Episode 1
Aired Sep 25, 2005
Raindrops Keep Falling on My Head
As Meredith and Cristina discuss their relationship woes at the Emerald City Bar, the bartender collapses.
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Episode 2
Aired Oct 2, 2005
Enough Is Enough (No More Tears)
When a family arrives at Seattle Grace Hospital after a serious car accident, Alex learns that their injuries are only the beginning of their problems.
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Episode 3
Aired Oct 9, 2005
Make Me Lose Control
Some family secrets become public when Meredith's mother, who has Alzheimer's disease, is brought to Seattle Grace for surgery; frightening news about Cristina's health comes into the open.
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Episode 4
Aired Oct 16, 2005
Deny, Deny, Deny
Cristina proves to be a difficult patient as she continues to recover; Meredith's mother keeps the hospital staff running in circles; Dr. Shepherd's involvement in the case of a cystic fibrosis patient could delay her departure.
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Episode 5
Aired Oct 23, 2005
Bring the Pain
Meredith and Dr. Shepherd have to use more than medicine when a young woman's traditionalist, religious father forbids her to have a life-saving operation.
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Episode 6
Aired Oct 30, 2005
Into You Like a Train
A train crash brings several seriously injured patients to the hospital, providing a distraction for Meredith as she awaits Derek's final decision.
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Episode 7
Aired Nov 6, 2005
Something to Talk About
A male patient who seems to have a hysterical pregnancy fascinates the staff.
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Episode 8
Aired Nov 13, 2005
Let It Be
Derek and Addison's close friends come to Seattle Grace seeking radical surgery to avoid breast and ovarian cancer.
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Episode 9
Aired Nov 20, 2005
Thanks for the Memories
The Thanksgiving holiday is more difficult for the interns and residents than any of them is willing to admit.
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Episode 10
Aired Nov 27, 2005
Much Too Much
A man comes to the hospital with priapism, and Meredith awkwardly realizes that he is her one-night stand.
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Episode 11
Aired Dec 4, 2005
Owner of a Lonely Heart
Cristina Yang has little sympathy for an inmate (Rosanna Arquette), who jeopardizes her health to get out of solitary confinement.
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Episode 12
Aired Dec 11, 2005
Grandma Got Run Over by a Reindeer
Burke and Yang disagree on how to treat a young boy who does not seem to want a needed heart-transplant.
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Episode 13
Aired Jan 15, 2006
Begin the Begin
Izzie cannot ignore the chemistry she shares with a patient awaiting a heart transplant; George treats Bex, a teenage hermaphrodite.
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Episode 14
Aired Jan 22, 2006
Tell Me Sweet Little Lies
Meredith and Cristina lie to each other about their relationships; George must discharge an elderly patient who is no longer sick but refuses to leave the hospital.
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Episode 15
Aired Jan 29, 2006
Break on Through
The nurses at Seattle Grace Hospital go on strike, leaving the doctors to fend for themselves; an elderly patient's friends (June Lockhart, Betty Garrett and Rae Allen) bring Meredith's mistake to light.
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Episode 16
Aired Feb 5, 2006
It's the End of the World
Meredith's premonition of having a bad day is realized when a medical case arrives threatening the lives of everyone in the OR.
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Episode 17
Aired Feb 5, 2006
As We Know It
Despite the best efforts of the Seattle Grace staff, the code-black situation escalates.
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Episode 18
Aired Feb 19, 2006
Yesterday
Someone from Derek and Addison's past arrives in Seattle; Burke learns Christina's secret; Meredith looks into her family's dirty laundry after a visit with her mother.
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Episode 19
Aired Feb 26, 2006
What Have I Done to Deserve This?
Meredith and George suddenly find themselves at odds at work; Bailey, although technically still on maternity leave, finds herself treating Addison for an unusual feminine issue.
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Episode 20
Aired Mar 12, 2006
Band-Aid Covers the Bullet Hole
It becomes a bad day for Christina when Bailey instructs her to take care of her baby; Derek and Addison come to terms with their relationship.
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Episode 21
Aired Mar 19, 2006
Superstition
When a series of deaths occurs at Seattle Grace, the uncanny events bring out the doctors' superstitious sides and make Izzie nervous about Denny's surgery.
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Episode 22
Aired Apr 2, 2006
The Name of the Game
George begins to overstay his welcome; Meredith learns a secret about her father; Bailey gets back into a surgery room; Alex gets a lesson in bedside manners.
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Episode 23
Aired Apr 30, 2006
Blues for Sister Someone
Izzie grills George about the personal details of his life; Addison takes Alex to task about a sensitive case, and Burke treats his musical hero.
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Episode 24
Aired May 7, 2006
Damage Case
The interns care for a family involved in a car accident; Derek lets his emotions get the better of him; Burke and Izzie have a new suggestion for Denny.
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Episode 25
Aired May 14, 2006
17 Seconds
Finn offers a health update on Doc; Meredith must work with Callie for a day; George works with Derek; Burke and Izzie continue to search for a new heart for Denny.
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Episode 26
Aired May 15, 2006
Deterioration of the Fight or Flight Response
Pressure to find a new heart for Denny increases; Callie confronts George about his feelings for her.
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Episode 27
Aired May 15, 2006
Losing My Religion
Pressure to find a new heart for Denny increases; Callie confronts George about his feelings for her.
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