI) is a common consequence of perinatal asphyxia, occurring in up
to 56% of these infants. A major difficulty in diagnosing this condition is the lack of a …

The SLC9 gene family encodes Na + /H + exchangers (NHEs). These transmembrane
proteins transport ions across lipid bilayers in a diverse array of species from prokaryotes to …

Results In total, 25,532 (0.8%) participants had at least one kidney stone, and 91,465 (3%)
individuals had at least one cardiovascular event during follow-up. Compared with people …

Kidney stones are a prevalent clinical condition imposing a large economic burden on the
healthcare system. Hypercalciuria remains the major risk factor for development of a Ca 2+ -…

Disturbed calcium (Ca 2+) homeostasis, which is implicit to the aging phenotype of klotho-deficient
mice, has been attributed to altered vitamin D metabolism, but alternative possibilities …