An investigation leading to a pool of blood leads to the discovery that their latest victim was retrieved by a cryogenics company.
- Artistic License – Law: Part of the problem with the case involves Lester’s body being removed from the scene. Weiss's cryonics company technically violated the law by moving the body in the first place, and could be charged with a crime under New York's Penal Code § 195.05 "Obstructing governmental administration in the second degree." As such, the legal wrangling in the episode to get the body would never have been necessary.
- Cyanide Pill: Ultimately Lester’s wife Cynthia takes one while in protective custody so that she can join her husband in death/cryogenic suspension.
- Losing Your Head: People essentially treat Lester Hamilton’s head as “alive” in the sense that he could be revived in future so long as the head is preserved in cold storage.
- Mercy Kill: Ultimately Lester’s wife Cynthia basically argues that she did this by having her husband killed before he could submit the paperwork withdrawing him from the cryogenic freezing. If Lester let the tumor kill him he would be in no state to be revived after being cryogenically frozen, but killing him now allowed him to be preserved for the future, and his wife believed that he only wanted to withdraw from the procedure because the tumor was compromising his ability to think rationally.
- Off with His Head!: As a compromise with the NYPD, Weiss agrees to let the police study Lester’s body once his staff have removed his head, reasoning that cryogenics is about preserving the brain and by the time technology has advanced to allow Lester to be revived they will be able to clone him a new body.
- Professor Guinea Pig: It’s ultimately revealed that Lester volunteered to be this to his friend Doctor Philip Boyd, as Doctor Boyd was working on a new treatment for targeting tumors and Lester knew that his current condition would be untreatable by existing medical procedures.
- Who Wants to Live Forever?: Talking with Castle about the idea of living forever, Kate observes that she personally wouldn’t be interested in that kind of life as extended life creates the risk of wasting it.
