The episode began in an unusual way for The 4400, with narration given from a brand new character. That character was the title character, Audrey (Constance Towers), an elderly woman suffering from many healthy ailments, including arthritis. Audrey however had taken the promicin shot and it's given her a very specific gift; astral projection. She can send an invisible and intangible ghost-like vision of herself out into the world to watch and observe anything she sees fit to. On top of that, this astral version of Audrey is not how she is now, but how she once was; a beautiful, sexy woman who broke a lot of hearts in the 1950's.
Having Audrey die while her astral projection was outside her body was a very clever device - it both turned the episode into a murder mystery and also added an extra layer to the supernatural strangeness of what Audrey was doing, as she saw herself dead, and now realized there was no going back into her body. Audrey was a very strong single-episode character, given a lot of strength and dignity by Towers, that was reflected in Laura Mennell, as the younger and appropriately swoon-worthy astral projection of Audrey.
Okay, the murder mystery wasn't the most complex ever; once it was clear it wasn't the criminal Audrey had threatened with her knowledge of his past, it was a pretty sure bet it was going to be the son of Audrey's nurse, simply because the boy had little reason to be in the episode otherwise. But it didn't stop it from being an involving story about a woman solving her own death, as she is able to send messages to Tom and Diana through the white noise in their electronic devices. Audrey's story came to a close in every way possible at the end, as she faded away into nothingness after telling Diana who the killer was, but it's a testament to how well she worked that we wouldn't mind seeing her pop up again somehow.
Meanwhile, Shawn decided to reopen The 4400 center and resume healing people despite the government's insistence that no 4400 use their power without their express permission. I have to be honest, if we'd heard that was the official law before, I'd forgotten, but it definitely adds to the tension on the series, as questions are raised about government control and what the harm could be in a power as beneficial as Shawn's. It was also good to so quickly get payoff on Meghan's sick father, as with Tom's help, she has Shawn heal him. Ultimately, the government allows the center to stay open, setting the stage for Shawn to perhaps amass new followers that might be on his side rather than Jordan's.
As for Kyle, he was still learning to deal with the fact that his 4400 ability is apparently one that has given him an informative invisible friend, Cassie, who continues to have a lot to say about what's in store for both Kyle and Jordan. This storyline was on the backburner for most of the episode, but had an exciting conclusion, as Cassie told Kyle to go to a random intersection one night, saying something important would happen. And indeed it did, as a car accident caused a prison vehicle to get sideswiped allowing the person inside to make her escape. That prisoner was of course Isabelle, which certainly changes things, as she and Kyle seem to have been paired together for an as yet unknown reason. Considering Kyle is Jordan's "Shaman" according to Cassie, I'm guessing Kyle, Isabelle and Jordan will all be in close proximity soon, which sounds like quite an interesting trio.