From the same production team that conceived "Two and a Half Men" comes "Four Fully Formed Nerds." Actually, the series is called "The Big Bang Theory" and it exploded onto CBS with a big bang! A ratings blockbuster, the sitcom chronicles the professional, personal and romantic misadventures of a quartet of scientists who are co-workers at Caltech and fast friends. Sheldon (Jim Parsons) is a persnickety, self-aggrandizing brainiac who rooms with the equally smart, but reserved Leonard (Johnny Galecki). Their other best buds are loquacious Lothario-wannabe Howard (Simon Helberg) and girl-shy, lovelorn Rajeesh (Kunai Nayyar). As hyper-intelligent as they are, they initially just can't seem to make the grade, either socially or romantically. Across the hall from Sheldon and Leonard, dishy, aspiring-actress Penny (Kaley Cuoco) moved in and captivated Leonard, who used what few moves he had to woo and win the pretty Penny. And through several seasons, they experienced an on-again, off-again relationship---mostly on. As the series rolled on, Sheldon discovered a mate in gawky neurobiologist Amy Farrah Fowler (Mayim Bialik), while Howard courted and married adorable microbiologist Bernadette Rostenkowski (Melissa Rauch), and Raj continued to search for someone with whom he could generate some romantic chemistry. The nerd-com was also positively charged with cameos by a number of cultural icons, including renowned physicist Stephen Hawking, comic-book whiz Stan Lee, astronaut Buzz Aldrin, computer guru Steve Wozniak and "Star Trek" star George Takei. The Big Bang Theory premiered on September 24, 2007.